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1.发明授权Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen 有权使用OmpC抗原诊断，预防和治疗克罗恩病公开(公告)号：US07993865B2
公开(公告)日：2011-08-09
申请号：US11561024
申请日：2006-11-17
IPC分类号： G01N33/564 , G01N33/569
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
摘要翻译： 本发明提供了一种通过测定受试者中存在或不存在或IgA抗OmpC抗体来诊断受试者中的克罗恩病的方法，其中IgA抗OmpC抗体的存在表明受试者患有克罗恩氏病。
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2.发明申请DIAGNOSIS, PREVENTION AND TREATMENT OF CROHN'S DISEASE USING THE OMPC ANTIGEN 有权使用OMPC抗原诊断，预防和治疗胆囊疾病公开(公告)号：US20090221006A1
公开(公告)日：2009-09-03
申请号：US12352578
申请日：2009-01-12
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
摘要翻译： 本发明提供了一种通过测定受试者中存在或不存在或IgA抗OmpC抗体来诊断受试者中的克罗恩病的方法，其中IgA抗OmpC抗体的存在表明受试者患有克罗恩氏病。
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3.发明授权Diagnosis, prevention and treatment of crohn's disease using the OmpC antigen 有权使用OmpC抗原诊断，预防和治疗克罗恩病公开(公告)号：US07993867B2
公开(公告)日：2011-08-09
申请号：US12352579
申请日：2009-01-12
IPC分类号： G01N33/564 , G01N33/569
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
摘要翻译： 本发明提供了一种通过测定受试者中存在或不存在或IgA抗OmpC抗体来诊断受试者中的克罗恩病的方法，其中IgA抗OmpC抗体的存在表明受试者患有克罗恩氏病。
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4.发明授权Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen 有权使用OmpC抗原诊断，预防和治疗克罗恩病公开(公告)号：US07138237B1
公开(公告)日：2006-11-21
申请号：US09575061
申请日：2000-05-19
IPC分类号： G01N33/53 , G01N33/563 , G01N33/564
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence of IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
摘要翻译： 本发明提供了一种通过测定受试者中存在或不存在IgA抗OmpC抗体来诊断受试者中的克罗恩病的方法，其中IgA抗OmpC抗体的存在表明受试者患有克罗恩氏病。
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公开(公告)号：US07993866B2
公开(公告)日：2011-08-09
申请号：US12352578
申请日：2009-01-12
IPC分类号： G01N33/569 , G01N33/564
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
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公开(公告)号：US20090221007A1
公开(公告)日：2009-09-03
申请号：US12352579
申请日：2009-01-12
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
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7.发明申请METHODS OF DIAGNOSING AND CHARACTERIZING CANNABINOID SIGNALING IN CROHN'S DISEASE 审中-公开诊断和表征冠状动脉疾病的CANNABINOID信号的方法公开(公告)号：US20110124644A1
公开(公告)日：2011-05-26
申请号：US12993685
申请日：2009-05-20
申请人： Stephan R. Targan , Jerome I. Rotter , Kent D. Taylor , David Ziring , Jonathan Braun , Bo Wei
发明人： Stephan R. Targan , Jerome I. Rotter , Kent D. Taylor , David Ziring , Jonathan Braun , Bo Wei
IPC分类号： A61K31/5377 , C12Q1/68 , A61P1/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： Diagnosis of Crohn's Disease by determining the presence or absence of variants at the CNR2 (cannabinoid) genetic locus and serological markers is disclosed Methods of diagnosing a Crohn's Disease sub-type by determining the presence or absence of one or more risk variants at the CNR2 5 locus and the presence or absence of ASCA, OmpC, 12 and/or anti-Cbir1 antibodies are included
摘要翻译： 公开了通过确定CNR2（大麻素）遗传基因座和血清学标记物存在或不存在变异的克罗恩病的诊断方法，通过确定CNR2 5中一种或多种风险变体的存在或不存在来诊断克罗恩病亚型的方法 并且包括ASCA，OmpC，12和/或抗Cbir1抗体的存在或不存在
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8.发明授权Methods of screening for ulcerative colitis and crohn's disease by detecting VH3-15 autoantibody and panca 失效通过检测VH3-15自身抗体和panca筛查溃疡性结肠炎和克罗恩病的方法
公开(公告)号：US5691151A
公开(公告)日：1997-11-25
申请号：US320515
申请日：1994-10-07
申请人： Jonathan Braun , Stephan R. Targan
发明人： Jonathan Braun , Stephan R. Targan
IPC分类号： C07K16/42 , G01N33/569 , G01N33/68 , G01N33/564
CPC分类号： C07K16/4258 , G01N33/56922 , G01N33/56972 , G01N33/686 , Y10S435/961 , Y10S435/965 , Y10S435/975
摘要： The present invention provides novel methods of screening for ulcerative colitis and Crohn's disease which include the detection of two disparate autoantibodies: pANCA and VH3-15 autoantibody. The present invention also provides kits for screening ulcerative colitis and Crohn's disease.
摘要翻译： 本发明提供筛选溃疡性结肠炎和克罗恩病的新方法，其包括检测两种不同的自身抗体：pANCA和VH3-15自身抗体。 本发明还提供了用于筛选溃疡性结肠炎和克罗恩病的试剂盒。
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公开(公告)号：US09290543B2
公开(公告)日：2016-03-22
申请号：US12036588
申请日：2008-02-25
发明人： Robert M. Hershberg , Nancy Ann Hosken , Michael J. Lodes , Raodoh Mohamath , Stephan R. Targan
IPC分类号： G01N33/50 , C07K14/195 , C07K14/205 , A61K38/00 , A61K39/00 , C07K14/00 , G01N33/68
CPC分类号： C07K16/1232 , A61K38/00 , A61K39/00 , A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/523 , A61K2039/53 , C07K14/001 , C07K14/195 , C07K14/205 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/00 , G01N33/505 , G01N33/6893 , G01N2800/065
摘要： Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
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10.发明申请公开(公告)号：US20130012602A1
公开(公告)日：2013-01-10
申请号：US13521199
申请日：2011-01-13
IPC分类号： C12Q1/68 , G01N27/447 , A61P1/00 , C40B30/04 , A61K35/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates to prognosing, diagnosing and treating of Crohn's disease. The invention also provides prognosis, diagnosis, and treatment that are based upon the presence of one or more genetic risk factors at the ZNF365 genetic locus
摘要翻译： 本发明涉及克罗恩病的预后，诊断和治疗。 本发明还提供了基于在ZNF365遗传基因座上存在一种或多种遗传危险因素的预后，诊断和治疗
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