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21.发明授权Isolated nucleic acid molecules which encode T cell inducible factors (TIFs), the proteins encoded, and uses therefor 失效编码T细胞诱导因子（TIFs）的分离的核酸分子，编码的蛋白质及其用途公开(公告)号：US06359117B1
公开(公告)日：2002-03-19
申请号：US09354243
申请日：1999-07-16
IPC分类号： C07K1452
CPC分类号： C07K14/52
摘要： The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the molecules are disclosed. The molecules are referred to as T cell inducible factors.
摘要翻译： 本发明涉及分离核酸分子，其表达被白介素-9上调。 对应于核酸分子的蛋白质的氨基酸序列显示细胞因子的一些结构特征。 除了核酸分子和蛋白质之外，还公开了分子的各种用途。 这些分子被称为T细胞诱导因子。
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公开(公告)号：US5824551A
公开(公告)日：1998-10-20
申请号：US541905
申请日：1995-10-10
IPC分类号： A61K38/00 , A61K38/19 , A61P31/18 , C07K14/52 , C07K14/54 , G01N33/50 , C12N5/06 , A61K39/395 , C12N5/00 , C12N5/08
CPC分类号： G01N33/505 , C07K14/523 , C07K14/5412 , G01N33/5008 , G01N33/5011 , G01N33/5017 , A61K38/00 , G01N2510/00
摘要： The invention is based upon the newly recognized ability of .beta. chemokines to inhibit cell apoptosis. In particular, apoptosis of T cells is described. The known .beta. chemokines I-309 and TCA-3 are examples of the .beta. chemokines which inhibit apoptosis. One aspect of the invention is the use of these molecules to inhibit apoptosis. A second aspect of the invention is the use of .beta. chemokine inhibitors or antagonists to provoke apoptosis.
摘要翻译： 本发明基于新认可的β趋化因子抑制细胞凋亡的能力。 特别地，描述了T细胞的凋亡。 已知的β趋化因子I-309和TCA-3是抑制凋亡的β趋化因子的实例。 本发明的一个方面是使用这些分子来抑制细胞凋亡。 本发明的第二方面是使用β趋化因子抑制剂或拮抗剂来引发凋亡。
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23.发明授权Method for producing antibody using “naked” expression vector expressing type II transmembrane fusion protein 有权使用表达II型跨膜融合蛋白的“裸”表达载体产生抗体的方法公开(公告)号：US09234042B2
公开(公告)日：2016-01-12
申请号：US13275845
申请日：2011-10-18
申请人： Jean-Christophe Renauld , Muriel Lemaire , Laurie Dumoutier , Yannick Nizet , Alain Vanderplasschen , Laurent Gillet
发明人： Jean-Christophe Renauld , Muriel Lemaire , Laurie Dumoutier , Yannick Nizet , Alain Vanderplasschen , Laurent Gillet
CPC分类号： C07K16/2875 , A61K2039/505 , C07K14/70575 , C07K16/244 , C07K16/2866 , C07K2317/34 , C07K2317/73 , C07K2317/76
摘要： Methods are disclosed for generating antibodies and an expression vector used to express protein(s) which provoke the antibody response. The expression vector may be useful in generating an antibody directed to an antigen, comprising a gene in operable linkage with a promoter, which gene encodes upon expressing a fusion protein comprising (i) CD134L, a fragment or homologous protein thereof as N-terminal moiety of the fusion protein; and (ii) all or part of an antigenic protein as C-terminal moiety of the fusion protein. To generate the antibodies, the vector is injected into a subject animal, which produces a fusion protein, against which antibodies are generated.
摘要翻译： 公开了用于产生抗体的方法和用于表达引发抗体应答的蛋白质的表达载体。 表达载体可用于产生针对抗原的抗体，其包含与启动子可操作连接的基因，所述基因编码表达融合蛋白，所述融合蛋白包含（i）CD134L，其片段或同源蛋白作为N-末端部分 的融合蛋白; 和（ii）作为融合蛋白的C末端部分的全部或部分抗原蛋白。 为了产生抗体，将载体注射到受试动物中，产生融合蛋白，产生抗体。
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24.发明授权Isolated soluble IL-TIF/IL-22 receptor or binding protein which binds to IL-TIF/IL-22, and uses thereof 失效与IL-TIF / IL-22结合的分离的可溶性IL-TIF / IL-22受体或结合蛋白及其用途公开(公告)号：US07569667B2
公开(公告)日：2009-08-04
申请号：US11429115
申请日：2006-05-04
IPC分类号： C07K14/00
CPC分类号： C07K14/7155 , C07H21/04
摘要： The invention relates to soluble proteins which bind to the molecule known as IL-TIF/IL-22. The proteins can antagonize the effect of IL-TIF/IL-22 on target cells. The nucleic acid molecules encoding the proteins, and uses of the protein, are also described.
