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公开(公告)号：US07993866B2
公开(公告)日：2011-08-09
申请号：US12352578
申请日：2009-01-12
IPC分类号： G01N33/569 , G01N33/564
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
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公开(公告)号：US20090221007A1
公开(公告)日：2009-09-03
申请号：US12352579
申请日：2009-01-12
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
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3.发明授权Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen 有权使用OmpC抗原诊断，预防和治疗克罗恩病公开(公告)号：US07993865B2
公开(公告)日：2011-08-09
申请号：US11561024
申请日：2006-11-17
IPC分类号： G01N33/564 , G01N33/569
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
摘要翻译： 本发明提供了一种通过测定受试者中存在或不存在或IgA抗OmpC抗体来诊断受试者中的克罗恩病的方法，其中IgA抗OmpC抗体的存在表明受试者患有克罗恩氏病。
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4.发明申请DIAGNOSIS, PREVENTION AND TREATMENT OF CROHN'S DISEASE USING THE OMPC ANTIGEN 有权使用OMPC抗原诊断，预防和治疗胆囊疾病公开(公告)号：US20090221006A1
公开(公告)日：2009-09-03
申请号：US12352578
申请日：2009-01-12
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
摘要翻译： 本发明提供了一种通过测定受试者中存在或不存在或IgA抗OmpC抗体来诊断受试者中的克罗恩病的方法，其中IgA抗OmpC抗体的存在表明受试者患有克罗恩氏病。
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5.发明授权Diagnosis, prevention and treatment of crohn's disease using the OmpC antigen 有权使用OmpC抗原诊断，预防和治疗克罗恩病公开(公告)号：US07993867B2
公开(公告)日：2011-08-09
申请号：US12352579
申请日：2009-01-12
IPC分类号： G01N33/564 , G01N33/569
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
摘要翻译： 本发明提供了一种通过测定受试者中存在或不存在或IgA抗OmpC抗体来诊断受试者中的克罗恩病的方法，其中IgA抗OmpC抗体的存在表明受试者患有克罗恩氏病。
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6.发明授权Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen 有权使用OmpC抗原诊断，预防和治疗克罗恩病公开(公告)号：US07138237B1
公开(公告)日：2006-11-21
申请号：US09575061
申请日：2000-05-19
IPC分类号： G01N33/53 , G01N33/563 , G01N33/564
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence of IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
摘要翻译： 本发明提供了一种通过测定受试者中存在或不存在IgA抗OmpC抗体来诊断受试者中的克罗恩病的方法，其中IgA抗OmpC抗体的存在表明受试者患有克罗恩氏病。
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7.发明申请METHODS OF DIAGNOSING AND CHARACTERIZING CANNABINOID SIGNALING IN CROHN'S DISEASE 审中-公开诊断和表征冠状动脉疾病的CANNABINOID信号的方法公开(公告)号：US20110124644A1
公开(公告)日：2011-05-26
申请号：US12993685
申请日：2009-05-20
申请人： Stephan R. Targan , Jerome I. Rotter , Kent D. Taylor , David Ziring , Jonathan Braun , Bo Wei
发明人： Stephan R. Targan , Jerome I. Rotter , Kent D. Taylor , David Ziring , Jonathan Braun , Bo Wei
IPC分类号： A61K31/5377 , C12Q1/68 , A61P1/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： Diagnosis of Crohn's Disease by determining the presence or absence of variants at the CNR2 (cannabinoid) genetic locus and serological markers is disclosed Methods of diagnosing a Crohn's Disease sub-type by determining the presence or absence of one or more risk variants at the CNR2 5 locus and the presence or absence of ASCA, OmpC, 12 and/or anti-Cbir1 antibodies are included
摘要翻译： 公开了通过确定CNR2（大麻素）遗传基因座和血清学标记物存在或不存在变异的克罗恩病的诊断方法，通过确定CNR2 5中一种或多种风险变体的存在或不存在来诊断克罗恩病亚型的方法 并且包括ASCA，OmpC，12和/或抗Cbir1抗体的存在或不存在
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8.发明授权Methods of screening for ulcerative colitis and crohn's disease by detecting VH3-15 autoantibody and panca 失效通过检测VH3-15自身抗体和panca筛查溃疡性结肠炎和克罗恩病的方法
公开(公告)号：US5691151A
公开(公告)日：1997-11-25
申请号：US320515
申请日：1994-10-07
申请人： Jonathan Braun , Stephan R. Targan
发明人： Jonathan Braun , Stephan R. Targan
IPC分类号： C07K16/42 , G01N33/569 , G01N33/68 , G01N33/564
CPC分类号： C07K16/4258 , G01N33/56922 , G01N33/56972 , G01N33/686 , Y10S435/961 , Y10S435/965 , Y10S435/975
摘要： The present invention provides novel methods of screening for ulcerative colitis and Crohn's disease which include the detection of two disparate autoantibodies: pANCA and VH3-15 autoantibody. The present invention also provides kits for screening ulcerative colitis and Crohn's disease.
摘要翻译： 本发明提供筛选溃疡性结肠炎和克罗恩病的新方法，其包括检测两种不同的自身抗体：pANCA和VH3-15自身抗体。 本发明还提供了用于筛选溃疡性结肠炎和克罗恩病的试剂盒。
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公开(公告)号：US20100196509A1
公开(公告)日：2010-08-05
申请号：US11884806
申请日：2006-02-28
IPC分类号： A61K33/24 , C12Q1/68 , G01N33/53 , A61K31/4355 , A61K31/56 , A61K31/7088 , A61P35/00
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57442 , G01N2500/02 , G01N2500/10
摘要： The present invention discloses methods of using endothelial membrane protein 2 (EMP2) as a biomarker for stratification of endometrial premalignancy, diagnosing, staging and imaging of endometrial neoplasia. Further, methods for identifying pharmaceutical/therapeutic modalities are described, including compositions which modulate glycolipid-enriched lipid raft microdomains (GEMs).
摘要翻译： 本发明公开了使用内皮膜蛋白2（EMP2）作为子宫内膜癌前期分期，诊断，分期和成像子宫内膜瘤形成的生物标志物的方法。 此外，描述了用于鉴定药物/治疗方式的方法，包括调节富含糖脂的脂筏微结构域（GEM））的组合物。
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公开(公告)号：US20080181889A1
公开(公告)日：2008-07-31
申请号：US11868788
申请日：2007-10-08
IPC分类号： A61K39/395 , A61K38/02 , A61K31/7052 , A61K38/16 , A61K38/10 , G01N33/53 , C12N5/00 , C07K16/00
CPC分类号： C07K16/125 , C07K2317/622 , C07K2317/76
摘要： The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The compositions include EMP2 nucleic acids and polypeptides as well as anti-EMP2 antibodies.
摘要翻译： 本发明提供了用于治疗或预防衣原体感染的方法和组合物。 方法和组合物通过干扰衣原体和EMP2之间的相互作用来抑制衣原体进入表达EMP2的宿主细胞。 组合物包括EMP2核酸和多肽以及抗EMP2抗体。
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