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36 条记录 (耗时 0.024 秒)

    Process for producing de(mycinosyloxy)tylosin
    21.
    发明授权
    Process for producing de(mycinosyloxy)tylosin 失效
    生产de（霉素氧基）泰乐菌素的方法

    公开(公告)号：US4334019A

    公开(公告)日：1982-06-08

    申请号：US261826

    申请日：1981-05-08

    申请人： Richard H. Baltz ,  Gene M. Wild ,  Eugene T. Seno

    发明人： Richard H. Baltz ,  Gene M. Wild ,  Eugene T. Seno

    IPC分类号： C07H17/08 ,  C12P19/62 ,  C12N1/20

    CPC分类号： C07H17/08 ,  C12P19/62 ,  C12R1/54 ,  Y10S435/896

    摘要： 23-De(mycinosyloxy)tylosin (DMOT) which has the formula: ##STR1## 20-dihydro-DMOT, specified acyl ester derivatives, and the acid addition salts thereof are useful antibacterial agents. New methods of making 23-deoxy-5-O-mycaminosyltylonolide (DOMT) and 20-dihydro-DOMT by mild acid hydrolysis of DMOT and 20-dihydro-DMOT, respectively, are included.

    摘要翻译： 具有下式的23-De（霉素氧基）泰乐菌素（DMOT）及其酸加成盐是有用的抗菌剂，其具有下式：20-dihydro-DMOT，特定的酰基酯衍生物及其酸加成盐。 包括分别通过DMOT和20-dihydro-DMOT的温和酸解来制备23-脱氧-5-O-碳霉糖基太乐内酯（DOMT）和20-二氢-NDTT的新方法。

    Ultra-High Throughput Screening of Natural Products
    22.
    发明申请
    Ultra-High Throughput Screening of Natural Products 审中-公开
    天然产物超高通量筛选

    公开(公告)号：US20100311107A1

    公开(公告)日：2010-12-09

    申请号：US12844046

    申请日：2010-07-27

    申请人： Richard H. Baltz ,  Catherine Monahan ,  Christopher Murphy ,  Julia Penn ,  Daniel Ritz ,  Stephen Wrigley

    发明人： Richard H. Baltz ,  Catherine Monahan ,  Christopher Murphy ,  Julia Penn ,  Daniel Ritz ,  Stephen Wrigley

    IPC分类号： C12Q1/18

    CPC分类号： C12Q1/18 ,  C12N1/20

    摘要： The present invention provides cells having more than two drug resistance genes and at least two different resistance genes that have been recombined into the chromosome of a cell. It also teaches the processes for preparing cells by recombining two or more different drug resistance genes into the chromosome of a cell. The invention further shows a screening method using the cells of described herein that may be used to accomplish high throughput screening of, among other things, natural products and/or whole cells isolated from the environment.

    摘要翻译： 本发明提供具有两个以上药物抗性基因的细胞和已经重组到细胞染色体中的至少两个不同的抗性基因。 它还教导了通过将两个或多个不同的耐药基因重组到细胞的染色体中来制备细胞的过程。 本发明还显示了使用本文所述的细胞的筛选方法，其可用于实现除了其它方面从天然产物和/或从环境分离的全细胞的高通量筛选。

    Macrocin derivatives
    24.
    发明授权
    Macrocin derivatives 失效
    Macrocin衍生物

    公开(公告)号：US4656258A

    公开(公告)日：1987-04-07

    申请号：US743243

    申请日：1985-06-11

    申请人： Jan R. Turner ,  Veronica M. Krupinski ,  David S. Fukuda ,  Richard H. Baltz

    发明人： Jan R. Turner ,  Veronica M. Krupinski ,  David S. Fukuda ,  Richard H. Baltz

    IPC分类号： C07H17/08 ,  C12P19/62

    CPC分类号： C07H17/08 ,  C12P19/62 ,  C12R1/465

    摘要： New macrocin and lactenocin ester derivatives of the formula: ##STR1## wherein R is formyl or hydroxymethyl; R.sup.1 is hydrogen, acetyl or propionyl; R.sup.2 is hydrogen or ##STR2## and R.sup.3 is hydrogen, acetyl, propionyl, n-butyryl or isovaleryl; provided that one of R.sup.1 or R.sup.3 must be other than hydrogen; and the acid addition salts thereof; prepared by bioconversion of macrocin or lactenocin with an acylating enzyme system produced by Streptomyces thermotolerans strains, have improved activity against Mycoplasma species.

