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21.发明授权Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides 失效生物降解聚酯和生物活性多肽的离子分子共轭物
公开(公告)号：US5863985A
公开(公告)日：1999-01-26
申请号：US867308
申请日：1997-06-02
IPC分类号： A61K38/00 , C07K14/655 , A61K9/16 , A61K9/52 , A61K37/02
CPC分类号： C07K14/655 , A61K38/00 , Y10S514/80 , Y10S514/806 , Y10S514/807 , Y10S514/808 , Y10S514/809
摘要： Disclosed is a sustained release pharmaceutical composition. The composition includes a polyester containing a free COOH group ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein at least 50% by weight of the polypeptide present in the composition is ionically conjugated to the polyester.
摘要翻译： 公开了缓释药物组合物。 所述组合物包括含有游离COOH基团的聚酯，所述游离COOH基团与包含至少一种有效的离子型胺的生物活性多肽离子地缀合，其中所述组合物中存在的多肽的至少50重量％与所述聚酯离子共轭。
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22.发明授权Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof 失效水凝胶形成，自溶溶性可吸收聚酯共聚物及其使用方法
公开(公告)号：US5714159A
公开(公告)日：1998-02-03
申请号：US740646
申请日：1996-10-31
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61K47/48 , A61K9/00 , A61K47/34 , A61L31/06 , A61L31/14 , C08G63/66 , C08G63/664 , C08K5/00 , C08L67/00 , C08L67/02 , A61F2/00
CPC分类号： A61K9/0024 , A61K47/34 , A61L31/06 , A61L31/145 , C08G63/664
摘要： The present invention provides novel hydrogel-forming, self-solvating, absorbable polyester copolymers capable of selective, segmental association into compliant hydrogels upon contacting an aqueous environment. Methods of using the novel polyester copolymers of the invention in humans are also disclosed for providing a protective barrier to prevent post-surgical adhesion, treatment of defects in conduits such as blood vessels, and controlled release of a biologically active agent for modulating cellular events such as wound healing and tissue regeneration or therapeutic treatment of diseases such as infection of the periodontium, dry socket, bone, skin, vaginal, and nail infections
摘要翻译： 本发明提供了新颖的水凝胶形成，自溶性，可吸收的聚酯共聚物，其能够在与水性环境接触时能够选择性地，分段地缔合到顺应性水凝胶中。 还公开了将本发明的新型聚酯共聚物用于人体的方法，用于提供保护屏障以防止手术后粘连，治疗管道如血管中的缺陷，以及控制释放用于调节细胞事件的生物活性剂 作为伤口愈合和组织再生或治疗性治疗诸如牙周膜炎，干燥窝，骨骼，皮肤，阴道和指甲感染的疾病
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23.发明授权Molecularly bonded inherently conductive polymers on substrates and shaped articles thereof 失效分子结合的固有导电聚合物在基材和其成型制品上
公开(公告)号：US5691062A
公开(公告)日：1997-11-25
申请号：US390066
申请日：1995-02-16
CPC分类号： C08J7/047 , C08G61/124 , C08J7/12 , C23C14/20 , C08J2323/02 , C08J2465/00 , Y10T428/31504 , Y10T428/31533 , Y10T428/31536 , Y10T428/31551 , Y10T428/31609 , Y10T428/31678 , Y10T428/31692 , Y10T428/31725 , Y10T428/31786 , Y10T428/31935
摘要： Organic inherently conductive polymers, such as those based on polyaniline, polypyrrole and polythiophene, are formed in-situ onto polymeric surfaces that are chemically activated to bond ionically the conductive polymers to the substrates. The polymeric substrate is preferably a preshaped or preformed thermoplastic film, fabric, or tube, although other forms of thermoplastic and thermoset polymers can be used as the substrates for pretreatment using, most preferably, phosphonylation-based processes followed by exposure to an oxidatively polymerizable compound capable of forming an electrically conductive polymer. The resultant conductive surface imparts unique properties to the substrates and allows their use in antistatic clothing, surface conducting films for electronic components and the like, and electromagnetic interference shielding.
