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42 条记录 (耗时 0.087 秒)

    Glycopegylated Erythropoietin Formulations
    22.
    发明申请
    Glycopegylated Erythropoietin Formulations 审中-公开
    糖基化促红细胞生成素制剂

    公开(公告)号：US20110003744A1

    公开(公告)日：2011-01-06

    申请号：US11914104

    申请日：2006-05-25

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf ,  Jichao Kang ,  Walter Scott Willett

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf ,  Jichao Kang ,  Walter Scott Willett

    IPC分类号： C07K14/505 ,  A61K38/18

    CPC分类号： A61K38/1816 ,  A61K9/0019 ,  A61K47/26 ,  C07K14/505

    摘要： The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供红细胞生成素和PEG部分之间的缀合物。 缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。 通过糖基转移酶的作用，由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。

    GLYCOPEGYLATED FACTOR VII AND FACTOR VIIA
    23.
    发明申请
    GLYCOPEGYLATED FACTOR VII AND FACTOR VIIA 审中-公开
    糖蛋白因子VII和因子VIIA

    公开(公告)号：US20090305967A1

    公开(公告)日：2009-12-10

    申请号：US12064012

    申请日：2006-08-21

    申请人： Shawn DeFrees ,  David A. Zopf ,  Susann Taudte ,  Walter S. Willett ,  Mattew Kalo ,  Robert J. Bayer

    发明人： Shawn DeFrees ,  David A. Zopf ,  Susann Taudte ,  Walter S. Willett ,  Mattew Kalo ,  Robert J. Bayer

    IPC分类号： A61K38/36 ,  C12P21/02 ,  A61P7/04

    CPC分类号： C07K14/745 ,  A61K47/549 ,  A61K47/60

    摘要： The present invention provides conjugates between Factor VII or Factor VIIa peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

    摘要翻译： 本发明提供因子VII或因子VIIa肽和PEG部分之间的缀合物。 缀合物经由完整的糖基连接基团连接，该基团介于并共价连接到肽和修饰基团之间。 通过糖基转移酶的作用，缀合物由糖基化和未糖基化的肽形成。 糖基转移酶将修饰的糖部分连接到肽上的氨基酸或糖基残基上。 还提供了包括缀合物的药物制剂。 缀合物的制备方法也在本发明的范围内。

    Glycopegylated erythropoietin
    25.
    发明申请
    Glycopegylated erythropoietin 审中-公开

    公开(公告)号：US20080300175A1

    公开(公告)日：2008-12-04

    申请号：US11981483

    申请日：2007-10-31

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf

    IPC分类号： C07K14/505 ,  A61K38/18 ,  A61P7/06

    CPC分类号： C07K14/505 ,  A61K38/00 ,  A61K47/60 ,  C07H19/10

    摘要： The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    Glycopegylated Factor Ix
    27.
    发明申请
    Glycopegylated Factor Ix 审中-公开
    糖基化因子Ix

    公开(公告)号：US20080255026A1

    公开(公告)日：2008-10-16

    申请号：US11915239

    申请日：2006-05-25

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe ,  Panneerselvam Krishnasamy

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe ,  Panneerselvam Krishnasamy

    IPC分类号： A61K38/02 ,  C07K2/00 ,  C12P21/06

    CPC分类号： A61K38/4846 ,  A61K47/549 ,  A61K47/60 ,  C12N9/644 ,  C12Y304/21022

    摘要： The present invention provides conjugates between Factor Ix and PEG moieties. The conjugates are linked via a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. Conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供因子Ix和PEG部分之间的缀合物。 缀合物通过插入在肽和修饰基团之间并共价连接到肽上的糖基连接基团连接。 通过糖基转移酶的作用由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。

    Glycopegylated Follicle Stimulating Hormone
    28.
    发明申请
    Glycopegylated Follicle Stimulating Hormone 审中-公开
    糖基化卵泡刺激激素

    公开(公告)号：US20080015142A1

    公开(公告)日：2008-01-17

    申请号：US10581538

    申请日：2004-12-03

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe

    IPC分类号： A61K38/24 ,  C07K14/59

    CPC分类号： C07K14/59 ,  A61K38/17 ,  Y02A50/471

    摘要： The present invention provides conjugates between follicle stimulating hormone and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

    摘要翻译： 本发明提供了促卵泡激素和PEG部分之间的缀合物。 缀合物经由完整的糖基连接基团连接，该基团介于并共价连接到肽和修饰基团之间。 通过糖基转移酶的作用，缀合物由糖基化和未糖基化的肽形成。 糖基转移酶将修饰的糖部分连接到肽上的氨基酸或糖基残基上。 还提供了包括缀合物的药物制剂。 缀合物的制备方法也在本发明的范围内。