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38 条记录 (耗时 0.043 秒)

    Aminoindazole derivatives active as kinase inhibitors
    24.
    发明授权
    Aminoindazole derivatives active as kinase inhibitors 有权
    作为激酶抑制剂活性的氨基吲唑衍生物

    公开(公告)号：US07511136B2

    公开(公告)日：2009-03-31

    申请号：US10490189

    申请日：2002-09-19

    申请人： Raffaella Amici ,  Matteo D'Anello ,  Katia Martina ,  Barbara Salom ,  Anna Vulpetti

    发明人： Raffaella Amici ,  Matteo D'Anello ,  Katia Martina ,  Barbara Salom ,  Anna Vulpetti

    IPC分类号： C07D413/00 ,  C07D231/00

    CPC分类号： C07D231/56 ,  C07D403/04 ,  C07D403/12

    摘要： Compounds which are 3-aminoindazole derivatives or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.

    摘要翻译： 公开了3-氨基吲唑衍生物或其药学上可接受的盐以及包含它们的药物组合物的化合物; 这些化合物或组合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。

    Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
    26.
    发明申请
    Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them 审中-公开
    作为激酶抑制剂活性的双环吡唑，其制备方法和包含它们的药物组合物

    公开(公告)号：US20060135508A1

    公开(公告)日：2006-06-22

    申请号：US10522253

    申请日：2003-07-16

    申请人： Manuela Villa ,  Francesca Abrate ,  Daniele Fancelli ,  Mario Varasi ,  Anna Vulpetti

    发明人： Manuela Villa ,  Francesca Abrate ,  Daniele Fancelli ,  Mario Varasi ,  Anna Vulpetti

    IPC分类号： A61K31/55 ,  A61K31/4745 ,  C07D487/02 ,  C07D471/02

    CPC分类号： C07D487/04 ,  A61K31/415 ,  A61K45/06 ,  C07D471/04 ,  A61K2300/00

    摘要： The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a pyrrolo-pyrazole or pyrazolo-azepine. The invention also provides specific pyrrolo-pyrazoles and pyrazolo-azepines, useful intermediates, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.

    摘要翻译： 本发明提供了治疗由变化的蛋白激酶活性引起和/或与其相关的疾病的方法，其包括向有需要的哺乳动物施用有效量的吡咯并吡唑或吡唑并氮。 本发明还提供特定的吡咯并吡唑和吡唑并氮杂，有用的中间体，包含其中至少两个的文库，其制备方法和含有它们的药物组合物，其可用于治疗由和/或 与改变的蛋白激酶活性如癌症，细胞增殖性病症，病毒感染，自身免疫疾病和神经变性疾病有关。

    Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
    27.
    发明申请
    Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them 审中-公开
    作为激酶抑制剂活性的双环吡唑，其制备方法和包含它们的药物组合物

    公开(公告)号：US20060100233A1

    公开(公告)日：2006-05-11

    申请号：US10522254

    申请日：2003-07-01

    申请人： Manuela Villa ,  Francesca Abrate ,  Daniele Fancelli ,  Mario Varasi ,  Anna Vulpetti

    发明人： Manuela Villa ,  Francesca Abrate ,  Daniele Fancelli ,  Mario Varasi ,  Anna Vulpetti

    IPC分类号： A61K31/4745 ,  C07D471/02

    CPC分类号： C07D471/04

    摘要： The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a pyrazole-tetrahydro pyridine derivative. The invention also provides specific pyrazole-tetrahydro pyridines, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.

    摘要翻译： 本发明提供了治疗由变化的蛋白激酶活性引起和/或与其相关的疾病的方法，其包括向有需要的哺乳动物施用有效量的吡唑 - 四氢吡啶衍生物。 本发明还提供特异性的吡唑 - 四氢吡啶，其中包含其中至少两个的文库，其制备方法和含有它们的药物组合物，其可用于治疗由改变的蛋白激酶引起的和/或与其相关的疾病 活动如癌症，细胞增殖性疾病，病毒感染，自身免疫性疾病和神经变性疾病。

    Novel Amino Pyrimidine Derivatives
    29.
    发明申请
    Novel Amino Pyrimidine Derivatives 审中-公开
    新型氨基嘧啶衍生物

    公开(公告)号：US20160235746A1

    公开(公告)日：2016-08-18

    申请号：US15135296

    申请日：2016-04-21

    申请人： Daniela Angst ,  François Gessier ,  Anna Vulpetti

    发明人： Daniela Angst ,  François Gessier ,  Anna Vulpetti

    IPC分类号： A61K31/506 ,  A61K31/505

    CPC分类号： C07D239/47 ,  A61K31/505 ,  A61K31/506 ,  A61P29/00 ,  A61P35/02 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12

    摘要： The present invention describes new amino pyrimidine derivatives and pharmaceutically acceptable salts thereof which appear to interact with Bruton's tyrosine kinase (Btk). Accordingly, the novel amino pyrimidines may be effective in the treatment of autoimmune disorders, inflammatory diseases, allergic diseases, airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), transplant rejection, cancers e.g. of hematopoietic origin or solid tumors.

    摘要翻译： 本发明描述了与Bruton酪氨酸激酶（Btk）相互作用的新的氨基嘧啶衍生物及其药学上可接受的盐。 因此，新的氨基嘧啶可能有效治疗自身免疫性疾病，炎性疾病，过敏性疾病，气道疾病如哮喘和慢性阻塞性肺疾病（COPD），移植排斥反应，癌症。 的造血起源或实体瘤。