摘要翻译： 有机固有导电聚合物，例如基于聚苯胺，聚吡咯和聚噻吩的聚合物原位形成在化学活化的聚合物表面上，以将导电聚合物离子地键合到基底上。 聚合物基材优选为预成型或预成型的热塑性薄膜，织物或管，尽管其它形式的热塑性和热固性聚合物可用作预处理的底物，最优选基于膦酰基化的方法，随后暴露于氧化可聚合化合物 能够形成导电聚合物。 所得到的导电表面赋予基底独特的性能，并且允许它们用于抗静电服装，用于电子部件的表面导电膜等以及电磁干扰屏蔽。
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公开(公告)号：US5584857A
公开(公告)日：1996-12-17
申请号：US338404
申请日：1994-11-14
CPC分类号： A61B17/06166 , A61L17/08 , A61L17/145
摘要： A coating and tubing fluid for sutures, especially gut sutures, is provided. The coating composition includes linseed oil, an organic solvent and a catalyst. The tubing fluid includes water, a softening agent, a C.sub.2 -C.sub.4 alcohol and a lubricant of fatty acids, fatty acid alcohols and/or triglycerides of fatty acids. Gut sutures coated with the coating composition may be stored or packaged in the tubing fluid to provide sutures with improved flexibility, pliability, run-down performance and superior resistance to fraying and breaking.
摘要翻译： 提供用于缝线的涂层和管道液，特别是肠缝线。 涂料组合物包括亚麻子油，有机溶剂和催化剂。 管道液体包括水，软化剂，C 2 -C 4醇和脂肪酸的润滑剂，脂肪酸醇和/或脂肪酸的甘油三酯。 涂覆有涂料组合物的肠缝线可以储存或包装在管道液体中，以提供具有改善的柔韧性，柔韧性，破坏性能和优异的抗磨损和破裂性能的缝合线。
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25.发明授权Absorbable .EPSILON.-caprolactone polymers as suture coatings displaying auto catalyzed hydrolysis 失效可吸收的EPSILON-己内酯聚合物作为显示自动催化水解的缝线涂层
公开(公告)号：US5522842A
公开(公告)日：1996-06-04
申请号：US212174
申请日：1994-03-11
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61L17/12 , A61L17/14 , A61L24/04 , A61L27/18 , A61L27/34 , A61L29/08 , C08G63/91 , A61B17/04 , A61L17/00
CPC分类号： C08G63/912 , A61L17/12 , A61L17/145 , A61L24/046 , A61L27/18 , A61L27/34 , A61L29/085
摘要： Crystalline, low melting .epsilon.-Caprolactone polymers which undergo accelerated hydrolysis for use, for example, as absorbable coatings for surgical sutures; the polymers bearing basic amine functionalities, ionically or covalently linked to the ester chain, which induce autocatalyzed hydrolysis.
摘要翻译： 经过加速水解的结晶，低熔点ε-己内酯聚合物，例如用作外科缝合线的可吸收涂层; 具有碱性胺官能团的聚合物，其与酯链离子或共价连接，其诱导自动催化的水解。
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公开(公告)号：US5171148A
公开(公告)日：1992-12-15
申请号：US374676
申请日：1989-06-30
CPC分类号： A61K9/0063 , A61C8/0006 , A61F2/30907 , A61F2002/30062 , A61F2002/30454 , A61F2002/30457 , A61F2002/30461 , A61F2210/0004 , A61F2220/0058 , A61F2220/0075
摘要： An absorbable mesh material useful as a dental implant. The mesh is cut by lasers to afford smooth edges which will not unravel. The implant may be attached by a ligature or suture material, generally formed from the same material as the implant, and attached to the implant by, among other things, laser or ultrasonic welding or interweaving.
