公开(公告)号：US09089139B2

公开(公告)日：2015-07-28

申请号：US13979306

申请日：2011-12-27

申请人： Masaaki Sakai ,  Tomoaki Matsumura ,  Satohiro Midorikawa ,  Takashi Nomoto ,  Tomoko Muraki ,  Ryutaro Katsuki

发明人： Masaaki Sakai ,  Tomoaki Matsumura ,  Satohiro Midorikawa ,  Takashi Nomoto ,  Tomoko Muraki ,  Ryutaro Katsuki

IPC分类号： A61K31/517 ,  A01N55/00 ,  A01N37/34 ,  A01N37/50 ,  A01N37/52 ,  A01N43/42 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/653 ,  A01N43/78 ,  A01N43/84 ,  A01N43/90 ,  A01N47/24 ,  A01N47/34 ,  A01N47/44 ,  A01N43/82 ,  A01N53/00 ,  A01N57/26 ,  A01N59/16

CPC分类号： A01N55/00 ,  A01N37/34 ,  A01N37/50 ,  A01N37/52 ,  A01N43/42 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/653 ,  A01N43/78 ,  A01N43/82 ,  A01N43/84 ,  A01N43/90 ,  A01N47/24 ,  A01N47/34 ,  A01N47/44 ,  A01N53/00 ,  A01N57/26 ,  A01N59/16 ,  A01N37/36 ,  A01N37/38 ,  A01N37/46 ,  A01N43/40 ,  A01N47/12 ,  A01N47/14 ,  A01N51/00 ,  A01N57/28 ,  A01N2300/00

摘要： Agri-horticultural pest control compositions having outstanding control effect on pests, in particular, agri-horticultural pests, which comprise as active ingredients one or more 4-(3-butynyl)aminopyrimidine derivatives represented by the general formula [I], namely, where R1 is typically selected from among: a) phenyl c) —SiR5R6R7 (R5, R6, and R7 which may be the same or different represent a linear or branched alkyl having 1-6 carbon atoms, a linear or branched haloalkyl having 1-3 carbon atoms which is substituted by one halogen atom, a linear or branched cyanoalkyl having 1-3 carbon atoms which is substituted by one cyano group, and phenyl); d) hydropgen atom; R2 typically represents a hydrogen atom; R3 typically represents a hydrogen atom; R4 represents a hydrogen atom and one or more agri-horticultural pest control compounds selected from among agri-horticultural antimicrobial compounds, say, multi-site contact active compounds, nucleic acids synthesis inhibitory active compounds, mitosis and cell division inhibitory active compounds, and/or agri-horticultural insecticidal, miticidal or nematicidal compounds, say, acetylcholinesterase inhibitors, GABA-gated chloride antagonists, and sodium channel modulators. Since the 4-(3-butynyl)aminopyrimidine derivatives and the existing antimicrobial active compounds and/or insecticidal active compounds are used in admixture, the 4-(3-butynyl)aminopyrimidine derivatives which are useful as pest control agents, particularly as agri-horticultural pest control agents, need be used in smaller amounts and yet their antimicrobial or insecticidal activity can be improved.

摘要翻译： 具有对害虫，特别是农业园艺害虫具有突出防治效果的农业园艺害虫防治组合物，其包含作为活性成分的一种或多种由通式[I]表示的4-（3-丁炔基）氨基嘧啶衍生物，即其中 R1通常选自：a）苯基c）-SiR 5 R 6 R 7（可以相同或不同的R 5，R 6和R 7表示具有1-6个碳原子的直链或支链烷基，具有1-3个直链或支链烷基的直链或支链烷基） 被一个卤素原子取代的碳原子，被一个氰基取代的具有1-3个碳原子的直链或支链氰基烷基和苯基）; d）氢原子; R2通常表示氢原子; R3通常表示氢原子; R4表示氢原子和一种或多种选自农业园艺抗微生物化合物，例如多位点接触活性化合物，核酸合成抑制活性化合物，有丝分裂和细胞分裂抑制活性化合物的农业园艺害虫控制化合物和/ 或农业园艺杀虫，杀螨或杀线虫化合物，例如乙酰胆碱酯酶抑制剂，GABA门控氯化物拮抗剂和钠通道调节剂。 由于4-（3-丁炔基）氨基嘧啶衍生物和现有的抗微生物活性化合物和/或杀虫活性化合物混合使用，可用作害虫防治剂的4-（3-丁炔基）氨基嘧啶衍生物，特别是农业 - 园艺害虫防治剂需要较少量使用，但可以提高其抗微生物或杀虫活性。

