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    ROLE OF IFNG METHYLATION IN INFLAMMATORY BOWEL DISEASE
    21.
    发明申请
    ROLE OF IFNG METHYLATION IN INFLAMMATORY BOWEL DISEASE 审中-公开
    IFNG甲基化在炎症性皮肤病中的作用

    公开(公告)号：US20140018448A1

    公开(公告)日：2014-01-16

    申请号：US14007400

    申请日：2012-03-26

    申请人： Rebecca Gonsky ,  Richard Deem ,  Stephan R. Targan

    发明人： Rebecca Gonsky ,  Richard Deem ,  Stephan R. Targan

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： The invention relates to method of diagnosing susceptibility to inflammatory bowel disease (IBD) in an individual by obtaining a sample from the individual, assaying the sample to determine the presence or absence of one or more risk genetic variants and/or an increase in IFNG DNA methylation. In one embodiment, the present invention provides a method of diagnosing susceptibility to inflammatory bowel disease (IBD) in an individual by obtaining a sample from the individual, assaying the sample to determine the presence or absence of one or more risk genetic variants and/or an increase in IFNG DNA methylation relative to a normal subject, and diagnosing susceptibility to inflammatory bowel disease based on the presence of one or more risk genetic variants and/or an increase in IFNG DNA methylation relative to a normal subject. In another embodiment, the IBD is ulcerative colitis.

    摘要翻译： 本发明涉及通过从个体获得样品来诊断个体对炎症性肠病（IBD）的易感性的方法，测定样品以确定一种或多种风险遗传变异体的存在或不存在和/或IFNG DNA的增加 甲基化。 在一个实施方案中，本发明提供了通过从个体获得样品来诊断个体中对炎症性肠病（IBD）易感性的方法，测定样品以确定是否存在一种或多种风险遗传变体和/或 相对于正常受试者，IFNG DNA甲基化的增加，以及基于一种或多种风险遗传变异体的存在和/或IFNG DNA甲基化相对于正常受试者的增加诊断对炎症性肠病的易感性。 在另一个实施方案中，IBD是溃疡性结肠炎。

    METHODS OF ASSESSING CROHN'S DISEASE PATIENT PHENOTYPE BY I2 SEROLOGIC RESPONSE
    22.
    发明申请
    METHODS OF ASSESSING CROHN'S DISEASE PATIENT PHENOTYPE BY I2 SEROLOGIC RESPONSE 有权
    通过I2感染反应评估冠心病患者的方法

    公开(公告)号：US20100240077A1

    公开(公告)日：2010-09-23

    申请号：US12645394

    申请日：2009-12-22

    申请人： Stephan R. Targan ,  Eric A. Vasiliauskas ,  William S. Mow ,  Huiying Yang ,  Phillip R. Fleshner ,  Jerome I. Rotter

    发明人： Stephan R. Targan ,  Eric A. Vasiliauskas ,  William S. Mow ,  Huiying Yang ,  Phillip R. Fleshner ,  Jerome I. Rotter

    IPC分类号： G01N33/53

    CPC分类号： G01N33/686 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/6893 ,  G01N2469/20 ,  G01N2800/065

    摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.

    摘要翻译： 本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明 该受试者具有克罗恩病的临床亚型。 在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法 ）。 本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型 结肠炎。

    Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease
    23.
    发明授权
    Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease 有权
    NOD2的突变与克罗恩病患者的纤维化疾病有关

    公开(公告)号：US07790370B2

    公开(公告)日：2010-09-07

    申请号：US10526256

    申请日：2003-07-30

    申请人： Maria T. Abreu ,  Kent D. Taylor ,  Jerome I. Rotter ,  Huiying Yang ,  Stephan R. Targan

    发明人： Maria T. Abreu ,  Kent D. Taylor ,  Jerome I. Rotter ,  Huiying Yang ,  Stephan R. Targan

    IPC分类号： C07H21/04 ,  C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： The present invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease characterized by fibrostenosing disease by determining the presence or absence in an individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, where the presence of the fibrostenosis-predisposing allele is diagnostic of or predictive of susceptibility to the clinical subtype of Crohn's disease characterized by fibrostenosing disease. In a method of the invention, the clinical subtype of Crohn's disease can be, for example, characterized by fibrostenosing disease independent of small bowel involvement. The invention also provides a method of optimizing therapy in an individual by determining the presence or absence in the individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, diagnosing individuals in which the fibrostenosis-predisposing allele is present as having a fibrostenosing subtype of Crohn's disease, and treating the individual having a fibrostenosing subtype of Crohn's disease based on the diagnosis.

