公开(公告)号：US20120277684A1

公开(公告)日：2012-11-01

申请号：US13513087

申请日：2010-12-03

申请人： Richard Cronenberg ,  Lionel Vedrine ,  Patrick Begley

发明人： Richard Cronenberg ,  Lionel Vedrine ,  Patrick Begley

IPC分类号： A61M5/31 ,  B21D51/16 ,  A61M5/34

CPC分类号： A61M5/24 ,  A61J1/062 ,  A61M5/2448 ,  A61M5/2466 ,  A61M5/28 ,  A61M5/284 ,  A61M5/3134 ,  A61M5/3135 ,  A61M5/31525 ,  A61M5/31533 ,  A61M5/347 ,  A61M2005/2488 ,  A61M2005/2492 ,  A61M2005/3123 ,  A61M2005/3126 ,  A61M2005/3132 ,  A61M2005/31516 ,  A61M2207/00 ,  B65B3/003 ,  B65B3/022 ,  B65B7/2821 ,  B65B63/08 ,  Y10T29/494

摘要： A cartridge (100) for containing and dispensing a medicament, the cartridge (100) including a cartridge body (104) having an interior cavity (10B) therein, a stopper (112) movably disposed within the interior cavity (108), and a septum (116, 148) disposed at an opposite end of the interior cavity (108) from the stopper (112), for containing the medicament within the Interior cavity (108). The cartridge (100) also Includes a connection thread (120) integrally formed as a unitary construction of the cartridge body (104), the thread (120) being disposed at a first end of the cartridge body (104) for connecting a pen needle directly to the cartridge body (104) to pierce the septum (116, 148) and provide communication between the medicament and a patient end of the pen needle.

摘要翻译： 一种用于容纳和分配药物的药筒（100），所述药筒（100）包括其中具有内腔（10B）的药筒本体（104），可移动地设置在所述内腔（108）内的止动件（112） 所述隔膜（116,148）设置在所述内部空腔（108）的与所述止动件（112）的相对的端部处，用于将所述药物容纳在所述内腔（108）内。 盒（100）还包括整体形成为盒体（104）的整体结构的连接螺纹（120），螺纹（120）设置在药筒主体（104）的第一端，用于连接笔针 直接到药筒体（104）刺穿隔膜（116,148），并提供药物与笔针的患者端之间的连通。

公开(公告)号：US07967010B2

公开(公告)日：2011-06-28

申请号：US12690159

申请日：2010-01-20

申请人： Lionel Vedrine ,  Frederic Perot ,  Laurent Barrelle

发明人： Lionel Vedrine ,  Frederic Perot ,  Laurent Barrelle

IPC分类号： B05B7/00 ,  B05B11/00

CPC分类号： A61M5/2429 ,  A61M5/2459 ,  A61M5/315 ,  A61M5/31595 ,  A61M11/007 ,  A61M11/06 ,  A61M15/0065 ,  A61M15/08 ,  B05B11/02 ,  B05B11/025

摘要： A spray or injection device that includes a casing or a pusher that includes at least one tab radially moveable between a first radial position, in which the tab does not impede the movement of the pusher with respect to the casing, and a second radial position in which the tab opposes movement of the pusher. The pusher or the casing, respectively, includes at least one ramp-shaped projection configured to bring the tab into the second radial position and then allow it to return to the first radial position. The pusher or the casing further includes at least one stop between the pusher and casing to delineate the end of a first stroke corresponding to a first dose of medicament, and the beginning of a second stroke corresponding to a second dose of medicament.

摘要翻译： 一种喷雾或注射装置，其包括外壳或推动器，其包括至少一个突出部，其可在第一径向位置和第二径向位置之间径向移动，所述突片在第一径向位置之间，其中突片不阻碍推动器相对于外壳的移动， 该卡舌反对推动器的移动。 推动器或壳体分别包括至少一个斜面形突起，其被构造成使突片进入第二径向位置，然后允许其返回到第一径向位置。 推动器或套管还包括推动器和套管之间的至少一个止动件，以描绘对应于第一剂量的药物的第一冲程的结束，以及对应于第二剂量的药物的第二冲程的开始。

公开(公告)号：US07875007B2

公开(公告)日：2011-01-25

申请号：US10520980

申请日：2003-07-10

申请人： Frederic Perot ,  Lionel Vedrine

发明人： Frederic Perot ,  Lionel Vedrine

IPC分类号： A61M5/00 ,  A61M5/31

CPC分类号： A61M5/344 ,  A61F9/0017 ,  A61M2005/3139

摘要： According to the invention, the accessory (1) comprises a body (15) of roughly semi-tubular shape, first means of holding the syringe comprising a distal transverse wall (20) connected to one end of said body (15), and pierced with a hole (22) for the passage of the needle (7) through it, and second means of holding the syringe comprising a bearing zone (61) against which the proximal flange (10) or the lateral lugs that the syringe body (5) comprises is or are intended to bear so as to provide support for the user's fingers; the distance between said distal transverse wall (20) and said bearing zone (61) is such that the adapter (8) connecting the needle (7) to the syringe body (5) is kept bearing against said distal transverse wall (20) when said flange (10) or said lateral lugs are bearing against said bearing zone (61).

