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公开(公告)号：US07977071B2
公开(公告)日：2011-07-12
申请号：US11628475
申请日：2005-06-02
申请人： Stewart Nuttal , Victor Streltsov , Katherine Merne Griffiths , Jennifer Ann Carmichael , Peter Hudson , Robert Alexander Irving , Joseph Noozhumurry Varghese , Miles Mackay Barraclough , David Peter Simmons , Kylie Anne Henderson
发明人： Stewart Nuttal , Victor Streltsov , Katherine Merne Griffiths , Jennifer Ann Carmichael , Peter Hudson , Robert Alexander Irving , Joseph Noozhumurry Varghese , Miles Mackay Barraclough , David Peter Simmons , Kylie Anne Henderson
CPC分类号： C07K16/464 , C07K14/461 , C07K16/00 , C07K2299/00 , C07K2317/20 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to immunoglobulin new antigen receptors (IgNARs) from fish and uses thereof. In particular, the present invention relates to modified IgNAR variable domains and to domains from members of the immunoglobulin superfamily that have been modified to include structural features derived from IgNAR variable domains.
摘要翻译： 本发明涉及来自鱼的免疫球蛋白新抗原受体（IgNAR）及其用途。 特别地，本发明涉及修饰的IgNAR可变结构域和来自免疫球蛋白超家族成员的结构域，其已被修饰以包括来自IgNAR可变结构域的结构特征。
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公开(公告)号：US20090148438A1
公开(公告)日：2009-06-11
申请号：US11628475
申请日：2005-06-02
申请人： Stewart Nuttal , Victor Streltsov , Katherine Merne Griffiths , Jennifer Ann Carmichael , Peter Hudson , Robert Alexander Irving , Joseph Noozhumurry Varghese , Miles MacKay Barraclough , David Peter Simmons , Kylie Anne Henderson
发明人： Stewart Nuttal , Victor Streltsov , Katherine Merne Griffiths , Jennifer Ann Carmichael , Peter Hudson , Robert Alexander Irving , Joseph Noozhumurry Varghese , Miles MacKay Barraclough , David Peter Simmons , Kylie Anne Henderson
IPC分类号： A61K39/395 , C07K16/18 , C40B40/08
CPC分类号： C07K16/464 , C07K14/461 , C07K16/00 , C07K2299/00 , C07K2317/20 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to immunoglobulin new antigen receptors (IgNARs) from fish and uses thereof. In particular, the present invention relates to modified IgNAR variable domains and to domains from members of the immunoglobulin superfamily that have been modified to include structural features derived from IgNAR variable domains.
摘要翻译： 本发明涉及来自鱼的免疫球蛋白新抗原受体（IgNAR）及其用途。 特别地，本发明涉及修饰的IgNAR可变结构域和来自免疫球蛋白超家族成员的结构域，其已被修饰以包括来自IgNAR可变结构域的结构特征。
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公开(公告)号：US20120003214A1
公开(公告)日：2012-01-05
申请号：US13157205
申请日：2011-06-09
申请人： Stewart Nuttall , Victor Streltsov , Katherine Merne Griffiths , Jennifer Ann Carmichael , Peter Hudson , Robert Alexander Irving , Joseph Noozhumurry Varghese , Miles Mackay Barraclough , David Peter Simmons , Kylie Anne Henderson
发明人： Stewart Nuttall , Victor Streltsov , Katherine Merne Griffiths , Jennifer Ann Carmichael , Peter Hudson , Robert Alexander Irving , Joseph Noozhumurry Varghese , Miles Mackay Barraclough , David Peter Simmons , Kylie Anne Henderson
IPC分类号： A61K39/395 , C40B40/08 , C07K16/00
CPC分类号： C07K16/464 , C07K14/461 , C07K16/00 , C07K2299/00 , C07K2317/20 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to immunoglobulin new antigen receptors (IgNARs) from fish and uses thereof. In particular, the present invention relates to modified IgNAR variable domains and to domains from members of the immunoglobulin superfamily that have been modified to include structural features derived from IgNAR variable domains.
摘要翻译： 本发明涉及来自鱼的免疫球蛋白新抗原受体（IgNAR）及其用途。 特别地，本发明涉及修饰的IgNAR可变结构域和来自免疫球蛋白超家族成员的结构域，其已被修饰以包括来自IgNAR可变结构域的结构特征。
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公开(公告)号：US20080312610A1
公开(公告)日：2008-12-18
申请号：US12020079
申请日：2008-01-25
申请人： Peter Nicholas Binks , Michelle Marie Critchley , Robert Alexander Irving , Colin William Pouton , Paul James White
发明人： Peter Nicholas Binks , Michelle Marie Critchley , Robert Alexander Irving , Colin William Pouton , Paul James White
CPC分类号： A61K9/14 , A61K9/0021 , A61K9/51 , A61M37/0015 , A61M2037/0038 , A61M2037/0046 , B29L2031/7544 , B29L2031/756
摘要： A device is provided which is suitable for delivering at least one nanoparticle(s) to a subject. The device can be used to deliver a variety of nanoparticles, for example, therapeutic agents, directly through the outer layers of the skin without passing completely through the epidermis of the subject. Thus the device can be used to deliver therapeutic agents to a predetermined depth and avoid disturbing the pain receptors in the skin. Thus the device can be used to deliver agents, including therapeutic agents, in a non-invasive manner. A method of fabricating devices with associated nanoparticles is also provided.
