公开(公告)号：US20090281072A1

公开(公告)日：2009-11-12

申请号：US12235189

申请日：2008-09-22

申请人： Shinya Nagashima ,  Hiroshi Nagata ,  Masashiro Iwata ,  Masaki Yokota ,  Hiroyuki Moritomo ,  Eiichi Nakai ,  Sadao Kuromitsu ,  Keiko Ohga ,  Makoto Takeuchi

发明人： Shinya Nagashima ,  Hiroshi Nagata ,  Masashiro Iwata ,  Masaki Yokota ,  Hiroyuki Moritomo ,  Eiichi Nakai ,  Sadao Kuromitsu ,  Keiko Ohga ,  Makoto Takeuchi

IPC分类号： A61K31/5377 ,  A61K31/551 ,  A61K31/397 ,  A61P11/06

CPC分类号： C07D403/12 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D451/04 ,  C07D453/02 ,  C07D471/10 ,  C07D487/08

摘要： A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided.A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.

摘要翻译： 提供了可用于预防或治疗其中涉及STAT6的呼吸系统疾病的化合物，特别是哮喘，慢性阻塞性肺病等。 具有可以被特定取代基取代的芳基氨基或芳基乙氨基的嘧啶衍生物或其盐在2-位被苄基取代的氨基或4-位上的氨基甲酰基和氨基甲酰基， 可以在5位被提供。

公开(公告)号：US07592465B2

公开(公告)日：2009-09-22

申请号：US11466789

申请日：2006-08-24

申请人： Makoto Takeuchi ,  Yuki Miyazawa ,  Hiroyuki Sato ,  Masazumi Date

发明人： Makoto Takeuchi ,  Yuki Miyazawa ,  Hiroyuki Sato ,  Masazumi Date

IPC分类号： C07D207/28

CPC分类号： A01N43/36 ,  C05F11/10 ,  A01N25/00 ,  A01N25/02

摘要： Contamination by microorganism of an aqueous proline solution is prevented by adjusting a proline concentration of the solution to 20% (W/W/) or more. Such solutions are useful as fertilizers and/or plan vitalizers. Preservation of the novel solutions are possible over a significant period of time, allowing for more flexibility in the distribution and application of commercial products made from the solutions.

摘要翻译： 通过将溶液的脯氨酸浓度调节至20％（W / W /）以上）来防止脯氨酸水溶液的微生物污染。 这样的解决方案可用作肥料和/或计划增效剂。 保护新颖的解决方案在很长一段时间内是可行的，从而在解决方案产生的商业产品的分销和应用方面有更大的灵活性。

公开(公告)号：US07559844B2

公开(公告)日：2009-07-14

申请号：US11701508

申请日：2007-02-02

申请人： Tomohiro Saeki ,  Satoshi Nakagaito ,  Makoto Takeuchi ,  Masanori Suzuki ,  Masaru Ebata

发明人： Tomohiro Saeki ,  Satoshi Nakagaito ,  Makoto Takeuchi ,  Masanori Suzuki ,  Masaru Ebata

IPC分类号： F16F15/139 ,  F16D3/14 ,  F16D47/02 ,  F16D69/00

CPC分类号： F16F15/129

摘要： A torque fluctuation absorber includes a disc fixed to a flywheel, a hub fixed to a transmission, first and second side plates fixed to the disc, a damper member, first and second control plates provided at axial both sides of the hub, the first and second control plates being riveted by a stopper pin, a first hysteresis mechanism including first and second low friction members and generating a small hysteresis, and a second hysteresis mechanism including first and second high friction members and generating a large hysteresis. The hub includes a flange portion having a through-hole into which the stopper pin is inserted. A relative rotational angle between the control plates and the hub is defined by a clearance formed between the through-hole and the hub. The first hysteresis mechanism is activated when the relative rotational angle is defined within the clearance.

