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公开(公告)号：US20110201610A1
公开(公告)日：2011-08-18
申请号：US13045209
申请日：2011-03-10
IPC分类号： A61K31/5377 , C12N5/00 , A61P29/00 , A61P37/00 , C07D213/89 , A61K31/44 , A61K31/4409 , C07D213/42 , C07D405/06 , A61K31/443 , C07D217/14 , A61K31/472 , C07D233/64 , A61K31/417 , C07D413/12
CPC分类号： C07D233/64 , C07C311/21 , C07C311/29 , C07D213/53 , C07D213/89 , C07D217/14 , C07D257/04 , C07D405/04 , C07D471/04
摘要： The present invention relates to compounds that modulate various chemokine receptors. These compounds are useful for treating inflammatory and immune diseases.
摘要翻译： 本发明涉及调节各种趋化因子受体的化合物。 这些化合物可用于治疗炎症和免疫疾病。
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公开(公告)号：US20110021523A1
公开(公告)日：2011-01-27
申请号：US12896114
申请日：2010-10-01
申请人： Solomon Ugashe , Zheng Wei , J.J. Wright , Andrew Pennell
发明人： Solomon Ugashe , Zheng Wei , J.J. Wright , Andrew Pennell
IPC分类号： A61K31/4439 , C07D413/12 , C07D213/50 , C07D239/26 , C07D413/04 , C07D213/70 , C07D241/12 , C07D213/84 , A61K31/4409 , A61K31/505 , A61K31/5377 , A61K31/44 , A61K31/4965 , A61P29/00 , A61P37/00 , A61P1/00 , A61P37/08 , A61P37/06 , A61P17/06 , A61P11/06 , A61P17/00 , A61P19/02 , A61P35/00 , A61P35/02
CPC分类号： C07C311/29 , C07C311/21 , C07C311/46 , C07C317/14 , C07D213/26 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要： Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
摘要翻译： 提供了作为CCR9受体的有效拮抗剂的化合物，并且已经在用于CCR9的标志性疾病状态之一的炎症的动物试验中进一步证实了这些化合物。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR9介导的疾病的方法，以及用于鉴定CCR9拮抗剂的测定中的对照。
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公开(公告)号：US20090118307A1
公开(公告)日：2009-05-07
申请号：US12251829
申请日：2008-10-15
申请人： Solomon Ugashe , Zheng Wei , J.J. Wright , Andrew Pennell
发明人： Solomon Ugashe , Zheng Wei , J.J. Wright , Andrew Pennell
IPC分类号： A61K31/4409 , C07D213/46 , C07D239/24 , A61K31/4965 , A61P1/00 , A61K31/505 , C07D403/06
CPC分类号： C07C311/29 , C07C311/21 , C07C311/46 , C07C317/14 , C07D213/26 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要： Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
摘要翻译： 提供了作为CCR9受体的有效拮抗剂的化合物，并且已经在用于CCR9的标志性疾病状态之一的炎症的动物试验中进一步证实了这些化合物。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR9介导的疾病的方法，以及用于鉴定CCR9拮抗剂的测定中的对照。
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公开(公告)号：US07420055B2
公开(公告)日：2008-09-02
申请号：US10846241
申请日：2004-05-13
申请人： Solomon Ungashe , J. J. Wright , Andrew Pennell , Zheng Wei , Anita Melikan
发明人： Solomon Ungashe , J. J. Wright , Andrew Pennell , Zheng Wei , Anita Melikan
IPC分类号： C07D413/10
CPC分类号： C07D417/12 , A61K31/4409 , A61K31/443 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D213/26 , C07D213/50 , C07D213/52 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D239/26 , C07D241/12 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
摘要翻译： 提供了作为CCR9受体的有效拮抗剂的化合物，并且已经在用于CCR9的标志性疾病状态之一的炎症的动物试验中进一步证实了这些化合物。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR9介导的疾病的方法，以及用于鉴定CCR9拮抗剂的测定中的对照。
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公开(公告)号：US20080039504A1
公开(公告)日：2008-02-14
申请号：US11775601
申请日：2007-07-10
申请人： Trevor Charvat , Cheng Hu , Jeff Jin , Yandong Li , Anita Melikian , Andrew Pennell , Sreenivas Punna , Solomon Ungashe , Yibin Zeng
发明人： Trevor Charvat , Cheng Hu , Jeff Jin , Yandong Li , Anita Melikian , Andrew Pennell , Sreenivas Punna , Solomon Ungashe , Yibin Zeng
IPC分类号： A61K31/44 , A61P43/00 , C07D401/00
CPC分类号： C07D401/14
摘要： Compounds are provided that act as potent antagonists of the CCR2 or CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2 and CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, CCR9-mediated diseases, as controls in assays for the identification of CCR2 antagonists and as controls in assays for the identification of CCR9 antagonists.
