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29 条记录 (耗时 0.037 秒)

    pH triggerable polymeric particles
    21.
    发明申请
    pH triggerable polymeric particles 有权
    pH可触发聚合物颗粒

    公开(公告)号：US20050244504A1

    公开(公告)日：2005-11-03

    申请号：US11002542

    申请日：2004-12-02

    申请人： Steven Little ,  David Lynn ,  Daniel Anderson ,  Robert Langer

    发明人： Steven Little ,  David Lynn ,  Daniel Anderson ,  Robert Langer

    IPC分类号： A61K9/127 ,  A61K9/14 ,  A61K9/16 ,  A61K48/00 ,  C12N5/08 ,  C12N15/87 ,  C12N15/88

    CPC分类号： A61K9/1617 ,  A61K9/1623 ,  A61K9/1647 ,  A61K9/1658

    摘要： A drug delivery system comprising pH triggerable particles is described. The pH triggerable particles comprise and agent(s) to be delivered, which is encapsulated in a matrix comprising a pH trigger agent and a polymer. Agents including nucleic acids may be delivered intracellularly using the inventive pH triggerable particles. Upon exposure to an acidic environment such as the endosome or phagosome of a cell, the particles dissolve or disrupt due to protonation or an increase in solubility of the pH triggering agent. Pharmaceutical compositions and methods of preparing and administering these particles are also described. These particles may be particularly useful in genetic vaccination.

    摘要翻译： 描述了包含pH可触发颗粒的药物递送系统。 pH可触发颗粒包含待运送的试剂，其被包封在包含pH触发剂和聚合物的基质中。 包含核酸的试剂可以使用本发明的pH可触发颗粒在细胞内递送。 当暴露于诸如细胞的内体或吞噬体的酸性环境中时，由于质子化或pH引发剂的溶解度的增加，颗粒溶解或破坏。 还描述了制备和施用这些颗粒的药物组合物和方法。 这些颗粒在基因疫苗接种中可能特别有用。

    Infinitely variable transmission for a combine header unit
    23.
    发明申请
    Infinitely variable transmission for a combine header unit 有权
    用于组合报头单元的无级变速器

    公开(公告)号：US20050193698A1

    公开(公告)日：2005-09-08

    申请号：US10791328

    申请日：2004-03-02

    申请人： Joseph Teijido ,  Jeffrey Wigand ,  Daniel Anderson ,  Robert Hawkins ,  Werner Stettler ,  Helmut Weis ,  Bernd Kempf ,  Johann Pierce

    发明人： Joseph Teijido ,  Jeffrey Wigand ,  Daniel Anderson ,  Robert Hawkins ,  Werner Stettler ,  Helmut Weis ,  Bernd Kempf ,  Johann Pierce

    IPC分类号： A01D41/127 ,  A01D69/00 ,  A01F29/14

    CPC分类号： A01D41/1274 ,  A01D41/142 ,  A01D69/005

    摘要： A mechanism for powering a combine header unit at infinitely variable speeds. A primary motor is coupled to a primary input shaft via a clutch, a variable-speed secondary motor is directly coupled to a secondary input shaft, and the header unit coupled to a header output shaft. A planetary gear-train couples the primary input shaft, the secondary input shaft, and the header output shaft to each other. A primary brake is coupled to the primary input shaft, and a secondary brake coupled to the secondary input shaft. A control circuit is employed to command the operation of the clutch, the secondary motor, the primary brake, and the secondary brake in response to operator commands.

    摘要翻译： 用于以无限可变速度为组合报头单元供电的机构。 主电动机通过离合器联接到主输入轴，可变速次级电动机直接耦合到次级输入轴，并且头部单元联接到集管输出轴。 行星齿轮系将主输入轴，副输入轴和集管输出轴相互连接。 主制动器联接到主输入轴，并且次级制动器联接到次级输入轴。 根据操作人员的指令，采用控制电路来指示离合器，二次电动机，主制动器和二次制动器的操作。

    METHODS AND A SYSTEM FOR PROVIDING DIGITAL MEDIA CONTENT
    25.
    发明申请
    METHODS AND A SYSTEM FOR PROVIDING DIGITAL MEDIA CONTENT 审中-公开
    用于提供数字媒体内容的方法和系统