    摘要翻译： 新的大分子和乳内酯酯衍生物，其分子式如下：其中R是甲酰基或羟甲基; R1是氢，乙酰基或丙酰基; R 2是氢或者R 3是氢，乙酰基，丙酰基，正丁酰基或异戊酰基; 条件是R1或R3中的一个必须不是氢; 及其酸加成盐; 通过使用由嗜热链霉菌菌株产生的酰化酶体系的大分子或乳清素生物转化制备，具有改善的针对支原体物种的活性。

    Method of obtaining streptomyces protoplasts capable of efficient cell regeneration
    25.
    发明授权
    Method of obtaining streptomyces protoplasts capable of efficient cell regeneration 失效
    获得能够高效细胞再生的链霉菌原生质体的方法

    公开(公告)号：US4159226A

    公开(公告)日：1979-06-26

    申请号：US812084

    申请日：1977-07-01

    申请人： Richard H. Baltz

    发明人： Richard H. Baltz

    IPC分类号： C12N15/02 ,  C12N1/20 ,  C12N15/03 ,  C12K1/02

    CPC分类号： C12N15/03 ,  Y10S435/886

    摘要： A method of obtaining Streptomyces protoplasts which are able to regenerate viable cells with high efficiency is disclosed. The method involves growing Streptomyces cells to a particular physiological state, the transition phase between the exponential and stationary growth phases, and then forming protoplasts. The physiological state of the cells at the time of protoplast formation is crucial for efficient cell regeneration. Protoplasts obtained by this method enhance the use of protoplast-fusion techniques to effect genetic exchange within the genus Streptomyces, thereby facilitating the construction of hybrid or recombinant Streptomyces strains with useful properties.

    摘要翻译： 公开了能够以高效率再生活细胞的获得链霉菌原生质体的方法。 该方法包括将链霉菌细胞生长至特定生理状态，指数和稳定生长期之间的过渡期，然后形成原生质体。 原生质体形成时细胞的生理状态对于有效的细胞再生是至关重要的。 通过该方法获得的原生质体增强了原生质体融合技术在链霉菌属中进行遗传交换的用途，从而有助于构建具有有用特性的杂交或重组链霉菌属菌株。

    Process for the production of mycaminosyltylonolide
    30.
    发明授权
    Process for the production of mycaminosyltylonolide 失效
    生产霉菌酰基太乐内酯的方法

    公开(公告)号：US4537957A

    公开(公告)日：1985-08-27

    申请号：US503986

    申请日：1983-06-13

    申请人： Richard H. Baltz ,  Gene M. Wild ,  Eugene T. Seno

    发明人： Richard H. Baltz ,  Gene M. Wild ,  Eugene T. Seno

    IPC分类号： C07H17/08 ,  C12P19/62

    CPC分类号： C07H17/08 ,  C12P19/62 ,  C12R1/54

    摘要： 23-Demycinosyltylosin (DMT) which has the formula: ##STR1## 20-dihydro-DMT, specified acyl ester derivatives, and their acid addition salts are useful antibacterial agents. Improved methods of making 5-O-mycaminosyltylonolide (OMT) and 20-dihydro-OMT by mild acid hydrolysis of DMT and 20-dihydro-DMT, respectively, are included.

    摘要翻译： 具有下式的23-霉菌霉素（DMT）：具有20-dihydro-DMT，特定酰基酯衍生物及其酸加成盐的有用的抗菌剂。 包括分别通过DMT和20-dihydro-DMT的温和酸解制备5-O-碳霉糖基太乐内酯（OMT）和20-二氢-OMT的改进方法。