公开(公告)号：US07867482B2

公开(公告)日：2011-01-11

申请号：US12555759

申请日：2009-09-08

申请人： Haitao Wang ,  Chungsheng Mao ,  Jizhi Li ,  Jing Xu ,  Rui Zhang ,  Ling Wang ,  Yong Du ,  Longbin Liu

发明人： Haitao Wang ,  Chungsheng Mao ,  Jizhi Li ,  Jing Xu ,  Rui Zhang ,  Ling Wang ,  Yong Du ,  Longbin Liu

IPC分类号： A61K38/21 ,  C07K14/00 ,  C12P21/04 ,  C07H21/04 ,  A61K38/00

CPC分类号： C07K14/56 ,  A61K38/00 ,  C07K14/555

摘要： This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer.

公开(公告)号：US20100042606A1

公开(公告)日：2010-02-18

申请号：US12605033

申请日：2009-10-23

申请人： Divesh SRIVASTAVA ,  Nick Koudas ,  Rui Zhang

发明人： Divesh SRIVASTAVA ,  Nick Koudas ,  Rui Zhang

IPC分类号： G06F7/10 ,  G06F17/30

CPC分类号： G06F17/30516 ,  G06F17/30489 ,  H04L69/22

摘要： A system for a data stream management system includes a filter transport aggregate for a high speed input data stream with a plurality of packets each packet comprising attributes. The system includes an evaluation system to evaluate the high speed input data stream and partitions the packets into groups the attributes and a table, wherein the table stores the attributes of each packets using a hash function. A phantom query is used to define partitioned groups of packets using attributes other than those used to group the packets for solving user queries without performing the user queries on the high speed input data stream.

摘要翻译： 用于数据流管理系统的系统包括具有多个分组的高速输入数据流的过滤器传输聚合，每个分组包括属性。 该系统包括一个评估系统，用于评估高速输入数据流，并将数据包划分成属性和一个表，其中该表使用散列函数存储每个数据包的属性。 虚幻查询用于使用不同于用于对用于分组用户查询的分组进行分组的属性来定义分组分组，而不对高速输入数据流执行用户查询。

公开(公告)号：US20090078578A1

公开(公告)日：2009-03-26

申请号：US12195844

申请日：2008-08-21

申请人： Cheng-Hsien Lin ,  Yao-Wen Bai ,  Rui Zhang ,  Wen-Chin Lee

发明人： Cheng-Hsien Lin ,  Yao-Wen Bai ,  Rui Zhang ,  Wen-Chin Lee

IPC分类号： H05K3/00 ,  B82B3/00

CPC分类号： H05K3/424 ,  B82Y10/00 ,  C23C18/1204 ,  C23C18/127 ,  C23C18/1287 ,  H05K3/427 ,  H05K2201/026 ,  H05K2201/0323

摘要： A pre-plating solution for making a printed circuit board includes carbon nanotubes of 0.01-3 wt %, a surfactant of 0.01-4 wt %, an alkaline substance of 0.01-l wt % and a solvent. A method for preparing a pre-plating solution comprising the steps of: providing a plurality of carbon nanotubes; purifying the carbon nanotubes; treating the purified carbon nanotubes with an acid; mixing the treated carbon nanotubes, an alkaline substance and a solvent to form suspension; and adding surfactant into suspension.

摘要翻译： 用于制造印刷电路板的预镀溶液包括0.01-3重量％的碳纳米管，0.01-4重量％的表面活性剂，0.01-1重量％的碱性物质和溶剂。 一种制备预镀液的方法，包括以下步骤：提供多个碳纳米管; 纯化碳纳米管; 用酸处理纯化的碳纳米管; 混合处理的碳纳米管，碱性物质和溶剂以形成悬浮液; 并将表面活性剂加入悬浮液中。

公开(公告)号：US20090031281A1

公开(公告)日：2009-01-29

申请号：US11829590

申请日：2007-07-27

申请人： Rui Zhang ,  John R. Hajdukiewicz

发明人： Rui Zhang ,  John R. Hajdukiewicz

IPC分类号： G06F9/44

CPC分类号： G06F8/34

摘要： Disclosed herein are a method and system for creating visual programs using a graphical notation. In a preferred embodiment, a visual programming system is provided. The visual programming system comprises (a) a processor; (b) data storage; and (c) program code stored in the data storage and executable by the processor. The program code is executable to implement a graphical notation that can be used to create visual programs displayable on a monitor, wherein the graphical notation comprises objects and connectors that connect the objects to other objects, wherein the objects comprise control flow objects and standard objects, and wherein the control flow objects substantially direct execution of the visual program. The program code is further executable to implement a visual program engine operable to execute visual programs created using the graphical notation, thereby causing the processor to carry out processes as indicated by the visual programs.

