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公开(公告)号：US08603076B2
公开(公告)日：2013-12-10
申请号：US13098067
申请日：2011-04-29
IPC分类号： A61K9/22
CPC分类号： A61K9/0004 , A61K9/0024 , A61K9/0097 , A61K9/1694 , A61K9/4808 , A61K31/7004 , A61K38/02 , A61K38/19 , A61K38/27 , A61K38/38 , A61K38/47 , A61M5/14276 , A61M5/16804 , A61M31/002 , A61M2207/00 , C12Y302/01017
摘要： A drug delivery device that includes a capsule for implantation into the body; the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for allowing the substance to diffuse from or otherwise exit the reservoir, and a nanopore membrane in communication with the capsule at or near the exit port for controlling the rate of diffusion of the substance from the exit port. The device also includes an optional screen for providing structural stability to the nanopore membrane and for keeping the pores of the nanopore membrane clear. One embodiment of the drug delivery device includes an osmotic engine internal to the device for creating fluid flow through the device.
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22.发明授权公开(公告)号：US07955614B2
公开(公告)日：2011-06-07
申请号：US11530729
申请日：2006-09-11
IPC分类号： A61F2/02
CPC分类号： A61K9/0004 , A61K9/0024 , A61K9/0097 , A61K9/1694 , A61K9/4808 , A61K31/7004 , A61K38/02 , A61K38/19 , A61K38/27 , A61K38/38 , A61K38/47 , A61M5/14276 , A61M5/16804 , A61M31/002 , A61M2207/00 , C12Y302/01017
摘要： A drug delivery device that includes a capsule for implantation into the body; the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for allowing the substance to diffuse from or otherwise exit the reservoir, and a nanopore membrane in communication with the capsule at or near the exit port for controlling the rate of diffusion of the substance from the exit port. The device also includes an optional screen for providing structural stability to the nanopore membrane and for keeping the pores of the nanopore membrane clear. One embodiment of the drug delivery device includes an osmotic engine internal to the device for creating fluid flow through the device.
摘要翻译： 一种药物输送装置，其包括用于植入体内的胶囊; 胶囊还包括用于容纳诸如治疗剂的物质的储存器，用于允许物质从储存器扩散或以其他方式排出的至少一个端口，以及与出口处或附近的胶囊连通的纳米孔膜，用于控制 物质从出口口的扩散速率。 该装置还包括用于为纳米孔膜提供结构稳定性和用于保持纳米孔膜的孔隙的可选屏幕。 药物递送装置的一个实施方案包括用于产生流过装置的流体的装置内部的渗透发动机。
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公开(公告)号：US20090114289A1
公开(公告)日：2009-05-07
申请号：US11934876
申请日：2007-11-05
申请人： Francis J. Martin
发明人： Francis J. Martin
IPC分类号： F16K17/10
CPC分类号： F16K17/10 , Y10T137/2642 , Y10T137/7852 , Y10T137/7853 , Y10T137/7925
摘要： A relief valve includes a body, a damping chamber in the body, a poppet in the body, wherein the poppet includes an end in the damping chamber, and a check valve in the damping chamber. The damping chamber is located adjacent an inlet side of the relief valve, and the check valve includes a sealing member to prevent fluid flow into the damping chamber at the inlet side. The sealing member is unseated during opening of the poppet to permit fluid to flow into the damping chamber at the inlet side.