摘要翻译： 根据本发明，附件（1）包括大致半管形的主体（15），第一装置保持注射器，其包括连接到所述主体（15）的一端的远侧横向壁（20） 具有用于针（7）通过其的通孔（22），以及保持注射器的第二装置，其包括轴承区（61），近侧凸缘（10）或侧向凸耳与注射器主体（5） ）包括或旨在承担以便为用户的手指提供支持; 所述远端横向壁（20）和所述支承区域（61）之间的距离使得将针（7）连接到注射器主体（5）的适配器（8）保持抵靠所述远侧横向壁（20） 所述凸缘（10）或所述侧向凸耳与所述轴承区（61）相对。

公开(公告)号：US20090069754A1

公开(公告)日：2009-03-12

申请号：US10573226

申请日：2004-09-14

申请人： Lionel Vedrine

发明人： Lionel Vedrine

IPC分类号： A61M5/315

CPC分类号： A61M5/2429 ,  A61M5/2033 ,  A61M5/2459 ,  A61M5/326 ,  A61M2005/3263

摘要： The present invention relates to a device (1) for injection of a product, comprising: a body (2) receiving a hollow injection needle (4) and a container (10) containing the product to be injected; means (5 to 7; 28, 29) for holding the needle in position, means (39, 41, 45) for holding the container (10) in position,; and a piston (11) engaged in the container (10), characterized in that it additionally comprises: first actuating means (42) of means (5 à 7; 28, 29) for holding the needle (4) in position, second actuating means (32) of means (39, 41, 45) for holding the container (10) in position, said first and second actuating means (42, 32) making it possible, at the end of the injection, to respectively release the means (5 à 7; 28, 29) for holding the needle (4) in position before, or simultameously to, the release of the means (39, 41, 45) for holding the container (10) in position, a container support (9) which is mounted slidably on the body (2) and is displaceable relative to the latter in order to perform the injection, means (3, 47, 48) for holding the container support (9) in position, means (49) actuating the release of the means (3, 20, 47, 48) for holding the container support (9) permitting injection in position.

摘要翻译： 本发明涉及一种用于注射产品的装置（1），包括：容纳中空注射针（4）的主体（2）和容纳待注射产品的容器（10）; 用于将针保持在适当位置的装置（5至7; 28,29），用于将容器（10）保持在适当位置的装置（39,41,45）; 以及接合在所述容器（10）中的活塞（11），其特征在于，其还包括：用于将针（4）保持在适当位置的装置（5; 7; 28,29）的第一致动装置（42） 用于将容器（10）保持在适当位置的装置（39,41,45）的装置（32），所述第一和第二致动装置（42,32）使得在注射结束时可以分别释放装置 （5→7; 28,29），用于在将容器（10）保持在适当位置之前或相似地将所述针（4）保持在适当位置的位置，容器支架（ 用于将容器支撑件（9）保持在适当位置的装置（3,47,48），该装置（49）致动（9），所述装置可滑动地安装在所述主体（2）上并且可相对于所述主体 用于保持容器支撑件（9）的装置（3,20,47,48）的释放允许注射就位。

公开(公告)号：US07468055B2

公开(公告)日：2008-12-23

申请号：US10634567

申请日：2003-08-05

申请人： A. Wesley Prais ,  Eric Borin ,  Lionel Vedrine ,  Judith L. Doyle ,  Steven L. Koziol

发明人： A. Wesley Prais ,  Eric Borin ,  Lionel Vedrine ,  Judith L. Doyle ,  Steven L. Koziol

IPC分类号： A61M5/32

CPC分类号： A61M5/3202 ,  A61M5/3286 ,  A61M2205/195 ,  B24B19/16

摘要： A syringe assembly including a needle cannula having a five-beveled point and a needle shield formed of a styrene block poly(ethylene/butylene) thermoplastic elastomer which significantly reduces needle penetration force and may reduce the cycle time for gas sterilization. The multi-beveled needle cannula point includes a primary bevel, a pair of tip bevels and a pair of middle bevels each intermediate the primary bevel and a respective tip bevel, wherein the angles of rotation of the primary bevel and the intermediate bevels are substantially equal resulting in reduced heights of intercepts between the bevels, therby reducing needle penetration force. The needle shield maintains the sharpness of the needle cannula during application, sterilization and removal of the shield and it is believed that the needle shield will also reduce the cycle time of gas sterilization as compared to rubber needle shields and vulcanizate thermoplastic elastomers.

