公开(公告)号：US20070135373A1

公开(公告)日：2007-06-14

申请号：US11602476

申请日：2006-11-20

申请人： Chuan-Yuan Li ,  Qian Huang ,  Mark Dewhirst

发明人： Chuan-Yuan Li ,  Qian Huang ,  Mark Dewhirst

IPC分类号： A61K48/00 ,  A61N1/39

CPC分类号： A61K38/191 ,  A61K38/208 ,  A61K48/00 ,  A61K48/0058 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2830/002 ,  C12N2830/85 ,  C12N2840/203

摘要： A method for controlling in vivo heat-inducible gene expression for provision of therapeutic polypeptide. The method includes the steps of: (a) providing a construct comprising a polynucleotide encoding a therapeutic polypeptide, wherein the polynucleotide is operatively linked to a heat-inducible promoter; (b) administering the construct to a warm-blooded vertebrate at a site at or near the tumor; and (c) applying heat to the site at or near the tumor to express the therapeutic polypeptide, whereby anti-tumor activity is observed.

摘要翻译： 用于控制体内热诱导基因表达以提供治疗性多肽的方法。 该方法包括以下步骤：（a）提供包含编码治疗性多肽的多核苷酸的构建体，其中所述多核苷酸可操作地连接于热诱导型启动子; （b）将该构建体施用于在肿瘤处或其附近的部位的温血脊椎动物; 和（c）向肿瘤处或附近的部位施加热量以表达治疗性多肽，由此观察到抗肿瘤活性。

公开(公告)号：US20050048079A1

公开(公告)日：2005-03-03

申请号：US10885523

申请日：2004-07-01

申请人： Qian Huang ,  Joan Richmond ,  Bryan Cho ,  Deborah Palliser ,  Jianzhu Chen ,  Herman Eisen ,  Richard Young

发明人： Qian Huang ,  Joan Richmond ,  Bryan Cho ,  Deborah Palliser ,  Jianzhu Chen ,  Herman Eisen ,  Richard Young

IPC分类号： A61K45/00 ,  A61K38/00 ,  A61K39/00 ,  A61K39/02 ,  A61K39/04 ,  A61K39/12 ,  A61K39/21 ,  A61K47/48 ,  A61P31/04 ,  A61P31/18 ,  A61P35/00 ,  A61P37/04 ,  C07K14/35 ,  A61K39/385

CPC分类号： C07K14/35 ,  A61K39/00 ,  A61K47/62 ,  A61K47/6425 ,  A61K2039/57 ,  C07K2319/00

摘要： The present invention relates to a method of inducing a CD8+ CTL response to a molecule in an individual deficient in CD4+ T cells comprising administering to the individual an hsp or a portion of an ATP binding domain of an hsp joined to the molecule. In one embodiment, the present invention relates to a method of treating HIV in an individual deficient in CD4+ T cells comprising administering to the individual an hsp or a portion of an ATP binding domain of an hsp joined to the molecule. Also encompassed by the present invention is a method of inducing a CD4+ independent CTL response in an individual comprising administering to the individual a portion of an ATP binding domain of an hsp joined to the molecule. The present invention also relates to a method of inducing a CD8+ CTL response in an individual comprising administering to the individual a portion of an ATP binding domain of an hsp joined to the molecule. In addition, the present invention relates to a composition characterized by a portion of an ATP biding domain of an hsp joined to a molecule.

摘要翻译： 本发明涉及对CD4 + T细胞缺陷的个体中的分子诱导CD8 + CTL应答的方法，包括向所述个体施用hsp或一部分ATP结合结构域的hsp连接到 分子。 在一个实施方案中，本发明涉及在CD4 + T细胞缺陷的个体中治疗HIV的方法，其包括向所述个体施用与所述分子连接的hsp的hsp或一部分ATP结合结构域。 本发明还包括在个体中诱导CD4 +独立CTL应答的方法，其包括向所述个体施用连接到分子的hsp的ATP结合结构域的一部分。 本发明还涉及在个体中诱导CD8 + CTL应答的方法，其包括向所述个体施用连接到分子的hsp的ATP结合结构域的一部分。 此外，本发明涉及一种组合物，其特征在于与分子连接的hsp的ATP结合域的一部分。