摘要翻译： 本文公开了一种使用图形符号创建可视程序的方法和系统。 在优选实施例中，提供了视觉编程系统。 视觉编程系统包括（a）处理器; （b）数据存储; 和（c）存储在数据存储器中并由处理器执行的程序代码。 程序代码是可执行的，以实现可用于创建可显示在监视器上的可视化程序的图形符号，其中图形符号包括将对象连接到其他对象的对象和连接器，其中对象包括控制流对象和标准对象， 并且其中所述控制流对象基本上直接执行所述可视程序。 程序代码还可执行以实现可操作以执行使用图形符号创建的可视程序的可视程序引擎，从而使处理器执行如可视程序所指示的处理。

公开(公告)号：US20080085927A1

公开(公告)日：2008-04-10

申请号：US11872417

申请日：2007-10-15

申请人： Gee-Hong Kuo ,  Rui Zhang ,  Aihua Wang ,  Alan DeAngelis

发明人： Gee-Hong Kuo ,  Rui Zhang ,  Aihua Wang ,  Alan DeAngelis

IPC分类号： A61K31/38 ,  A61K31/185 ,  A61P43/00 ,  C07C53/21 ,  C07D333/16 ,  C07D303/08 ,  C07C321/00 ,  A61K31/335

CPC分类号： A61K31/277 ,  A61K31/192 ,  C07C59/68 ,  C07C59/70 ,  C07C317/22 ,  C07C323/20 ,  C07C323/60 ,  C07C323/62 ,  C07D333/16 ,  C07D333/28

摘要： The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.

摘要翻译： 本发明具有4 - （（苯氧基烷基）硫基） - 苯氧基乙酸及其类似物，含有它们的组合物，以及使用它们作为PPARδ调节剂治疗或抑制例如血脂异常进展的方法。

公开(公告)号：US07281771B1

公开(公告)日：2007-10-16

申请号：US11675747

申请日：2007-02-16

申请人： Jiangtao Wen ,  Rui Zhang

发明人： Jiangtao Wen ,  Rui Zhang

IPC分类号： H03M7/00

CPC分类号： H03M7/4006 ,  H04N19/91

摘要： A method for performing entropy coding comprising the steps of (A) receiving an input stream and side information and (B) replacing the input stream with an index to a list of a number of valid input streams that satisfy all constraints associated with each specific type of the side information, where the list of the number of valid input streams that satisfy all constraints associated with each specific type of side information is based on an amount of redundancy in a system.

摘要翻译： 一种用于执行熵编码的方法，包括以下步骤：（A）接收输入流和副信息，以及（B）用满足与每个特定类型相关联的所有约束的许多有效输入流的列表的索引替换输入流 的边信息，其中满足与每个特定类型的侧信息相关联的所有约束的有效输入流的数量的列表是基于系统中的冗余量。

公开(公告)号：US20070240130A1

公开(公告)日：2007-10-11

申请号：US11590439

申请日：2006-10-31

申请人： Rui Zhang ,  Yujun Zhang

发明人： Rui Zhang ,  Yujun Zhang

IPC分类号： G06F9/45

CPC分类号： G06F9/445 ,  G06F8/20

摘要： A process assembles and/or reassembles a software application. In an embodiment, assemblies are loaded from an architecture description markup language (ADML) document. Class objects and type objects are activated based on the ADML document. Components and connectors are created based on the ADML document. The components are serialized, and an architecture is assembled based on connections described in the ADML document. A main active component designated in the ADML document is then activated.

摘要翻译： 过程组装和/或重新组装软件应用程序。 在一个实施例中，从架构描述标记语言（ADML）文档加载组件。 基于ADML文档激活类对象和类型对象。 组件和连接器是基于ADML文档创建的。 这些组件是串行化的，并且基于ADML文档中描述的连接来组织架构。 然后激活在ADML文档中指定的主要活动组件。

公开(公告)号：US20070178112A1

公开(公告)日：2007-08-02

申请号：US11340661

申请日：2006-01-27

申请人： Haitao Wang ,  Yong Du ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

发明人： Haitao Wang ,  Yong Du ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

IPC分类号： A61K39/395 ,  C12P21/06 ,  C07K16/46 ,  C07H21/04 ,  C12N5/06

CPC分类号： C07K14/505 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/6811 ,  C07K2317/53 ,  C07K2319/30

摘要： A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy.

