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公开(公告)号：US20070298037A1
公开(公告)日：2007-12-27
申请号：US11556854
申请日：2006-11-06
申请人： Brian Fox , James Holloway , Paul Sheppard , Stacey Dillon
发明人： Brian Fox , James Holloway , Paul Sheppard , Stacey Dillon
IPC分类号： A61K39/395 , A61K38/17 , A61P1/00 , A61P17/06 , A61P25/00
CPC分类号： C07K14/7151 , A61K38/1793 , A61K2039/505 , C07K16/2878 , C07K2317/71 , C07K2319/30 , C07K2319/32 , C07K2319/40
摘要： Novel tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligand, as well as agonists and antagonists. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate tumor growth, metastasis, and immunity such as separating resting from stimulated immune cells.
摘要翻译： 公开了新型肿瘤坏死因子受体（TNFR）多肽，编码多肽的多核苷酸，抗体及相关组合物和方法。 多肽可用于检测配体，以及激动剂和拮抗剂。 多肽，多核苷酸和抗体也可以用于调节肿瘤生长，转移和免疫的方法，例如从刺激的免疫细胞分离休息。
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公开(公告)号：US20070264684A1
公开(公告)日：2007-11-15
申请号：US11539061
申请日：2006-10-05
申请人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
发明人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
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公开(公告)号：US20070129538A1
公开(公告)日：2007-06-07
申请号：US11539052
申请日：2006-10-05
申请人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
发明人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
IPC分类号： C07K16/10
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
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公开(公告)号：US20070128205A1
公开(公告)日：2007-06-07
申请号：US11539078
申请日：2006-10-05
申请人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
发明人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
IPC分类号： A61K39/42
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class TI cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是TI类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
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公开(公告)号：US20050255496A1
公开(公告)日：2005-11-17
申请号：US11013247
申请日：2004-12-15
申请人： Zeren Gao , Paul Sheppard , Brian Fox , James Holloway , Stephen Jaspers
发明人： Zeren Gao , Paul Sheppard , Brian Fox , James Holloway , Stephen Jaspers
IPC分类号： C07H21/04 , C07K14/525 , C07K14/715 , C07K16/24 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/525 , A61K2039/505 , C07K14/7151 , C07K16/241 , C07K2317/34 , C07K2319/30 , C12Q1/6883 , C12Q2600/158 , G01N33/6863 , G01N2500/00
摘要： Novel tumor necrosis factor ligand polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides may be used within methods relating to immune response, and may also be used in the development of immuno-regulatory therapeutics. Also provided are antibodies, binding proteins, agonists and antagonists of the ligand polypeptides.
摘要翻译： 公开了新型肿瘤坏死因子配体多肽，编码多肽的多核苷酸，以及相关的组合物和方法。 多肽可用于与免疫应答相关的方法中，并且也可用于开发免疫调节治疗。 还提供了配体多肽的抗体，结合蛋白，激动剂和拮抗剂。
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公开(公告)号：US20050250126A1
公开(公告)日：2005-11-10
申请号：US11015546
申请日：2004-12-16
申请人： Zeren Gao , Paul Sheppard , Brian Fox , James Holloway , Stephen Jaspers , Mark Appleby
发明人： Zeren Gao , Paul Sheppard , Brian Fox , James Holloway , Stephen Jaspers , Mark Appleby
IPC分类号： C07H21/04 , C07K14/525 , C07K14/705 , C07K16/24 , C07K16/28 , C12P21/02 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/525 , C07K16/2875 , C07K2317/34
摘要： Novel tumor necrosis factor ligand polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides may be used within methods relating to immune response, and may also be used in the development of immuno-regulatory therapeutics. Also provided are antibodies, binding proteins, agonists and antagonists of the ligand polypeptides.
摘要翻译： 公开了新型肿瘤坏死因子配体多肽，编码多肽的多核苷酸，以及相关的组合物和方法。 多肽可用于与免疫应答相关的方法中，并且也可用于开发免疫调节治疗。 还提供了配体多肽的抗体，结合蛋白，激动剂和拮抗剂。
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公开(公告)号：US20070141056A1
公开(公告)日：2007-06-21
申请号：US11552362
申请日：2006-10-24
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO: 2 or residues 235-345 of SEQ ID NO: 2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。多肽的多聚体也被公开。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US20070117967A1
公开(公告)日：2007-05-24
申请号：US11551129
申请日：2006-10-19
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
IPC分类号： C07K16/24
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
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公开(公告)号：US20070065404A1
公开(公告)日：2007-03-22
申请号：US11548819
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
摘要翻译： 本发明提供使用Zven1和Zven2多肽来增加趋化因子产生的方法。 本发明还提供了用Zven1和Zven2多肽治疗肠蠕动障碍和改善胃肠功能的方法。
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公开(公告)号：US20070055052A1
公开(公告)日：2007-03-08
申请号：US11550877
申请日：2006-10-19
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
IPC分类号： C07K16/24
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
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