公开(公告)号：US20130012904A1

公开(公告)日：2013-01-10

申请号：US13581034

申请日：2011-03-31

申请人： Takashi Nomoto ,  Takashi Onozuka ,  Kenji Oba

发明人： Takashi Nomoto ,  Takashi Onozuka ,  Kenji Oba

IPC分类号： A61F13/84

CPC分类号： A61F13/5514

摘要： A sanitary napkin provided with an absorbent body which includes a liquid permeable skin contact side sheet, a liquid impermeable non-skin contact side sheet, and an absorbent core which is arranged between these skin contact side sheet and non-skin contact side sheet and with a cover sheet which covers the surface of the skin contact side sheet. An individually wrapped product is formed by wrapping the napkin in the ready-to-wrap state by the wrapping material. The wrapping material includes a belt-shaped material which surrounds the ready-to-wrap napkin across the entire circumference of the ready-to-wrap napkin. A width of the belt-shaped material is shorter than a length of the ready-to-wrap napkin in the width direction of the belt-shaped material.

摘要翻译： 一种设置有吸收体的卫生巾，其包括透液性皮肤接触侧片，不透液性非皮肤接触侧片和吸收芯，所述吸收体配置在这些皮肤接触侧片与非皮肤接触侧片之间， 覆盖皮肤接触侧片的表面的覆盖片。 通过包装材料将卫生巾包裹在即将包装状态中，形成单独包装的产品。 包裹材料包括一条带状材料，该带状材料围绕准备包裹的卫生巾围绕准备包裹的卫生巾的整个圆周。 带状材料的宽度比带状材料的宽度方向上的即将包装的卫生巾的长度短。

公开(公告)号：US20120022483A1

公开(公告)日：2012-01-26

申请号：US13262320

申请日：2009-09-18

申请人： Takashi Nomoto ,  Akiyasu Nagata

发明人： Takashi Nomoto ,  Akiyasu Nagata

IPC分类号： A61F13/56

CPC分类号： A61F13/4753 ,  A61F13/476 ,  A61F13/5514 ,  A61F13/5616

摘要： A sanitary napkin comprises an absorbing body. The absorbing body includes a fluid-permeable top sheet, a fluid-impermeable back sheet, and an absorber arranged between the top sheet and the back sheet. The napkin comprises a cover sheet for covering the surface of the top sheet. A circumferential edge region of the cover sheet is joined to the absorbing body. A plurality of flaps for fixing the absorbing body to underwear are sectionalized by a sectionalizing line in the central region of the cover sheet. At the time of use, the flaps are folded in the folding regions and are expanded so as to be fixed to the underwear. The flaps include a front flat and a rear flap that expand in the back-and-forth direction, and a left flap and a right flap that expand in the right-and-left direction.

摘要翻译： 卫生巾包括吸收体。 吸收体包括流体可透过的顶片，流体不可渗透的底片和布置在顶片和背片之间的吸收体。 卫生巾包括用于覆盖顶片表面的覆盖片。 覆盖片的周缘区域与吸收体接合。 用于将吸收体固定到内衣的多个襟翼通过覆盖片的中心区域中的分割线分段。 在使用时，将折片折叠在折叠区域中，并将其膨胀以固定在内衣上。 翼片包括在前后方向上扩展的前平面和后翼片，以及沿左右方向扩展的左翼片和右翼片。

