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公开(公告)号：US07973169B2
公开(公告)日：2011-07-05
申请号：US10936448
申请日：2004-09-07
申请人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D. J. Grootenhuis
发明人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D. J. Grootenhuis
IPC分类号： C07D277/20 , A61K31/427
CPC分类号： A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D263/48 , C07D277/46 , C07D277/82 , C07D295/15 , C07D417/04 , C07D417/06 , C07D417/12 , G01N33/5076
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US08741939B2
公开(公告)日：2014-06-03
申请号：US13848970
申请日：2013-03-22
申请人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D. J. Grootenhuis
发明人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D. J. Grootenhuis
IPC分类号： A61K31/427 , C07D277/20
CPC分类号： A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D263/48 , C07D277/46 , C07D277/82 , C07D295/15 , C07D417/04 , C07D417/06 , C07D417/12 , G01N33/5076
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号：US08431605B2
公开(公告)日：2013-04-30
申请号：US13174844
申请日：2011-07-01
申请人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D. J. Grootenhuis
发明人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D. J. Grootenhuis
IPC分类号： A61K31/427 , C07D277/20
CPC分类号： A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D263/48 , C07D277/46 , C07D277/82 , C07D295/15 , C07D417/04 , C07D417/06 , C07D417/12 , G01N33/5076
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US07598412B2
公开(公告)日：2009-10-06
申请号：US10961485
申请日：2004-10-08
申请人： Sara S. Hadida Ruah , Ashvani K. Singh , Mark T. Miller , Matthew Hamilton , Peter D. J. Grootenhuis
发明人： Sara S. Hadida Ruah , Ashvani K. Singh , Mark T. Miller , Matthew Hamilton , Peter D. J. Grootenhuis
IPC分类号： C07C229/00 , C07C233/00
CPC分类号： C07D307/87 , A61K31/00 , A61K31/335 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/495 , A61K45/06 , C07C233/22 , C07C233/60 , C07C233/65 , C07C233/73 , C07C235/34 , C07C235/46 , C07C235/48 , C07C311/16 , C07C311/17 , C07C323/60 , C07C2601/08 , C07D209/42 , C07D213/82 , C07D215/54 , C07D217/26 , C07D231/14 , C07D231/56 , C07D237/28 , C07D261/20 , C07D307/68 , C07D307/85 , C07D333/32 , C07D333/70 , C07D407/12
摘要： The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.
摘要翻译： 本发明提供了可用作ABC转运蛋白活性调节剂的式I化合物或其药学上可接受的盐，其中RB，n，B，RC，RD，RE，A和Z通常在下面的类别和亚类中进行描述。 本发明还提供了与式I相关的药物组合物，方法和试剂盒，其用作调节剂，以及用于治疗与ABC转运蛋白相关的疾病和疾病状况。
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公开(公告)号：US20100125090A1
公开(公告)日：2010-05-20
申请号：US12541196
申请日：2009-08-14
IPC分类号： A61K31/47 , C07D307/80 , C07D333/56 , C07D215/04 , C07D213/63 , C07D231/56 , A61K31/4406 , A61K31/416 , A61K31/381 , A61K31/343 , G01N33/53 , A61P11/00
CPC分类号： C07D307/87 , A61K31/00 , A61K31/335 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/495 , A61K45/06 , C07C233/22 , C07C233/60 , C07C233/65 , C07C233/73 , C07C235/34 , C07C235/46 , C07C235/48 , C07C311/16 , C07C311/17 , C07C323/60 , C07C2601/08 , C07D209/42 , C07D213/82 , C07D215/54 , C07D217/26 , C07D231/14 , C07D231/56 , C07D237/28 , C07D261/20 , C07D307/68 , C07D307/85 , C07D333/32 , C07D333/70 , C07D407/12
摘要： The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below.The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.
摘要翻译： 本发明提供了可用作ABC转运蛋白活性调节剂的式I化合物或其药学上可接受的盐，其中RB，n，B，RC，RD，RE，A和Z通常在下面的类别和亚类中进行描述。 本发明还提供了与式I相关的药物组合物，方法和试剂盒，其用作调节剂，以及用于治疗与ABC转运蛋白相关的疾病和疾病状况。
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公开(公告)号：US20130012536A1
公开(公告)日：2013-01-10
申请号：US13534796
申请日：2012-06-27
IPC分类号： A61K31/343 , A61K31/455 , A61K31/416 , A61P11/00 , A61P7/02 , A61P3/06 , A61P1/12 , A61P13/12 , A61P3/10 , A61P5/18 , A61P35/00 , A61P19/00 , A61P25/28 , A61P25/16 , A61P25/00 , A61P27/02 , A61P17/00 , C12N5/07 , G01N33/566 , A61K31/47
CPC分类号： C07D307/87 , A61K31/00 , A61K31/335 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/495 , A61K45/06 , C07C233/22 , C07C233/60 , C07C233/65 , C07C233/73 , C07C235/34 , C07C235/46 , C07C235/48 , C07C311/16 , C07C311/17 , C07C323/60 , C07C2601/08 , C07D209/42 , C07D213/82 , C07D215/54 , C07D217/26 , C07D231/14 , C07D231/56 , C07D237/28 , C07D261/20 , C07D307/68 , C07D307/85 , C07D333/32 , C07D333/70 , C07D407/12
摘要： The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below.The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.
