公开(公告)号：US20060166971A1

公开(公告)日：2006-07-27

申请号：US10541460

申请日：2004-02-12

申请人： Peter Hudson ,  Andrzej Batt ,  Celine Heeney ,  Andrew Baxter ,  Michael Roe ,  Peter Robson

发明人： Peter Hudson ,  Andrzej Batt ,  Celine Heeney ,  Andrew Baxter ,  Michael Roe ,  Peter Robson

IPC分类号： A61K31/5513 ,  A61K31/551 ,  C07D487/12

CPC分类号： C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D495/04

摘要： Novel compounds according to general formula 1, wherein G1 is NR5R6 or a fused polycyclic group that are specific OT receptor agonists and/or V1a receptor antagonists. Pharmaceutical compositions comprising such compounds are useful in the treatment of, inter alia, primary dysmenorrhoea.

摘要翻译： 根据通式1的新型化合物，其中G 1是NR 5 R 6或作为特异性OT受体激动剂的融合多环基团和/ 或V 1a受体拮抗剂。 包含这些化合物的药物组合物可用于治疗尤其是原发性痛经。

公开(公告)号：US10328384B2

公开(公告)日：2019-06-25

申请号：US15439177

申请日：2017-02-22

申请人： Larry Baxter ,  Christopher Hoeger ,  Aaron Sayre ,  Skyler Chamberlain ,  Kyler Stitt ,  Eric Mansfield ,  Stephanie Burt ,  Andrew Baxter ,  Jacom Chamberlain ,  Nathan Davis

发明人： Larry Baxter ,  Christopher Hoeger ,  Aaron Sayre ,  Skyler Chamberlain ,  Kyler Stitt ,  Eric Mansfield ,  Stephanie Burt ,  Andrew Baxter ,  Jacom Chamberlain ,  Nathan Davis

IPC分类号： B01F3/04 ,  B04C5/00 ,  B01D53/18 ,  B01D53/00 ,  B01D7/00 ,  B04C5/04 ,  B04C5/13 ,  B04C9/00 ,  B04C5/08 ,  B04C5/14 ,  B01D5/00 ,  B01D7/02 ,  F25J3/06

摘要： A hydrocyclone for separating a vapor from a carrier gas is disclosed. The hydrocyclone comprises one or more nozzles. A cryogenic liquid is injected to a tangential feed inlet at a velocity that induces a tangential flow and a cyclone vortex in the hydrocyclone. The carrier gas is injected into the cryogenic liquid, causing the vapor to dissolve, condense, desublimate, or a combination thereof, forming a vapor-depleted carrier gas and a vapor-enriched cryogenic liquid. The vapor-depleted carrier gas is drawn through a vortex finder and the vapor-enriched cryogenic liquid is drawn through an apex nozzle outlet. In this manner, the vapor is removed from the carrier gas.

公开(公告)号：US20180306495A1

公开(公告)日：2018-10-25

申请号：US15495217

申请日：2017-04-24

申请人： Larry Baxter ,  Christopher Hoeger ,  Stephanie Burt ,  Kyler Stitt ,  Eric Mansfield ,  Aaron Sayre ,  David Frankman ,  Andrew Baxter ,  Nathan Davis

发明人： Larry Baxter ,  Christopher Hoeger ,  Stephanie Burt ,  Kyler Stitt ,  Eric Mansfield ,  Aaron Sayre ,  David Frankman ,  Andrew Baxter ,  Nathan Davis

IPC分类号： F25J3/02 ,  B01D53/26

摘要： A process for forming a solid product or products is disclosed. The process is provided with n desublimating exchangers. An exchanger E1 being associated with a first exchanger and an exchanger En being associated with an nth exchanger, n representing the number of exchangers. The n exchangers comprise at least one direct-contact exchanger comprising a contact fluid. A process fluid is passed through the n exchangers in order from E1 through En. The process fluid comprises a product component or components. The solid product or products form from the product component or components in the plurality of exchangers by desublimation. The solid product or products are separated from the process fluid. In this manner, a solid product or products is formed.