公开(公告)号：US20110272547A1

公开(公告)日：2011-11-10

申请号：US13064932

申请日：2011-04-27

申请人： Hiroki Gotou ,  Takashi Nomoto

发明人： Hiroki Gotou ,  Takashi Nomoto

IPC分类号： H05K7/00

CPC分类号： H02G3/32 ,  B60R16/0215 ,  F16B21/086 ,  Y10S411/913 ,  Y10T24/303 ,  Y10T24/42

摘要： A wiring clip 1 includes: an attaching portion 10 configured to be overlapped with a wiring harness; a locking portion 11 extended vertically from the attaching portion 10 and configured to be locked in a hole provided on a panel; and a pressing portion 12 configured to press the panel in a direction away from the attaching portion 10 when the locking portion 11 is locked in the hole. The pressing portion 12 includes: an inclined portion 19 continued to the attaching portion 10 and inclined with respect to both a vertically extending direction of the locking portion 11 from the attaching portion 10 and a longitudinal direction of the wiring harness overlapped with the attaching portion 10; and a parallel portion 20 continued to the inclined portion 19 and extended parallel to the locking portion 11 from the inclined portion 19. A surface 21a away from the panel of an intersecting portion 21 continued to both the inclined portion 19 and the parallel portion 20 is disposed further away from the panel than a surface 14a nearest the panel of the attaching portion 10.

摘要翻译： 接线夹1包括：配置成与线束重叠的安装部分10; 锁定部分11，其从安装部分10垂直延伸并且被构造成锁定在设置在面板上的孔中; 以及按压部12，其构造成当锁定部11锁定在孔中时沿着远离安装部10的方向按压面板。 按压部12包括：连接到安装部10的倾斜部19，并且从安装部10相对于锁定部11的上下延伸方向和与安装部10重叠的线束的长度方向倾斜 ; 并且平行部分20连续到倾斜部分19并且从倾斜部分19平行于锁定部分11延伸。远离与倾斜部分19和平行部分20两者相交的交叉部分21的面板的表面21a是 远离面板的布置远离最靠近安装部分10的面板的表面14a。

公开(公告)号：US6140333A

公开(公告)日：2000-10-31

申请号：US244985

申请日：1999-02-04

申请人： Yoshimi Tsuchiya ,  Takashi Nomoto ,  Hirokazu Ohsawa ,  Kumiko Kawakami ,  Kenji Ohwaki ,  Masaru Nishikibe

发明人： Yoshimi Tsuchiya ,  Takashi Nomoto ,  Hirokazu Ohsawa ,  Kumiko Kawakami ,  Kenji Ohwaki ,  Masaru Nishikibe

IPC分类号： C07D211/26 ,  C07D211/58 ,  C07D211/70 ,  C07D221/20 ,  C07D471/08 ,  C07D471/10 ,  C07D487/08 ,  C07D487/10 ,  A61K31/505 ,  A61K31/445 ,  C07D211/30 ,  C07D219/00 ,  C07D409/00

CPC分类号： C07D221/20 ,  C07D211/26 ,  C07D211/58 ,  C07D211/70 ,  C07D471/08 ,  C07D471/10 ,  C07D487/08 ,  C07D487/10

摘要： The invention relates to compounds represented by the general formula [I] ##STR1## [wherein Ar means an aryl group or a heteroaryl group which may have a substitutive group selected from a group consisting of a halogen atom, a lower alkyl group and a lower alkoxy group; R.sup.1 means a C.sub.3 -C.sub.6 cycloalkyl group which is substitutable with a fluorine atom; R.sup.2 and R.sup.4 mean hydrogen atoms, groups represented by --(A.sup.1).sub.m --NH--B or the like; R.sup.3 and R.sup.5 mean hydrogen atoms, C.sub.1 -C.sub.6 aliphatic hydrocarbon groups or the like which are substitutable with a lower alkyl group(s); n means 0 or 1; and X means an oxygen atom or a sulfur atom].Compounds according to the invention, since they not only have potent selective antagonistic activity against muscarinic M.sub.3 receptors but also exhibit excellent oral activity, durability of action and pharmacokinetics, are very useful as safe and effective remedies against respiratory, urinary and digestive diseases with little adverse side effects.

