利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

74 条记录 (耗时 0.046 秒)

    Alphavirus vectors having attentuated virion structural proteins
    25.
    发明申请
    Alphavirus vectors having attentuated virion structural proteins 审中-公开
    具有病毒粒子结构蛋白的甲病毒载体

    公开(公告)号：US20060099587A1

    公开(公告)日：2006-05-11

    申请号：US10517083

    申请日：2003-06-20

    申请人： Robert Johnston ,  Nancy Davis ,  Ande West ,  Jonathan Smith

    发明人： Robert Johnston ,  Nancy Davis ,  Ande West ,  Jonathan Smith

    IPC分类号： C12Q1/68 ,  C12N7/00 ,  C12N7/01

    CPC分类号： C07K14/005 ,  A61K2039/5154 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  C12N15/86 ,  C12N2740/16222 ,  C12N2770/36122 ,  C12N2770/36143

    摘要： The present invention provides immunogenic compositions and methods that may be used to administer safer (i.e., attenuated) alphavirus vectors (such as alphavirus vectors comprising a VEE virion shell) that retain improved immunogenicity as compared with other attenuated alphaviruses (e.g., the VEE 3014 mutant, described below). In particular embodiments of the invention, the alphavirus vector comprises VEE structural proteins comprising an attenuating mutation in the E1 glycoprotein. In other particular embodiments, the attenuating mutation is in the fusogenic region of the E1 glycoprotein. The present invention enables administration of lower dosages of a safer (i.e., attenuated) virus and, thus, can further reduce manufacturing costs. The present inventors have found that immunogenicity of alphavirus vectors may be influenced by a number of factors including species, site and route of administration.

    摘要翻译： 本发明提供免疫原性组合物和方法，其可用于与其他减毒的甲病毒（例如，VEE 3014突变体）相比，其保持更高（即减毒）的甲病毒载体（例如包含VEE病毒粒子的甲病毒载体），其保持改善的免疫原性 ， 如下面所描述的）。 在本发明的具体实施方案中，甲病毒载体包含在E1糖蛋白中包含减毒突变的VEE结构蛋白。 在其它具体实施方案中，减毒突变位于E1糖蛋白的融合区。 本发明使得能够施用较低剂量的更安全（即，减毒）的病毒，因此可以进一步降低制造成本。 本发明人已经发现甲病毒载体的免疫原性可能受许多因素的影响，包括物种，部位和给药途径。

    Migrating data integration processes through use of externalized metadata representations
    27.
    发明申请
    Migrating data integration processes through use of externalized metadata representations 审中-公开
    通过使用外部化元数据表示来迁移数据集成过程

    公开(公告)号：US20050251533A1

    公开(公告)日：2005-11-10

    申请号：US11083040

    申请日：2005-03-16

    申请人： Richard Harken ,  Robert Johnston

    发明人： Richard Harken ,  Robert Johnston

    IPC分类号： G06F7/00 ,  G06F17/22

    CPC分类号： G06F17/2247 ,  G06F17/2264

    摘要： Methods and systems are provided for migrating a data integration facility, such as an ETL job, from a source data integration platform to a target data integration platform. Certain embodiments involve externalizing a metadata representation of a source data integration job; parsing the metadata representation; importing the parsed metadata into a plurality of object representations of the source data integration job; generating an intermediate representation of the source data integration platform based on the plurality of object representations; and translating the intermediate representation to generate a target data integration job; wherein the target data integration job is adapted perform substantially the same functions as the source data integration job.

    摘要翻译： 提供了方法和系统，用于将数据集成工具（如ETL作业）从源数据集成平台迁移到目标数据集成平台。 某些实施例涉及外部化源数据集成作业的元数据表示; 解析元数据表示; 将解析的元数据导入到源数据集成作业的多个对象表示中; 基于所述多个对象表示生成所述源数据集成平台的中间表示; 以及翻译所述中间表示以生成目标数据集成作业; 其中所述目标数据集成作业适于执行与所述源数据集成作业基本相同的功能。

    Method and apparatus for improved interaction with an application program according to data types and actions performed by the application program
    28.
    发明申请
    Method and apparatus for improved interaction with an application program according to data types and actions performed by the application program 失效
    根据应用程序执行的数据类型和动作，改进与应用程序的交互的方法和装置

