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公开(公告)号：US06362324B1
公开(公告)日：2002-03-26
申请号：US09345650
申请日：1999-06-30
IPC分类号： C07H2104
CPC分类号： C12Q1/37 , A61K38/00 , C12N9/48 , G01N2500/00 , Y02A50/475
摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.
摘要翻译： 本发明涉及新鉴定的人类氨基肽酶。 本发明还涉及编码氨基肽酶的多核苷酸。 本发明还涉及使用氨基肽酶多肽和多核苷酸作为在氨基肽酶相关疾病中进行诊断和治疗的靶标的方法。 本发明还涉及使用氨基肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于氨基肽酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及生产氨基肽酶多肽和多核苷酸的方法。
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22.发明授权Human protein kinase, phosphatase, and protease family members and uses thereof 失效人蛋白激酶，磷酸酶和蛋白酶家族成员及其用途公开(公告)号：US07070947B2
公开(公告)日：2006-07-04
申请号：US10170789
申请日：2002-06-13
申请人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
发明人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
CPC分类号： C12N9/12 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/40 , C07K2319/00 , C12N9/1205 , C12N9/14 , C12N9/16 , C12N9/6424 , C12N9/6427 , C12N9/6437 , C12Q1/34 , C12Q1/44 , C12Y207/01001 , C12Y301/02015 , C12Y304/21004 , C12Y304/21021 , G01N33/5011 , G01N33/502 , G01N33/5041 , G01N33/6893 , G01N2500/00
摘要： The invention provides isolated nucleic acids molecules, designated 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, hexokinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新的人蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族的分离的核酸分子，命名为2504,15977,14760,53070,15985,5042,56583,21953，m32404,14089和23436核酸分子 成员，己糖激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供了反义核酸分子，含有2504,15977,14760,53070,15985,5042,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞， 和非人类转基因动物，其中引入或破坏了2504,15977,14760,53070,15985,550365,26583,21953，m32404,14089或23436基因。 本发明还进一步提供分离的2504,15977,14760,53070,15985,5038,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗2504,15977,14760,53070,15985,50365， 26583,21953，m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。
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23.发明授权Human protein kinase, phosphatase, and protease family members and uses thereof 失效新型人类蛋白激酶，磷酸酶和蛋白酶家族成员及其用途公开(公告)号：US07282360B2
公开(公告)日：2007-10-16
申请号：US11636948
申请日：2006-12-11
申请人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
发明人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
CPC分类号： C12N9/1205 , A61K38/00 , C07K16/40 , C12N9/12 , C12N9/16 , C12N9/48 , C12N9/6424 , C12N9/6427 , C12N9/6472 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156
摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为53070,15985,26583,21953，m32404,14089和23436核酸分子，其编码新的人类蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员 ，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供反义核酸分子，含有53070,15985,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中53070 ，15985,26583,21953，m32404,14089或23436基因已被引入或破坏。 本发明还进一步提供了分离的53070,15985,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗-53070,15985,26583,21953，m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US07034111B2
公开(公告)日：2006-04-25
申请号：US10039073
申请日：2001-12-31
CPC分类号： C12Q1/37 , A61K38/00 , C12N9/48 , G01N2500/00 , Y02A50/475
摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.
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公开(公告)号：US07977059B2
公开(公告)日：2011-07-12
申请号：US12129509
申请日：2008-05-29
IPC分类号： C12Q1/00 , G01N33/00 , G01N33/53 , G01N33/567 , G01N33/573
CPC分类号： C12Q1/37 , A61K38/00 , C12N9/48 , G01N2500/00 , Y02A50/475
摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.
摘要翻译： 本发明涉及新鉴定的人类氨基肽酶。 本发明还涉及编码氨基肽酶的多核苷酸。 本发明还涉及使用氨基肽酶多肽和多核苷酸作为在氨基肽酶相关疾病中进行诊断和治疗的靶标的方法。 本发明还涉及使用氨基肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于氨基肽酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及生产氨基肽酶多肽和多核苷酸的方法。
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26.发明授权公开(公告)号：US06673564B2
公开(公告)日：2004-01-06
申请号：US09420190
申请日：1999-10-18
IPC分类号： C12Q144
摘要： The present invention relates to methods for using a human cyclic nucleotide phosphodiesterase belonging to the superfamily of mammalian phosphodiesterases. The invention also relates to methods for using polynucleotides encoding the phosphodiesterase. The invention relates to methods using the phosphodiesterase polypeptides and polynucleotides as a target for diagnosis and treatment in phosphodiesterase-mediated or -related disorders. The invention further relates to drug-screening methods using the phosphodiesterase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the phosphodiesterase polypeptides and polynucleotides. The invention further relates to agonists and antagonists identifiefd by drug screening methods with the phosphodiesterase polypeptides and polynucleotides as a target.
