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公开(公告)号：US20180273613A1
公开(公告)日：2018-09-27
申请号：US16004622
申请日：2018-06-11
Applicant: Samsung Electronics Co., Ltd.
Inventor： Seok Kyun Kim , Sunghyun Kim , Sang Yeul Han , Seung Hyun Lee , Su Jin Kim , Yong In Kim , Hyung-Chan Kim , Kwang Hoon Lee , Hyo Seon Lee
IPC: C07K16/22 , G01N33/68 , A61K39/395 , C07K14/705 , C07K14/515 , A61K39/00 , A61K38/00
CPC classification number: C07K16/22 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/515 , C07K14/705 , C07K2317/24 , C07K2317/567 , C07K2317/622 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/6887 , G01N33/6893 , G01N2333/515
Abstract: An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with a Tie2 receptor through Ang2, and methods of using the same.
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公开(公告)号：US10000569B2
公开(公告)日：2018-06-19
申请号：US14692934
申请日：2015-04-22
Applicant: Samsung Electronics Co., Ltd.
Inventor： Kwang Ho Cheong , Jae Woong Hwang , Seung Hyun Lee , Powei Lin , Mi Young Cho
CPC classification number: C07K16/2863 , A61K39/395 , A61K39/39558 , A61K2039/505 , A61K2039/507 , C07K16/32 , C07K16/40 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/09
Abstract: An anti-EGFR/anti-HER3 antibody or antigen binding fragment thereof, and a method of preventing and/or treating a cancer using the same.
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公开(公告)号：US09808507B2
公开(公告)日：2017-11-07
申请号：US14835376
申请日：2015-08-25
Applicant: Samsung Electronics Co., Ltd.
Inventor： Seungja Oh , Kyung Ah Kim , Bo Gyou Kim , Seung Hyun Lee , Ji Min Lee
CPC classification number: A61K38/18 , A61K38/1891 , A61K2039/507 , A61K2039/545 , C07K16/22 , C07K16/2863 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2317/73 , C07K2317/92 , A61K2300/00
Abstract: An anti-c-Met/anti-Ang2 bispecific antibody including (a) an anti-c-Met antibody or antigen-binding fragment thereof and (b) an anti-Ang2 antibody or antigen-binding fragment thereof, a pharmaceutical composition including the anti-c-Met/anti-Ang2 bispecific antibody, and a method using the anti-c-Met/anti-Ang2 bispecific antibody.
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公开(公告)号：US09717715B2
公开(公告)日：2017-08-01
申请号：US14081886
申请日：2013-11-15
Applicant: Samsung Electronics Co., Ltd.
Inventor： Seung Hyun Lee , Geun Woong Kim , Kyung Ah Kim , Hye Won Park , Ho Yeong Song , Young Mi Oh , Saet Byoul Lee , Ji Min Lee , Kwang Ho Cheong , Yun Ju Jeong , Mi Young Cho , Jae Hyun Choi , Yun Jeong Song , Yoon Aa Choi
IPC: A61K39/395 , A61K31/437 , A61K31/517 , A61K31/44 , C07K16/28 , C12N5/16
CPC classification number: A61K31/437 , A61K31/44 , A61K31/517 , A61K39/3955 , A61K39/39558 , C07K16/2863 , C07K2317/24 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2319/30 , C12N5/163 , A61K2300/00
Abstract: A method for prevention or treatment of a cancer, comprising co-administering (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib or a combination thereof, to a subject in need thereof, and a pharmaceutical composition comprising (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib, or a combination thereof are provided.
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公开(公告)号：US09650443B2
公开(公告)日：2017-05-16
申请号：US14228521
申请日：2014-03-28
Applicant: Samsung Electronics Co., Ltd.
Inventor： Yun Jeong Song , Ho Yeong Song , Seung Hyun Lee , Kyung Ah Kim , Yun Ju Jeong
CPC classification number: C07K16/2863 , A61K2039/505 , C07K14/71 , C07K2317/10 , C07K2317/24 , C07K2317/515 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: There are provided a fusion protein formed by coupling of anti-c-Met antibody and VEGF-binding fragment, a bispecific antibody comprising the fusion protein, a polynucleotide encoding the fusion protein, a transformant comprising the polynucleotide, a pharmaceutical composition comprising the bispecific antibody as an active ingredient, and a method for preparing the bispecific antibody which is targeted at c-Met and VEGF at the same time, with improved anticancer and anti-angiogenesis effects, comprising coupling an anti-c-Met antibody with a VEGF-binding fragment.
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Patent Agency Ranking
26.发明申请POLYPEPTIDE, ANTI-VEGF ANTIBODY, AND ANTI-C-MET/ANTI-VEGF BISPECIFIC ANTIBODIES COMPRISING THE SAME 审中-公开多肽，抗VEGF抗体和包含该抗体的抗-C-MET /抗-VEGF-BISPECIFIC抗体公开(公告)号：US20160090427A1
公开(公告)日：2016-03-31
申请号：US14869636
申请日：2015-09-29
Applicant: Samsung Electronics Co., Ltd.