公开(公告)号：US20180236460A1

公开(公告)日：2018-08-23

申请号：US15438245

申请日：2017-02-21

申请人： Larry Baxter ,  Christopher Hoeger ,  Aaron Sayre ,  Skyler Chamberlain ,  Kyler Stitt ,  Stephanie Burt ,  Eric Mansfield ,  Jacom Chamberlain ,  Andrew Baxter ,  Nathan Davis

发明人： Larry Baxter ,  Christopher Hoeger ,  Aaron Sayre ,  Skyler Chamberlain ,  Kyler Stitt ,  Stephanie Burt ,  Eric Mansfield ,  Jacom Chamberlain ,  Andrew Baxter ,  Nathan Davis

IPC分类号： B03D1/14 ,  F25J3/06 ,  B04C7/00

CPC分类号： B03D1/1425 ,  B01F3/04 ,  B01F13/02 ,  B04C5/10 ,  B04C7/00 ,  B04C2009/008 ,  C10L3/101 ,  C10L3/102 ,  C10L2290/06 ,  C10L2290/18 ,  C10L2290/548

摘要： A method for separating a vapor from a carrier gas is disclosed. An air-sparged hydrocyclone is provided with a porous sparger covered by an outer gas plenum. A cryogenic liquid is provided to the tangential feed inlet at a velocity that induces a tangential flow and a cyclone vortex in the cyclone. The carrier gas is injected into the air-sparged hydrocyclone through the porous sparger. The vapor dissolves, condenses, desublimates, or a combination thereof, forming a vapor-depleted carrier gas and a vapor-enriched cryogenic liquid. The vapor-depleted gas is drawn through a vortex finder while the vapor-enriched cryogenic liquid is drawn through an apex nozzle outlet. In this manner, the vapor is removed from the carrier gas.

公开(公告)号：US20090181962A1

公开(公告)日：2009-07-16

申请号：US11949273

申请日：2007-12-03

申请人： Andrew Baxter ,  Stephen Brough ,  Alan Faull ,  Craig Johnstone ,  Thomas Mcinally

发明人： Andrew Baxter ,  Stephen Brough ,  Alan Faull ,  Craig Johnstone ,  Thomas Mcinally

IPC分类号： A61K31/5377 ,  C07D333/38 ,  A61K31/381 ,  C07D413/04 ,  A61P11/06

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D413/04 ,  C07D417/04

摘要： The invention relates to heteroaromatic carboxamides of formula (I), wherein A, R1, R2, and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

摘要翻译： 本发明涉及式（I）的杂芳族羧酰胺，其中A，R 1，R 2和X如说明书中所定义，其制备中使用的方法和中间体，含有它们的药物组合物及其在治疗中的用途。

公开(公告)号：US06946478B2

公开(公告)日：2005-09-20

申请号：US10339261

申请日：2003-01-09

申请人： Andrew Baxter ,  Stephen Brough ,  Nicholas Kindon ,  Thomas McInally ,  Bryan Roberts ,  Stephen Thom

发明人： Andrew Baxter ,  Stephen Brough ,  Nicholas Kindon ,  Thomas McInally ,  Bryan Roberts ,  Stephen Thom

IPC分类号： C07D295/18 ,  A61K31/427 ,  A61K31/4375 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/4523 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/541 ,  A61P1/00 ,  A61P3/10 ,  A61P9/10 ,  A61P11/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/14 ,  A61P19/00 ,  A61P19/02 ,  A61P29/00 ,  A61P31/00 ,  A61P31/18 ,  A61P37/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07D20060101 ,  C07D211/14 ,  C07D211/22 ,  C07D211/32 ,  C07D211/36 ,  C07D211/40 ,  C07D211/46 ,  C07D211/58 ,  C07D217/14 ,  C07D241/04 ,  C07D295/192 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

CPC分类号： C07D401/12 ,  C07D211/32 ,  C07D211/46 ,  C07D211/58 ,  C07D217/14 ,  C07D295/192 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

摘要： The invention provides compounds of general formula wherein R1, m, Q, T, n, R2, R3, V, W, X and R4 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

摘要翻译： 本发明提供通式的化合物其中R 1，m，Q，T，n，R 2，R 3，V，W， X和R 4如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

公开(公告)号：US06812226B2

公开(公告)日：2004-11-02

申请号：US10149760

申请日：2002-06-13

申请人： Andrew Baxter ,  Nicholas Kindon ,  Garry Pairaudeau ,  Bryan Roberts ,  Stephen Thom

发明人： Andrew Baxter ,  Nicholas Kindon ,  Garry Pairaudeau ,  Bryan Roberts ,  Stephen Thom

IPC分类号： A61K3133

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D453/02

摘要： The invention provides piperidine compounds of general formula (I) in which A, B, X, Y, Z, R, R1 and R2 are as defined in the specification, their use as medicaments, compositions containing them and processes for their for their preparation.

