公开(公告)号：US6063039A

公开(公告)日：2000-05-16

申请号：US759698

申请日：1996-12-06

Applicant: David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young

Inventor： David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young

IPC: A61B5/00 ,  A61B5/15 ,  A61B10/00

CPC classification number: A61B5/411 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/157 ,  A61B5/14532 ,  A61B5/15136

Abstract: Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of:(a) forming an unobstructed opening in the area of the skin from which the sample of blood is to be extracted; and(b) extracting the sample of blood from the unobstructed opening in the skin, with the aid of a vacuum and a stretching of the skin.In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises:(a) a device for forming an unobstructed opening in an area of skin from which said sample is to be extracted, preferably a lancing assembly; and(b) a vacuum pump.Preferably, the apparatus also includes a housing.

Abstract translation: 用于从患者获得血样的方法和装置用于随后的诊断测试，例如葡萄糖监测。 在本发明的一个方面，所述方法包括以下步骤：（a）在要从其中提取血液样本的皮肤区域中形成无障碍的开口; 和（b）借助于真空和皮肤拉伸从皮肤中的无阻塞的开口提取血液样品。 在本发明的另一方面，提供一种用于执行前述方法的装置。 该装置包括：（a）用于在皮肤区域形成无障碍的开口的装置，所述皮肤区域将从所述皮肤区域中提取所述样品，优选为采血组件; 和（b）真空泵。 优选地，该装置还包括壳体。

公开(公告)号：US5807274A

公开(公告)日：1998-09-15

申请号：US890762

申请日：1997-07-11

Applicant: Timothy P. Henning ,  Eric B. Shain ,  Tuan A. Elstrom ,  Kevin C. Warnke

Inventor： Timothy P. Henning ,  Eric B. Shain ,  Tuan A. Elstrom ,  Kevin C. Warnke

IPC: A61B5/00 ,  A61B5/103 ,  A61B5/15 ,  A61B5/154 ,  A61B10/00

CPC classification number: A61B5/441 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/15134 ,  A61B5/157

Abstract: This disclosure relates to a device and method for the non-invasive or minimally invasive withdrawal of fluids from a patient by the use of a self-actuated pump connected to a analyte sensing unit. The self-actuated pump is preferably mounted in the patient's shoe.

Abstract translation: 本公开涉及一种用于通过使用连接到分析物感测单元的自动泵来从患者非侵入性或微创性地取出流体的装置和方法。 自动泵优选安装在患者的鞋中。

公开(公告)号：US20120296187A1

公开(公告)日：2012-11-22

申请号：US13453448

申请日：2012-04-23

Applicant: Timothy P. Henning ,  John Bhogal ,  Andrew H. Naegeli

Inventor： Timothy P. Henning ,  John Bhogal ,  Andrew H. Naegeli

IPC: A61B5/1473 ,  B23P17/04

CPC classification number: A61B5/14503 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2017/00761 ,  A61B2017/320004 ,  A61B2562/00 ,  Y10T29/49 ,  Y10T29/4998 ,  Y10T29/49995

Abstract: Devices, systems and methods for accessing bodily fluid beneath the skin surface by abrading the skin, whereby such bodily fluid may be extracted for ex vivo analysis or whereby an in vivo analyte sensor is implanted at the abrasion site.

Abstract translation: 用于通过研磨皮肤来接触皮肤表面下方的体液的装置，系统和方法，由此可以提取这样的体液以进行离体分析，或者将体内分析物传感器植入磨损部位。

公开(公告)号：US20110031110A1

公开(公告)日：2011-02-10

申请号：US12907345

申请日：2010-10-19

Applicant: Yi Wang ,  Timothy P. Henning ,  Edmund T. Marciniec

Inventor： Yi Wang ,  Timothy P. Henning ,  Edmund T. Marciniec

IPC: C23C14/14 ,  C23C14/34

CPC classification number: C23C14/3464 ,  C23C14/0694 ,  C23C14/205 ,  H01M4/8885 ,  Y02E60/50

Abstract: The subject invention provides conductive stripes, suitable for use as electrodes, and methods of making conductive stripes.

