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公开(公告)号：US20060029721A1
公开(公告)日：2006-02-09
申请号：US10911228
申请日：2004-08-03
Applicant: Ralph Chappa
Inventor： Ralph Chappa
CPC classification number: A61L29/085 , A61L27/34 , A61L31/10 , A61L2420/02 , B05D1/60 , B05D3/0218 , B05D2202/15 , C08L65/04
Abstract: The present application relates to a method for vapor depositing a polymeric coating onto a substrate. In an embodiment, the invention is a method for applying a polymer coating to a substrate comprising performing a bake-out cycle with a chemical vapor deposition system and performing a deposition cycle with the chemical vapor deposition system.
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公开(公告)号：US20060024350A1
公开(公告)日：2006-02-02
申请号：US11165884
申请日：2005-06-24
Applicant: Signe Varner , Patrick Guire , Kristin Taton , Jie Wen , Nathan Beeley , Laurie Lawin , Robert Hergenrother , Ralph Chappa , Aron Anderson
Inventor： Signe Varner , Patrick Guire , Kristin Taton , Jie Wen , Nathan Beeley , Laurie Lawin , Robert Hergenrother , Ralph Chappa , Aron Anderson
IPC: A61F2/00
CPC classification number: A61K9/0051 , A61F9/0017 , A61F2210/0004 , A61L31/06 , C08L67/025
Abstract: The invention provides implantable medical devices that are fabricated of biodegradable materials for delivery of bioactive agent to limited access regions of a patient's body, such as the eye. The invention further provides methods of treatment utilizing the devices.
Abstract translation: 本发明提供了由可生物降解材料制成的植入式医疗装置，用于将生物活性剂递送到患者身体如眼睛的有限进入区域。 本发明还提供了利用这些装置的治疗方法。
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Patent Agency Ranking
公开(公告)号：US20060013835A1
公开(公告)日：2006-01-19
申请号：US11225301
申请日：2005-09-12
Applicant: Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
Inventor： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
CPC classification number: A61K31/58 , A61F2310/00353 , A61K9/0051
Abstract: The invention provides a controlled release bioactive agent delivery device for treatment of an eye that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The first polymer and the second polymer are hydrophobic, and the body member has a length such that, upon placement of the device at an implantation site within a posterior segment of an eye, the device does not enter a central visual field of the eye. The invention also provides methods method of delivering bioactive agent to a posterior region of an eye.
Abstract translation: 本发明提供一种用于治疗眼睛的控制释放生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中至少一部分 身体构件偏离延伸方向，以及与本体构件的表面接触的聚合物涂覆的组合物，聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。 第一聚合物和第二聚合物是疏水性的，并且本体构件具有这样的长度，使得当将该装置放置在眼睛后部的植入部位时，该装置不进入眼睛的中心视野。 本发明还提供了将生物活性剂递送到眼后部区域的方法。
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公开(公告)号：US20050281857A1
公开(公告)日：2005-12-22
申请号：US11138733
申请日：2005-05-25
Applicant: Toni Heyer , Dale Swan , Stephen Chudzik , Joseph Chinn , Ralph Chappa
Inventor： Toni Heyer , Dale Swan , Stephen Chudzik , Joseph Chinn , Ralph Chappa
CPC classification number: A61L27/34 , A61L33/0029 , C08L33/06
Abstract: Polymeric coatings that include coupled biomolecules are formed on the surface of articles, such as medical devices. A coated layer that includes a synthetic polymer including a reactive group is formed on a surface and then a biomolecule is attached to the reactive group. The synthetic polymer can be an acrylate polymer or an amine-containing polymer having pendent photoreactive groups.
Abstract translation: 包括偶联的生物分子的聚合物涂层形成在诸如医疗装置的制品的表面上。 在表面上形成包括含有反应性基团的合成聚合物的涂层，然后将生物分子连接到反应性基团上。 合成聚合物可以是具有侧基光反应性基团的丙烯酸酯聚合物或含胺聚合物。
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公开(公告)号：US20050276837A1
公开(公告)日：2005-12-15
申请号：US11204195
申请日：2005-08-15
Applicant: Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
Inventor： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
CPC classification number: A61K31/58 , A61F2310/00353 , A61K9/0051
Abstract: The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.
Abstract translation: 本发明提供一种控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 所述延伸方向以及与所述主体构件接触的聚合物涂覆组合物，所述聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。 本发明还提供了以受控释放方式将生物活性剂递送到患者的方法，以及制备受控释放的生物活性剂递送装置的方法。
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公开(公告)号：US20050271703A1
公开(公告)日：2005-12-08
申请号：US11203879
申请日：2005-08-15
Applicant: Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
Inventor： Aron Anderson , Laurie Lawin , Byron Shen , Eugene de Juan , Signe Varner , Ralph Chappa
CPC classification number: A61K31/58 , A61F2310/00353 , A61K9/0051
Abstract: The invention provides implantable sustained release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The polymeric coated composition is formulated to provide controlled release of bioactive agent over time when introduced into physiological conditions. Methods of preparing implantable devices configured and formulated to provide controlled release of bioactive agent are also provided.
Abstract translation: 本发明提供可植入的缓释生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 延伸方向; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。 配制聚合物涂覆的组合物以在引入生理条件时随时间提供生物活性剂的受控释放。 还提供了配制和配制以提供生物活性剂的受控释放的可植入装置的制备方法。
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公开(公告)号：US20050232970A1
公开(公告)日：2005-10-20
申请号：US11090517
申请日：2005-03-25
Applicant: Sean Stucke , Ralph Chappa , Joseph Chinn
Inventor： Sean Stucke , Ralph Chappa , Joseph Chinn
IPC: A61F2/00 , A61K31/4745 , A61K31/727 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/00
CPC classification number: A61K31/4745 , A61K31/727 , A61L31/10 , A61L31/16 , A61L33/0029 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/608
Abstract: The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity that are able to release a bioactive agent, wherein the coatings are formed using biostable or biodegradable polymeric material and photoreactive groups.
Abstract translation: 本发明提供了用于向医疗制品提供生物相容性表面的方法和组合物。 特别地，本发明提供具有能够释放生物活性剂的肝素活性的生物相容性涂层，其中使用生物稳定或可生物降解的聚合物材料和光反应性基团形成涂层。
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