利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

48 条记录 (耗时 0.034 秒)

    EGF/Liposome gel composition and method
    1.
    发明授权
    EGF/Liposome gel composition and method 失效
    EGF /脂质体凝胶组成及方法

    公开(公告)号：US4944948A

    公开(公告)日：1990-07-31

    申请号：US315392

    申请日：1989-02-24

    申请人： Paul S. Uster ,  Robert M. Fielding ,  Francis J. Martin

    发明人： Paul S. Uster ,  Robert M. Fielding ,  Francis J. Martin

    IPC分类号： A61K9/127 ,  A61K38/18

    CPC分类号： A61K38/1808 ,  A61K9/127

    摘要： A composition and method for treating a wound or surgical incision, by sustained-released delivery of epidermal growth factor (EGF). The composition includes a high-viscosity aqueous dispersion of negatively charged liposomes with liposome-entrapped EGF. The EGF/liposome composition is formed, in one embodiment of the invention, by suspending a lipid mixture typically containing equimolar amounts of neutral and negatively charged phopholipids and cholesterol in a low-conductivity aqueous medium containing EGF and a zwitterionic compound whose isoelectric point is between pH 5.5 and 8.5 to form a gel-like composition. One embodiment of the invention contains EGF entrapped by surface adsorption to the liposomes, for slow release from the composition.

    摘要翻译： 用于通过持续释放的表皮生长因子（EGF）递送来治疗伤口或手术切口的组合物和方法。 该组合物包括具有脂质体包埋的EGF的带负电荷的脂质体的高粘度水分散体。 在本发明的一个实施方案中，通过将通常含有等摩尔量的中性和带负电荷的磷脂酰胆碱和胆固醇的脂质混合物悬浮在含有EGF和两性离子化合物的低电导率水性介质中，形成EGF /脂质体组合物，其等电点在 pH 5.5和8.5以形成凝胶状组合物。 本发明的一个实施方案包含通过表面吸附到脂质体上的EGF，从组合物缓慢释放。

    Microfabricated nanopore device for sustained release of therapeutic agent
    4.
    发明授权
    Microfabricated nanopore device for sustained release of therapeutic agent 有权
    用于缓释治疗剂的微制纳米孔装置

    公开(公告)号：US07955614B2

    公开(公告)日：2011-06-07

    申请号：US11530729

    申请日：2006-09-11

    申请人： Francis J. Martin ,  Anthony A. Boiarski

    发明人： Francis J. Martin ,  Anthony A. Boiarski

    IPC分类号： A61F2/02

    CPC分类号： A61K9/0004 ,  A61K9/0024 ,  A61K9/0097 ,  A61K9/1694 ,  A61K9/4808 ,  A61K31/7004 ,  A61K38/02 ,  A61K38/19 ,  A61K38/27 ,  A61K38/38 ,  A61K38/47 ,  A61M5/14276 ,  A61M5/16804 ,  A61M31/002 ,  A61M2207/00 ,  C12Y302/01017

    摘要： A drug delivery device that includes a capsule for implantation into the body; the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for allowing the substance to diffuse from or otherwise exit the reservoir, and a nanopore membrane in communication with the capsule at or near the exit port for controlling the rate of diffusion of the substance from the exit port. The device also includes an optional screen for providing structural stability to the nanopore membrane and for keeping the pores of the nanopore membrane clear. One embodiment of the drug delivery device includes an osmotic engine internal to the device for creating fluid flow through the device.

    摘要翻译： 一种药物输送装置，其包括用于植入体内的胶囊; 胶囊还包括用于容纳诸如治疗剂的物质的储存器，用于允许物质从储存器扩散或以其他方式排出的至少一个端口，以及与出口处或附近的胶囊连通的纳米孔膜，用于控制 物质从出口口的扩散速率。 该装置还包括用于为纳米孔膜提供结构稳定性和用于保持纳米孔膜的孔隙的可选屏幕。 药物递送装置的一个实施方案包括用于产生流过装置的流体的装置内部的渗透发动机。

    RELIEF VALVE INCLUDING A CHECK VALVE IN A DAMPING CHAMBER
    5.
    发明申请
    RELIEF VALVE INCLUDING A CHECK VALVE IN A DAMPING CHAMBER 有权
    减压阀包括在阻尼室中的检查阀

    公开(公告)号：US20090114289A1

    公开(公告)日：2009-05-07

    申请号：US11934876

    申请日：2007-11-05

    申请人： Francis J. Martin

    发明人： Francis J. Martin

    IPC分类号： F16K17/10

    CPC分类号： F16K17/10 ,  Y10T137/2642 ,  Y10T137/7852 ,  Y10T137/7853 ,  Y10T137/7925

    摘要： A relief valve includes a body, a damping chamber in the body, a poppet in the body, wherein the poppet includes an end in the damping chamber, and a check valve in the damping chamber. The damping chamber is located adjacent an inlet side of the relief valve, and the check valve includes a sealing member to prevent fluid flow into the damping chamber at the inlet side. The sealing member is unseated during opening of the poppet to permit fluid to flow into the damping chamber at the inlet side.

    摘要翻译： 安全阀包括主体，主体中的阻尼室，主体中的提升阀，其中提升阀包括阻尼室中的端部和阻尼室中的止回阀。 阻尼室位于安全阀的入口侧附近，止回阀包括密封构件，以防止流体在入口侧流入阻尼室。 在打开提升阀的过程中，密封件是脱开的，以允许流体在入口侧流入阻尼室。

    Polymer-lipid conjugate for fusion of target membranes
    9.
    发明授权
    Polymer-lipid conjugate for fusion of target membranes 有权
    用于融合靶膜的聚合物 - 脂质缀合物

    公开(公告)号：US06224903B1

    公开(公告)日：2001-05-01

    申请号：US09208684

    申请日：1998-12-10

    申请人： Francis J. Martin ,  Samuel Zalipsky

    发明人： Francis J. Martin ,  Samuel Zalipsky

    IPC分类号： A61K9127

    CPC分类号： A61K9/1272 ,  A61K9/1271

    摘要： A fusogenic liposome composition for delivering a liposome-entrapped compound into the cytoplasm of a target cell is described. The liposomes have an outer surface coating of chemically releasable hydrophilic polymer chains which shield hydrophobic polymers on the liposome outer surface. Release of the hydrophilic polymer chains exposes the hydrophobic polymers for interaction with outer cell membranes of the target cells to promote fusion of the liposome with the target cells. Also disclosed is a polymer-lipid conjugate for use in promoting fusion between target membranes. The conjugate is composed of a first segment composed of a hydrophilic polymer and a second hydrophobic polymer segment. The second segment is joined to the first segment by a bond effective to release the first segment in response to an existing or an induced physiologic condition. Attached to the second segment is a vesicle-forming lipid member.

    摘要翻译： 描述了用于将脂质体包埋的化合物递送到靶细胞的细胞质中的融合脂质体组合物。 脂质体具有化学上可释放的亲水性聚合物链的外表面涂层，其在脂质体外表面上屏蔽疏水性聚合物。 亲水性聚合物链的释放使疏水性聚合物暴露于与靶细胞的外细胞膜相互作用，以促进脂质体与靶细胞的融合。 还公开了用于促进靶膜之间的融合的聚合物 - 脂质缀合物。 缀合物由由亲水性聚合物和第二疏水性聚合物链段构成的第一链段组成。 第二段通过有效释放第一段的键与第一段连接，以响应于现有或诱导的生理状况。 附着于第二段是形成囊泡的脂质成分。