公开(公告)号：US06714909B1

公开(公告)日：2004-03-30

申请号：US09716278

申请日：2000-11-21

申请人： David Crawford Gibbon ,  Qian Huang ,  Zhu Liu ,  Aaron Edward Rosenberg ,  Behzad Shahraray

发明人： David Crawford Gibbon ,  Qian Huang ,  Zhu Liu ,  Aaron Edward Rosenberg ,  Behzad Shahraray

IPC分类号： G10L1700

CPC分类号： G06F17/30787 ,  G06F17/30796 ,  G06F17/30843 ,  G10L17/00 ,  Y10S707/99933 ,  Y10S707/99943

摘要： The invention provides a system and method for automatically indexing and retrieving multimedia content. The method may include separating a multimedia data stream into audio, visual and text components, segmenting the audio, visual and text components based on semantic differences, identifying at least one target speaker using the audio and visual components, identifying a topic of the multimedia event using the segmented text and topic category models, generating a summary of the multimedia event based on the audio, visual and text components, the identified topic and the identified target speaker, and generating a multimedia description of the multimedia event based on the identified target speaker, the identified topic, and the generated summary.

公开(公告)号：US20190388816A1

公开(公告)日：2019-12-26

申请号：US16560972

申请日：2019-09-04

申请人： Qian Huang

发明人： Qian Huang

IPC分类号： B01D39/16 ,  D01D5/00

摘要： The invention provides a melt-blown non-woven filter material, which is prepared by the following method: provide a polylactic acid raw material; dissolve the polylactic acid raw material into a DMF solvent; the polylactic acid electrospinning layer is prepared by electrospinning method using polylactic acid spinning solution as raw material; provide polylactic acid raw material again and provide polyphenylene sulfide raw material; and perform surface treatment. Polylactic acid raw material, polyphenylene sulfide raw material, nano-titania powder are mixed well with the processing assistant to obtain a mixture: the mixture is extruded into modified polylactic acid particles; then a modified polylactic acid melt-blown fiber layer is formed on the polylactic acid electrospinning layer by using the melt-blown method. The invention innovatively implements loading, nano-titania particles into the synthetic fiber, which makes the fiber material presented in this invention not only have filtering effects, but also have photocatalytic ability.

公开(公告)号：US08778048B2

公开(公告)日：2014-07-15

申请号：US13205929

申请日：2011-08-09

申请人： Qian Huang ,  Yu Haiyan

发明人： Qian Huang ,  Yu Haiyan

IPC分类号： C05F11/08 ,  A62D3/02

CPC分类号： C12P1/04 ,  C05F11/00 ,  C05F17/0036 ,  C12P7/44 ,  C12P7/66 ,  C12P17/188 ,  C12P19/44 ,  Y02P20/145 ,  Y02W30/43

摘要： The present invention discloses a new resource processing method of kitchen waste, in particular, provides a method of preparing biochemical humic acid from kitchen waste and biochemical humic acid product prepared therefrom. The kitchen waste treated by technical solution of the present invention has a high conversion rate of organic matter, reaching over 90%. Meanwhile, the biochemical humic acid product prepared by the invention is nutritious, the amount of the total humic acid, free humic acid and water soluble humic acid in the product reach up to 38-42%, 35-40% and 14-16%, respectively; it contains not only the major elements such as nitrogen, phosphorus and potassium, but also the trace elements such as zinc, iron and manganese as well as other active substances. Thus the product is suitable for fertilizer in agricultural production.

