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公开(公告)号：US20060173019A1
公开(公告)日：2006-08-03
申请号：US11332786
申请日：2006-01-13
申请人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor Charvat , Jeff Jin , Jimmie Moore , Yibin Zang , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew Pennell , John Wright
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor Charvat , Jeff Jin , Jimmie Moore , Yibin Zang , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew Pennell , John Wright
IPC分类号： A61K31/496 , A61K31/4545 , C07D403/02 , C07D401/02
CPC分类号： C07C311/21 , C07D213/48 , C07D213/61 , C07D213/643 , C07D213/70 , C07D213/73 , C07D213/76 , C07D213/79 , C07D213/81 , C07D213/89 , C07D241/22 , C07D263/32 , C07D401/04 , C07D405/04 , C07D409/12 , C07D413/06 , C07D413/10 , C07D417/12 , C07D471/04
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
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公开(公告)号：US20070037794A1
公开(公告)日：2007-02-15
申请号：US11486974
申请日：2006-07-14
申请人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew Pennell , John Wright
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew Pennell , John Wright
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/444 , C07D417/14 , C07D413/14 , C07D403/14
CPC分类号： A61K31/444 , A61K31/437 , A61K31/4439 , A61K45/06 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
摘要翻译： 提供了作为CCR2受体的有效拮抗剂的化合物。 动物实验表明，这些化合物可用于治疗炎症，CCR2的标志性疾病。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病的方法，以及用于鉴定CCR2拮抗剂的测定中的对照。
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公开(公告)号：US07622583B2
公开(公告)日：2009-11-24
申请号：US11486974
申请日：2006-07-14
申请人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright
IPC分类号： C07D471/02 , C07D237/00 , A61K31/495 , A61K31/44
CPC分类号： A61K31/444 , A61K31/437 , A61K31/4439 , A61K45/06 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
摘要翻译： 提供了作为CCR2受体的有效拮抗剂的化合物。 动物实验表明，这些化合物可用于治疗炎症，CCR2的标志性疾病。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病的方法，以及用于鉴定CCR2拮抗剂的测定中的对照。
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公开(公告)号：US20110118248A1
公开(公告)日：2011-05-19
申请号：US12309314
申请日：2009-01-13
申请人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright , Antoni Krasinski , Qiang Wang
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright , Antoni Krasinski , Qiang Wang
IPC分类号： A61K31/538 , C07C311/29 , C07D213/76 , C07D401/12 , C07D401/06 , C07D413/06 , C07D405/04 , C07D471/04 , C07D417/12 , C07D498/04 , C07D401/04 , C07D413/10 , C07D401/10 , A61K31/18 , A61K31/44 , A61K31/444 , A61K31/443 , A61K31/5377 , A61K31/4375 , A61K31/4439 , A61K31/5383 , A61K31/517 , A61K31/437 , A61K31/502 , A61K31/519 , C12N5/071 , A61P9/10 , A61P9/00 , A61P25/28 , A61P29/00 , A61P3/04 , A61P3/10 , A61P13/12 , A61P1/00 , A61P11/00 , A61P37/06 , A61P35/00 , A61P25/04
CPC分类号： A61K31/5383 , A61K31/44 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4965 , A61K31/502 , A61K31/5377 , A61K31/538 , A61K45/06 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
摘要翻译： 提供了作为CCR2受体的有效拮抗剂的化合物。 动物实验表明，这些化合物可用于治疗炎症，CCR2的标志性疾病。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病的方法，以及用于鉴定CCR2拮抗剂的测定中的对照。
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公开(公告)号：US08093247B2
公开(公告)日：2012-01-10
申请号：US12582001
申请日：2009-10-20
申请人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright
CPC分类号： A61K31/444 , A61K31/437 , A61K31/4439 , A61K45/06 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
摘要翻译： 提供了作为CCR2受体的有效拮抗剂的化合物。 动物实验表明，这些化合物可用于治疗炎症，CCR2的标志性疾病。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病的方法，以及用于鉴定CCR2拮抗剂的测定中的对照。
