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    Alzheimer's related proteins and methods of use
    22.
    发明申请
    Alzheimer's related proteins and methods of use 审中-公开

    公开(公告)号：US20090087875A1

    公开(公告)日：2009-04-02

    申请号：US11801893

    申请日：2007-05-11

    申请人： Peter H. St. George-Hyslop ,  Paul E. Fraser

    发明人： Peter H. St. George-Hyslop ,  Paul E. Fraser

    IPC分类号： C12Q1/02 ,  G01N33/68

    CPC分类号： C07K14/4711 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/6875 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2500/00 ,  G01N2800/2821

    摘要： Disclosed is a method for identifying substances that alter the interaction of a presenilin protein with a presenilin-binding protein, including contacting at least the interacting domain of a presenilin protein to a presenilin-binding protein in the presence of a test substance, and measuring the interaction of the presenilin protein and the presenilin-binding protein. Also disclosed is method for identifying substances that modulate the nuclear translocation of an armadillo protein, including providing a culture of cells that express the armadillo protein and a mutant presenilin protein, or a functional fragment thereof that binds an armadillo protein; contacting the culture with a test substance; inducing nuclear translocation of the armadillo protein in the cells; and measuring levels of nuclear armadillo protein as compared to a control as an indication of modulatory activity of the test substance. Further disclosed is method for screening individuals for presenilin alleles associated with Alzheimer's Disease or related disorders, including obtaining cells from an individual to be tested for Alzheimer's Disease or a related disorder; inducing nuclear translocation of an armadillo protein in the cells; and measuring levels of the nuclear armadillo protein as compared to a control as an indication of the presence or absence of presenilin alleles associated with Alzheimer's Disease or a related disorder.

    Antibody specific for presenilin 1 and method of use thereof
    25.
    发明授权
    Antibody specific for presenilin 1 and method of use thereof 失效
    早老素1特异性抗体及其使用方法

    公开(公告)号：US06998467B1

    公开(公告)日：2006-02-14

    申请号：US09689159

    申请日：2000-10-12

    申请人： Peter H. St. George-Hyslop ,  Johanna M. Rommens ,  Paul E. Fraser

    发明人： Peter H. St. George-Hyslop ,  Johanna M. Rommens ,  Paul E. Fraser

    IPC分类号： C12N5/16 ,  C07K16/00 ,  C12P21/08

    CPC分类号： C07K16/28 ,  C07K2317/34

    摘要： The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the construction of transgenic animals expressing the mutant genes.

    摘要翻译： 本发明描述了染色体14上的阿尔茨海默氏相关膜蛋白（ARMP）基因和染色体1上的相关基因E5-1的鉴定，分离，克隆和测定。两种基因的正常和突变拷贝都呈现。 这些基因的记录和产物可用于检测和诊断阿尔茨海默病，开发用于治疗阿尔茨海默病的治疗剂，以及蛋白质的分离和制备以及表达突变基因的转基因动物的构建。

    Genetic sequences and proteins related to alzheimer's disease
    26.
    发明授权
    Genetic sequences and proteins related to alzheimer's disease 失效
    与阿尔茨海默病相关的遗传序列和蛋白质

    公开(公告)号：US06210919B1

    公开(公告)日：2001-04-03

    申请号：US08496841

    申请日：1995-06-28

    申请人： Peter H. St. George-Hyslop ,  Johanna M. Rommens ,  Paul E. Fraser

    发明人： Peter H. St. George-Hyslop ,  Johanna M. Rommens ,  Paul E. Fraser

    IPC分类号： C12N1563

    CPC分类号： C07K14/4711 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0312 ,  A61K38/00 ,  C12N15/8509

    摘要： The present invention describes the identification, isolation, cloning, and sequencing of the Alzheimer Related Membrane Protein (ARMP) gene for both normal and mutant forms. An analogous mouse gene, mARMP gene, has also been isolated, cloned, and sequenced. The gene transcript and gene products are used in developing DNA diagnosis for and detection of carriers of the gene, Alzheimer's Disease diagnosis, gene therapy, protein therapy, immunotherapy, as well as the isolation and manufacture of the protein and the development of transgenic animals carrying mutations in the ARMP gene.

    摘要翻译： 本发明描述了用于正常和突变形式的阿尔茨海默氏相关膜蛋白（ARMP）基因的鉴定，分离，克隆和测序。 类似的小鼠基因mARMP基因也已被分离，克隆和测序。 基因转录本和基因产物用于开发基因载体的DNA诊断和检测，阿尔茨海默病诊断，基因治疗，蛋白质治疗，免疫治疗，以及蛋白质的分离和制备以及携带 ARMP基因突变。