公开(公告)号：US20090302209A1

公开(公告)日：2009-12-10

申请号：US12297481

申请日：2007-04-30

Applicant: Martin Green ,  Jason Wildgoose ,  Steven Derek Pringle ,  Daniel James Kenny

Inventor： Martin Green ,  Jason Wildgoose ,  Steven Derek Pringle ,  Daniel James Kenny

IPC: H01J49/28

CPC classification number: H01J49/065 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/062 ,  H01J49/36 ,  H01J49/4235 ,  Y10T436/24

Abstract: An ion guide or mass analyser (2) is disclosed comprising a plurality of electrodes (2a) having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser (2). The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages (4) are applied to the electrodes (2a) of the ion guide or mass analyser (2) in order to urge ions along the length of the ion guides or mass analyser (2). The amplitude of the transient DC voltage (4) applied to the electrode (2a) may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser (2) in reverse order of their mass to charge ratio.

Abstract translation: 公开了一种离子导向器或质量分析器（2），其包括具有孔的多个电极（2a），在使用中通过该孔具有离子。 在离子导向器或质量分析器（2）的出口处产生伪势垒。 伪势垒的幅度或深度与离子的质荷比成反比。 一个或多个瞬态DC电压（4）被施加到离子导向器或质量分析器（2）的电极（2a），以促使沿着离子导向器或质量分析器（2）的长度的离子。 施加到电极（2a）的瞬态直流电压（4）的振幅可以随时间增加，从而离子引导或质量分析器（2）以与其质荷比相反的顺序发射离子。

公开(公告)号：US09080936B2

公开(公告)日：2015-07-14

申请号：US13055612

申请日：2009-07-27

Applicant: Jeffery Mark Brown ,  Martin Raymond Green ,  Steven Derek Pringle

Inventor： Jeffery Mark Brown ,  Martin Raymond Green ,  Steven Derek Pringle

IPC: G01N24/00 ,  H01J49/00 ,  H01J49/10 ,  H01J49/12 ,  H01J49/16 ,  H01J49/04

CPC classification number: H01J49/12 ,  G01N24/00 ,  H01J49/0009 ,  H01J49/0072 ,  H01J49/0495 ,  H01J49/107 ,  H01J49/165 ,  Y10T436/24

Abstract: A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapor may be provided through the tubular electrode (14) which is then subsequently ionized by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.

Abstract translation: 公开了质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。 辉光放电装置可以包括设置在真空室中的隔离阀（15）内的管状电极（14）。 可以通过管状电极（14）提供试剂蒸汽，然后其随后通过辉光放电电离。 所得的试剂离子可用于由大气压离子源产生的分析物离子的电子转移离解。 考虑其他实施例，其中由辉​​光放电装置产生的离子可用于通过质子转移反应来减少分析物离子的电荷状态，或者可以作为锁定质量或参考离子。

公开(公告)号：US20140326867A1

公开(公告)日：2014-11-06

申请号：US14270433

申请日：2014-05-06

Applicant: Martin Raymond Green ,  Steven Derek Pringle ,  Jason Lee Wildgoose

Inventor： Martin Raymond Green ,  Steven Derek Pringle ,  Jason Lee Wildgoose

IPC: H01J49/00 ,  H01J49/40

CPC classification number: H01J49/0036 ,  H01J49/40

Abstract: A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum.

Abstract translation: 公开了一种质谱仪，其中离子信号被分成第一和第二信号。 第一和第二信号乘以不同的增益并被数字化。 对于两个数字化信号计算到达时间和强度对，并且将所得到的时间和强度对组合以形成高动态范围谱。 然后将光谱与其他对应的光谱组合以形成相加光谱。

公开(公告)号：US08735808B2

公开(公告)日：2014-05-27

申请号：US13576344

申请日：2011-02-14

Applicant: Richard Denny ,  Keith Richardson ,  Martin Raymond Green ,  Steven Derek Pringle ,  Anthony James Gilbert ,  John Skilling ,  Jason Lee Wildgoose

Inventor： Richard Denny ,  Keith Richardson ,  Martin Raymond Green ,  Steven Derek Pringle ,  Anthony James Gilbert ,  John Skilling ,  Jason Lee Wildgoose

IPC: H01J49/40 ,  G01R23/16

CPC classification number: H01J49/0036 ,  H01J49/40

Abstract: A method of mass spectrometry is disclosed wherein a signal output from an ion detector is digitized by an Analogue to Digital Converter and is then deconvoluted to determine one or more ion arrival times and one more ion arrival intensities. The process of deconvoluting the ion signal involves determining a point spread function characteristic of an ion arriving at and being detected by the ion detector. A distribution of ion arrival times which produces a best fit to the digitised signal is then determined given that each ion arrival is assumed to produce a response given by the point spread function. A plurality of ion arrival times are then combined to produce a composite ion arrival time-intensity spectrum.