摘要翻译： 扭矩波动吸收器包括固定到飞轮的盘，固定到变速器的轮毂，固定到盘的第一和第二侧板，阻尼器构件，设置在轮毂的轴向两侧的第一和第二控制板，第一和第二侧板 第二控制板由止动销铆接，包括第一和第二低摩擦构件并产生小滞后的第一滞后机构，以及包括第一和第二高摩擦构件并产生大的滞后的第二滞后机构。 轮毂包括具有止动销插入其中的通孔的凸缘部分。 控制板和轮毂之间的相对旋转角度由形成在通孔和轮毂之间的间隙限定。 当相对旋转角度在间隙内限定时，第一个滞后机构被激活。

公开(公告)号：US20070155513A1

公开(公告)日：2007-07-05

申请号：US11716577

申请日：2007-03-12

申请人： Satoshi Nakagaito ,  Masaru Ebata ,  Makoto Takeuchi ,  Hiroshi Ichikawa

发明人： Satoshi Nakagaito ,  Masaru Ebata ,  Makoto Takeuchi ,  Hiroshi Ichikawa

IPC分类号： F16D7/02 ,  F16F15/121

CPC分类号： F16F15/129

摘要： A torque fluctuation absorbing device includes a first rotational member which transmits a torque from a driving power source, a damping mechanism connected with an input shaft of a transmission, the damping mechanism having a pair of frictional members of approximately annular-shaped fixed at both surfaces of a disc, and a limiter portion for frictionally engaging the pair of frictional members with the first rotational member in a substantially direct manner or in a substantially indirect manner via a pair of frictional plates. An actual length of at least one of the pair of frictional members ranges substantially between 1 percent and 6 percent of a major diameter of the at least one of the pair of frictional members.

摘要翻译： 扭矩波动吸收装置包括：传递来自驱动动力源的转矩的第一旋转构件，与变速器的输入轴连接的阻尼机构，所述阻尼机构具有在两面固定的大致环状的一对摩擦构件 以及限制器部分，用于通过一对摩擦板以基本上直接的方式或以基本上间接的方式摩擦地与所述第一旋转部件摩擦接合所述一对摩擦部件。 一对摩擦构件中的至少一个的实际长度基本上在一对摩擦构件中的至少一个的大直径的1％至6％之间。

公开(公告)号：US07176219B2

公开(公告)日：2007-02-13

申请号：US11128238

申请日：2005-05-13

申请人： Masahiko Hayakawa ,  Kiyohiro Samizu ,  Hiroshi Uebayashi ,  Ken Ikeda ,  Makoto Takeuchi

发明人： Masahiko Hayakawa ,  Kiyohiro Samizu ,  Hiroshi Uebayashi ,  Ken Ikeda ,  Makoto Takeuchi

IPC分类号： A61K31/44

CPC分类号： C07D453/02

摘要： There is provided an acid addition salt of (−)-(3R)-quinuclidin-3-yl(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate with an acid selected from the group consisting of (−)-(2S,3S)-tartaric acid, (+)-(2S,3S)-di-O-benzoyltartaric acid, (+)-(2S,3S)-di-O-(4-methylbenzoyl)tartaric acid, (−)-L-phenylalanine, benzenesulfonic acid, cyclohexanesulfamic acid, hydrobromic acid, naphthalene-2-sulfonic acid, sebacic acid, (+)-camphor-10-sulfonic acid, p-toluenesulfonic acid, ethanesulfonic acid, methanesulfonic acid and methyl phosphate, which has little hygroscopicity that affects the use as a drug or its drug substance, and is very useful as a drug or its drug substance.

摘要翻译： 提供了（ - ） - （3R） - 奎宁环-3-基（1R）-1-苯基-1,2,3,4-四氢异喹啉-2-羧酸的酸加成盐，其中酸选自 的（ - ） - （2S，3S） - 酒石酸，（+） - （2S，3S） - 二-O-苯甲酰基酒石酸，（+） - （2S，3S） - 二-O-（4-甲基苯甲酰基） 酒石酸，（ - ） - L-苯丙氨酸，苯磺酸，环己烷氨基磺酸，氢溴酸，萘-2-磺酸，癸二酸，（+） - 樟脑-10-磺酸，对甲苯磺酸，乙磺酸，甲磺酸 酸和磷酸甲酯，其吸湿性几乎不影响作为药物或其药物物质的用途，并且作为药物或其药物物质是非常有用的。