公开(公告)号：US09833562B2

公开(公告)日：2017-12-05

申请号：US13516169

申请日：2009-12-16

申请人： Ralph Sonderegger ,  Curt Bingham ,  Lionel Vedrine

发明人： Ralph Sonderegger ,  Curt Bingham ,  Lionel Vedrine

IPC分类号： A61M5/142 ,  A61M5/20 ,  A61M5/145 ,  A61M5/158

CPC分类号： A61M5/14244 ,  A61M5/14586 ,  A61M5/2033 ,  A61M2005/14506 ,  A61M2005/1585

摘要： A drug delivery device, including a body having a reservoir disposed therein for containing a medicament, the reservoir including a flexible wall; a plunger movable within the body for causing the medicament to be expelled from the reservoir, the plunger having a contact surface that is not affixed to said flexible reservoir wall; a spring biasing the plunger toward the reservoir; and means for selectively maintaining the plunger in a pre-activated position with respect to the reservoir and, upon releasing the plunger from the pre-activated position, for guiding the plunger to move under the force of the spring such that the contact surface of the plunger contacts the flexible reservoir wall to pressurize the reservoir for delivery of the medicament to a patient.

公开(公告)号：US09345835B2

公开(公告)日：2016-05-24

申请号：US12737453

申请日：2009-07-17

申请人： Ying Xu ,  Robert Banik ,  Lionel Vedrine

发明人： Ying Xu ,  Robert Banik ,  Lionel Vedrine

IPC分类号： A61M5/00 ,  A61M5/315 ,  A61M5/24

CPC分类号： A61M5/31511 ,  A61M5/24 ,  A61M5/2466 ,  A61M5/31515 ,  A61M5/31551 ,  A61M5/31573 ,  A61M5/31585 ,  A61M2005/2407

摘要： A device for delivering a medicament intradermally includes a cartridge (112) having a first end (110) and a second end (114) and defining a volume (111) therebetween. The volume (111) is adapted to contain the medicament. A driving member (121) has a first end (126) and a second end (128). The first end (126) of the driving member (121) is disposed in the cartridge (112) and the second end (128) of the driving member (121) is disposed outside the cartridge (112). A stopper (115) is slidably disposed in the cartridge volume (111). The driving member (121) is releasably disposed in the stopper (115) such that when the driving member (121) is retracted from the cartridge (112) the stopper (115) is disengaged from the driving member (121) and remains in the cartridge volume (111).

摘要翻译： 用于皮内递送药物的装置包括具有第一端（110）和第二端（114）并且在其间限定体积（111）的药筒（112）。 体积（111）适于容纳药物。 驱动构件（121）具有第一端（126）和第二端（128）。 驱动构件（121）的第一端（126）设置在盒（112）中，并且驱动构件（121）的第二端（128）设置在盒（112）的外部。 止动器（115）可滑动地设置在盒体积（111）中。 驱动构件（121）可释放地设置在止动件（115）中，使得当驱动构件（121）从盒（112）缩回时，止动件（115）与驱动构件（121）脱离并保持在 盒体积（111）。

公开(公告)号：US09174010B2

公开(公告)日：2015-11-03

申请号：US12867920

申请日：2009-02-02

申请人： Lionel Vedrine

发明人： Lionel Vedrine

IPC分类号： B05B11/00 ,  A61M11/00 ,  A61M15/00 ,  B65D41/34

CPC分类号： A61M11/00 ,  A61M11/007 ,  A61M15/0025 ,  B05B11/0027 ,  B65D41/3409 ,  Y10T29/49945

摘要： A sprayer includes a container of product to be sprayed, provided with a delivery opening for this product, and a spraying assembly. The spraying assembly is in fluid communication with the delivery opening and is securable onto the container by insertion about a mounting axis. The spraying assembly includes a sprayer body delimiting a proximal area conformed so as to be securable to the container, and includes a distal wall, transverse to the mounting axis, in which a spraying aperture is arranged, and a cap intended to be mounted on the sprayer body. The cap includes a wall transverse to the mounting axis, which is sufficiently rigid so as to bear, without substantial damaging, a force from 50 to 100 N necessary to secure the sprayer body to the container and thus to enable the transmission to the sprayer body of this force.

