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61 条记录 (耗时 0.053 秒)

    Binding constructs and methods for use thereof
    21.
    发明申请
    Binding constructs and methods for use thereof 有权
    结合结构及其使用方法

    公开(公告)号：US20050136049A1

    公开(公告)日：2005-06-23

    申请号：US10627556

    申请日：2003-07-26

    申请人： Jeffrey Ledbetter ,  Martha Hayden-Ledbetter ,  Peter Thompson

    发明人： Jeffrey Ledbetter ,  Martha Hayden-Ledbetter ,  Peter Thompson

    IPC分类号： C07K16/28 ,  C07K16/46 ,  A61K39/395 ,  C07K16/44

    CPC分类号： C07K16/2809 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/2878 ,  C07K16/2896 ,  C07K16/462 ,  C07K16/464 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2319/00 ,  C07K2319/30

    摘要： The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a wild-type IgG1, IGA or IgE hinge-acting region, i.e., IgE CH2, region polypeptide or a mutant IgG1 hinge region polypeptide having either zero, one or two cysteine residues, and immunoglobulin CH2 and CH3 domains, and that are capable of ADCC and/or CDC while occurring predominantly as polypeptides that are compromised in their ability to form disulfide-linked multimers. The fusion proteins can be recombinantly produced at high expression levels. Also provided are related compositions and methods, including cell surface forms of the fusion proteins and immunotherapeutic applications of the fusion proteins and of polynucleotides encoding such fusion proteins.

    摘要翻译： 本发明涉及新颖的结合域 - 免疫球蛋白融合蛋白，其特征在于一种同源结构的结合域，例如抗原，反向受体等，野生型IgG1，IGA或IgE铰链作用区，即IgE CH2， 区域多肽或具有零个，一个或两个半胱氨酸残基和免疫球蛋白CH2和CH3结构域的突变IgG1铰链区多肽，并且能够产生ADCC和/或CDC，同时主要作为其形成二硫键的能力受损的多肽 链接的多聚体。 可以以高表达水平重组产生融合蛋白。 还提供了相关的组合物和方法，包括融合蛋白的细胞表面形式和融合蛋白的免疫治疗应用以及编码这种融合蛋白的多核苷酸。

    Zero emissions reciprocating pump
    25.
    发明授权
    Zero emissions reciprocating pump 有权
    零排放往复泵

    公开(公告)号：US07784395B2

    公开(公告)日：2010-08-31

    申请号：US11729439

    申请日：2007-03-28

    申请人： Herbert H. Tackett ,  James A. Cripe ,  Gary Dyson ,  Peter Thompson

    发明人： Herbert H. Tackett ,  James A. Cripe ,  Gary Dyson ,  Peter Thompson

    IPC分类号： F04B53/16 ,  F16J10/00

    CPC分类号： F04B53/164 ,  F04B15/04 ,  F04B53/143 ,  F04B2201/0208 ,  F16J15/406 ,  Y10S277/926

    摘要： A sealing system for a pump having a plunger includes a housing having an internal chamber adapted to receive a portion of the plunger. Primary and secondary seals are located within the internal chamber and adapted to sealingly engage the plunger. The primary seal communicates with the fluid being pumped. A barrier fluid chamber contains a barrier fluid in contact with the primary seal and the secondary seal. A pressure referencing device has an inlet port in communication with the pumped fluid and an outlet port providing fluid at a pressure magnitude equal to a peak pressure of the pumped fluid. A pressurizing device is in communication with the fluid at the peak pressure and the barrier fluid to maintain the barrier fluid pressure at a magnitude greater than the peak pressure of the pumped fluid such that the pumped fluid is restricted from leaking past the primary seal.

    摘要翻译： 用于具有柱塞的泵的密封系统包括具有适于容纳柱塞的一部分的内部腔的壳体。 主密封件和次密封件位于内部腔室内并且适于密封地接合柱塞。 主密封件与被泵送的流体相通。 隔离流体室包含与初级密封件和次级密封件接触的阻挡流体。 压力参考装置具有与泵送流体连通​​的入口端口和出口端口，其以等于泵送流体的峰值压力的压力幅度提供流体。 加压装置与峰值压力下的流体和阻挡流体连通，以将阻挡流体压力保持在大于泵送流体的峰值压力的幅度，使得泵送的流体被限制超过主密封件泄漏。

    Handling information
    26.
    发明申请
    Handling information 有权
    处理信息

    公开(公告)号：US20100091763A1

    公开(公告)日：2010-04-15

    申请号：US12311077

    申请日：2007-09-18

    申请人： Peter Thompson

    发明人： Peter Thompson

    IPC分类号： H04M15/06 ,  H04L12/66

    CPC分类号： H04W12/08 ,  H04L9/0643 ,  H04L9/0833 ,  H04L9/0866 ,  H04L29/12132 ,  H04L29/12188 ,  H04L45/745 ,  H04L61/1552 ,  H04L61/1588 ,  H04L63/102 ,  H04L67/02 ,  H04L2209/80 ,  H04W4/12 ,  H04W12/02