    摘要翻译： 本发明提供一种诊断或预测以特征在于纤维化疾病的克罗恩病的临床亚型的易感性的方法，其通过确定个体中存在或不存在与NOD2 / CARD15基因座连锁的纤维化狭窄等位基因，其中存在 纤维狭窄 - 易感性等位基因是以特征为纤维化疾病的克罗恩病的临床亚型的易感性的诊断或预测。 在本发明的方法中，克罗恩病的临床亚型可以是例如独立于小肠受累的纤维化疾病的特征。 本发明还提供了一种通过确定个体中存在或不存在与NOD2 / CARD15基因座连锁的纤维化狭窄等位基因来诊断个体的方法，其中存在纤维狭窄 - 倾向性等位基因的个体具有纤维化 克罗恩病的亚型，并基于诊断治疗患有克罗恩病的纤维化亚型的个体。

    METHODS OF USING GENES AND GENETIC VARIANTS TO PREDICT OR DIAGNOSE INFLAMMATORY BOWEL DISEASE
    25.
    发明申请
    METHODS OF USING GENES AND GENETIC VARIANTS TO PREDICT OR DIAGNOSE INFLAMMATORY BOWEL DISEASE 审中-公开
    使用基因和遗传变异体预测或诊断炎症性皮肤疾病的方法

    公开(公告)号：US20100021917A1

    公开(公告)日：2010-01-28

    申请号：US12527376

    申请日：2008-02-14

    申请人： Jerome I. Rotter ,  Kent D. Taylor ,  Stephan R. Targan

    发明人： Jerome I. Rotter ,  Kent D. Taylor ,  Stephan R. Targan

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/172

    摘要： This invention provides methods of diagnosing or predicting susceptibility to inflammatory bowel disease by determining the presence or absence of genetic variants. In one embodiment, a the invention is practiced by determining the presence or absence of NOD2 variants in an individual where the presence of NOD2 variants are indicative of susceptibility to Crohn's Disease in the individual. In another embodiment, the invention further determines the presence or absence of TLR8 variants where the presence of TLR8 variants are inflammatory bowel disease in female individuals. In another embodiment, the invention further determines the presence or absence of TR2 variant P631H where the presence of TLR2 variant P631H is indicative of susceptibility to Crohn's Disease.

    摘要翻译： 本发明提供通过确定遗传变异体的存在或不存在来诊断或预测对炎症性肠病易感性的方法。 在一个实施方案中，本发明通过确定个体中NOD2变体的存在或不存在来实施，其中NOD2变体的存在指示个体对克罗恩病的易感性。 在另一个实施方案中，本发明进一步确定TLR8变体的存在或不存在，其中TLR8变体的存在是女性个体中的炎症性肠病。 在另一个实施方案中，本发明还确定TR2变体P631H的存在或不存在，其中TLR2变体P631H的存在表示对克罗恩病的易感性。

    METHODS FOR DIAGNOSIS AND TREATMENT OF CROHN'S DISEASE
    26.
    发明申请
    METHODS FOR DIAGNOSIS AND TREATMENT OF CROHN'S DISEASE 审中-公开
    CROHN病的诊断和治疗方法

    公开(公告)号：US20100021455A1

    公开(公告)日：2010-01-28

    申请号：US11720785

    申请日：2005-12-08

    申请人： Stephan R. Targan ,  Carol J. Landers

    发明人： Stephan R. Targan ,  Carol J. Landers

    IPC分类号： A61K39/395 ,  G01N33/00 ,  C12Q1/68 ,  G01N33/68 ,  G01N33/53 ,  A61K35/74 ,  A61P1/00 ,  G01N27/26

    CPC分类号： G01N33/6854 ,  G01N33/6893 ,  G01N2800/065 ,  Y10T436/143333

    摘要： The inventors have discovered an elevated serum response to CBir1 flagellin in Crohn's disease patients. The present invention relates to methods for diagnosis and treatment of Crohn's disease and/or subtypes of Crohn's disease. Diagnosis is accomplished by determining the presence of the anti-CBir1 expression or determining the presence of anti-CBir1 expression and detection of the presence of pANCA. Treatment methods include antigen-directed therapy targeting CBir1 flagellin and manipulating the bacteria in the colon and/or small intestine.

    摘要翻译： 本发明人已经发现克罗恩病患者对CBir1鞭毛蛋白的血清反应升高。 本发明涉及克罗恩病和/或克罗恩病亚型的诊断和治疗方法。 通过确定抗CBIR1表达的存在或确定抗CBir1表达的存在和检测pANCA的存在来实现诊断。 治疗方法包括靶向CBir1鞭毛蛋白的抗原定向治疗和操纵结肠和/或小肠中的细菌。