摘要翻译： 喷雾器包括一个待喷射的产品的容器，该容器设置有用于该产品的输送开口和一个喷涂组件。 喷射组件与输送口流体连通，并通过围绕安装轴线的插入而固定在容器上。 喷涂组件包括一个喷涂器主体，其限定适合于容器的近侧区域，并且包括横向于安装轴线的远侧壁，其中布置有喷射孔，以及盖子，其将安装在 喷雾器体。 盖子包括横向于安装轴线的壁，其具有足够的刚性，从而承受50到100N的力而不会将喷雾器本体固定在容器上，从而能够传递到喷雾器体 的力量

公开(公告)号：US08469923B2

公开(公告)日：2013-06-25

申请号：US12679508

申请日：2008-09-29

申请人： Lionel Vedrine ,  Roger W. Groskopf ,  Matthew Sweeney ,  Dnyanesh A. Talpade ,  Min Wei ,  Ruane Jeter

发明人： Lionel Vedrine ,  Roger W. Groskopf ,  Matthew Sweeney ,  Dnyanesh A. Talpade ,  Min Wei ,  Ruane Jeter

IPC分类号： A61M37/00

CPC分类号： A61M5/284 ,  A61M5/2448 ,  A61M5/288 ,  A61M5/3134 ,  A61M5/31513 ,  A61M5/345 ,  A61M5/347 ,  A61M5/348 ,  A61M2005/3104 ,  A61M2005/31516 ,  B65B3/003

摘要： A cartridge or injector for holding and mixing a medical product is provided herein including a tubular body having a cylindrical wall having first and second opposing ends. The wall includes inner and outer surfaces with the inner surface having a generally constant cross-section along at least a drug mixing area. A first stopper is slidably disposed within the wall between the first and second ends, the first stopper defining a liquid-tight seal with the inner surface. A second stopper is slidably disposed within the wall between the first stopper and the first end, the second stopper defining a liquid-tight seal with the inner surface. A flexible insert is disposed at or in proximity to the second end, the insert forming a liquid-tight seal with the wall, the insert being pierceable by a medical needle or other piercing instrument. A rigid retainer is fixed to the wall having an opening therein for providing access to the insert for piercing by a medical needle. The insert extends into the retainer and forms a liquid-tight seal across the opening. Advantageously, with the subject invention, a reconstitution assembly may be provided which has a sufficiently large distal opening during assembly which allows a dry component to be introduced into the device in a dry state.

摘要翻译： 本文提供了用于保持和混合医疗产品的药筒或注射器，其包括具有圆柱形壁的管状体，其具有第一和第二相对端。 该壁包括内表面和外表面，其中内表面至少沿着药物混合区域具有大致恒定的横截面。 第一止动件可滑动地设置在第一和第二端之间的壁内，第一止动件限定与内表面的液密密封。 第二止动件可滑动地设置在第一止挡件和第一端之间的壁内，第二止动件限定与内表面的液密密封。 柔性插入件设置在第二端处或附近，插入件与壁形成液密密封，插入件可被医用针或其它穿刺器械刺穿。 刚性保持器固定到其上具有开口的壁上，用于提供通过医用针穿刺插入物的通路。 插入件延伸到保持器中并且跨越开口形成液密密封。 有利地，对于本发明，可以提供在组装期间具有足够大的远端开口的重构组件，其允许在干燥状态下将干燥部件引入装置。

公开(公告)号：US20120310175A1

公开(公告)日：2012-12-06

申请号：US13516547

申请日：2009-12-16

申请人： Lionel Vedrine ,  Ralph Sonderegger ,  Curt Bingham

发明人： Lionel Vedrine ,  Ralph Sonderegger ,  Curt Bingham

IPC分类号： A61M5/315 ,  A61M5/31

CPC分类号： A61M5/1452 ,  A61M5/14248 ,  A61M2005/14252

摘要： A device (100) for delivering a medicament into a patient's body by injection into or through the patient's skin, including a main body having a top enclosure (116) and a bottom enclosure (104), a reservoir (160) disposed within the main body for containing the medicament, and an injection needle (152) for penetrating the skin of the patient, the needle (152) having a lumen and selectively communicating with the reservoir (160). The device also includes a pressurizing system (600, 140) for selectively pressurizing the reservoir (160). In a pre-activated position, the pressurizing system (600, 140) contacts and compresses the reservoir (160) to reduce the initial volume of the reservoir (160), thereby allowing for partial filling of the reservoir (160).

摘要翻译： 一种用于通过注入或穿过患者皮肤将药物输送到患者体内的装置（100），包括具有顶部外壳（116）和底部外壳（104）的主体，设置在主体内的储存器（160） 用于容纳药物的主体和用于穿透患者皮肤的注射针（152），所述针（152）具有内腔并选择性地与储存器（160）连通。 该装置还包括用于选择性地加压储存器（160）的加压系统（600,140）。 在预启动位置，加压系统（600,140）接触和压缩储存器（160）以减小储存器（160）的初始容积，从而允许储存器（160）的部分填充。