Abstract translation: 公开了一种质谱法，其中从离子检测器输出的信号被模拟数字转换器数字化，然后进行解卷积，以确定一个或多个离子到达时间和一个离子到达强度。 去卷积离子信号的过程涉及确定到达并被离子检测器检测的离子的点扩散函数特征。 因此，假设每个离子到达产生由点扩散函数给出的响应，则确定产生与数字化信号最佳拟合的离子到达时间的分布。 然后将多个离子到达时间组合以产生复合离子到达时间强度谱。

公开(公告)号：US08354634B2

公开(公告)日：2013-01-15

申请号：US12601094

申请日：2008-05-22

Applicant: Martin Green ,  Steven Derek Pringle ,  Jason Lee Wildgoose

Inventor： Martin Green ,  Steven Derek Pringle ,  Jason Lee Wildgoose

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/0036 ,  H01J49/40

Abstract: A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum.

Abstract translation: 公开了一种质谱仪，其中离子信号被分成第一和第二信号。 第一和第二信号乘以不同的增益并被数字化。 对于两个数字化信号计算到达时间和强度对，并且将所得到的时间和强度对组合以形成高动态范围谱。 然后将光谱与其他对应的光谱组合以形成相加光谱。

公开(公告)号：US20120199734A1

公开(公告)日：2012-08-09

申请号：US13435877

申请日：2012-03-30

Applicant: Kevin Giles ,  Martin Green ,  Steven Derek Pringle ,  Jason Lee Wildgoose

Inventor： Kevin Giles ,  Martin Green ,  Steven Derek Pringle ,  Jason Lee Wildgoose

IPC: H01J49/40 ,  H01J49/26

CPC classification number: H01J49/427 ,  H01J49/4235

Abstract: An ion guide or ion trap is disclosed having an entrance electrode and an exit electrode. The potential of the exit electrode is periodically dropped for a relatively short period of time allowing some ions to escape from the ion guide or ion trap via an aperture in the exit electrode. The period of time that the potential of the exit electrode is dropped for is progressively increased and ions emerge from the ion guide or ion trap in a mass to charge ratio dependent manner. The ion guide or ion trap may be operated as a mass separator or low resolution mass analyser.

Abstract translation: 公开了一种具有入口电极和出射电极的离子导向器或离子阱。 出口电极的电位周期性地下降相当短的时间段，允许一些离子通过出射电极的孔离开离子导向器或离子阱。 出口电极的电位下降的时间段逐渐增加，并且离子导向器或离子阱以质荷比依赖的方式出现离子。 离子导向器或离子阱可以作为质量分离器或低分辨率质量分析器来操作。

公开(公告)号：US07919747B2

公开(公告)日：2011-04-05

申请号：US12297481

申请日：2007-04-30

Applicant: Martin Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle ,  Daniel James Kenny

Inventor： Martin Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle ,  Daniel James Kenny

IPC: H01J49/00 ,  H01J49/44

CPC classification number: H01J49/065 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/062 ,  H01J49/36 ,  H01J49/4235 ,  Y10T436/24

Abstract: An ion guide or mass analyser (2) is disclosed comprising a plurality of electrodes (2a) having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser (2). The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages (4) are applied to the electrodes (2a) of the ion guide or mass analyser (2) in order to urge ions along the length of the ion guides or mass analyser (2). The amplitude of the transient DC voltage (4) applied to the electrode (2a) may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser (2) in reverse order of their mass to charge ratio.