Abstract translation: 本发明提供适合用作电极的导电条纹，以及制造导电条纹的方法。

公开(公告)号：US06206841B1

公开(公告)日：2001-03-27

申请号：US09546948

申请日：2000-04-11

Applicant: David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young ,  Michael G. Lowery ,  Thomas G. Schapira

Inventor： David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young ,  Michael G. Lowery ,  Thomas G. Schapira

IPC: A61B500

CPC classification number: A61B5/15186 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150076 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150664 ,  A61B5/15113 ,  A61B5/15125 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/157 ,  A61B5/411 ,  A61B2562/0295

Abstract: Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of: (a) forming an unobstructed opening in the area of the skin from which the sample of blood is to be extracted; and (b) extracting the sample of blood from the unobstructed opening in the skin, with the aid of a vacuum and a stretching of the skin. In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises: (a) a device for forming an unobstructed opening in an area of skin from which said sample is to be extracted, preferably a lancing assembly; and (b) a vacuum pump. Preferably, the apparatus also includes a housing. In another aspect of this invention, an article is provided for an article capable of both collecting blood and detecting an analyte in that blood is provided. The article, which contains an appropriate detection element for determining the amount of analyte in the blood, can be used in conjunction with a meter that measures the signal generated by the detection element of the article. In one embodiment, the article is a multiple-layer element comprising: (a) a layer capable of receiving blood and transporting the blood received by means of chemically aided wicking; (b) a layer capable of detecting the presence of analyte or measuring the amount of analyte in blood; and (c) a layer that can be placed in contact with a meter, the meter-contactable layer overlying the blood-transporting layer, said layer (a) capable of transporting blood to said layer (b).

Abstract translation: 用于从患者获得血样的方法和装置用于随后的诊断测试，例如葡萄糖监测。 在本发明的一个方面，所述方法包括以下步骤：（a）在要从其中提取血液样本的皮肤区域中形成无障碍的开口; 并且（b）借助于皮肤的真空和拉伸，从皮肤中的无障碍的开口提取血液样品。在本发明的另一方面，提供了一种用于执行前述方法的装置。 该装置包括：（a）用于在皮肤区域形成无障碍的开口的装置，所述皮肤区域将从所述皮肤区域中提取所述样品，优选为采血组件; 优选地，该装置还包括壳体。在本发明的另一方面，提供了一种能够收集血液并检测血液中的分析物的物品。 包含用于确定血液中分析物的量的合适的检测元件的物品可以与测量由物品的检测元件产生的信号的计量器结合使用。 在一个实施方案中，制品是多层元件，其包括：（a）能够接收血液并通过化学辅助芯吸输送接收到的血液的层;（b）能够检测分析物的存在或测量 血液中分析物的量; 以及（c）可以与仪表接触的层，覆盖在血液输送层上的可测量接触层，所述层（a）能够将血液输送到所述层（b）。

公开(公告)号：US6071251A

公开(公告)日：2000-06-06

申请号：US982323

申请日：1997-12-02

Applicant: David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young ,  Michael G. Lowery ,  Thomas G. Schapira

Inventor： David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young ,  Michael G. Lowery ,  Thomas G. Schapira

IPC: A61B5/151 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/15 ,  A61B5/154 ,  A61B5/157 ,  G01N33/48 ,  G01N33/66

CPC classification number: A61B5/15186 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150076 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150664 ,  A61B5/15113 ,  A61B5/15125 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/157 ,  A61B5/411 ,  A61B2562/0295 ,  A61B5/150358

Abstract: Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of:(a) forming an unobstructed opening in the area of the skin from which the sample of blood is to be extracted; and(b) extracting the sample of blood from the unobstructed opening in the skin, with the aid of a vacuum and a stretching of the skin.In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises:(a) a device for forming an unobstructed opening in an area of skin from which said sample is to be extracted, preferably a lancing assembly; and(b) a vacuum pump.Preferably, the apparatus also includes a housing.In another aspect of this invention, an article is provided for an article capable of both collecting blood and detecting an analyte in that blood is provided. The article, which contains an appropriate detection element for determining the amount of analyte in the blood, can be used in conjunction with a meter that measures the signal generated by the detection element of the article. In one embodiment, the article is a multiple-layer element comprising:(a) a layer capable of receiving blood and transporting the blood received by means of chemically aided wicking;(b) a layer capable of detecting the presence of analyte or measuring the amount of analyte in blood; and(c) a layer that can be placed in contact with a meter, the meter-contactable layer overlying the blood-transporting layer, said layer (a) capable of transporting blood to said layer (b).

