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21.发明授权Method and system for 3-D acoustic microscopy using short pulse excitation and 3-D acoustic microscope for use therein 失效使用短脉冲激发和三维声学显微镜的三维声学显微镜的使用方法和系统
公开(公告)号：US5615675A
公开(公告)日：1997-04-01
申请号：US635361
申请日：1996-04-19
CPC分类号： G01N29/069 , G01N29/0681 , G01N29/2418 , G01S15/8965 , G01N2291/02475 , G01N2291/0421
摘要： A method and system are provided for 3-D acoustic microscopy using short pulse laser excitation. A 3-D acoustic microscope for use in such a system is also provided. In a first embodiment, wherein optical detection is utilized, a focused excitation beam is scanned by a first acoustooptic scanning device across an absorbing layer of an opto-acoustic transducer (if needed) coupled to an object under investigation to create spherical ultrasonic waves within the object which may be living tissue. The reflected spherical ultrasonic waves are detected through the use of an unfocused probe beam and an optical detector array or a focused probe beam and a single photodetector which receive the probe beam from a reflecting surface of the opto-acoustic transducer. A second acoustooptic scanning device scans the probe beam at a plurality of positions on the reflecting surface of the opto-acoustic transducer. In another embodiment, an ultrasound transducer is utilized to acoustically detect the reflected spherical ultrasonic waves. Signals from the optical detector array, the photodetector, or the ultrasound transducer are subsequently digitized and reconstructed via 3-D synthetic aperture beam-forming equations to generate a 3-D representation of the object. Then the 3-D representation of the image is displayed as an image. The microscope includes the first and second acoustooptic scanning devices and the opto-acoustic transducer housed in a housing to define a needle probe such as a conventional biopsy needle.
摘要翻译： 提供了使用短脉冲激光激发的三维声学显微镜的方法和系统。 还提供了一种用于这种系统的3-D声学显微镜。 在其中使用光学检测的第一实施例中，聚焦的激发光束被第一声光扫描装置扫过耦合到被研究对象的光声换能器的吸收层（如果需要的话），以在其内产生球形超声波 可能是活体组织的物体。 通过使用未聚焦的探针光束和光学检测器阵列或聚焦探针光束以及从光声换能器的反射表面接收探测光束的单个光电检测器来检测反射的球形超声波。 第二声光扫描装置在光声换能器的反射表面上的多个位置扫描探测光束。 在另一个实施例中，使用超声换能器来声学地检测反射的球面超声波。 随后，通过3D合成孔径波束形成方程将来自光学检测器阵列，光电探测器或超声波换能器的信号数字化并重建，以产生物体的3-D表示。 然后，图像的3-D表示显示为图像。 显微镜包括第一和第二声光扫描装置和容纳在壳体中的光声换能器，以限定诸如常规活检针的针探针。
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公开(公告)号：US5235982A
公开(公告)日：1993-08-17
申请号：US767460
申请日：1991-09-30
申请人： Matthew O'Donnell
发明人： Matthew O'Donnell
IPC分类号： G10K11/34
CPC分类号： G10K11/345
摘要： A phased array sector scanning (PASS) ultrasonic imaging system produces a fixed focus, steered transmit beam with an array of transducer elements. A receiver forms the echo signals received from an ultrasonic energy reflecting object at the array elements into a receive beam steered in the same direction as the transmit beam and dynamically focused. A midprocessor in the receiver makes corrections to the receive beam samples to offset errors caused by the transmit beam being out of focus at all but its fixed focal range.
摘要翻译： 相控阵扫描（PASS）超声波成像系统产生一个固定焦距的转向发射光束与一组换能器元件。 接收器形成从阵列元件处的超声波能量反射物体接收的回波信号转换成与发射波束相同的方向并被动态聚焦的接收波束。 接收机中的中间处理器对接收波束样本进行校正，以抵消由发射波束所有焦点失真造成的误差，但其固定焦距范围。
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23.发明授权
公开(公告)号：US5203335A
公开(公告)日：1993-04-20
申请号：US844031
申请日：1992-03-02
CPC分类号： G10K11/346 , G01N29/0645 , G01S15/8909 , G01S7/52028
摘要： A beam former in a PASS ultrasonic imaging system includes a set of sigma-delta modulators which operate to separately digitize the received echo signal from each transducer element. The oversampled one-bit digital representations of each echo signal are delayed as required for beam steering and focusing, and are summed together. A decimator filter reduces the sample rate of the digitized receive beam prior to display of the image resulting from the receive beam.