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公开(公告)号：US5047048A
公开(公告)日：1991-09-10
申请号：US472134
申请日：1990-01-30
申请人： Rao S. Bezwada , Shalaby W. Shalaby , Mo Erneta
发明人： Rao S. Bezwada , Shalaby W. Shalaby , Mo Erneta
CPC分类号： C08G63/664 , A61L17/105 , A61L31/06 , C08G63/08
摘要： Crystalline copolymers of .epsilon.-caprolactone and a monomer having the formula: ##STR1## Surgical filaments, especially monofilament sutures, prepared by melt spinning the crystalline copolymers described above.
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28.发明授权
公开(公告)号：US4470416A
公开(公告)日：1984-09-11
申请号：US505160
申请日：1983-06-17
CPC分类号： C08G63/664 , A61L17/12 , A61L17/145 , A61L27/18
摘要： Copolymers are prepared from 1,5-dioxepan-2-one and lactide and/or glycolide. The copolymers are useful in surgical applications such as sutures, suture lubricants, and allied surgical products. 1,5-Dioxepan-2-one is produced by a new process comprising first reacting ethylene glycol with an alkyl acrylate to form alkyl 3-(2-hydroxyethoxy)propionate, which is then cyclized by contacting with a trans-esterification catalyst.
摘要翻译： 共聚物由1,5-二氧杂环庚烷-2-酮和丙交酯和/或乙交酯制备。 共聚物可用于外科应用，例如缝合线，缝线润滑剂和相关的手术产品。 通过包括首先使乙二醇与丙烯酸烷基酯反应形成3-（2-羟基乙氧基）丙酸烷基酯的新工艺生产1,5-二氧杂环庚烷-2-酮，然后通过与酯交换催化剂接触使其环化。
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公开(公告)号：US4461298A
公开(公告)日：1984-07-24
申请号：US401661
申请日：1982-07-26
IPC分类号： D06M15/00 , A61L17/00 , A61L17/14 , D02G3/40 , D06M101/00 , D06M101/02 , D06M101/10 , D06M101/12
CPC分类号： A61L17/145
摘要： Composite suture of multifilament silk embedded in a highly flexible, hydrophobic highly deformable matrix made of thermoplastic elastomer. This suture exhibits minimal irritation to living tissue and retains its strength in vivo for extended periods of time and also retains the desirable handling qualities of silk. The suture is prepared by treating a multifilament silk suture with a solution of a suitable polymer in a solvent and heating the moving suture to obtain a continuous impregnation of the silk with the elastomer.
摘要翻译： 复丝缝合的复丝丝线嵌入高弹性，疏水高度可变形的基质由热塑性弹性体制成。 这种缝线对生物组织表现出极小的刺激性，并且在体内长时间保持其强度，并且还保留丝绸所需的处理质量。 通过用合适的聚合物溶液在溶剂中处理复丝丝缝合物并加热移动的缝线以获得丝与弹性体的连续浸渍来制备缝合线。
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公开(公告)号：US4140678A
公开(公告)日：1979-02-20
申请号：US806048
申请日：1977-06-13
CPC分类号： D01F6/84 , A61L17/105 , A61L27/18 , C08G63/16 , D01F6/625 , Y10S623/926
摘要： Synthetic filaments composed of homopolymers and copolymers of poly(alkylene oxalates) are absorbable in animal tissue with minimal adverse tissue reaction. Polymers prepared by reacting a dialkyl oxalate with an alkylene diol are melt spun and drawn to obtain oriented fibers having good tensile properties and a high level of flexibility and softness. The filaments are particularly useful in the preparation of surgical prosthesis comprising woven or knitted fabrics and meshes. Other absorbable surgical devices including films and molded items may also be prepared from the disclosed polymer.
摘要翻译： 由聚（亚烷基草酸酯）的均聚物和共聚物组成的合成长丝在动物组织中是可吸收的，具有最小的不利组织反应。 通过使草酸二烷基酯与亚烷基二醇反应制备的聚合物被熔融纺丝并拉伸，得到具有良好拉伸性能和高柔性和柔软度的取向纤维。 长丝在制备包含织造或针织织物和网眼的手术假体中特别有用。 其它可吸收外科装置，包括膜和模制品也可以由所公开的聚合物制备。
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