    公开(公告)号：US20050010927A1

    公开(公告)日：2005-01-13

    申请号：US10911147

    申请日：2004-08-03

    申请人： Mark Stern ,  Robert Johnston ,  Elizabeth Moller

    发明人： Mark Stern ,  Robert Johnston ,  Elizabeth Moller

    IPC分类号： G06F3/033 ,  G06F3/048 ,  G06F9/00

    CPC分类号： G06F3/0486 ,  G06F9/451

    摘要： A method and apparatus for performing actions while selecting objects on a user interface display. A user may select a first item in an area of a display controlled by a first process and drag that item to a second area on a display controlled by a second process. The second process may negotiate with the first process to provide certain data types, and based upon those data types, the second process will determine a list of actions in hierarchical fashion which may be performed upon the data. Such actions may include, but are not limited to, printing, sending electronic mail, and performing other actions in the computer system. Alternative and primary actions may also be specified by a user, such as by selecting various keys on a keyboard or other input device. Further, a user may specify that the second process display a list of actions which may be performed upon the selected item and allow the user to select an action from a list.

    摘要翻译： 一种用于在用户界面显示器上选择对象时执行动作的方法和装置。 用户可以选择由第一进程控制的显示区域中的第一项目，并将该项目拖动到由第二进程控制的显示器上的第二区域。 第二进程可以与第一进程协商以提供某些数据类型，并且基于这些数据类型，第二进程将以分层方式确定可以对数据执行的动作列表。 这样的动作可以包括但不限于在计算机系统中打印，发送电子邮件和执行其他动作。 替代和主要动作也可以由用户指定，例如通过选择键盘或其他输入设备上的各种键。 此外，用户可以指定第二处理显示可以对所选择的项目执行的动作列表，并允许用户从列表中选择动作。

    Topical cooling device
    29.
    发明授权
    Topical cooling device 失效
    局部冷却装置

    公开(公告)号：US6023932A

    公开(公告)日：2000-02-15

    申请号：US139868

    申请日：1998-08-25

    申请人： Robert Johnston

    发明人： Robert Johnston

    IPC分类号： A61B17/00 ,  A61F7/00 ,  F25B21/02

    CPC分类号： A61F7/007 ,  F25B21/02 ,  A61B2017/00119 ,  A61F2007/0075 ,  A61F2007/0086 ,  F25B2321/0251

    摘要： A portable topical heat transfer device for topically cooling an animal or human when required such as to relieve pain and swelling from injured joints or muscles or the like. The device comprises a thermoelectric unit having a cold side and a warm side, a DC source which is connected to the thermoelectric unit, a heat sink which is mounted in a heat conductive relationship with the warm side of the thermoelectric unit, a fan for removing heat from the heat sink, and a strap or the like for securing the device to the body of a person.

    摘要翻译： 一种便携式局部传热装置，用于在需要时局部冷却动物或人，以减轻受伤关节或肌肉等的疼痛和肿胀。 该装置包括具有冷侧和暖侧的热电单元，连接到热电单元的DC源，与热电单元的暖侧以热传导关系安装的散热器，用于去除 来自散热器的热量以及用于将设备固定在人体上的带子等。

    Apparatus and method for storing and providing a portion of media content to a communication device
    30.
    发明授权
    Apparatus and method for storing and providing a portion of media content to a communication device 有权
    一种用于存储和提供媒体内容的一部分到通信设备的装置和方法

    公开(公告)号：US08634704B2

    公开(公告)日：2014-01-21

    申请号：US12560869

    申请日：2009-09-16

    申请人： Robert Johnston ,  Frank Coppa ,  James Wood

    发明人： Robert Johnston ,  Frank Coppa ,  James Wood

    IPC分类号： H04N5/91 ,  H04N7/16 ,  H04N5/445 ,  G06F13/00 ,  G06F3/00

    CPC分类号： H04N5/76 ,  H04N7/17318 ,  H04N21/2747 ,  H04N21/41407 ,  H04N21/4147 ,  H04N21/4181 ,  H04N21/4333

    摘要： A system that incorporates teachings of the present disclosure may include, for example, a mobile device having a controller to present media content provided by an interactive television (iTV) network, select a function during presentation of the media content to store at least a remaining portion of the media content, wherein the function is selected when the presentation of the media content is to be interrupted, store the media content in a memory location of the mobile device, select the function to retrieve the remaining portion of the media content from the memory location, and present the remaining portion of the media content. Other embodiments are disclosed.

    摘要翻译： 结合本公开的教导的系统可以包括例如具有控制器以呈现由交互式电视（iTV）网络提供的媒体内容的移动设备，在呈现媒体内容期间选择功能以存储至少剩余的 媒体内容的一部分，其中当要中断媒体内容的呈现时选择该功能，将媒体内容存储在移动设备的存储器位置中，选择功能以从媒体内容中检索媒体内容的剩余部分 存储位置，并显示媒体内容的剩余部分。 公开了其他实施例。