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公开(公告)号：US5121364A
公开(公告)日：1992-06-09
申请号：US741874
申请日：1991-08-07
申请人： Matthew O'Donnell
发明人： Matthew O'Donnell
IPC分类号： G01S7/52
CPC分类号： G01S7/52046 , G01S7/52033 , Y10S367/90
摘要： A phased array sector scanning ultrasonic imaging system produces digitized baseband samples of the received ultrasonic echo signals amplified by a time gain control (TGC) to compensate for dispersion losses in the media in which the ultrasonic signals propagate. A time frequency control filter employs the same TGC control signal to calculate a phase shift correction as well as the coefficients which determine the characteristics of a bandpass filter such that the frequency dependent dispersion losses in the ultrasonic echo signals are compensated.
摘要翻译： 相控阵扫描超声成像系统产生通过时间增益控制（TGC）放大的接收的超声波回波信号的数字化基带样本，以补偿超声信号传播的介质中的色散损失。 时间频率控制滤波器采用相同的TGC控制信号来计算相移校正以及确定带通滤波器的特性的系数，使得超声回波信号中的频率相关色散损耗得到补偿。
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25.发明授权Method and apparatus for high speed digital phased array coherent imaging system 失效高速数字相控阵相干成像系统的方法与装置
公开(公告)号：US4839652A
公开(公告)日：1989-06-13
申请号：US56177
申请日：1987-06-01
申请人： Matthew O'Donnell , William E. Engeler , Thomas L. Vogelsong , Steven G. Karr , Sharbel E. Noujaim
发明人： Matthew O'Donnell , William E. Engeler , Thomas L. Vogelsong , Steven G. Karr , Sharbel E. Noujaim
CPC分类号： H03H17/0664 , G01S15/8918 , G01S7/52034 , G01S7/52046 , G10K11/346 , H03H2218/04
摘要： A method for generating an output stream of digital data words, with each data word representing the amplitude of an analog signal at one of a multiplicity F samples each second and with substantially equally spaced time intervals T therebetween, is obtained from a digital baseband demodulation system used for array beam forming. A data stream, formed of interleaved ADC output digital data words acquired from a set of converters, is at a rate of F total samples/second. Subsequent digital demodulation, filtration, and decimation provides digital output signals which need less delay resolution prior to the formation of coherent sum signals, thereby reducing overall channel memory requirements. The output baseband data stream has enhanced dynamic range, thereby reducing the ADC bit density requirements.
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公开(公告)号：US4609872A
公开(公告)日：1986-09-02
申请号：US639567
申请日：1984-08-10
申请人： Matthew O'Donnell
发明人： Matthew O'Donnell
IPC分类号： G01P13/00 , A61B5/02 , A61B5/0265 , A61B5/055 , A61B10/00 , G01F1/716 , G01R33/48 , G01R33/563 , G01R33/20
CPC分类号： G01R33/56308 , G01R33/56316
摘要： A method for magnetic resonance imaging of fluid flow, and particularly in vivo blood flow, uses multiple-echo phase-contrast sequences of signals both in the magnetic field gradient in the direction in which fluid flow is to be determined, and in the radio-frequency (RF) magnetic field utilized with the magnetic field gradient. The magnetic field gradient has a pair of phase-encoding pulses having a zero mean value effect upon the sample, either alone or with inversion by an intermediate 180.degree. RF pulse signal. A first multi-echo sequence, provided with the phase-encoding pulse pair, provides information of both the amplitude and phase-shift of each pixel of the imaged flowing material while a second multiple echo sequence, devoid of the phase-encoding-gradient pulses, provides information as to the amplitude and the undesired initial phase-shift of each pixel of both stationary and flowing material. Information provided responsive to the second sequence is subtracted from the information provided responsive to the first sequence to provide an image having an intermediate grey-scale value for stationary sample material and with differential grey-scale encoding for differential flow velocities of fluid passing through the image plane.
摘要翻译： 用于流体流动，特别是体内血流的磁共振成像的方法使用在要确定流体流动的方向上的磁场梯度中的信号的多重回波相位对比序列， 频率（RF）磁场与磁场梯度一起使用。 磁场梯度具有一对相位编码脉冲，对于采样单独或由中间180°RF脉冲信号反转，均具有零平均值效应。 提供有相位编码脉冲对的第一多回波序列提供成像流体的每个像素的幅度和相移的信息，而没有相位编码梯度脉冲的第二多回波序列 提供关于固定和流动材料的每个像素的幅度和不期望的初始相移的信息。 从响应于第一序列提供的信息中减去提供的响应于第二序列的信息，以提供具有用于静止样品材料的中间灰度值的图像，以及用于通过图像的流体的差分流速的差分灰度编码 飞机
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公开(公告)号：US09198842B2
公开(公告)日：2015-12-01
申请号：US13381392
申请日：2010-06-30
申请人： Matthew O'Donnell
IPC分类号： A61K33/08 , A61K33/16 , A61K33/42 , A61K8/19 , A61K8/25 , A61K8/27 , A61Q11/00 , A61L27/10 , C03C3/062 , C03C3/097 , C03C3/112 , C03C4/00 , C03C12/00 , A61K8/02 , A61K8/21 , A61K8/24
CPC分类号： A61K8/25 , A61K8/022 , A61K8/19 , A61K8/21 , A61K8/24 , A61K8/27 , A61K33/08 , A61K33/16 , A61L27/10 , A61L2430/12 , A61Q11/00 , C03C3/062 , C03C3/097 , C03C3/112 , C03C4/0007 , C03C4/0021 , C03C4/0035 , C03C12/00
摘要： The present invention relates to multicomponent glasses and their use in powdered form as an additive in personal care products such as toothpastes.
