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    Cell-specific gene delivery vehicles
    25.
    发明授权
    Cell-specific gene delivery vehicles 失效
    细胞特异性基因递送载体

    公开(公告)号：US06962686B2

    公开(公告)日：2005-11-08

    申请号：US08541191

    申请日：1995-10-11

    申请人： Jon F. Kayyem ,  Thomas J. Meade ,  Scott E. Fraser

    发明人： Jon F. Kayyem ,  Thomas J. Meade ,  Scott E. Fraser

    IPC分类号： A61K49/12 ,  A61K51/00 ,  A61M36/14

    CPC分类号： A61K49/146 ,  A61K49/12 ,  A61K49/189 ,  B82Y5/00

    摘要： A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous physiological agents, particularly paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and physiological agents, including contrast agents and therapeutic agents, are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.

    摘要翻译： 描述了能够特异性结合并进入靶细胞的递送载体，递送许多生理剂，特别是顺磁离子用于细胞的磁共振成像（MRI）。 递送载体包含具有与具有净负电荷的另一个聚合物分子络合的净正电荷的聚合物分子。 细胞靶向部分和生理剂，包括造影剂和治疗剂，连接到一个或两个聚合物分子。 在一个实施方案中，具有净负电荷的聚合物分子是核酸。 因此，递送载体可以用于其中用于基因治疗的核酸和用于MRI对比的药剂共同转运到特定细胞的临床方案，允许核酸递送的医学成像监测。

    Cell-specific contrast agent and gene delivery vehicles
    30.
    发明授权
    Cell-specific contrast agent and gene delivery vehicles 失效
    细胞特异性造影剂和基因递送载体

    公开(公告)号：US06232295B1

    公开(公告)日：2001-05-15

    申请号：US08321552

    申请日：1994-10-12

    申请人： Jon Faiz Kayyem ,  Thomas J. Meade ,  Scott E. Fraser

    发明人： Jon Faiz Kayyem ,  Thomas J. Meade ,  Scott E. Fraser

    IPC分类号： A61K4800

    CPC分类号： A61K49/146 ,  A61K47/645 ,  A61K49/085 ,  Y10S977/808 ,  Y10S977/927 ,  Y10S977/93

    摘要： A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and MRI contrast agents are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.

    摘要翻译： 描述了能够特异性结合并进入目标细胞的递送载体，为细胞的磁共振成像（MRI）递送许多顺磁离子。 递送载体包含具有与具有净负电荷的另一个聚合物分子络合的净正电荷的聚合物分子。 细胞靶向部分和MRI造影剂连接到一个或两个聚合物分子。 在一个实施方案中，具有净负电荷的聚合物分子是核酸。 因此，递送载体可以用于其中用于基因治疗的核酸和用于MRI对比的药剂共同转运到特定细胞的临床方案，允许对核酸递送进行医学成像监测。