摘要翻译： 本发明涉及由通式[I]表示的化合物[其中Ar表示可以具有选自卤素原子，低级烷基和低级烷氧基的取代基的芳基或杂芳基; R1表示可与氟原子取代的C3-C6环烷基; R2和R4表示氢原子，由 - （A1）m-NH-B等表示的基团; R3和R5表示可被低级烷基取代的氢原子，C1-C6脂族烃基等; n表示0或1; X表示氧原子或硫原子]。 根据本发明的化合物，因为它们不仅对毒蕈碱M3受体具有有效的选择性拮抗活性，而且还表现出优异的口服活性，作用的耐久性和药代动力学，对于呼吸，尿和消化疾病的安全和有效的治疗方法是非常有用的 副作用。

公开(公告)号：US5750540A

公开(公告)日：1998-05-12

申请号：US682785

申请日：1996-07-31

申请人： Yoshimi Tsuchiya ,  Takashi Nomoto ,  Hirokazu Ohsawa ,  Kumiko Kawakami ,  Kenji Ohwaki ,  Masaru Nishikibe

发明人： Yoshimi Tsuchiya ,  Takashi Nomoto ,  Hirokazu Ohsawa ,  Kumiko Kawakami ,  Kenji Ohwaki ,  Masaru Nishikibe

IPC分类号： C07D211/46 ,  C07D211/58 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  A61K31/445 ,  A61K31/505

CPC分类号： C07D401/12 ,  C07D211/46 ,  C07D211/58 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

摘要： This invention provides novel 1,4-di-substituted piperidine derivatives of the general formula �I! ##STR1## and the pharmaceutically acceptable salts thereof, wherein: Ar represents a phenyl group or a five- or six-membered heteroaromatic group having one or two hetero atoms selected from the group consisting of an oxygen atom, a sulfur atom and a nitrogen atom in which one or two optional hydrogen atoms on the ring may be replaced by substituent groups selected from the group consisting of a halogen atom and a lower alkyl group; R.sup.1 represents a cycloalkyl group of 3 to 6 carbon atoms or a cycloalkenyl group of 3 to 6 carbon atoms; R.sup.2 represents a saturated or unsaturated aliphatic hydrocarbon radical of 5 to 15 carbon atoms; and X represents O or NH. These compounds have selective antagonistic activity against the muscarinic M.sub.3 receptors and can hence be used safely with a minimum of side effects.

摘要翻译： PCT No.PCT / JP96 / 01128 Sec。 371日期：1996年7月31日 102（e）1996年7月31日PCT PCT 1996年4月25日PCT公布。 公开号WO96 / 33973 日期：1996年10月31日本发明提供通式[I]＆lt; IMAGE＆gt;的新型1,4-二取代哌啶衍生物及其药学上可接受的盐，其中：Ar表示苯基或五元或六元 具有一个或两个选自氧原子，硫原子和氮原子的杂原子的杂芳族基团，其中环上的一个或两个任选的氢原子可以被选自卤素 原子和低级烷基; R1表示3〜6个碳原子的环烷基或3〜6个碳原子的环烯基; R 2表示5至15个碳原子的饱和或不饱和脂族烃基; X表示O或NH。 这些化合物对毒蕈碱M3受体具有选择性的拮抗作用，因此可以以最少的副作用安全使用。

公开(公告)号：US5616803A

公开(公告)日：1997-04-01

申请号：US540628

申请日：1995-10-06

申请人： Takashi Nomoto ,  Masahiro Hayashi ,  Jun Shibata ,  Yoshikazu Iwasawa ,  Morihiro Mitsuya ,  Yoshiaki Iida ,  Katsumasa Nonoshita ,  Yasufumi Nagata

