摘要:
The present invention relates to immunoglobulin new antigen receptors (IgNARs) from fish and uses thereof. In particular, the present invention relates to modified IgNAR variable domains and to domains from members of the immunoglobulin superfamily that have been modified to include structural features derived from IgNAR variable domains.
摘要:
A user device for connecting symptom, disease, procedure, and facility based information into actionable services for medical care and cost analysis is presented. The user device may include the functionality of linking medical information and providing user specific information. The user-specific information allows the user to make an informed decision about medical treatment. The user device may further be operative to tailor information in light of user characteristics such as location or healthcare network membership.
摘要:
The present invention relates to immunoglobulin new antigen receptors (IgNARs) from fish and uses thereof. In particular, the present invention relates to modified IgNAR variable domains and to domains from members of the immunoglobulin superfamily that have been modified to include structural features derived from IgNAR variable domains.
摘要:
The present invention relates to binding moieties comprising at least one monomeric V-like domain (VLD) derived from a non-antibody ligand, the at least one monomeric V-like domain being characterised in that at least one CDR loop structure or part thereof is modified or replaced such that the solubility of the modified VLD is improved when compared with the unmodified VLD.
摘要:
Novel compounds according to general formula 1, wherein G1 is NR5R6 or a fused polycyclic group that are specific OT receptor agonists and/or V1a receptor antagonists. Pharmaceutical compositions comprising such compounds are useful in the treatment of, inter alia, primary dysmenorrhoea.
摘要翻译:根据通式1的新型化合物,其中G 1是NR 5 R 6或作为特异性OT受体激动剂的融合多环基团和/ 或V 1a受体拮抗剂。 包含这些化合物的药物组合物可用于治疗尤其是原发性痛经。
摘要:
A soccer shoe includes an upper and a cleat assembly coupled to the upper. The cleat assembly further includes a medial support bar located on the medial side and a lateral support bar located on the lateral side. A portion of the cleat assembly located near a midfoot section of the medial support bar is stiffer than a portion of the cleat assembly located near a midfoot section of the lateral support bar. The medial support bar extends approximately from a region corresponding to the rear of the calcaneous of a properly fitted wearer to approximately the head of the first metatarsal of the wearer. The lateral support bar extends approximately from a region corresponding to the rear of the calcaneous of the wearer to approximately the head of the fifth metatarsal of the wearer. The cleat assembly is bonded to a cushioning midsole formed from heated and compressed ethylene vinyl acetate foam. The upper lacks a full-length lasting board and is bonded directly to the cushioning midsole. A lining covers a padded collar and extends inside a foot-receiving region of the shoe, with a portion of the foot-receiving region around a wearer's heel being substantially free of discontinuities.
摘要:
A cleated article of footwear includes a chassis assembly having a sole plate having a plurality of bosses extending from a lower surface thereof. A heel counter extends upwardly from a heel portion of the sole plate. An outer assembly is secured to the chassis assembly and includes a sole portion and an upper secured to the sole portion. A plurality of cleats extends downwardly from a lower surface of the sole portion. Each of a plurality of apertures extends downwardly into a corresponding cleat and receives a boss.
摘要:
Compounds according to general formula (1), wherein G1 is NR5R6 or a fused polycyclic group are novel. They are selective and potent oxytocin agonists. Pharmaceutical compositions of such compounds are useful in the treatment of, inter alia, erectile dysfunction.
摘要翻译:根据通式(1)的化合物,其中G 1为NR 5 R 6或稠合多环基团。 它们是选择性和有效的催产素。 这些化合物的药物组合物可用于治疗勃起功能障碍。
摘要:
Systems and method for communication of information to one or more medical care providers. The systems and methods may utilize a client with which a user may interact. As such, the user may utilize the client to research, display, and/or select a medical care provider. The user may input information to the client which is transmitted to a selected medical care provider prior to the user arriving at the medical care provider's facility. This may include an indication of the user's intent to visit the medical care provider. As such, the medical care provider may utilize the data received to generate a chart and make preparations (e.g., reserve resources) in anticipation of the user's visit. The user may also use the client to access and/or share a personal health record.