摘要翻译： 提供了适合于将至少一种纳米颗粒递送到受试者的装置。 该装置可以用于直接通过皮肤的外层递送各种纳米颗粒，例如治疗剂，而不会完全穿过受试者的表皮。 因此，该装置可用于将治疗剂递送至预定深度并避免干扰皮肤中的疼痛受体。 因此，该装置可用于以非侵入性方式递送包括治疗剂在内的药剂。 还提供了一种制造具有相关纳米颗粒的器件的方法。
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公开(公告)号：US5844094A
公开(公告)日：1998-12-01
申请号：US403853
申请日：1995-05-30
申请人： Peter John Hudson , Maria Lah , Alex Andrew Kortt , Robert Alexander Irving , John Leslie Atwell , Robyn Louise Malby , Barbara Elaine Power , Peter Malcolm Colman
发明人： Peter John Hudson , Maria Lah , Alex Andrew Kortt , Robert Alexander Irving , John Leslie Atwell , Robyn Louise Malby , Barbara Elaine Power , Peter Malcolm Colman
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P37/00 , C07K16/00 , C07K16/10 , C07K16/18 , C07K16/28 , C07K16/30 , C07K19/00 , C12N15/12 , C12P21/08
CPC分类号： C07K16/1018 , C07K16/00 , C07K16/18 , A61K38/00 , C07K2317/55 , C07K2317/622 , C07K2319/02 , C07K2319/43
摘要： A target-binding polypeptide having (a) a stable core polypeptide region (SCR); and (b) at least one target-binding region (TBR), in which the target-binding region(s) are covalently attached to the SCR and which have optionally been subjected to a maturation step in order to modify the specificity, the affinity or the avidity of binding to the target. The polypeptides may self associate to form stable dimers, aggregates or arrays. The polypeptides of the invention have utility in the diagnostic, therapeutic, predictive or preventative fields of the pharmaceutical and health care industries, as well as more general application in the detection and assay of chemical entities.
摘要翻译： PCT No.PCT / AU93 / 00491 Sec。 371日期：1995年5月30日 102（e）日期1995年5月30日PCT提交1993年9月24日PCT公布。 第WO94 / 07921号公报 日期1994年04月14日具有（a）稳定核心多肽区域（SCR）的靶结合多肽; 和（b）至少一个靶结合区域（TBR），其中靶结合区域共价连接到SCR，并且其任选地进行成熟步骤以改变特异性，亲和力 或绑定到目标的亲合力。 多肽可以自身缔合以形成稳定的二聚体，聚集体或阵列。 本发明的多肽可用于制药和保健行业的诊断，治疗，预测或预防领域，以及在化学实体的检测和测定中更一般的应用。
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公开(公告)号：US07405288B2
公开(公告)日：2008-07-29
申请号：US11588966
申请日：2006-10-27
CPC分类号： C07K14/70521 , A61K38/00 , C07K16/3061 , C07K16/40 , C07K2317/21 , C07K2317/22 , C07K2319/00 , Y10S530/808 , Y10S530/81 , Y10S530/812
摘要： The present invention relates to binding moieties comprising at least one monomeric V-like domain (VLD) derived from a non-antibody ligand, the at least one monomeric V-like domain being characterised in that at least one CDR loop structure or part thereof is modified or replaced such that the solubility of the modified VLD is improved when compared with the unmodified VLD.
摘要翻译： 本发明涉及包含至少一种衍生自非抗体配体的单体V样结构域（VLD）的结合部分，所述至少一个单体V样结构域的特征在于至少一个CDR环结构或其部分是 修饰或替换，使得当与未修饰的VLD相比时，修饰的VLD的溶解度得到改善。
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公开(公告)号：US20120016309A1
公开(公告)日：2012-01-19
申请号：US13214549
申请日：2011-08-22
申请人： Peter Nicholas Binks , Michelle Marie Critchley , Robert Alexander Irving , Colin William Pouton , Paul James White
发明人： Peter Nicholas Binks , Michelle Marie Critchley , Robert Alexander Irving , Colin William Pouton , Paul James White
IPC分类号： A61M5/00
CPC分类号： A61K9/14 , A61K9/0021 , A61K9/51 , A61M37/0015 , A61M2037/0038 , A61M2037/0046 , B29L2031/7544 , B29L2031/756
摘要： A device is provided which is suitable for delivering at least one nanoparticle(s) to a subject. The device can be used to deliver a variety of nanoparticles, for example, therapeutic agents, directly through the outer layers of the skin without passing completely through the epidermis of the subject. Thus the device can be used to deliver therapeutic agents to a predetermined depth and avoid disturbing the pain receptors in the skin. Thus the device can be used to deliver agents, including therapeutic agents, in a non-invasive manner. A method of fabricating devices with associated nanoparticles is also provided.