摘要翻译： 本发明公开了一种厨房垃圾的新资源处理方法，特别是提供从厨房垃圾中制备生化腐殖酸和由其制备的生化腐殖酸产品的方法。 通过本发明的技术方案处理的厨房垃圾具有高的有机物转化率，达到90％以上。 同时，本发明制备的生化腐殖酸产品营养丰富，产品中总腐殖酸，游离腐殖酸，水溶性腐殖酸含量达到38-42％，35-40％和14-16％ ， 分别; 它不仅含有氮，磷和钾等主要元素，还含有锌，铁和锰等微量元素以及其他活性物质。 因此该产品适用于农业生产中的肥料。

公开(公告)号：US08620914B1

公开(公告)日：2013-12-31

申请号：US13110907

申请日：2011-05-18

申请人： Michael Noth ,  Chee Heng Chew ,  Rahul Roy-Chowdhury ,  Erik Kay ,  Qian Huang ,  Qinming Fang

发明人： Michael Noth ,  Chee Heng Chew ,  Rahul Roy-Chowdhury ,  Erik Kay ,  Qian Huang ,  Qinming Fang

IPC分类号： G06F7/00 ,  G06F17/30

CPC分类号： G06Q30/0609 ,  G06F3/04842 ,  G06F8/61 ,  G06F8/62 ,  G06F9/54 ,  G06F11/0766 ,  G06F17/30861 ,  G06F17/3089 ,  G06F21/53 ,  G06F21/57 ,  H04L51/12 ,  H04L63/0823 ,  H04L63/1483 ,  H04L67/02 ,  H04L67/10 ,  H04L67/2842 ,  H04L67/289 ,  H04L67/34 ,  H04L67/42

摘要： According to one general aspect, a method of presenting to a user a subset of applications that may be executed by a computing device is described. The subset of applications may be selected from a plurality of applications available an online marketplace for such applications. The method may include ranking the applications based on signals relevant to the relative desirability to the user of different applications, wherein at least one of the signals is based on information that is generated outside of the marketplace. The method may further include selecting the subset of applications based on their respective rankings. The method may also include presenting the selected subset to the user.

摘要翻译： 根据一个一般方面，描述了向用户呈现可由计算设备执行的应用的子集的方法。 可以从可用于这种应用的在线市场的多个应用中选择应用的子集。 该方法可以包括基于与不同应用的用户的相对可取性相关的信号对应用进行排序，其中信号中的至少一个基于在市场外产生的信息。 该方法还可以包括基于它们各自的排名选择应用子集。 该方法还可以包括将所选择的子集呈现给用户。

公开(公告)号：US20120047974A1

公开(公告)日：2012-03-01

申请号：US13205929

申请日：2011-08-09

申请人： Qian Huang ,  Yu Haiyan

发明人： Qian Huang ,  Yu Haiyan

IPC分类号： C05F11/08 ,  C05F9/00

CPC分类号： C12P1/04 ,  C05F11/00 ,  C05F17/0036 ,  C12P7/44 ,  C12P7/66 ,  C12P17/188 ,  C12P19/44 ,  Y02P20/145 ,  Y02W30/43

摘要： The present invention discloses a new resource processing method of kitchen waste, in particular, provides a method of preparing biochemical humic acid from kitchen waste and biochemical humic acid product prepared therefrom. The kitchen waste treated by technical solution of the present invention has a high conversion rate of organic matter, reaching over 90%. Meanwhile, the biochemical humic acid product prepared by the invention is nutritious, the amount of the total humic acid, free humic acid and water soluble humic acid in the product reach up to 38-42%, 35-40% and 14-16%, respectively; it contains not only the major elements such as nitrogen, phosphorus and potassium, but also the trace elements such as zinc, iron and manganese as well as other active substances. Thus the product is suitable for fertilizer in agricultural production.

摘要翻译： 本发明公开了一种厨房垃圾的新资源处理方法，特别是提供从厨房垃圾中制备生化腐殖酸和由其制备的生化腐殖酸产品的方法。 通过本发明的技术方案处理的厨房垃圾具有高的有机物转化率，达到90％以上。 同时，本发明制备的生化腐殖酸产品营养丰富，产品中总腐殖酸，游离腐殖酸，水溶性腐殖酸含量达到38-42％，35-40％和14-16％ ， 分别; 它不仅含有氮，磷和钾等主要元素，还含有锌，铁和锰等微量元素以及其他活性物质。 因此该产品适用于农业生产中的肥料。

公开(公告)号：US07319964B1

公开(公告)日：2008-01-15

申请号：US10862728

申请日：2004-06-07

申请人： Qian Huang ,  Zhu Liu

发明人： Qian Huang ,  Zhu Liu

IPC分类号： G10L21/00

CPC分类号： G10L25/48

摘要： The present invention provides for a method and apparatus for segmenting a multi-media program based upon audio events. In an embodiment a method of classifying an audio stream is provided. This method includes receiving an audio stream. Sampling the audio stream at a predetermined rate and then combining a predetermined number of samples into a clip. A plurality of features are then determined for the clip and are analyzed using a linear approximation algorithm. The clip is then characterized based upon the results of the analysis conducted with the linear approximation algorithm.

