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    Induction of Apoptosis by Cellular Stress
    21.
    发明申请
    Induction of Apoptosis by Cellular Stress 失效
    诱导细胞凋亡的细胞应激

    公开(公告)号：US20070105772A1

    公开(公告)日：2007-05-10

    申请号：US11538186

    申请日：2006-10-03

    申请人： Donald Kufe ,  Rima Kaddurah-Daouk ,  Ralph Weichselbaum

    发明人： Donald Kufe ,  Rima Kaddurah-Daouk ,  Ralph Weichselbaum

    IPC分类号： A61K38/55 ,  C12Q1/30

    CPC分类号： G01N33/5011 ,  C12Q1/30 ,  G01N33/5079 ,  G01N2510/00

    摘要： The invention provides methods of screening to identify compounds that modulate the ability of a protein to translocate to the mitochondria when a cell is subjected to cellular stress. Such compounds can be useful to modulate the level of apoptosis in a cell. For example, compounds identified according to the methods described herein can be used to treat disorders characterized by excessive apoptosis, e.g., a neurological disorder, or insufficient apoptosis, e.g., cancer.

    摘要翻译： 本发明提供筛选方法，以鉴定当细胞经受细胞应激时调节蛋白质转移至线粒体的能力的化合物。 这样的化合物可用于调节细胞凋亡的水平。 例如，根据本文描述的方法鉴定的化合物可用于治疗以过度凋亡为特征的疾病，例如神经障碍或细胞凋亡不足，例如癌症。

    Use of creatine or creatine compounds for skin preservation
    25.
    发明授权
    Use of creatine or creatine compounds for skin preservation 有权
    使用肌酸或肌酸化合物进行皮肤保养

    公开(公告)号：US06242491B1

    公开(公告)日：2001-06-05

    申请号：US09344427

    申请日：1999-06-25

    申请人： Rima Kaddurah-Daouk

    发明人： Rima Kaddurah-Daouk

    IPC分类号： A61K31195

    CPC分类号： A61Q19/08 ,  A61K8/44 ,  A61K8/55 ,  A61K31/155 ,  A61K31/195 ,  A61K31/198 ,  A61K2800/92 ,  A61Q19/02 ,  Y10S514/859 ,  Y10S514/861 ,  Y10S514/864

    摘要： The present invention relates to the use of creatine compounds such as, for example, creatine, creatine phosphate or analogs of creatine, such as creatine-pyruvate, creatine-ascorbate, cyclocreatine, 3 guanidinopropionic acid, guanidinoacetate, homocyclocreatine, guanidino benzoates as energy generating systems and antioxidants for preservation of skin against adverse aging effects and damage secondary to insults such as harmful sun radiations, stress and fatigue. The creatine compounds which can be used in the present method include (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) molecules that mimic the biological activity of creatine (3) molecules that modulate the creatine kinase system.

    摘要翻译： 本发明涉及肌酸化合物例如肌酸，肌酸磷酸酯或肌酸类似物如肌酸 - 丙酮酸，肌酸 - 抗坏血酸酯，环磷酸，胍胍丙酸，胍基乙酸酯，高碘环酸，苯胍酸胍等作为能量的产生 系统和抗氧化剂，用于保护皮肤免受不利的老化作用和继发于诸如有害的太阳辐射，压力和疲劳等侮辱之类的损伤。 可用于本方法的肌酸化合物包括（1）肌酸，磷酸肌酸和这些化合物的类似物，其可以作为肌酸激酶的底物或底物类似物; （2）模仿肌酸（3）分子调节肌酸激酶系统的生物活性的分子。

    Use of Creatine or Creatine Compounds for Skin Preservation
    28.
    发明申请
    Use of Creatine or Creatine Compounds for Skin Preservation 审中-公开
    使用肌酸或肌酸化合物进行皮肤保护