    公开(公告)号：US20080033725A1

    公开(公告)日：2008-02-07

    申请号：US11782296

    申请日：2007-07-24

    申请人： David Peak ,  Daniel Anderson ,  Paul Hletko

    发明人： David Peak ,  Daniel Anderson ,  Paul Hletko

    IPC分类号： G10L13/00 ,  G06F15/16

    CPC分类号： G06F16/48

    摘要： The present disclosure includes methods for providing digital media content. A method includes capturing content, receiving the captured content as a file, and determining a recipient of the received file. The received file is converted to a digital media file and automatically transmitted to the recipient. Another method includes providing a first content and a second content. The first content is automatically transmitted to a first recipient group, which includes multiple recipients. The second content is automatically transmitted to a second recipient group, which also includes multiple recipients.

    摘要翻译： 本公开包括用于提供数字媒体内容的方法。 一种方法包括捕获内容，接收所捕获的内容作为文件，以及确定所接收的文件的接收者。 接收的文件被转换为数字媒体文件，并自动发送给收件人。 另一种方法包括提供第一内容和第二内容。 第一内容被自动发送到包括多个收件人的第一收件人组。 第二内容被自动发送到第二个收件人组，其中还包括多个收件人。

    Golf ball with water immersion indicator
    26.
    发明申请
    Golf ball with water immersion indicator 有权
    高尔夫球与水浸指示器

    公开(公告)号：US20050227789A1

    公开(公告)日：2005-10-13

    申请号：US10821763

    申请日：2004-04-09

    申请人： Robert Winskowicz ,  Edward Kingsley ,  David Lynn ,  Daniel Anderson

    发明人： Robert Winskowicz ,  Edward Kingsley ,  David Lynn ,  Daniel Anderson

    IPC分类号： A63B37/00 ,  A63B37/12 ,  A63B43/00 ,  A63B69/36

    CPC分类号： A63B37/12 ,  A63B37/0003 ,  A63B37/0013 ,  A63B37/0022 ,  A63B37/0074 ,  A63B43/00 ,  A63B43/008 ,  A63B69/3655 ,  A63B2225/60

    摘要： In order to provide a golf ball with a water immersion indicator, a golf ball with indicia or a particular recognizable color is overlain with an opacification layer that provides a mask over the indicia or the colored ball until such time as the ball has been immersed in water for a predetermined period of time affecting the ball's performance. The opacification layer when removed or otherwise made transparent, while providing for a change in the appearance of the golf ball upon water immersion, does not need to have a layer or indicia which changes color in reaction to the infusion of water. Rather the opacification layer is either removed or made transparent to expose an underlying colored surface or a surface bearing pre-determined indicia, thus to alter the appearance of the ball when it has been immersed in water for a period of time which affects golf ball properties. The subject system provides an easy way to make indicia visible upon water immersion since one does not have to create the indicia in response to water activation, but rather uncover already-printed indicia due to the removal or transparency of the opacification layer. Opacification reduction or elimination is accomplished through a number of physical processes involving a water-activated binder and either insoluble pigment particles, effervescing bubbles, the use of transparent oils, agglomeration or the complete or partial removal of the opacification layer.

    摘要翻译： 为了提供具有水浸指示器的高尔夫球，具有标记或特定可识别颜色的高尔夫球覆盖有在标记或彩色球上提供面罩的不透明层，直到球已经浸入 水预定一段时间影响球的表现。 当去除或以其它方式制成透明的同时提供在浸水时高尔夫球的外观变化的不透明层不需要具有改变反映于水的颜色的层或标记。 相反地​​，不透明层被去除或制成透明以暴露下面的着色表面或承载预定标记的表面，从而当球浸入水中一段时间​​以改变球的外观，这影响高尔夫球的性质 。 主题系统提供了一种简单的方法，使水印上可见的标记，因为不必为响应于水的激活而产生标记，而是由于不透明层的去除或透明度而露出已打印的标记。 通过涉及水活化粘合剂和不溶性颜料颗粒，起泡泡，使用透明油，凝聚或完全或部分去除不透明层的物理过程来实现不透明化的还原或消除。

    pH-triggered microparticles
    28.
    发明申请
    pH-triggered microparticles 审中-公开
    pH触发微粒