摘要翻译： 本发明提供一种用于基于音频事件分割多媒体节目的方法和装置。 在一个实施例中，提供了对音频流进行分类的方法。 该方法包括接收音频流。 以预定速率对音频流进行采样，然后将预定数量的样本组合成剪辑。 然后为剪辑确定多个特征，并使用线性近似算法进行分析。 然后基于使用线性近似算法进行的分析的结果来表征该剪辑。

公开(公告)号：US07135307B2

公开(公告)日：2006-11-14

申请号：US10486265

申请日：2002-08-08

申请人： Ming-Chih Crouthamel ,  Stephen J. Gardell ,  Qian Huang ,  Ming-Tain Lai ,  Yueming Li

发明人： Ming-Chih Crouthamel ,  Stephen J. Gardell ,  Qian Huang ,  Ming-Tain Lai ,  Yueming Li

IPC分类号： C12Q1/37 ,  C12N9/50 ,  A23J1/00

CPC分类号： C12N9/6478 ,  A61K38/00 ,  C07K14/4711 ,  C12Q1/37 ,  G01N33/6896 ,  G01N2333/96472 ,  G01N2500/04

摘要： Gamma three protease is provided, a novel aspartyl class protease that is capable of taking part in the processing of amyloid precursor protein (APP) to Aβ peptide. Gamma three protease may be involved in the development and/or progression of Alzheimers disease. Methods of identifying inhibitors of gamma three protease, useful in the prevention or treatment of Alzheimers disease, are disclosed.

摘要翻译： 提供Gamma三蛋白酶，一种能够参与淀粉样蛋白前体蛋白（APP）加工成Abeta肽的新型天冬氨酰基类蛋白酶。 伽玛三蛋白酶可能参与阿尔茨海默病的发展和/或发展。 公开了可用于预防或治疗阿尔茨海默病的γ三蛋白酶抑制剂的方法。

公开(公告)号：US20060099709A1

公开(公告)日：2006-05-11

申请号：US10529071

申请日：2003-10-01

申请人： Chuan-Yuan Li ,  Qian Huang ,  Mark Dewhirst

发明人： Chuan-Yuan Li ,  Qian Huang ,  Mark Dewhirst

IPC分类号： C12N15/861 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K35/761 ,  A61K38/2013 ,  A61K38/208 ,  A61K48/00 ,  A61K48/0058 ,  C07K14/4702 ,  C07K14/52 ,  C07K14/525 ,  C12N15/85 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2830/002 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/20

摘要： The presently claimed subject matter provides conditionally replication competent adenoviral vectors that confer selective cytotoxicity on cells expressing HIF-1 by infecting cells that allow HIF-1 inducible promoters present within the vectors to function. Also provided are compositions and host cells based upon the vectors, as well as methods of propagating and using the vectors. The presently claimed subject matter further provides a method of inhibiting tumor growth by co-infecting cells in a tumor with a conditionally replication competent adenovirus vector in conjunction with a replication deficient adenovirus vector.

摘要翻译： 目前要求保护的主题提供了条件复制的腺病毒载体，其通过感染允许存在于载体内的HIF-1诱导型启动子起作用的细胞赋予表达HIF-1的细胞的选择性细胞毒性。 还提供了基于载体的组合物和宿主细胞，以及传播和使用载体的方法。 目前要求保护的主题还提供了通过与复制缺陷型腺病毒载体结合的条件复制型腺病毒载体共同感染肿瘤中的细胞来抑制肿瘤生长的方法。