公开(公告)号：US20180326388A1

公开(公告)日：2018-11-15

申请号：US16039256

申请日：2018-07-18

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： William BANYAI ,  Bill James PECK ,  Andres FERNANDEZ ,  Siyuan CHEN ,  Pierre INDERMUHLE

IPC: B01J19/00 ,  C12N15/10 ,  C12N15/66 ,  C12N15/74 ,  C40B50/18 ,  C12N15/09 ,  C40B40/06 ,  C40B50/00 ,  C40B50/14

CPC classification number: B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/00497 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00623 ,  B01J2219/00637 ,  B01J2219/00709 ,  B01J2219/00722 ,  C12N15/09 ,  C12N15/1093 ,  C12N15/1096 ,  C12N15/66 ,  C12N15/74 ,  C40B40/06 ,  C40B50/00 ,  C40B50/14 ,  C40B50/18

Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.

公开(公告)号：US20170362589A1

公开(公告)日：2017-12-21

申请号：US15603013

申请日：2017-05-23

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： William BANYAI ,  Bill James PECK ,  Andres FERNANDEZ ,  Siyuan CHEN ,  Pierre INDERMUHLE

IPC: C12N15/10 ,  C12N15/74 ,  C40B50/18 ,  C12N15/66 ,  B01J19/00 ,  C12N15/09

CPC classification number: B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/00497 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00623 ,  B01J2219/00637 ,  B01J2219/00709 ,  B01J2219/00722 ,  C12N15/09 ,  C12N15/1093 ,  C12N15/1096 ,  C12N15/66 ,  C12N15/74 ,  C40B40/06 ,  C40B50/00 ,  C40B50/14 ,  C40B50/18

Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein

公开(公告)号：US20170095785A1

公开(公告)日：2017-04-06

申请号：US15377547

申请日：2016-12-13

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： William BANYAI ,  Bill James PECK ,  Andres FERNANDEZ ,  Siyuan CHEN ,  Pierre INDERMUHLE

IPC: B01J19/00 ,  C12N15/10

CPC classification number: B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/00497 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00623 ,  B01J2219/00637 ,  B01J2219/00709 ,  B01J2219/00722 ,  C12N15/09 ,  C12N15/1093 ,  C12N15/1096 ,  C12N15/66 ,  C12N15/74 ,  C40B40/06 ,  C40B50/00 ,  C40B50/14 ,  C40B50/18

Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.

公开(公告)号：US20160339409A1

公开(公告)日：2016-11-24

申请号：US15187714

申请日：2016-06-20

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： William BANYAI ,  Bill James PECK ,  Andres FERNANDEZ ,  Siyuan CHEN ,  Pierre INDERMUHLE

IPC: B01J19/00 ,  C12N15/10

CPC classification number: B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/00497 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00623 ,  B01J2219/00637 ,  B01J2219/00709 ,  B01J2219/00722 ,  C12N15/09 ,  C12N15/1093 ,  C12N15/1096 ,  C12N15/66 ,  C12N15/74 ,  C40B40/06 ,  C40B50/00 ,  C40B50/14 ,  C40B50/18

Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.

公开(公告)号：US20160303535A1

公开(公告)日：2016-10-20

申请号：US15187721

申请日：2016-06-20

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： William BANYAI ,  Bill James PECK ,  Andres FERNANDEZ ,  Siyuan CHEN ,  Pierre INDERMUHLE

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/00497 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00623 ,  B01J2219/00637 ,  B01J2219/00709 ,  B01J2219/00722 ,  C12N15/09 ,  C12N15/1093 ,  C12N15/1096 ,  C12N15/66 ,  C12N15/74 ,  C40B40/06 ,  C40B50/00 ,  C40B50/14 ,  C40B50/18

Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.