发明人： Takashi Nomoto ,  Masahiro Hayashi ,  Jun Shibata ,  Yoshikazu Iwasawa ,  Morihiro Mitsuya ,  Yoshiaki Iida ,  Katsumasa Nonoshita ,  Yasufumi Nagata

IPC分类号： C07C69/34 ,  C07C211/27 ,  C07C211/29 ,  C07C215/52 ,  C07C217/60 ,  C07C233/05 ,  C07C233/13 ,  C07C233/18 ,  C07C235/06 ,  C07D213/38 ,  C07D213/40 ,  C07D215/12 ,  C07D215/48 ,  C07D263/32 ,  C07D307/14 ,  C07D307/52 ,  C07D307/81 ,  C07D317/58 ,  C07D333/20 ,  C07D333/28 ,  C07D333/54 ,  C07D333/58

CPC分类号： C07D213/40 ,  C07C211/27 ,  C07C211/29 ,  C07C215/52 ,  C07C217/60 ,  C07C233/05 ,  C07C233/13 ,  C07C233/18 ,  C07C235/06 ,  C07C69/34 ,  C07D213/38 ,  C07D215/12 ,  C07D215/48 ,  C07D263/32 ,  C07D307/14 ,  C07D307/52 ,  C07D307/81 ,  C07D317/58 ,  C07D333/20 ,  C07D333/28 ,  C07D333/54 ,  C07D333/58

摘要： A compound of the formula (I) or its pharmaceutically acceptable salt or ester: ##STR1## wherein each of the substituents are herein defined.

摘要翻译： 式（I）化合物或其药学上可接受的盐或酯：其中每个取代基在本文中定义。

公开(公告)号：US08586505B2

公开(公告)日：2013-11-19

申请号：US13378866

申请日：2010-07-15

申请人： Masaaki Sakai ,  Tomoaki Matsumura ,  Satohiro Midorikawa ,  Takashi Nomoto ,  Ryutaro Katsuki ,  Tomoko Muraki

发明人： Masaaki Sakai ,  Tomoaki Matsumura ,  Satohiro Midorikawa ,  Takashi Nomoto ,  Ryutaro Katsuki ,  Tomoko Muraki

IPC分类号： C07D239/42 ,  C07D239/94 ,  C07D417/12 ,  C07D487/04 ,  C07D495/04 ,  A01N43/90 ,  A01N47/02 ,  A01N47/24 ,  A01N55/00

CPC分类号： C07D239/42 ,  A01N43/54 ,  A01N43/90 ,  C07D239/70 ,  C07D239/94 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F7/081 ,  C07F7/0812 ,  C07F7/1804

摘要： Novel 4-(3-butynyl)aminopyrimidine derivatives represented by general formula [I] are useful as pest control agents. In general formula [I], R1 is a mono- or bi-cyclic ring which may contain 0 to 3 heteroatoms, for example, phenyl or oxazolyl; R2 is a hydrogen atom, —R, —OR, —C(O)OR, —C(O)NHR, —CONR2 (wherein R is straight-chain or branched C1-8 alkyl, or the like), hydroxyalkyl, or the like; R3 is a hydrogen atom, a halogen atom, acyloxy represented by (straight-chain or branched C1-8 aliphatic hydrocarbon group) —CO—O—, or the like; and R4 is a hydrogen atom, a halogen atom, C1-6 alkyl, or the like, or alternatively, R4 and R3 together with the carbon atoms on the pyrimidine ring may form a thiophene ring, a pyrrole ring, an imidazole ring, a benzene ring, a pyrimidine ring, a furan ring, a pyrazine ring, or a pyrrolidine ring.