摘要翻译： 本发明涉及与称为IL-TIF / IL-22的分子结合的可溶性蛋白质。 蛋白质可以拮抗IL-TIF / IL-22对靶细胞的作用。 还描述了编码蛋白质的核酸分子以及蛋白质的用途。
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公开(公告)号：US20080299134A1
公开(公告)日：2008-12-04
申请号：US12049566
申请日：2008-03-17
申请人： Jennifer Lynne Reed , William Dall'Acqua , Jacques Van Snick , Jean-Christophe Renauld , Francoise Cormont , Catherine Uyttenhove
发明人： Jennifer Lynne Reed , William Dall'Acqua , Jacques Van Snick , Jean-Christophe Renauld , Francoise Cormont , Catherine Uyttenhove
IPC分类号： A61K39/395 , C07K16/18 , A61P43/00
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： The application describes neutralizing chimeric and humanized anti-human IL-9 antibodies, and the use thereof to identify neutralizing epitopes on human IL-9 and as medicaments to prevent and treat asthma, bronchial hyperresponsiveness, atopic allergy, and other related disorders. Particularly disclosed are recombinant antibodies derived from three murine anti-human IL-9 antibodies identified infra as MH9A3, MH9D1, and MH9L1.
摘要翻译： 该应用描述了中和嵌合和人源化抗人IL-9抗体，以及其用于鉴定人IL-9上的中和表位以及用作预防和治疗哮喘，支气管高反应性，特应性变态反应和其它相关疾病的药物。 特别公开的是衍生自以下鉴定的三种鼠抗人IL-9抗体作为MH9A3，MH9D1和MH9L1的重组抗体。
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26.发明授权Isolated nucleic acid molecules which encode a soluble IL-TIF receptor or binding protein which binds to IL-TIF/IL-22, and uses thereof 失效编码结合IL-TIF / IL-22的可溶性IL-TIF受体或结合蛋白的分离的核酸分子及其用途公开(公告)号：US07268223B2
公开(公告)日：2007-09-11
申请号：US09919162
申请日：2001-07-31
IPC分类号： C07H21/04
CPC分类号： C07K14/7155 , A01K2217/05 , A61K38/00 , C07K2319/30
摘要： The invention relates to soluble proteins which bind to the molecule known as IL-TIF/IL-22. The proteins can antagonize the effect of IL-TIF/IL-22 on target cells. The nucleic acid molecules encoding the proteins, and uses of the protein, are also described.
摘要翻译： 本发明涉及与称为IL-TIF / IL-22的分子结合的可溶性蛋白质。 蛋白质可以拮抗IL-TIF / IL-22对靶细胞的作用。 还描述了编码蛋白质的核酸分子以及蛋白质的用途。
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公开(公告)号：US20060257408A1
公开(公告)日：2006-11-16
申请号：US11491761
申请日：2006-07-24
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/567
CPC分类号： G01N33/6869 , A61K38/00 , C07K14/54 , C07K14/7155 , C07K16/18 , C07K16/44 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5041 , G01N33/5044 , G01N33/505 , G01N33/566 , G01N2333/715 , G01N2333/91215 , G01N2500/02 , G01N2500/10 , G01N2500/20
摘要： Interleukin-22 interacts with its receptor, referred to as IL-22R, and instigates a series of reactions, leading to activation of various molecules, such as JAK-1, Tyk2, and others. One can identify molecules which mediate this interaction by measuring the activity of one or more of the molecules in the pathway, to identify agonists and antagonists. These, in turn, are useful therapeutic agents, where inappropriate expression of one of the activated molecules is at issue, and requires amelioration.
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公开(公告)号：US07033787B2
公开(公告)日：2006-04-25
申请号：US10026106
申请日：2001-12-21
CPC分类号： C07K14/715 , A61K38/00
摘要： The invention relates to new members of the Class II cytokine receptor family, such as LICR-2. The new member binds to AK155, and mediates STAT activation.
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公开(公告)号：US06274710B1
公开(公告)日：2001-08-14
申请号：US09178973
申请日：1998-10-26
IPC分类号： C12P2108
CPC分类号： C07K14/52
摘要： The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the molecules are disclosed. The molecules are referred to as T cell induceable factors.
摘要翻译： 本发明涉及分离核酸分子，其表达被白介素-9上调。 对应于核酸分子的蛋白质的氨基酸序列显示细胞因子的一些结构特征。 除了核酸分子和蛋白质之外，还公开了分子的各种用途。 分子被称为T细胞诱导因子。
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30.发明授权Methods for producing antibodies which specifically bind to interleukin-9 receptor 失效产生特异性结合白细胞介素-9受体的抗体的方法
公开(公告)号：US5962269A
公开(公告)日：1999-10-05
申请号：US456489
申请日：1995-06-01
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , C07H15/12 , C07H21/04 , C07K14/715 , C07K16/28 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/70 , C12P21/08 , C12Q1/00 , C12R1/19 , C12R1/91 , C12P21/04 , C07K16/00
CPC分类号： C07K16/2866 , C07K14/7155 , A61K38/00
摘要： The invention describes nucleic acid sequences which code for the interleukin 9 receptor (IL9-R) molecule. These sequences may be used as probes to identify cells expressing the molecule, and as agents to transfect recipient cells.
摘要翻译： 本发明描述了编码白介素9受体（IL9-R）分子的核酸序列。 这些序列可以用作探针以鉴定表达分子的细胞，以及作为转染受体细胞的试剂。
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