公开(公告)号：US20050067249A1

公开(公告)日：2005-03-31

申请号：US10950657

申请日：2004-09-28

申请人： Satoshi Nakagaito ,  Masaru Ebata ,  Makoto Takeuchi ,  Hiroshi Ichikawa

发明人： Satoshi Nakagaito ,  Masaru Ebata ,  Makoto Takeuchi ,  Hiroshi Ichikawa

IPC分类号： F16F15/139 ,  F16D7/02 ,  F16F15/129 ,  F16H35/10

CPC分类号： F16F15/129

摘要： A torque fluctuation absorbing device includes a first rotational member transmitted with a torque from a driving power source, a damping mechanism connected with an input shaft of a transmission, the damping mechanism having a pair of frictional members of approximately annular-shaped fixed at both surfaces of a disc, and a limiter portion for frictionally engaging the pair of frictional members with the first rotational member in a substantially direct manner or in a substantially indirect manner via a pair of frictional plates. An actual length of at least one of the pair of frictional members ranges substantially between 1 percent and 6 percents of a major diameter of the at least one of the pair of frictional members.

摘要翻译： 一种扭矩波动吸收装置，包括以驱动动力源的转矩传递的第一旋转构件，与变速器的输入轴连接的减震机构，该阻尼机构具有在两面固定的大致环状的一对摩擦构件 以及限制器部分，用于通过一对摩擦板以基本上直接的方式或以基本上间接的方式摩擦地与所述第一旋转部件摩擦接合所述一对摩擦部件。 一对摩擦构件中的至少一个的实际长度基本上在一对摩擦构件中的至少一个的大直径的1％至6％之间。

公开(公告)号：US06815191B1

公开(公告)日：2004-11-09

申请号：US09700993

申请日：2001-07-20

申请人： Kazuo Kobayashi ,  Makoto Takeuchi ,  Akihiko Iwamatsu ,  Kenji Yamamoto ,  Hidehiko Kumagai ,  Satoshi Yoshida

发明人： Kazuo Kobayashi ,  Makoto Takeuchi ,  Akihiko Iwamatsu ,  Kenji Yamamoto ,  Hidehiko Kumagai ,  Satoshi Yoshida

IPC分类号： C12N926

CPC分类号： C12Y302/01096 ,  C12N9/2402

摘要： An endo-&bgr;-N-acetylglucosaminidase gene encoding the following protein (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO: 3; and (b) a protein comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 3 by deletion, substitution, or addition of at least one amino acid and having the activity of endo-&bgr;-N-acetylglucosaminidase.

公开(公告)号：US06552992B2

公开(公告)日：2003-04-22

申请号：US09793165

申请日：2001-02-26

申请人： Makoto Takeuchi ,  Kazuhiko Kitamura

发明人： Makoto Takeuchi ,  Kazuhiko Kitamura

IPC分类号： G11B1920

CPC分类号： F16F15/363 ,  G01M1/36 ,  G11B19/2009 ,  G11B19/2027 ,  G11B25/043

摘要： A weight member is attached to a rotor so as to forcibly offset a center of gravity of a rotor from a rotating axis, centrifugal force moves two movable weight members to appropriate positions for canceling the unbalance due to the center of gravity offset from the rotating axis, and stoppers restrict the movement of the two movable weight members in a sectoral area opposite to the center of gravity so that the rotor is free from vibrations due to the characteristic angular velocity.

摘要翻译： 配重部件被安装在转子上，从而将转子的重心从旋转轴线上强制地偏移，离心力将两个可动配重件移动到合适的位置，以消除由于重心偏离旋转轴线的不平衡 并且止动件限制两个可移动重量件在与重心相反的扇形区域中的移动，使得转子由于特征角速度而没有振动。

公开(公告)号：US06338955B2

公开(公告)日：2002-01-15

申请号：US09117860

申请日：1998-08-12

申请人： Suguru Oguri ,  Mari Minowa ,  Aruto Yoshida ,  Naoyuki Taniguchi ,  Makoto Takeuchi

发明人： Suguru Oguri ,  Mari Minowa ,  Aruto Yoshida ,  Naoyuki Taniguchi ,  Makoto Takeuchi