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公开(公告)号：US20100056509A1
公开(公告)日：2010-03-04
申请号：US12582001
申请日：2009-10-20
申请人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M.K. Pennell , John J. Wright
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M.K. Pennell , John J. Wright
IPC分类号： A61K31/5377 , C07D471/02 , C07D401/06 , A61K31/444 , A61K31/4375 , A61K31/506 , C07D413/06 , C07D498/02
CPC分类号： A61K31/444 , A61K31/437 , A61K31/4439 , A61K45/06 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
摘要翻译： 提供了作为CCR2受体的有效拮抗剂的化合物。 动物实验表明，这些化合物可用于治疗炎症，CCR2的标志性疾病。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病的方法，以及用于鉴定CCR2拮抗剂的测定中的对照。
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公开(公告)号：US20100234364A1
公开(公告)日：2010-09-16
申请号：US12309329
申请日：2007-07-10
申请人： Arindrajit Basak , Jeff Jin , Jimmie Moore , Andrew M.K. Pennell , Sreenlvas Punna , Solomon Ungashe , Zheng Wei
发明人： Arindrajit Basak , Jeff Jin , Jimmie Moore , Andrew M.K. Pennell , Sreenlvas Punna , Solomon Ungashe , Zheng Wei
IPC分类号： A61K31/54 , C07C311/21 , A61K31/18 , C07D213/78 , A61K31/4409 , C07D265/30 , C07D263/32 , A61K31/5375 , A61K31/421 , C07D213/42 , A61K31/4418 , C07D207/04 , A61K31/40 , C07D207/16 , C07D279/12 , C07D231/18 , A61K31/415 , A61P29/00 , A61P37/00
CPC分类号： A61K31/44 , A61K31/47 , A61K31/5375 , C07C311/21 , C07D207/16 , C07D213/42 , C07D213/50 , C07D231/12 , C07D263/32 , C07D295/108 , C07D295/192
摘要： Compounds are provided that act as potent antagonists of the CCR2 or CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2 and CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, CCR9-mediated diseases, as controls in assays for the identification of CCR2 antagonists, and as controls in assays for the identification of CCR9 antagonists.
摘要翻译： 提供了作为CCR2或CCR9受体的有效拮抗剂的化合物。 动物试验表明，这些化合物可用于治疗炎症，CCR2和CCR9的标志性疾病。 化合物通常是芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病的方法，CCR9介导的疾病，作为用于鉴定CCR2拮抗剂的测定中的对照，以及用于鉴定CCR9的测定中的对照 拮抗剂
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公开(公告)号：US07087600B2
公开(公告)日：2006-08-08
申请号：US10161234
申请日：2002-05-31
申请人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhihong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
发明人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhihong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
IPC分类号： A61K31/535 , A61K31/407 , C07D487/02
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
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公开(公告)号：US07507420B2
公开(公告)日：2009-03-24
申请号：US11224580
申请日：2005-09-12
申请人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhi-Hong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
发明人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhi-Hong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
摘要翻译： 本发明提供了作为有效的细胞毒素的杜卡霉素的类似物。 还提供了在体内被切割的肽基和二硫键接头。 连接体可用于形成本发明的细胞毒素的前药和缀合物以及其它诊断和治疗部分。 本发明提供了杜卡霉素类似物与本发明的连接臂的前药和缀合物。
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公开(公告)号：USRE41252E1
公开(公告)日：2010-04-20
申请号：US12126731
申请日：2008-05-23
申请人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhi-Hong Li , Sanjeev Gangwar , Oliver L. Saunder , Irina Astafieva , Valeri Martichonok
发明人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhi-Hong Li , Sanjeev Gangwar , Oliver L. Saunder , Irina Astafieva , Valeri Martichonok
IPC分类号： A61K31/535 , A61K31/407 , C07D487/02
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
摘要翻译： 本发明提供了作为有效的细胞毒素的杜卡霉素的类似物。 还提供了在体内被切割的肽基和二硫键接头。 连接体可用于形成本发明的细胞毒素的前药和缀合物以及其它诊断和治疗部分。 本发明提供了杜卡霉素类似物与本发明连接臂的前药和缀合物。
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