公开(公告)号：US20240101699A1

公开(公告)日：2024-03-28

申请号：US18271205

申请日：2022-01-06

Applicant: The Regents of the University of California

Inventor： Bin Liu ,  Yang Su ,  Scott Bidlingmaier

IPC: C07K16/28 ,  A61K31/454 ,  A61K31/573 ,  A61K47/68 ,  A61P35/00

CPC classification number: C07K16/2896 ,  A61K31/454 ,  A61K31/573 ,  A61K47/68031 ,  A61K47/6849 ,  A61P35/00 ,  A61K2039/505

Abstract: A method to upregulate CD46 cell surface expression and combination therapies for various cancers employing an anti-CD46 antibody and an immunomodulatory imide drug (IMiD) or a Signal Transducer And Activator of Transcription 3 (STAT3) inhibitor or both are provided.

公开(公告)号：US10533056B2

公开(公告)日：2020-01-14

申请号：US15508059

申请日：2015-09-10

Applicant: The Regents of The University of California

Inventor： Bin Liu ,  Yang Su ,  Scott Bidlingmaier ,  Christopher R. Behrens ,  Namkyung Lee

IPC: C07K16/28 ,  G01N33/574 ,  C07K16/30 ,  A61K47/68 ,  A61K39/00

Abstract: In various embodiments human anti-CD46 antibodies that are internalizing and enter tumor cells via the macropinocytosis pathway are provided, as well as antibody-drug conjugates (ADCs) developed from these antibodies for diagnostic and/or therapeutic targeting of CD46-overexpressing tumors.

公开(公告)号：US10400045B2

公开(公告)日：2019-09-03

申请号：US15390378

申请日：2016-12-23

Applicant: The Regents of the University of California

Inventor： Bin Liu

IPC: C07K16/28 ,  G01N33/574 ,  C07K16/30 ,  A61K51/10 ,  A61K47/68

Abstract: In various embodiments various cancer specific antibodies and immunoconjugates are provided. In certain embodiments the antibodies specifically bind and are internalized into a prostate cancer cell, where the antibodies specifically binds cells that express or overexpress a CD46, and where the antibodies specifically bind sushi domain 1 of said CD46 (CD46 CPP1).

公开(公告)号：US10365271B2

公开(公告)日：2019-07-30

申请号：US15163525

申请日：2016-05-24

Applicant: The Regents of the University of California

Inventor： Guillermo C. Bazan ,  Brent S. Gaylord ,  Shu Wang ,  Bin Liu

IPC: G01N33/52 ,  G01N33/542 ,  G01N33/58 ,  C12Q1/6818 ,  C09B11/02 ,  C09B69/10 ,  C09K9/02 ,  C09K11/06 ,  C12Q1/68 ,  B82Y15/00

Abstract: Light harvesting luminescent multichromophores that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith are provided. Also provided are compositions for labelling a target. The labelling composition may include a donor light harvesting multichromophore and an acceptor signaling chromophore in energy-receiving proximity to the donor light harvesting multichromophore. Also provided is an aqueous composition for labelling a target, including: a donor light harvesting multichromophore; an acceptor signaling chromophore in energy-receiving proximity therewith; and a sensor biomolecule. Methods for using the subject compositions are also provided.

公开(公告)号：US10001473B2

公开(公告)日：2018-06-19

申请号：US15461426

申请日：2017-03-16

Applicant: The Regents of the University of California

Inventor： Guillermo C. Bazan ,  Brent S. Gaylord ,  Shu Wang ,  Bin Liu

IPC: G01N33/52 ,  C09K9/02 ,  C09K11/06 ,  C09B69/10 ,  C12Q1/68

CPC classification number: G01N33/542 ,  B82Y15/00 ,  C09B11/02 ,  C09B69/103 ,  C09K9/02 ,  C09K11/06 ,  C09K2211/1416 ,  C09K2211/1425 ,  C12Q1/6818 ,  C12Q2565/107 ,  G01N33/52 ,  G01N33/582 ,  C12Q2525/107 ,  C12Q2527/125

Abstract: Light harvesting luminescent multichromophores that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith are provided. Also provided are compositions for labelling a target. The labelling composition may include a donor light harvesting multichromophore and an acceptor signaling chromophore in energy-receiving proximity to the donor light harvesting multichromophore. Also provided is an aqueous composition for labelling a target, including: a donor light harvesting multichromophore; an acceptor signaling chromophore in energy-receiving proximity therewith; and a sensor biomolecule. Methods for using the subject compositions are also provided.

公开(公告)号：US20160341720A1

公开(公告)日：2016-11-24

申请号：US15163525

申请日：2016-05-24

Applicant: The Regents of the University of California

Inventor： Guillermo C. Bazan ,  Brent S. Gaylord ,  Shu Wang ,  Bin Liu

IPC: G01N33/542 ,  C12Q1/68 ,  C09B11/02 ,  G01N33/58

CPC classification number: G01N33/542 ,  B82Y15/00 ,  C09B11/02 ,  C09B69/103 ,  C09K9/02 ,  C09K11/06 ,  C09K2211/1416 ,  C09K2211/1425 ,  C12Q1/6818 ,  C12Q2565/107 ,  G01N33/52 ,  G01N33/582 ,  C12Q2525/107 ,  C12Q2527/125

Abstract: Light harvesting luminescent multichromophores that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith are provided. Also provided are compositions for labelling a target. The labelling composition may include a donor light harvesting multichromophore and an acceptor signaling chromophore in energy-receiving proximity to the donor light harvesting multichromophore. Also provided is an aqueous composition for labelling a target, including: a donor light harvesting multichromophore; an acceptor signaling chromophore in energy-receiving proximity therewith; and a sensor biomolecule. Methods for using the subject compositions are also provided.