    公开(公告)号：US20110008272A1

    公开(公告)日：2011-01-13

    申请号：US12701666

    申请日：2010-02-08

    申请人： Rima Kaddurah-Daouk

    发明人： Rima Kaddurah-Daouk

    IPC分类号： A61K8/44 ,  A61K8/55 ,  A61K8/49 ,  A61K8/73 ,  A61K8/98 ,  A61K8/99 ,  A61K8/97 ,  A61Q17/04 ,  A61P29/00 ,  A61P17/16

    CPC分类号： A61Q19/08 ,  A61K8/44 ,  A61K8/55 ,  A61K31/155 ,  A61K31/195 ,  A61K31/198 ,  A61K2800/92 ,  A61Q19/02 ,  Y10S514/859 ,  Y10S514/861 ,  Y10S514/864

    摘要： The present invention relates to the use of creatine compounds such as, for example, creatine, creatine phosphate or analogs of creatine, such as creatine-pyruvate, creatine-ascorbate, cyclocreatine, 3 guanidinopropionic acid, guanidinoacetate, homocyclocreatine, guanidino benzoates as energy generating systems and antioxidants for preservation of skin against adverse aging effects and damage secondary to insults such as harmful sun radiations, stress and fatigue. The creatine compounds which can be used in the present method include (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) molecules that mimic the biological activity of creatine (3) molecules that modulate the creatine kinase system.

    摘要翻译： 本发明涉及肌酸化合物例如肌酸，肌酸磷酸酯或肌酸类似物如肌酸 - 丙酮酸，肌酸 - 抗坏血酸酯，环磷酸，胍胍丙酸，胍基乙酸酯，高碘环酸，苯胍酸胍等作为能量的产生 系统和抗氧化剂，用于保护皮肤免受不利的老化作用和继发于诸如有害的太阳辐射，压力和疲劳等侮辱之类的损伤。 可用于本方法的肌酸化合物包括（1）肌酸，磷酸肌酸和这些化合物的类似物，其可以作为肌酸激酶的底物或底物类似物; （2）模仿肌酸（3）分子调节肌酸激酶系统的生物活性的分子。

    Use of creatine analogues and creatine kinase modulators for the prevention and treatment of obesity and its related disorders
    30.
    发明申请
    Use of creatine analogues and creatine kinase modulators for the prevention and treatment of obesity and its related disorders 审中-公开
    使用肌酸类似物和肌酸激酶调节剂来预防和治疗肥胖及其相关疾病

    公开(公告)号：US20090298943A1

    公开(公告)日：2009-12-03

    申请号：US12317782

    申请日：2008-12-29

    申请人： Rima Kaddurah-Daouk

    发明人： Rima Kaddurah-Daouk

    IPC分类号： A61K31/197 ,  A61P3/04

    CPC分类号： A61K31/00 ,  Y10S514/825 ,  Y10S514/866 ,  Y10S514/909

    摘要： The present invention relates to the use of creatine compounds for treating or preventing a metabolic disorder related to body weight control such as obesity, and it's associated diseases in a patient experiencing said disorder. The creatine compounds which can be used in the present method include (1) analogues of creatine which can act as substrates or substrate analogues for the enzyme creatine kinase; (2) compounds which can act as inhibitors of creatine kinase; (3) compounds which can modulate the creatine transporter (4) N-phosphocreatine analogues bearing transferable or non-transferable moieties which mimic the N-phosphoryl group. (5) compounds which modify the association of creatine kinase with other cellular components.

    摘要翻译： 本发明涉及肌酸化合物用于治疗或预防与体重控制相关的代谢紊乱（例如肥胖症）的用途，并且其在经历所述病症的患者中是相关疾病。 可用于本发明方法的肌酸化合物包括（1）可作为肌酸激酶的底物或底物类似物的肌酸类似物; （2）可作为肌酸激酶抑制剂的化合物; （3）可以调节肌酸转运蛋白的化合物（4）具有可转移或不可转移部分的N-磷酸肌酸类似物，其模拟N-磷酰基。 （5）改变肌酸激酶与其他细胞成分的关联的化合物。