摘要翻译： 由通式[I]表示的新型4-（3-丁炔基）氨基嘧啶衍生物可用作害虫控制剂。 在通式[I]中，R 1是可以含有0至3个杂原子的单环或双环，例如苯基或恶唑基; R2是氢原子，-R，-OR，-C（O）OR，-C（O）NHR，-CONR2（其中R是直链或支链C 1-8烷基等），羟基烷基或 类似; R3是氢原子，卤素原子，由（直链或支链C 1-8脂族烃基）-CO-O-代表的酰氧基等; R4是氢原子，卤素原子，C1-6烷基等，或者R4和R3与嘧啶环上的碳原子一起形成噻吩环，吡咯环，咪唑环， 苯环，嘧啶环，呋喃环，吡嗪环或吡咯烷环。

公开(公告)号：US08540690B2

公开(公告)日：2013-09-24

申请号：US13262320

申请日：2009-09-18

申请人： Takashi Nomoto ,  Akiyasu Nagata

发明人： Takashi Nomoto ,  Akiyasu Nagata

IPC分类号： A61F13/15 ,  A61F13/20

CPC分类号： A61F13/4753 ,  A61F13/476 ,  A61F13/5514 ,  A61F13/5616

摘要： A sanitary napkin comprises an absorbing body. The absorbing body includes a fluid-permeable top sheet, a fluid-impermeable back sheet, and an absorber arranged between the top sheet and the back sheet. The napkin comprises a cover sheet for covering the surface of the top sheet. A circumferential edge region of the cover sheet is joined to the absorbing body. A plurality of flaps for fixing the absorbing body to underwear are sectionalized by a sectionalizing line in the central region of the cover sheet. At the time of use, the flaps are folded in the folding regions and are expanded so as to be fixed to the underwear. The flaps include a front flat and a rear flap that expand in the back-and-forth direction, and a left flap and a right flap that expand in the right-and-left direction.

摘要翻译： 卫生巾包括吸收体。 吸收体包括流体可透过的顶片，流体不可渗透的底片和布置在顶片和背片之间的吸收体。 卫生巾包括用于覆盖顶片表面的覆盖片。 覆盖片的周缘区域与吸收体接合。 用于将吸收体固定到内衣的多个襟翼通过覆盖片的中心区域中的分割线分段。 在使用时，将折片折叠在折叠区域中，并将其膨胀以固定到内衣上。 翼片包括在前后方向上扩展的前平面和后翼片，以及沿左右方向扩展的左翼片和右翼片。

公开(公告)号：US07727213B2

公开(公告)日：2010-06-01

申请号：US11540029

申请日：2006-09-29

申请人： Takashi Nomoto ,  Chinatsu Nanbu

发明人： Takashi Nomoto ,  Chinatsu Nanbu

IPC分类号： A61F13/15

CPC分类号： A61F13/5376 ,  A61F13/4704 ,  A61F13/472 ,  A61F13/475 ,  A61F2013/15422 ,  A61F2013/53721

摘要： An absorbent article that prevents a discharged matter from leaking out, and also prevents a wearer's sensation of wearing a sanitary napkin from worsening is provided. The absorbent article of the present invention includes a liquid-permeable surface sheet, a liquid-permeable back sheet, an absorbent body disposed between the surface sheet and the back sheet, and an intermediate portion disposed between the surface sheet and the absorbent body. The absorbent part 4 includes an absorbent body center portion and an absorbent body posterior portion continuously formed on a posterior side in the longitudinal direction D of the absorbent body center portion. The intermediate portion includes a first intermediate sheet disposed between the surface sheet and the absorbent body center portion and a second intermediate sheet disposed between the surface sheet and at least the absorbent body posterior portion. The liquid-transport property of the second intermediate sheet is different from that of the first intermediate sheet.

摘要翻译： 提供了防止排出物泄漏的吸收性物品，并且还防止佩戴者佩戴卫生巾的感觉恶化。 本发明的吸收性物品包括透液性表面片，透液性底片，设置在表面片和背面片之间的吸收体以及设置在表面片和吸收体之间的中间部。 吸收体4包括在吸收体中心部的长边方向LD的后侧连续形成的吸收体中心部和吸收体后部。 中间部分包括设置在表面片和吸收体中心部之间的第一中间片和设置在表面片和至少吸收体后部之间的第二中间片。 第二中间片的液体输送性与第一中间片的液体输送性不同。