公开(公告)号：US20150226746A1

公开(公告)日：2015-08-13

申请号：US14624466

申请日：2015-02-17

Applicant: The Regents of the University of California

Inventor： Guillermo C. Bazan ,  Brent S. Gaylord ,  Shu Wang ,  Bin Liu

IPC: G01N33/58 ,  C12Q1/68

CPC classification number: G01N33/542 ,  B82Y15/00 ,  C09B11/02 ,  C09B69/103 ,  C09K9/02 ,  C09K11/06 ,  C09K2211/1416 ,  C09K2211/1425 ,  C12Q1/6818 ,  G01N33/52 ,  G01N33/582 ,  C12Q2525/107 ,  C12Q2527/125 ,  C12Q2565/107

Abstract: Light harvesting luminescent multichromophores that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith are provided. Also provided are compositions for labelling a target. The labelling composition may include a donor light harvesting multichromophore and an acceptor signaling chromophore in energy-receiving proximity to the donor light harvesting multichromophore. Also provided is an aqueous composition for labelling a target, including: a donor light harvesting multichromophore; an acceptor signaling chromophore in energy-receiving proximity therewith; and a sensor biomolecule. Methods for using the subject compositions are also provided.

Abstract translation: 提供了在激发下配置以将能量转移到能量接受邻近的受体信号发色团并从其扩增发射的光收集发光多色谱。 还提供了用于标记靶的组合物。 标记组合物可以包括供体光采集多色素和受体在发射能量接近供体光采集多色素的信号发生基团。 还提供了用于标记靶的水性组合物，包括：供体光收获多色素; 受体接受能量接收的信号发生器; 和传感器生物分子。 还提供了使用本发明组合物的方法。

公开(公告)号：US20230383005A1

公开(公告)日：2023-11-30

申请号：US17815514

申请日：2022-07-27

Applicant: The Regents of the University of California

Inventor： Bin Liu ,  Daniel W. Sherbenou ,  Blake T. Aftab ,  Yang Su ,  Christopher R. Behrens

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  C07K16/30 ,  C12Q1/6886 ,  C07K16/00 ,  G01N33/574

CPC classification number: C07K16/2896 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6813 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/3069 ,  C12Q1/6886 ,  A61K47/6803 ,  C07K16/00 ,  G01N33/57492 ,  A61K2039/55

Abstract: Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.

公开(公告)号：US11719691B2

公开(公告)日：2023-08-08

申请号：US16528440

申请日：2019-07-31

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Guillermo C. Bazan ,  Brent S. Gaylord ,  Shu Wang ,  Bin Liu

IPC: G01N33/542 ,  C12Q1/6818 ,  G01N33/58 ,  C09B11/02 ,  C09B69/10 ,  C09K9/02 ,  C09K11/06 ,  G01N33/52 ,  B82Y15/00

CPC classification number: G01N33/542 ,  C09B11/02 ,  C09B69/103 ,  C09K9/02 ,  C09K11/06 ,  C12Q1/6818 ,  G01N33/52 ,  G01N33/582 ,  B82Y15/00 ,  C09K2211/1416 ,  C09K2211/1425 ,  C12Q2565/107 ,  C12Q1/6818 ,  C12Q2525/107 ,  C12Q2527/125 ,  C12Q1/6818 ,  C12Q2525/107 ,  C12Q2565/107

Abstract: Light harvesting luminescent multichromophores that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith are provided. Also provided are compositions for labelling a target. The labelling composition may include a donor light harvesting multichromophore and an acceptor signaling chromophore in energy-receiving proximity to the donor light harvesting multichromophore. Also provided is an aqueous composition for labelling a target, including: a donor light harvesting multichromophore; an acceptor signaling chromophore in energy-receiving proximity therewith; and a sensor biomolecule. Methods for using the subject compositions are also provided.

公开(公告)号：US20230227574A1

公开(公告)日：2023-07-20

申请号：US17880556

申请日：2022-08-03

Applicant: The Regents of the University of California

Inventor： Bin Liu

IPC: C07K16/30 ,  G01N33/574 ,  C12N15/10 ,  G01N33/68 ,  A61K47/68 ,  C07K16/28 ,  A61K45/06 ,  A61K49/00 ,  C07K16/00

CPC classification number: C07K16/30 ,  G01N33/574 ,  C12N15/1037 ,  G01N33/6854 ,  A61K47/6801 ,  A61K47/6851 ,  A61K47/6889 ,  C07K16/2866 ,  A61K45/06 ,  A61K49/00 ,  C07K16/005 ,  C07K16/3069 ,  C40B40/10

Abstract: Methods are provided for identifying and selecting antibodies that are internalized into cells via the macropinocytosis pathway. Additionally antibodies that are internalized via this pathway are provided as well as immunoconjugates comprising such antibodies.