摘要翻译： 本发明涉及多组分玻璃及其在粉末形式中作为个人护理产品如牙膏中的添加剂的用途。
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公开(公告)号：US08057390B2
公开(公告)日：2011-11-15
申请号：US12019225
申请日：2008-01-24
CPC分类号： A61B5/0093 , A61B5/04 , A61B5/05 , A61B5/4064 , A61B5/4094
摘要： A current source density mapping system includes an ultrasound transducer emitting an ultrasound wave traveling along an ultrasound beam directed at a mapping field in a region of living tissue and an ultrasound pulser delivering a transmit pulse to said ultrasound transducer. The system includes a timing device producing controlled excitation of the transmit pulse; a plurality of recording electrodes positioned in contact with the living tissue detecting an acoustoelectric voltage signal generated at a bioelectric current source and within a focal zone of said ultrasound beam. An amplifier operatively connected to the recording electrodes amplifying the acoustoelectric voltage signal at a predetermined gain; and an analyzing component comprising a digitizer, a sampling device, a signal processor and a display unit operatively connected to the amplifier determining the location of the bioelectric current source by analyzing the acoustoelectric voltage signal detected by the recording electrodes in response to an interaction between the ultrasound wave and the presence of a current source in the mapping field.
摘要翻译： 电流源密度映射系统包括：超声波换能器，其发射沿着指向生物体组织区域中的映射场的超声波行进的超声波;以及超声脉冲发生器，其向所述超声换能器传送发射脉冲。 该系统包括产生发射脉冲的受控激励的定时装置; 多个记录电极，其与生物体组织接触，检测在生物电流源处产生的声电压信号，并且在所述超声波束的聚焦区域内。 可操作地连接到记录电极的放大器，以预定增益放大声电压信号; 以及包括数字转换器，采样装置，信号处理器和显示单元的分析部件，所述数字转换器，采样装置，信号处理器和显示单元，其可操作地连接到所述放大器，以通过分析响应于所述记录电极之间的相互作用而由所述记录电极检测的声电压信号 超声波和映射场中电流源的存在。
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公开(公告)号：US07549985B2
公开(公告)日：2009-06-23
申请号：US10603341
申请日：2003-06-25
申请人： Matthew O'Donnell
发明人： Matthew O'Donnell
CPC分类号： A61B18/26 , A61B2018/263
摘要： A method and system to create and acoustically manipulate without destroying a microbubble which, in biological applications, can manipulate structures such as cells and subcellular structures at a nanoscopic scale.
摘要翻译： 一种用于创建和声学操作而不破坏微生物的方法和系统，其在生物应用中可以以纳米尺度操纵诸如细胞和亚细胞结构的结构。
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30.发明申请公开(公告)号：US20080095490A1
公开(公告)日：2008-04-24
申请号：US11662154
申请日：2005-09-08
IPC分类号： G02B6/00
CPC分类号： G02B6/12007 , A61B5/0097 , G01H9/004 , G02B6/1221
摘要： A polymer waveguide resonator device for high-frequency ultrasound detection having a optical resonator coupled to a straight optical waveguide which serves as input and output ports. Acoustic waves irradiating the waveguide induce strain modifying the waveguide cross-section or other design property. As a consequence, the effective refractive index of optical waves propagating along the ring is modified. The sharp wavelength dependence of the high Q-factor resonator enhances the optical response to acoustic strain. High sensitivity is demonstrated experimentally in detecting broadband ultrasound pulses from a 10 MHz transducer.
摘要翻译： 一种用于高频超声检测的聚合物波导谐振器装置，其具有耦合到用作输入和输出端口的直线光波导的光谐振器。 辐射波导的声波诱导应变调整波导横截面或其他设计特性。 因此，沿着环传播的光波的有效折射率被改变。 高Q因子谐振器的尖锐波长依赖性增强了对声学应变的光学响应。 在10 MHz传感器检测宽带超声波脉冲中，实验证明了高灵敏度。
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