摘要翻译： 提供了作为CCR2或CCR9受体的有效拮抗剂的化合物。 动物试验表明，这些化合物可用于治疗炎症，CCR2和CCR9的标志性疾病。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病，CCR9介导的疾病的方法，作为用于鉴定CCR2拮抗剂的测定中的对照和用于鉴定CCR9拮抗剂的测定中的对照 。
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公开(公告)号：US20060173019A1
公开(公告)日：2006-08-03
申请号：US11332786
申请日：2006-01-13
申请人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor Charvat , Jeff Jin , Jimmie Moore , Yibin Zang , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew Pennell , John Wright
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor Charvat , Jeff Jin , Jimmie Moore , Yibin Zang , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew Pennell , John Wright
IPC分类号： A61K31/496 , A61K31/4545 , C07D403/02 , C07D401/02
CPC分类号： C07C311/21 , C07D213/48 , C07D213/61 , C07D213/643 , C07D213/70 , C07D213/73 , C07D213/76 , C07D213/79 , C07D213/81 , C07D213/89 , C07D241/22 , C07D263/32 , C07D401/04 , C07D405/04 , C07D409/12 , C07D413/06 , C07D413/10 , C07D417/12 , C07D471/04
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
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公开(公告)号：US20050165067A1
公开(公告)日：2005-07-28
申请号：US11046565
申请日：2005-01-27
申请人： Solomon Ungashe , Zheng Wei , J.J. Wright , Andrew Pennell
发明人： Solomon Ungashe , Zheng Wei , J.J. Wright , Andrew Pennell
IPC分类号： A61P29/00 , C07D213/26 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12 , A61K31/455 , C07D213/46
CPC分类号： C07C311/29 , C07C311/21 , C07C311/46 , C07C317/14 , C07D213/26 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要： Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
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公开(公告)号：US08211896B2
公开(公告)日：2012-07-03
申请号：US12896114
申请日：2010-10-01
申请人： Solomon Ungashe , Zheng Wei , J. J. Wright , Andrew Pennell
发明人： Solomon Ungashe , Zheng Wei , J. J. Wright , Andrew Pennell
IPC分类号： A61K31/4427 , A61K31/4523 , A61K31/501 , A61K31/506 , C07D213/34 , C07D239/26
CPC分类号： C07C311/29 , C07C311/21 , C07C311/46 , C07C317/14 , C07D213/26 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要： Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
摘要翻译： 提供了作为CCR9受体的有效拮抗剂的化合物，并且已经在用于CCR9的标志性疾病状态之一的炎症的动物试验中进一步证实了这些化合物。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR9介导的疾病的方法，以及用于鉴定CCR9拮抗剂的测定中的对照。
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公开(公告)号：US20120101097A9
公开(公告)日：2012-04-26
申请号：US13045209
申请日：2011-03-10
IPC分类号： A61K31/5377 , A61P29/00 , A61P37/00 , C07D213/89 , A61K31/44 , A61K31/4409 , C07D213/42 , C07D405/06 , A61K31/443 , C07D217/14 , A61K31/472 , C07D233/64 , A61K31/417 , C07D413/12 , C12N5/00
CPC分类号： C07D233/64 , C07C311/21 , C07C311/29 , C07D213/53 , C07D213/89 , C07D217/14 , C07D257/04 , C07D405/04 , C07D471/04
摘要： The present invention relates to compounds that modulate various chemokine receptors. These compounds are useful for treating inflammatory and immune diseases.
摘要翻译： 本发明涉及调节各种趋化因子受体的化合物。 这些化合物可用于治疗炎症和免疫疾病。
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公开(公告)号：US20090163498A1
公开(公告)日：2009-06-25
申请号：US12137006
申请日：2008-06-11
申请人： Solomon Ungashe , J. J. Wright , Andrew Pennell , Zheng Wei , Anita Melikan
发明人： Solomon Ungashe , J. J. Wright , Andrew Pennell , Zheng Wei , Anita Melikan
IPC分类号： A61K31/5377 , C07D413/12 , A61K31/4439 , A61K31/4433 , C07D405/12
CPC分类号： C07D417/12 , A61K31/4409 , A61K31/443 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D213/26 , C07D213/50 , C07D213/52 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D239/26 , C07D241/12 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
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