公开(公告)号：US20210338840A1

公开(公告)日：2021-11-04

申请号：US17231922

申请日：2021-04-15

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Gang HUANG ,  Tian ZHAO ,  Xinpeng MA ,  Yiguang WANG ,  Yang LI ,  Baran D. SUMER

IPC: A61K49/00 ,  G01N21/64 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/10 ,  G01N33/58 ,  G01N33/84

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US20210338579A1

公开(公告)日：2021-11-04

申请号：US17239742

申请日：2021-04-26

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Tongyi HUANG ,  Qiang FENG ,  Baran SUMER

IPC: A61K9/107 ,  A61K47/32 ,  A61K47/34 ,  A61K31/519 ,  A61K31/5025 ,  A61K45/06 ,  A61P35/00

Abstract: Described herein are therapeutic pH responsive compositions comprising a block copolymer and a therapeutic agent useful for the treatment of cancer.

公开(公告)号：US20210198410A1

公开(公告)日：2021-07-01

申请号：US17198006

申请日：2021-03-10

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  David BOOTHMAN ,  Kejin ZHOU ,  Xiaonan HUANG ,  Yiguang WANG

IPC: C08F293/00 ,  C07D311/92 ,  A61K47/58 ,  A61K47/62 ,  A61K9/127 ,  A61K49/00 ,  A61K31/352 ,  A61P35/00 ,  C08F299/02 ,  A61K47/69 ,  C08G81/02 ,  G01N33/58 ,  A61K9/50 ,  A61K31/337 ,  A61K31/704 ,  A61K9/107 ,  A61K47/68

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US20130330278A1

公开(公告)日：2013-12-12

申请号：US13827197

申请日：2013-03-14

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Kejin ZHOU ,  Baran SUMER

IPC: A61K49/00 ,  G01N21/64

CPC classification number: A61K49/0054 ,  A61K49/0032 ,  A61K49/0082 ,  G01N21/6486 ,  G01N33/502

Abstract: The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.

Abstract translation: 本发明涉及pH可调节的，高活性的多色荧光纳米平台，以及在各种应用中使用纳米平台的方法，包括但不限于研究基本细胞生理过程，如内吞泡囊中的pH调节，内体/溶酶体成熟， 以及pH对受体循环和运输亚细胞器的影响。