IPC分类号： C12N1554

CPC分类号： C12N9/1051

摘要： The present invention relates to a novel enzyme having &bgr;1→4 N-acetylglucosaminyltransferase (GnT-IV) activity; a gene encoding the enzyme; a recombinant DNA comprising the gene; a host cell comprising the recombinant DNA; a method for producing an enzyme protein having GnT-IV activity comprising culturing the host cell in a medium; and a saccharide in which the sugar chain is modified using a GnT-IV. According to the present invention, a novel GnT-IV, a method for producing the enzyme and a gene coding for the enzyme are provided. With the GnT-IV of the present invention, it has become possible to produce a saccharide having a branching structure which could not be formed with conventional glycosyltransferases. Thus, the GnT-IV of the invention is useful not only for producing or improving glycoconjugate type pharmaceuticals, reagents and foods, but also for modifying the sugar chain structure of any biopolymer.

摘要翻译： 本发明涉及具有β1-4N-乙酰葡糖胺基转移酶（GnT-IV）活性的新型酶; 编码酶的基因; 包含该基因的重组DNA; 包含重组DNA的宿主细胞; 制备具有GnT-IV活性的酶蛋白质的方法，包括在培养基中培养宿主细胞; 以及使用GnT-IV对糖链进行修饰的糖类。根据本发明，提供新的GnT-IV，该酶的制造方法和编码该酶的基因。 利用本发明的GnT-IV，可以制备具有不能用常规糖基转移酶形成的支化结构的糖类。 因此，本发明的GnT-IV不仅可用于生产或改进糖缀合物型药物，试剂和食品，而且用于改变任何生物聚合物的糖链结构。

公开(公告)号：US06334764B1

公开(公告)日：2002-01-01

申请号：US09588776

申请日：2000-06-07

申请人： Hiroyuki Kobayashi ,  Makoto Takeuchi ,  Takahide Itoh ,  Tetsuzou Ukai

发明人： Hiroyuki Kobayashi ,  Makoto Takeuchi ,  Takahide Itoh ,  Tetsuzou Ukai

IPC分类号： F04C1800

CPC分类号： F04C29/0021 ,  F04C27/005 ,  Y10S418/01

摘要： A scroll compressor having a simple structure is disclosed, which effectively decreases the thrust load imposed on the revolving scroll without degrading the compression efficiency. The scroll compressor includes a casing; a fixed scroll provided in the housing and comprising an end plate and a spiral protrusion built on one face of the end plate; and a revolving scroll provided in the casing and comprising an end plate and a spiral protrusion built on one face of the end plate, wherein the spiral protrusions of each scroll are engaged with each other so as to form a spiral compression chamber. In the above structure, an introduced working gas is compressed in the compression chamber and then discharged according to the revolution of the revolving scroll; a thrust member for thrust-supporting the end plate of the revolving scroll is provided at the back-face side of the end plate of the revolving scroll; a pressure pocket is formed in a face of one of the thrust member and the end plate of the revolving scroll, wherein the face faces the other of the thrust member and the end plate of the revolving scroll; and a high-pressure introduction hole for introducing a high-pressure fluid into the pressure pocket is provided at one of the thrust member side and the revolving scroll side.

摘要翻译： 公开了一种具有简单结构的涡旋压缩机，其有效地降低了施加在旋转涡卷上的推力负荷而不降低压缩效率。 涡旋压缩机包括壳体; 设置在所述壳体中的固定涡卷，包括端板和构成在所述端板的一个面上的螺旋突起; 以及旋转涡卷，其设置在所述壳体中并且包括端板和构成在所述端板的一个面上的螺旋突起，其中每个涡旋盘的螺旋形突起彼此接合以形成螺旋压缩室。 在上述结构中，引入的工作气体在压缩室中被压缩，然后根据回转涡卷的旋转而排出; 在回转涡卷的端板的背面设置有用于推力支撑回转涡卷的端板的推力构件， 在旋转涡旋件的推力构件和端板中的一个的表面上形成有压力袋，其中面朝向旋转涡卷的止推构件和端板中的另一个; 并且在推力构件侧和回转涡卷一侧设置有用于将高压流体引入压力槽的高压引入孔。