摘要翻译： 本发明涉及使用属于哺乳动物磷酸二酯酶超家族的人环状核苷酸磷酸二酯酶的方法。 本发明还涉及使用编码磷酸二酯酶的多核苷酸的方法。 本发明涉及使用磷酸二酯酶多肽和多核苷酸作为磷酸二酯酶介导的或相关疾病中的诊断和治疗的靶标的方法。 本发明还涉及使用磷酸二酯酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于磷酸二酯酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及用磷酸二酯酶多肽和多核苷酸作为靶标的药物筛选方法鉴定的激动剂和拮抗剂。
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公开(公告)号：US06369210B1
公开(公告)日：2002-04-09
申请号：US09345469
申请日：1999-06-30
IPC分类号： C07H2104
CPC分类号： C12N9/48 , A61K38/00 , C07K2319/00
摘要： The present invention relates to a newly identified human carboxypeptidase. The invention also relates to polynucleotides encoding the carboxypeptidase. The invention further relates to methods using the carboxypeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in carboxypeptidase-related disorders. The invention further relates to drug-screening methods using the carboxypeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the carboxypeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the carboxypeptidase polypeptides and polynucleotides.
摘要翻译： 本发明涉及一种新鉴定的人类羧肽酶。 本发明还涉及编码羧肽酶的多核苷酸。 本发明还涉及使用羧肽酶多肽和多核苷酸作为羧肽酶相关病症诊断和治疗的靶标的方法。 本发明还涉及使用羧肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于羧肽酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及产生羧肽酶多肽和多核苷酸的方法。
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28.发明申请Novel human protein kinase, phosphatase, and protease family members and uses thereof 审中-公开新型人蛋白激酶，磷酸酶和蛋白酶家族成员及其用途公开(公告)号：US20090324608A1
公开(公告)日：2009-12-31
申请号：US11899343
申请日：2007-09-05
申请人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
发明人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
IPC分类号： C12N15/52 , C12N15/85 , C12N5/10 , C12N9/12 , C12N9/48 , C12N9/76 , C07K16/40 , C12P21/02 , C12N9/99 , A61K38/02 , A61K39/395 , C12Q1/68
摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为53070,15985,26583,21953，m32404,14089和23436核酸分子，其编码新的人蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员 ，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供反义核酸分子，含有53070,15985,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中53070 ，15985,26583,21953，m32404,14089或23436基因已被引入或破坏。 本发明还进一步提供了分离的53070,15985,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗-53070,15985,26583,21953，m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。
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29.发明申请公开(公告)号：US20060088880A1
公开(公告)日：2006-04-27
申请号：US11300765
申请日：2005-12-15
IPC分类号： C12Q1/68 , A61K39/395 , G01N33/574 , A61K48/00 , A61K38/17
CPC分类号： G01N33/5011 , C07K14/47
摘要： The present invention relates to methods and compositions for the treatment and diagnosis of cellular proliferation disorders, including, but not limited to, breast cancer, ovarian cancer, lung cancer, and colon cancer. The invention further provides methods for identifying a compound capable of treating a cellular proliferation disorders disorder or modulating cellular proliferation. The invention also provides a method for modulating cellular proliferation, e.g., modulating cellular proliferation in a subject. In addition, the invention provides a method for treating a subject having a cellular proliferation disorder characterized by aberrant 25943 polypeptide activity or aberrant 25943 nucleic acid expression.
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公开(公告)号：US06767727B2
公开(公告)日：2004-07-27
申请号：US10314881
申请日：2002-12-09
IPC分类号： C12N916
摘要： The present invention relates to newly identified human sulfatases. In particular, the invention relates to sulfatase polypeptides and polynucleotides, methods of detecting the sulfatase polypeptides and polynucleotides, and methods of diagnosing and treating sulfatase-related disorders. Also provided are vectors, host cells, and recombinant methods for making and using the novel molecules.
摘要翻译： 本发明涉及新鉴定的人类硫酸酯酶。 特别地，本发明涉及硫酸酯酶多肽和多核苷酸，检测硫酸酯酶多肽和多核苷酸的方法，以及诊断和治疗硫酸酯酶相关病症的方法。 还提供了用于制备和使用新分子的载体，宿主细胞和重组方法。
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