    公开(公告)号：US20050123596A1

    公开(公告)日：2005-06-09

    申请号：US10948981

    申请日：2004-09-23

    申请人： Daniel Kohane ,  Daniel Anderson ,  Robert Langer ,  William Haining ,  Lee Nadler

    发明人： Daniel Kohane ,  Daniel Anderson ,  Robert Langer ,  William Haining ,  Lee Nadler

    IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A61K9/51 ,  A61K39/00 ,  A61K48/00 ,  A61L27/18 ,  C12N5/08 ,  C12N15/87 ,  C12N15/88

    CPC分类号： A61K9/1647 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1658 ,  A61K9/5031 ,  A61K9/5153 ,  A61K9/5192

    摘要： Microparticles that are designed to release their payload when exposed to acidic conditions are provided as a vehicle for drug delivery. Any therapeutic, diagnostic, or prophylatic agent may be encapsulated in a lipid-protein-sugar or polymeric matrix including a pH triggering agent to form pH triggerable microparticles. Preferably the diameter of the pH triggered microparticles ranges from 50 nm to 10 micrometers. The matrix of the particles may be prepared using any known lipid (e.g., DPPC), protein (e.g., albumin), or sugar (e.g., lactose). The matrix of the particles may also be prepared using any synthetic polymers such as polyesters. Methods of preparing and administering the particles are provided. Methods of immunization, transfection, and gene therapy are also provided by administering pH triggerable microparticles.

    摘要翻译： 被设计为在暴露于酸性条件下释放其有效载荷的微粒被提供作为用于药物递送的载体。 任何治疗，诊断或预防剂可以包封在包含pH引发剂的脂质蛋白质糖或聚合物基质中以形成pH可触发的微粒。 优选地，pH触发的微粒的直径范围为50nm至10微米。 可以使用任何已知的脂质（例如DPPC），蛋白质（例如白蛋白）或糖（例如乳糖）来制备颗粒的基质。 颗粒的基质也可以使用任何合成聚合物如聚酯来制备。 提供了制备和施用颗粒的方法。 免疫，转染和基因治疗的方法也通过施用pH可触发的微粒来提供。

    Production of human coagulation factor VIII from plant cells and whole plants
    29.
    发明申请
    Production of human coagulation factor VIII from plant cells and whole plants 审中-公开
    从植物细胞和整株植物生产人凝血因子VIII

    公开(公告)号：US20050060775A1

    公开(公告)日：2005-03-17

    申请号：US10863969

    申请日：2004-06-08

    申请人： Brian Hooker ,  Daniel Anderson ,  Johnway Gao ,  Ziyu Dai

    发明人： Brian Hooker ,  Daniel Anderson ,  Johnway Gao ,  Ziyu Dai

    IPC分类号： A01H1/00 ,  C12N15/82

    CPC分类号： C12N15/8257

    摘要： The invention includes methods for production of a polypeptide having factor VIII activity by introduction of a polynucleotide construct into a plant cell. The construct includes an encoding sequence for a polypeptide of coagulation factor VIII or a functional variant thereof. The plant cell is cultured or regenerated into a plant and the polypeptide or functional variant of factor VIII is expressed therein. The invention also includes vectors, plant cells, plant tissues, plants and seeds containing a polynucleotide sequence encoding a functional variant of human coagulation factor VIII. The invention further includes a recombinant DNA molecule having a promoter which is functional in plants operably linked to a coding sequence which codes for a polynucleotide having coagulation factor VIII activity.

    摘要翻译： 本发明包括通过将多核苷酸构建体引入植物细胞来生产具有因子VIII活性的多肽的方法。 该构建体包含凝血因子VIII多肽或其功能变体的编码序列。 将植物细胞培养或再生成植物，并在其中表达因子VIII的多肽或功能变体。 本发明还包括含有编码人凝血因子VIII功能变体的多核苷酸序列的载体，植物细胞，植物组织，植物和种子。 本发明还包括具有启动子的重组DNA分子，该启动子在与可编码具有凝血因子VIII活性的多核苷酸的编码序列可操作地连接的植物中是功能性的。