    摘要： A communication method, for use with a telecommunications system, enables special communications to be routed to respective devices in a group of the devices by addressing the devices with a respective special identifier. The telecommunications system includes a network core and a plurality of subscriber devices registered with the network core. The core enables communications to be routed to the devices by a respective ID allocated to each device. The method further includes maintaining a store of the special identifier of each device in the group and a corresponding value derived from the ID. The method enables the special identifier of a device in the group to be obtained from the store by providing the store with the corresponding value derived from that device's ID.

    摘要翻译： 与电信系统一起使用的通信方法使得能够通过用相应的特殊标识符寻址设备来将特殊通信路由到一组设备中的相应设备。 电信系统包括网络核心和登记在网络核心上的多个用户设备。 该核心使得能够通过分配给每个设备的相应ID将通信路由到设备。 该方法还包括维护组中每个设备的特殊标识符的存储以及从ID导出的对应值。 该方法通过向存储提供从该设备的ID导出的相应值来从商店获得该组中的设备的特殊标识符。

    GROUP COMMUNICATIONS
    27.
    发明申请
    GROUP COMMUNICATIONS 审中-公开
    集团通讯

    公开(公告)号：US20090221307A1

    公开(公告)日：2009-09-03

    申请号：US12066789

    申请日：2006-09-05

    申请人： Stephen Wolak ,  Peter Thompson

    发明人： Stephen Wolak ,  Peter Thompson

    IPC分类号： H04W4/12 ,  G06F15/16

    CPC分类号： H04L12/1822 ,  G06Q10/10 ,  H04L12/189 ,  H04L51/32 ,  H04L51/38 ,  H04L67/02 ,  H04L67/22 ,  H04L67/306 ,  H04W4/21

    摘要： The communications system is disclosed that includes a plurality of devices associated in a group. A server (50) administers communications between members of the group. Preferably, member devices of the group are provided with a client application (52) for communicating with the server (50). In the embodiment the client application is installed on a mobile or cellular telecommunications device, such as a GPRS or 3G mobile handset. The client facilitates communications of the user of the handset with the server, and provides an interface between the underlying device functionality (such as a built-in camera, the device's file system etc.) to allow content to be easily accessed and shared amongst members of the group. Communications between the client application and the server may be performed by XML over HTTP using a GPRS or 3G bearer.

    摘要翻译： 公开了包括在组中相关联的多个设备的通信系统。 服务器（50）管理组成员之间的通信。 优选地，该组的成员设备设置有用于与服务器（50）通信的客户端应用（52）。 在该实施例中，客户端应用安装在诸如GPRS或3G移动手持机的移动或蜂窝电信设备上。 客户端促进手机用户与服务器的通信，并且提供底层设备功能（例如内置相机，设备的文件系统等）之间的接口，以允许在成员之间容易地访问和共享内容 的组合。 客户端应用程序和服务器之间的通信可以通过使用GPRS或3G承载的HTTP通过HTTP执行。

    Application support and maintenance system, software, database and related methods
    29.
    发明申请
    Application support and maintenance system, software, database and related methods 审中-公开
    应用支持与维护系统，软件，数据库及相关方法

    公开(公告)号：US20070078863A1

    公开(公告)日：2007-04-05

    申请号：US11240480

    申请日：2005-10-03

    申请人： Peter Thompson

    发明人： Peter Thompson

    IPC分类号： G06F7/00

    CPC分类号： G06Q10/109 ,  G06Q10/06

    摘要： One or more databases for use in computer program application support and maintenance. An inventory of computer program applications (“application inventory”) is arranged in a multilevel hierarchy having descending levels. Line of business level, application level and technical module level. A support and maintenance work authorization and authorized workgroup are set at the line of business level, and requests for work are set at the application level and below. Automatically relates business functions to computer programs to determine performance of applications within business functions. The databases also include timesheets, each timesheet having time data recorded by a skilled person in a workgroup for work on a ticket. Computer system and methods utilizing the databases are also provided.

    摘要翻译： 用于计算机程序应用程序支持和维护的一个或多个数据库。 计算机程序应用程序（“应用程序清单”）的清单被布置在具有下降级别的多级别层次中。 业务线，应用级和技术模块级。 支持和维护工作授权和授权工作组被设置在业务层面，工作请求设置在应用程序级别和以下。 自动将业务功能与计算机程序相关联，以确定业务功能中应用程序的性能。 数据库还包括时间表，每个时间表具有技术人员在工作组中记录的用于工作票的时间数据。 还提供了使用数据库的计算机系统和方法。