Inventor： Seung Hyun Lee , Soo Yeon Jung , Bo Gyou Kim , Seung Ja Oh , Ji Min Lee
CPC classification number: C07K16/22 , A61K39/3955 , A61K39/39558 , C07K16/2863 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/74
Abstract: A polypeptide, an anti-VEGF antibody and an anti-c-Met/anti-VEGF bispecific antibody, which includes the polypeptide, a pharmaceutical composition including the antibody, and a method of treating cancer using the antibody.
Abstract translation: 包括该多肽的多肽，抗VEGF抗体和抗c-Met /抗VEGF双特异性抗体，包含该抗体的药物组合物和使用该抗体治疗癌症的方法。
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27.发明授权公开(公告)号：US09249221B2
公开(公告)日：2016-02-02
申请号：US14231470
申请日：2014-03-31
Applicant: Samsung Electronics Co., Ltd.
Inventor： Seung Hyun Lee , Kyung Ah Kim , Kwang Ho Cheong , Ho Yeong Song
IPC: A61K39/395 , C07K16/28 , C07K16/30
CPC classification number: C07K16/2863 , C07K16/3023 , C07K2317/24 , C07K2317/76 , C07K2317/92
Abstract: Provided is a humanized and affinity-matured anti-c-Met antibody, a pharmaceutical composition including the antibody, and a method of preventing and/or treating c-Met-related disease using the antibody.
Abstract translation: 提供人源化和亲和力成熟的抗c-Met抗体，包含该抗体的药物组合物，以及使用该抗体预防和/或治疗c-Met相关疾病的方法。
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28.发明申请ANTI-CMET/ANTI-EGFR/ANTI-HER3 MULTIPECIFIC ANTIBODIES AND USE THEREOF 有权抗CMET /抗EGFR /抗-IV3多种抗体及其用途公开(公告)号：US20150322165A1
公开(公告)日：2015-11-12
申请号：US14692934
申请日：2015-04-22
Applicant: Samsung Electronics Co., Ltd.
Inventor： Kwang Ho Cheong , Jae Woong Hwang , Seung Hyun Lee , Powei Lin , Mi Young Cho
CPC classification number: C07K16/2863 , A61K39/395 , A61K39/39558 , A61K2039/505 , A61K2039/507 , C07K16/32 , C07K16/40 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/09
Abstract: An anti-EGFR/anti-HER3 antibody or antigen binding fragment thereof, and a method of preventing and/or treating a cancer using the same
Abstract translation: 抗EGFR /抗HER3抗体或其抗原结合片段，以及使用其的预防和/或治疗癌症的方法
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29.发明申请ANTI-EGFR/ANTI-HER2 BISPECIFIC ANTIBODIES WITH ANTI-EGFR DARPINS 有权抗EGFR /抗HER2抗双抗体与抗EGFR DARPINS抗体公开(公告)号：US20150232573A1
公开(公告)日：2015-08-20
申请号：US14625296
申请日：2015-02-18
Applicant: Samsung Electronics Co., Ltd.
Inventor： Kwang Ho Cheong , Seung Hyun Lee , Powei Lin , Saet Byoul Lee , Jae Woong Hwang
CPC classification number: C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/73 , C07K2317/77 , C07K2317/92
Abstract: An anti-EGFR/anti-HER2 bispecific antibody including an anti-EGFR DARPin and an anti-HER2 antibody, a pharmaceutical composition including the bispecific antibody, a method of preparing the bispecific antibody, and a method of reducing a side effect and/or enhancing efficacy of an anti-HER2 antibody using an anti-EGFR DARPin.
Abstract translation: 包含抗EGFR DARPin和抗HER2抗体的抗EGFR /抗HER2双特异性抗体，包含双特异性抗体的药物组合物，制备双特异性抗体的方法和减少副作用的方法和/或 使用抗EGFR DARPin增强抗HER2抗体的功效。
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公开(公告)号：US20150030596A1
公开(公告)日：2015-01-29
申请号：US14444632
申请日：2014-07-28
Applicant: Samsung Electronics Co., Ltd.
Inventor： Kwang Ho CHEONG , Young Jun Koh , Min-Kyung Kim , Powei Lin , Seung Hyun Lee , Jung Wook Lee , Mi Young Cho , Jae Woong Hwang
IPC: C07K16/28 , C07K14/705
CPC classification number: C07K16/2863 , C07K14/705 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/53 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2318/20 , C07K2319/30 , C07K2319/33
Abstract: A bispecific chimeric protein including a designed ankyrin repeat protein (DARPin), and an IgG antibody, an scFv-Fc antibody fragment, or a combination thereof, linked to the DARPin; a method for treating or preventing cancer using the same; and related methods and compositions.
Abstract translation: 包含与DARPin连接的双特异性嵌合蛋白，包括设计的锚蛋白重复蛋白（DARPin）和IgG抗体，scFv-Fc抗体片段或其组合; 使用该方法治疗或预防癌症的方法; 以及相关方法和组成。
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