摘要翻译： 提供了适合于将至少一种纳米颗粒递送到受试者的装置。 该装置可用于直接通过皮肤的外层递送各种纳米颗粒，例如治疗剂，而不会完全穿过受试者的表皮。 因此，该装置可用于将治疗剂递送至预定深度并避免干扰皮肤中的疼痛受体。 因此，该装置可用于以非侵入性方式递送包括治疗剂在内的药剂。 还提供了一种制造具有相关纳米颗粒的器件的方法。
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公开(公告)号：US07166697B1
公开(公告)日：2007-01-23
申请号：US09623611
申请日：1999-03-05
IPC分类号： C07K14/00 , C12P21/08 , A61K39/395 , A01N37/18 , G01N33/53
CPC分类号： C07K14/70521 , A61K38/00 , C07K16/3061 , C07K16/40 , C07K2317/21 , C07K2317/22 , C07K2319/00 , Y10S530/808 , Y10S530/81 , Y10S530/812
摘要： The present invention relates to binding moieties comprising at least one monomeric V-like domain (VLD) derived from a non-antibody ligand, the at least one monomeric V-like domain being characterized in that at least one CDR loop structure or part thereof is modified or replaced such that the solubility of the modified VLD is improved when compared with the unmodified VLD.
摘要翻译： 本发明涉及包含至少一种衍生自非抗体配体的单体V样结构域（VLD）的结合部分，所述至少一个单体V样结构域的特征在于至少一个CDR环结构或其部分是 修饰或替换，使得当与未修饰的VLD相比时，修饰的VLD的溶解度得到改善。
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公开(公告)号：US20080305988A1
公开(公告)日：2008-12-11
申请号：US12120733
申请日：2008-05-15
申请人： Gregory Coia , Maria Galanis , Peter John Hudson , Robert Alexander Irving , Stewart Douglas Nuttall
发明人： Gregory Coia , Maria Galanis , Peter John Hudson , Robert Alexander Irving , Stewart Douglas Nuttall
CPC分类号： C07K14/70521 , A61K38/00 , C07K16/3061 , C07K16/40 , C07K2317/21 , C07K2317/22 , C07K2319/00 , Y10S530/808 , Y10S530/81 , Y10S530/812
摘要： The present invention relates to binding moieties comprising at least one monomeric V-like domain (VLD) derived from a non-antibody ligand, the at least one monomeric V-like domain being characterised in that at least one CDR loop structure or part thereof is modified or replaced such that the solubility of the modified VLD is improved when compared with the unmodified VLD.
摘要翻译： 本发明涉及包含至少一种衍生自非抗体配体的单体V样结构域（VLD）的结合部分，所述至少一个单体V样结构域的特征在于至少一个CDR环结构或其部分是 修饰或替换，使得当与未修饰的VLD相比时，修饰的VLD的溶解度得到改善。
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公开(公告)号：US20110066088A1
公开(公告)日：2011-03-17
申请号：US12801809
申请日：2010-06-25
IPC分类号： A61H1/02
CPC分类号： A61H3/00 , A61F2/72 , A61F2002/701 , A61H1/0255 , A61H1/0266 , A61H3/008 , A61H2201/1215 , A61H2201/1621 , A61H2201/163 , A61H2201/1635 , A61H2201/164 , A61H2201/1642 , A61H2201/165 , A61H2201/1676 , A61H2201/5058 , B25J9/0006
摘要： A walker by a mobility impaired disabled user while moving through a set of movements correlating to a walking motion. The walker comprises an exoskeleton, a power source in the form of a battery pack or other similar onboard power pack together with its associated power supply cables, and a control systemThe exoskeleton comprises a rigid pelvic support member including a pelvic harness and a pair of leg structures Each of the leg structures comprise an upper leg structural member, a lower leg structural member, a foot member, a main hip actuator, a knee actuator and a main foot actuator.
摘要翻译： 移动障碍者的行人在移动通过与行走运动相关的一组运动时被禁用。 助行器包括外骨骼，电池组或其它类似的车载电源组形式的电源及其相关联的电源电缆以及控制系统。外骨骼包括刚性骨盆支撑构件，其包括骨盆线束和一对 腿结构每个腿结构包括大腿结构构件，小腿结构构件，脚构件，主髋部致动器，膝盖致动器和主脚执行器。
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