公开(公告)号：US09108198B2

公开(公告)日：2015-08-18

申请号：US14052464

申请日：2013-10-11

Applicant: Samsung Electronics Co., Ltd.

Inventor： Minseok S. Kim ,  Hui-sung Moon ,  Jong-myeon Park

IPC: B01L3/00 ,  G01N21/07

CPC classification number: B01L3/502753 ,  B01L2300/0803 ,  B01L2300/0858 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/086 ,  G01N21/07

Abstract: Provided is a microfluidic apparatus that is mounted on a rotation driver and induces a flow of a fluid due to a centrifugal force, the microfluidic apparatus including: a separation unit that separates a target cell from a sample; a recovery chamber that is connected to the separation unit through a recovery channel and accommodates the target cell obtained by the separation; and an inclined portion that is disposed in the recovery chamber and tilted toward a bottom of the recovery chamber along a direction of the centrifugal force.

Abstract translation: 提供了一种微流体装置，其安装在旋转驱动器上并且由于离心力而引起流体流动，所述微流体装置包括：分离单元，其将目标细胞与样品分离; 回收室，其通过回收通道连接到分离单元，并容纳通过分离获得的靶单元; 以及倾斜部，其设置在所述回收室中并沿着所述离心力的方向朝向所述回收室的底部倾斜。

公开(公告)号：US09737889B2

公开(公告)日：2017-08-22

申请号：US14273697

申请日：2014-05-09

Applicant: Samsung Electronics Co., Ltd.

Inventor： Hui-sung Moon ,  Min-Seok S. Kim ,  Jong-myeon Park

IPC: G01N33/00 ,  B01L3/00

CPC classification number: B01L3/502738 ,  B01L3/50273 ,  B01L2200/0621 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677

Abstract: A microfluidic apparatus mounted on a rotation driving unit for inducing a fluid to flow due to a centrifugal force includes: a target chamber that houses a first fluid; a first chamber that houses a second fluid and is disposed closer to a rotation center of the microfluidic apparatus in a radius direction than the target chamber, the first chamber being connected to the target chamber by a first channel; a first valve that prevents a flow of the second fluid through the first channel; and a second chamber disposed closer to the rotation center in the radius direction than the target chamber and connected to the target chamber by a second channel, wherein the first fluid is transported to the second chamber by supplying the second fluid to the target chamber by the centrifugal force.

公开(公告)号：US09580677B2

公开(公告)日：2017-02-28

申请号：US14172576

申请日：2014-02-04

Applicant: Samsung Electronics Co., Ltd.

Inventor： Hun-joo Lee ,  Jong-myeon Park

IPC: C12N5/071 ,  C12M1/00 ,  B01D29/90 ,  G01N1/40

CPC classification number: C12M47/02 ,  B01D29/904 ,  C12N5/0602 ,  G01N1/4077

Abstract: Provided are an apparatus for filtering a fluid, the apparatus including a first flow channel and a second flow channel which are connected to each other in a fluid communicable manner via a filtration medium, and a method of isolating particles using the apparatus.

Abstract translation: 提供了一种用于过滤流体的装置，该装置包括通过过滤介质以可流体连通的方式彼此连接的第一流动通道和第二流动通道，以及使用该装置分离颗粒的方法。

公开(公告)号：US20150148243A1

公开(公告)日：2015-05-28

申请号：US14323812

申请日：2014-07-03

Applicant: Samsung Electronics Co., Ltd.

Inventor： Hun-joo LEE ,  Yeon-jeong Kim ,  Dong-hyun Park ,  Jong-myeon Park

IPC: G01N1/30

CPC classification number: G01N1/30 ,  G01N2001/305

Abstract: A photocleavable polymer comprising a photocleavable linker and a polymer having a functional group that binds to a protein, lipid, sugar of a cell, or any combination thereof, as well as a method of selectively lysing cells by incubating a sample comprising two or more cells with the photocleavable polymer to reversibly fix the cells; selectively irradiating the fixed cells or a target or non-target cell among the fixed cells to cleave the photocleavable polymer; and adding a cell lysis solution to selectively lyse the irradiated cells.

Abstract translation: 包含可光切割接头和具有结合蛋白质，脂质，细胞糖或其任何组合的官能团的聚合物的可光致透照聚合物，以及通过将包含两个或多个细胞的样品 用可透光聚合物可逆地固定细胞; 选择性地照射固定细胞中的固定细胞或靶或非靶细胞以切割可光裂解的聚合物; 并加入细胞裂解溶液以选择性地裂解照射的细胞。

公开(公告)号：US20150125864A1

公开(公告)日：2015-05-07

申请号：US14324950

申请日：2014-07-07

Applicant: Samsung Electronics Co., Ltd.

Inventor： Hyun Ju KANG ,  Ga-hee Kim ,  Ye-ryoung Yong ,  Kyung-hee Park ,  Jong-myeon Park

IPC: G01N1/40 ,  C12Q1/68

CPC classification number: G01N1/405 ,  G01N2015/0065 ,  Y10T436/25375

Abstract: Provided is a method of stabilizing vesicles in a sample by combining a sample comprising a vesicle with a chelating agent and a composition used in the stabilizing the vesicle in the sample.

Abstract translation: 提供了一种通过将包含囊泡的样品与螯合剂组合的样品和用于稳定样品中囊泡的组合物来稳定样品中的囊泡的方法。

公开(公告)号：US20140341788A1

公开(公告)日：2014-11-20

申请号：US14052464

申请日：2013-10-11

Applicant: Samsung Electronics Co., Ltd.

Inventor： Minseok S. KIM ,  Hui-sung Moon ,  Jong-myeon Park

IPC: B01L3/00

CPC classification number: B01L3/502753 ,  B01L2300/0803 ,  B01L2300/0858 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/086 ,  G01N21/07

Abstract: Provided is a microfluidic apparatus that is mounted on a rotation driver and induces a flow of a fluid due to a centrifugal force, the microfluidic apparatus including: a separation unit that separates a target cell from a sample; a recovery chamber that is connected to the separation unit through a recovery channel and accommodates the target cell obtained by the separation; and an inclined portion that is disposed in the recovery chamber and tilted toward a bottom of the recovery chamber along a direction of the centrifugal force.

Abstract translation: 提供了一种微流体装置，其安装在旋转驱动器上并且由于离心力而引起流体流动，所述微流体装置包括：分离单元，其将目标细胞与样品分离; 回收室，其通过回收通道连接到分离单元，并容纳通过分离获得的靶单元; 以及倾斜部，其设置在所述回收室中并沿着所述离心力的方向朝向所述回收室的底部倾斜。