摘要翻译： 安全阀包括主体，主体中的阻尼室，主体中的提升阀，其中提升阀包括阻尼室中的端部和阻尼室中的止回阀。 阻尼室位于安全阀的入口侧附近，止回阀包括密封构件，以防止流体在入口侧流入阻尼室。 在打开提升阀的过程中，密封件是脱开的，以允许流体在入口侧流入阻尼室。
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公开(公告)号：US5064655A
公开(公告)日：1991-11-12
申请号：US356262
申请日：1989-05-23
CPC分类号： A61K8/042 , A61K38/1808 , A61K47/183 , A61K8/14 , A61K9/0014 , A61K9/127 , A61Q19/00 , A61Q17/04 , A61Q19/007 , A61Q19/08 , Y10T428/2984
摘要： A liposome gel composition and method of preparing the same. The composition is composed of charged liposomes, at a relatively low lipid concentration, in a low-conductivity medium. The composition preferably contains a zwitterionic compound at its isoelectric point. The liposomes can be designed for cosmetic use, transdermal drug delivery, or enhanced retention on mucosal tissues, such as for ophthalmic use.
摘要翻译： 一种脂质体凝胶组合物及其制备方法。 该组合物由低电导率培养基中以相对低的脂质浓度的带电脂质体组成。 组合物优选在其等电点含有两性离子化合物。 脂质体可以设计用于化妆品用途，透皮药物递送或增强对粘膜组织的保留，例如用于眼科用途。
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公开(公告)号：US4737323A
公开(公告)日：1988-04-12
申请号：US829710
申请日：1986-02-13
CPC分类号： C04B38/0051 , A61K9/1277 , C04B2111/00793 , Y10S436/829 , Y10T428/2984
摘要： A suspension of liposomes whose sizes are predominantly greater than about 1 micron is passed through an asymmetric ceramic filter whose inner-surface pore size is about 1 micron. The processed liposomes have a selected average size of about 0.4 microns or less, depending on the number of filter cycles, and a narrow distribution.
摘要翻译： 尺寸主要大于约1微米的脂质体的悬浮液通过其内表面孔径为约1微米的不对称陶瓷过滤器。 经处理的脂质体具有约0.4微米或更小的选择的平均尺寸，这取决于过滤器循环的数量和窄的分布。
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公开(公告)号：US5843473A
公开(公告)日：1998-12-01
申请号：US858171
申请日：1992-03-27
CPC分类号： A61K9/1271 , C07F9/5537
摘要： A method of treating a site of systemic infection which includes administering a therapeutic compound entrapped in liposomes. Also included is a liposomal composition and a method of preparing a liposomal composition for use in concentrating a therapeutic compound to an infected region via the bloodstream. The liposomes, which contain the agent in entrapped form, are composed of vesicle-forming lipids, a vesicle-forming lipid derivatized with hydrophilic biocompatible polymer, and have sizes in a selected size range between 0.07 and 0.2 microns. After parenteral administration, the liposomes are selectively taken up by the infected region within 24-48 hours, for release of entrapped compound into the infected region.
摘要翻译： 一种治疗全身感染部位的方法，包括给予包埋在脂质体中的治疗化合物。 还包括脂质体组合物和制备用于通过血流浓缩治疗化合物到感染区域的脂质体组合物的方法。 含有夹带形式的试剂的脂质体由形成脂囊泡的脂质体，由亲水生物相容性聚合物衍生的形成囊泡的脂质组成，并且具有0.07-0.2微米的选定尺寸范围的尺寸。 在肠胃外给药后，脂质体在24-48小时内被感染区域选择性吸收，以将被截留的化合物释放到感染区域。
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公开(公告)号：US5013556A
公开(公告)日：1991-05-07
申请号：US425224
申请日：1989-10-20
IPC分类号： A61K47/44 , A61K20060101 , A61K9/127 , A61K31/70 , A61K38/00 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/27 , A61K38/43 , A61K38/44 , A61K38/46 , A61K39/00 , A61K39/015 , A61K39/21 , A61K39/29 , A61K47/24 , A61K47/34 , A61K47/48 , A61K49/00 , A61P31/04 , A61P35/00 , C07F9/553
CPC分类号： A61K47/48815 , A61K9/1271 , C07F9/5537
摘要： A liposome composition which contains between 1-20 mole percent of an amphipathic lipid derivatized with a polyalkylether, as exemplified by phosphatidylethanolamine derivatized with polyethyleneglycol. The derivatized lipid enchances the circulation time of the liposomes severalfold, and this enhancement is achieved with either fluid or membrane-rigidifying liposome components. Also disclosed are methods for delivering a drug for slow release from the bloodstream, and for targeting a selected tissue or cells with liposomes, via the bloodstream.