摘要翻译： 描述了包含与免疫球蛋白肽部分连接的人促红细胞生成素肽部分的重组融合蛋白。 与天然存在的或重组的天然人促红细胞生成素相比，融合蛋白在体内具有延长的半衰期。 在本发明的一个实施方案中，蛋白质的体内半衰期比天然人促红细胞生成素高至少三倍。 与天然人促红细胞生成素相比，融合蛋白也表现出增强的红细胞生物活性。 在一个实施方案中，融合蛋白包含人促红细胞生成素（EPO）分子的完整肽序列和人免疫球蛋白IgG1的Fc片段的肽序列。 融合蛋白中的Fc片段包括人免疫球蛋白IgG1的铰链区，CH2和CH3结构域。 EPO分子可以直接连接到Fc片段，以避免外来的肽接头并且当在体内施用时减轻免疫原性应答的风险。 在一个实施方案中，铰链区是在氨基酸6具有非半胱氨酸残基的人Fc片段变体。本发明还涉及编码融合蛋白和转染细胞系的核酸和氨基酸序列以及用于产生融合蛋白的方法。 本发明还包括包含融合蛋白的药物组合物和使用融合蛋白和/或药物组合物的方法，例如刺激需要治疗的受试者的红细胞生成。

公开(公告)号：US20070126528A1

公开(公告)日：2007-06-07

申请号：US11634917

申请日：2006-12-07

申请人： Raafat Mansour ,  Rui Zhang

发明人： Raafat Mansour ,  Rui Zhang

IPC分类号： H01P1/213 ,  H01P1/20 ,  H01P7/10

CPC分类号： H01P1/2002 ,  B33Y80/00 ,  H01P1/2084 ,  H01P7/10

摘要： A unitary resonator assembly for use in dielectric resonator filters and multiplexers. The unitary resonator assembly comprises a plurality of resonators joined by bridges, where the resonators and bridges are all constructed from a single piece of a dielectric material. The unitary resonator assemblies may be used in conjunction with unitary mounting structures that support a unitary resonator assembly in a filter or multiplexer. Also disclosed are 2-pole, 4-pole, and triplet filters implementing a unitary resonator assembly in conjunction with a unitary mounting structure, and a diplexer implementing a unitary resonator assembly in conjunction with a unitary mounting structure.

摘要翻译： 用于介质谐振滤波器和多路复用器的单一谐振器组件。 整体谐振器组件包括通过桥连接的多个谐振器，其中谐振器和桥均由单片电介质材料构成。 单一谐振器组件可以与在滤波器或多路复用器中支持单一谐振器组件的单一安装结构一起使用。 还公开了实施与单一安装结构相结合的单一谐振器组件的双极，4极和三线态滤波器，以及与单一安装结构相结合实现整体谐振器组件的双工器。

公开(公告)号：US20070094193A1

公开(公告)日：2007-04-26

申请号：US11186324

申请日：2005-07-21

申请人： Sindhu Joseph ,  Rui Zhang

发明人： Sindhu Joseph ,  Rui Zhang

IPC分类号： G06N5/02

CPC分类号： G06N5/042

摘要： Mixed mode inferencing is provided by creating an extension to a RETE network to handle both forward and backward chaining efficiently. The extended RETE network is traversed from a root node through intermediate nodes to the rules of the network. The intermediate nodes contain objects that have values assigned by rules, and the intermediate nodes are linked to those rules appropriately. When using the network in a backward chaining context, rules linked to the intermediate node of interest are checked to see if they are active and the rule is solvable. If not, the related rules are checked. Because the system takes advantage of the previously formed RETE network, these checks can be done at the rule nodes without the need to retest each condition.

摘要翻译： 通过创建到RETE网络的扩展来提供有效地处理向前和向后链接来提供混合模式推理。 扩展RETE网络从根节点通过中间节点遍历到网络规则。 中间节点包含具有由规则分配的值的对象，并且中间节点被适当地链接到那些规则。 当在反向链接上下文中使用网络时，检查链接到感兴趣的中间节点的规则，以查看它们是否是活动的，并且该规则是可解决的。 如果没有，则检查相关规则。 由于系统利用了先前形成的RETE网络，这些检查可以在规则节点进行，而无需重新测试每个条件。