摘要翻译： 本发明提供了可用作ABC转运蛋白活性调节剂的式I化合物或其药学上可接受的盐，其中RB，n，B，RC，RD，RE，A和Z通常在下面的类别和亚类中进行描述。 本发明还提供了与式I相关的药物组合物，方法和试剂盒，其用作调节剂，以及用于治疗与ABC转运蛋白相关的疾病和疾病状况。
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公开(公告)号：US20120035179A1
公开(公告)日：2012-02-09
申请号：US13043895
申请日：2011-03-09
IPC分类号： A61K31/502 , A61K31/166 , A61K31/18 , A61K31/341 , A61K31/4412 , A61K31/357 , A61K31/351 , A61K31/415 , A61K31/472 , C12N5/071 , C12Q1/02 , C12Q1/37 , G01N33/53 , A61P11/00 , A61P27/04 , A61P3/06 , A61P7/10 , A61P1/12 , A61P3/10 , A61P5/18 , A61P19/08 , A61P35/00 , A61P5/16 , A61P25/28 , A61P25/16 , A61K31/343
CPC分类号： C07D307/87 , A61K31/00 , A61K31/335 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/495 , A61K45/06 , C07C233/22 , C07C233/60 , C07C233/65 , C07C233/73 , C07C235/34 , C07C235/46 , C07C235/48 , C07C311/16 , C07C311/17 , C07C323/60 , C07C2601/08 , C07D209/42 , C07D213/82 , C07D215/54 , C07D217/26 , C07D231/14 , C07D231/56 , C07D237/28 , C07D261/20 , C07D307/68 , C07D307/85 , C07D333/32 , C07D333/70 , C07D407/12
摘要： The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below.The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.
摘要翻译： 本发明提供了可用作ABC转运蛋白活性调节剂的式I化合物或其药学上可接受的盐，其中RB，n，B，RC，RD，RE，A和Z通常在下面的类别和亚类中进行描述。 本发明还提供了与式I相关的药物组合物，方法和试剂盒，其用作调节剂，以及用于治疗与ABC转运蛋白相关的疾病和疾病状况。
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公开(公告)号：US20120004216A1
公开(公告)日：2012-01-05
申请号：US13174844
申请日：2011-07-01
申请人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D.J. Grootenhuis
发明人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D.J. Grootenhuis
IPC分类号： A61K31/541 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/506 , A61P11/00 , A61P7/00 , A61P7/04 , A61P3/00 , A61P9/00 , A61P3/06 , A61P43/00 , A61P13/12 , A61P1/12 , A61P3/10 , A61P5/18 , A61P35/00 , A61P5/14 , A61P19/08 , A61P25/28 , A61P25/00 , A61P1/02 , A61P25/16 , A61P27/02 , A61K31/426
CPC分类号： A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D263/48 , C07D277/46 , C07D277/82 , C07D295/15 , C07D417/04 , C07D417/06 , C07D417/12 , G01N33/5076
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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29.发明申请Thiazoles and Oxazoles Useful as Modulators of ATP-Binding Cassette Transporters 有权噻唑和恶唑可用作ATP结合盒转运蛋白的调节剂公开(公告)号：US20110144123A1
公开(公告)日：2011-06-16
申请号：US12913089
申请日：2010-10-27
IPC分类号： A61K31/426 , A61K31/427 , A61K31/421 , A61K31/4439 , A61K31/496 , A61P11/00 , A61P3/06 , A61P13/12 , A61P3/10 , A61P35/00 , A61P25/28 , A61P25/16 , C12N5/071
CPC分类号： C07D263/34 , A61K31/42 , A61K31/422 , A61K31/426 , A61K31/427 , C07D277/56 , C07D417/04 , C07D417/06 , C07D417/12
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括囊性纤维化跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20130252333A1
公开(公告)日：2013-09-26
申请号：US13848970
申请日：2013-03-22
申请人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D.J. Grootenhuis
发明人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D.J. Grootenhuis
IPC分类号： C07D277/46 , C07D295/15 , C07D417/06
CPC分类号： A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D263/48 , C07D277/46 , C07D277/82 , C07D295/15 , C07D417/04 , C07D417/06 , C07D417/12 , G01N33/5076
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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