公开(公告)号：US06806273B1

公开(公告)日：2004-10-19

申请号：US09403392

申请日：2001-10-21

申请人： Rupert Austin ,  Andrew Baxter ,  Roger Bonnert ,  Fraser Hunt ,  Elizabeth Kinchin ,  Paul Willis

发明人： Rupert Austin ,  Andrew Baxter ,  Roger Bonnert ,  Fraser Hunt ,  Elizabeth Kinchin ,  Paul Willis

IPC分类号： A61K31519

CPC分类号： C07D513/04

摘要： The invention provides certain thiazolopyrimidine compounds, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

摘要翻译： 本发明提供某些噻唑并嘧啶化合物，其制备中使用的方法和中间体，含有它们的药物组合物及其在治疗中的用途。

公开(公告)号：US20190192998A1

公开(公告)日：2019-06-27

申请号：US15852674

申请日：2017-12-22

申请人： Larry Baxter ,  David Frankman ,  Skyler Chamberlain ,  Kyler Stitt ,  Christopher Hoeger ,  Eric Mansfield ,  Andrew Baxter ,  Nathan Davis

发明人： Larry Baxter ,  David Frankman ,  Skyler Chamberlain ,  Kyler Stitt ,  Christopher Hoeger ,  Eric Mansfield ,  Andrew Baxter ,  Nathan Davis

IPC分类号： B01D21/00 ,  B01D21/02 ,  B01D21/24 ,  B01D17/02 ,  F25J3/08

CPC分类号： B01D21/009 ,  B01D17/0214 ,  B01D21/0024 ,  B01D21/10 ,  B01D21/2405 ,  F25J3/08 ,  F25J2205/02 ,  F25J2205/20 ,  F25J2220/66

摘要： Devices, systems, and methods for separating solids from liquids are disclosed. A vessel includes an inlet, a carrier liquid outlet, a product outlet, a purifying section, and a heater. The inlet directs a slurry into the purifying section. The slurry comprises particles of a solid and a carrier liquid. The purifying section preferentially drives the particles of the solid towards a heating zone of the purifying section versus the carrier liquid. This displaces a first portion of the carrier liquid away from the heating zone of the purifying section. The heater heats the slurry. The carrier liquid outlet drives a majority of the carrier liquid out of the vessel. The product outlet is adjacent to the heating zone of the purifying section.

公开(公告)号：US20180266761A1

公开(公告)日：2018-09-20

申请号：US15464250

申请日：2017-03-20

申请人： Larry Baxter ,  Skyler Chamberlain ,  Eric Mansfield ,  Andrew Baxter ,  Nathan Davis

发明人： Larry Baxter ,  Skyler Chamberlain ,  Eric Mansfield ,  Andrew Baxter ,  Nathan Davis

IPC分类号： F25J3/08

CPC分类号： F25J3/061 ,  B01D5/0003 ,  B01D8/00 ,  B01D53/002 ,  B01D2257/504 ,  B01D2258/0283 ,  F25J3/0625 ,  F25J3/067 ,  F25J5/002 ,  F25J2205/20 ,  F25J2210/70 ,  F25J2290/44 ,  F28D7/06 ,  F28D7/1623 ,  F28F17/00 ,  F28F19/01 ,  F28G7/00

摘要： A heat exchanger for separating a vapor component from a carrier gas is disclosed. The carrier gas is cooled in an outer chamber, causing a vapor component of the carrier gas to desublimate or condense onto an outer surface of an inner chamber, forming a solid product. A coolant is passed through the inner chamber to cool the carrier gas of the outer chamber. A means for causing the inner chamber to flex is provided, causing the solid product to fall from the outer surface of the inner chamber for collection. In this manner, the vapor component is separated from the carrier gas.