Abstract translation: 公开了一种离子导向器或质量分析器（2），其包括具有孔的多个电极（2a），在使用中通过该孔具有离子。 在离子导向器或质量分析器（2）的出口处产生伪势垒。 伪势垒的幅度或深度与离子的质荷比成反比。 一个或多个瞬态DC电压（4）被施加到离子导向器或质量分析器（2）的电极（2a），以促使沿着离子导向器或质量分析器（2）的长度的离子。 施加到电极（2a）的瞬态直流电压（4）的振幅可以随时间增加，从而离子引导或质量分析器（2）以与其质荷比相反的顺序发射离子。

公开(公告)号：US07683314B2

公开(公告)日：2010-03-23

申请号：US10599572

申请日：2005-04-04

Applicant: Martin Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle ,  Kevin Giles

Inventor： Martin Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle ,  Kevin Giles

IPC: H01J49/04

CPC classification number: H01J49/06 ,  Y10T436/24

Abstract: A mass spectrometer is disclosed comprising an ion beam attenuator which attenuates an ion beam repeatedly switching between a zero transmission mode of operation during a time period ΔT1 and a non-zero transmission mode of operation during a time period ΔT2. The degree of attenuation of the ion beam can be varied by varying the mark space ratio ΔT2/ΔT1. The ion beam attenuator may release ions in packets or pulses but the packets or pulses of ions may be converted into a continuous ion beam by a relatively high pressure ion guide or gas collision cell arranged downstream of the ion beam attenuator.

Abstract translation: 公开了一种质谱仪，其包括离子束衰减器，该离子束衰减器衰减离子束在时间段Dgr; T1期间的零传输操作模式和在时间段Dgr; T2期间的非零传输操作模式之间重复切换。 可以通过改变标记空间比＆Dgr; T2 /＆Dgr; T1来改变离子束的衰减程度。 离子束衰减器可以以分组或脉冲的形式释放离子，但是离子束或脉冲可以通过布置在离子束衰减器下游的相对高压的离子导向器或气体碰撞元件转换为连续的离子束。

公开(公告)号：US20100065733A1

公开(公告)日：2010-03-18

申请号：US12306162

申请日：2007-06-25

Applicant: Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

Inventor： Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/429 ,  G01N27/622 ,  H01J49/0031 ,  H01J49/004

Abstract: A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (6) arranged upstream of a collision or fragmentation cell (8). Ions are separated according to their ion mobility within the ion mobility spectrometer or separator (6). The kinetic energy of the ions exiting the ion mobility spectrometer or separator (6) is increased substantially linearly with time in order to optimise the fragmentation energy of ions as they enter the collision or fragmentation cell (8). During the time that the potential of the ion mobility spectrometer or separator (6) is being varied, the potential of ion-optical components upstream of the ion mobility spectrometer or separator (6) such as an ion source (1), ion guide (2), quadrupole mass filter (3), optional second collision or fragmentation cell (4) and an ion trapping device (5) are kept constant.

Abstract translation: 公开了一种质谱仪，其包括设置在碰撞或分裂单元（8）的上游的离子迁移谱仪或分离器（6）。 根据离子迁移谱仪或分离器（6）内的离子迁移率分离离子。 离子离子迁移谱仪或分离器（6）离子的动能随着时间的推移基本线性地增加，以优化离子进入碰撞或破碎电池（8）时的碎裂能。 在离子迁移谱仪或分离器（6）的电位变化的时间内，离子迁移谱仪或分离器（6）上游离子光学部件的离子源（1），离子导向器 2），四极质量过滤器（3），任选的第二碰撞或碎裂单元（4）和离子捕获装置（5）保持恒定。

公开(公告)号：US20090173880A1

公开(公告)日：2009-07-09

申请号：US11720520

申请日：2005-12-02

Applicant: Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle

Inventor： Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle

IPC: H01J49/00 ,  B01D59/44

CPC classification number: H01J49/065

Abstract: An ion guide (7a) is disclosed comprising one or more layers of intermediate planar, plate or mesh electrodes (2). A first array of first electrodes (8a-8e) is provided on an upper surface and a second array of second electrodes (9a-9e) is arranged on a lower surface. An ion guiding region is formed within the ion guide (7a). One or more transient DC voltages or potentials are preferably applied to the first and second array of second electrodes (8a-8e, 9a-9e) in order to urge, propel, force or accelerate ions through or along the ion guide (7a).

Abstract translation: 公开了一种离子导向器（7a），其包括一层或多层中间平面，板状或网状电极（2）。 第一电极阵列（8a-8e）设置在上表面上，第二电极阵列（9a-9e）布置在下表面上。 离子引导区域形成在离子导向器（7a）内。 优选地将一个或多个瞬态DC电压或电位施加到第一和第二第二电极阵列（8a-8e，9a-9e），以促使，推动，强迫或加速离子通过或沿着离子导向器（7a）。