摘要翻译： 脂质体组合物包含1-20摩尔％的用聚烷基醚衍生的两亲性脂质，例如用聚乙二醇衍生的磷脂酰乙醇胺。 衍生的脂质使脂质体的循环时间增加了几倍，并且这种增强通过流体或膜 - 硬化的脂质体组分实现。 还公开了用于递送药物用于从血液缓慢释放的药物，以及用于通过血流靶向选择的具有脂质体的组织或细胞的方法。
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公开(公告)号：US4944948A
公开(公告)日：1990-07-31
申请号：US315392
申请日：1989-02-24
CPC分类号： A61K38/1808 , A61K9/127
摘要： A composition and method for treating a wound or surgical incision, by sustained-released delivery of epidermal growth factor (EGF). The composition includes a high-viscosity aqueous dispersion of negatively charged liposomes with liposome-entrapped EGF. The EGF/liposome composition is formed, in one embodiment of the invention, by suspending a lipid mixture typically containing equimolar amounts of neutral and negatively charged phopholipids and cholesterol in a low-conductivity aqueous medium containing EGF and a zwitterionic compound whose isoelectric point is between pH 5.5 and 8.5 to form a gel-like composition. One embodiment of the invention contains EGF entrapped by surface adsorption to the liposomes, for slow release from the composition.
摘要翻译： 用于通过持续释放的表皮生长因子（EGF）递送来治疗伤口或手术切口的组合物和方法。 该组合物包括具有脂质体包埋的EGF的带负电荷的脂质体的高粘度水分散体。 在本发明的一个实施方案中，通过将通常含有等摩尔量的中性和带负电荷的磷脂酰胆碱和胆固醇的脂质混合物悬浮在含有EGF和两性离子化合物的低电导率水性介质中，形成EGF /脂质体组合物，其等电点在 pH 5.5和8.5以形成凝胶状组合物。 本发明的一个实施方案包含通过表面吸附到脂质体上的EGF，从组合物缓慢释放。
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公开(公告)号：US4927637A
公开(公告)日：1990-05-22
申请号：US297946
申请日：1989-01-17
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/1277
摘要： A suspension of heterogeneous size liposomes is passed through a polymer filter having a web-like construction providing a network of interconnected, tortuous-path capillary pores, and a membrane thickness of at least about 100 microns. The processed liposomes have a selected average size less than about 0.4 microns, and a narrow size distribution.
摘要翻译： 异种尺寸脂质体的悬浮液通过具有网状结构的聚合物过滤器，其提供相互连接的曲折路径毛细孔的网络，以及至少约100微米的膜厚度。 经处理的脂质体具有小于约0.4微米的选择的平均尺寸和窄的尺寸分布。
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公开(公告)号：US08397748B2
公开(公告)日：2013-03-19
申请号：US11938428
申请日：2007-11-12
申请人： Kenneth Bram , Francis J. Martin
发明人： Kenneth Bram , Francis J. Martin
IPC分类号： F16K31/12
CPC分类号： F16K11/105 , Y10T137/7781 , Y10T137/7866 , Y10T137/7925
摘要： A valve includes a body, a cavity in the body, and a check valve formed in the cavity. The check valve includes a poppet having a first end and a second end, and a first seat and a second seat, wherein the first seat is formed at the first end, the second seat is formed at the second end, and a diameter of the second seat is greater than a diameter of the first seat.
摘要翻译： 阀包括主体，主体中的空腔和形成在空腔中的止回阀。 止回阀包括具有第一端和第二端的提升阀，以及第一座和第二座，其中第一座形成在第一端，第二座形成在第二端，并且直径 第二座椅大于第一座椅的直径。
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