Abstract translation: 用于从患者获得血样的方法和装置用于随后的诊断测试，例如葡萄糖监测。 在本发明的一个方面，所述方法包括以下步骤：（a）在要从其中提取血液样本的皮肤区域中形成无障碍的开口; 和（b）借助于真空和皮肤拉伸从皮肤中的无阻塞的开口提取血液样品。 在本发明的另一方面，提供一种用于执行前述方法的装置。 该装置包括：（a）用于在皮肤区域形成无障碍的开口的装置，所述皮肤区域将从所述皮肤区域中提取所述样品，优选为采血组件; 和（b）真空泵。 优选地，该装置还包括壳体。 在本发明的另一方面，提供了一种能够收集血液并检测血液中分析物的物品。 包含用于确定血液中分析物的量的合适的检测元件的物品可以与测量由物品的检测元件产生的信号的计量器结合使用。 在一个实施方案中，制品是多层元件，其包括：（a）能够接收血液并通过化学辅助芯吸运送接收的血液的层; （b）能够检测分析物的存在或测量血液中分析物的量的层; 以及（c）可以与仪表接触的层，覆盖在血液输送层上的可测量接触层，所述层（a）能够将血液输送到所述层（b）。

公开(公告)号：US06027459A

公开(公告)日：2000-02-22

申请号：US982561

申请日：1997-12-02

Applicant: Eric B. Shain ,  Michael G. Lowery ,  David D. Cunningham ,  Timothy P. Henning ,  Douglas F. Young

Inventor： Eric B. Shain ,  Michael G. Lowery ,  David D. Cunningham ,  Timothy P. Henning ,  Douglas F. Young

IPC: A61B5/151 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/15 ,  A61B5/154 ,  A61B5/157 ,  G01N33/48 ,  G01N33/66 ,  A61B10/00

CPC classification number: A61B5/15186 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150076 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150664 ,  A61B5/15113 ,  A61B5/15125 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/157 ,  A61B5/411 ,  A61B2562/0295 ,  A61B5/150358

Abstract: Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of:(a) forming an unobstructed opening in the area of the skin from which the sample of blood is to be extracted; and(b) extracting the sample of blood from the unobstructed opening in the skin, with the aid of a vacuum and a stretching of the skin.In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises:(a) a device for forming an unobstructed opening in an area of skin from which said sample is to be extracted, preferably a lancing assembly; and(b) a vacuum pump.Preferably, the apparatus also includes a housing.In a further aspect of the invention, a pneumatic lancing assembly is provided. The pneumatic lancing assembly uses differential gas pressure to thrust a lancet into skin tissue. This lancing assembly effectively utilizes low-pressure gas, which is preferably provided by the aforementioned vacuum pump, and high-pressure gas, which is preferably provided by ambient air surrounding the apparatus, to thrust the lancet, puncture the skin, and then retract the lancet from the skin to produce an unobstructed opening to allow access to biological fluid.

Abstract translation: 用于从患者获得血样的方法和装置用于随后的诊断测试，例如葡萄糖监测。 在本发明的一个方面，所述方法包括以下步骤：（a）在要从其中提取血液样本的皮肤区域中形成无障碍的开口; 和（b）借助于真空和皮肤拉伸从皮肤中的无阻塞的开口提取血液样品。 在本发明的另一方面，提供一种用于执行前述方法的装置。 该装置包括：（a）用于在皮肤区域形成无障碍的开口的装置，所述皮肤区域将从所述皮肤区域中提取所述样品，优选为采血组件; 和（b）真空泵。 优选地，该装置还包括壳体。 在本发明的另一方面，提供一种气动采血组件。 气动采血组件使用差压气体将刺血针推入皮肤组织。 这种穿刺组件有效地利用优选由上述真空泵提供的低压气体和优选由围绕设备的环境空气提供的高压气体，以推动刺血针，刺穿皮肤，然后将 刺血针从皮肤产生无阻碍的开口，以允许进入生物流体。

公开(公告)号：US4564426A

公开(公告)日：1986-01-14

申请号：US723371

申请日：1985-04-15

Applicant: Timothy P. Henning ,  Robert D. Topa

Inventor： Timothy P. Henning ,  Robert D. Topa

IPC: C25D3/56

CPC classification number: C25D3/567

Abstract: A palladium-nickel alloy is deposited onto a substrate by electroplating from a plating bath containing palladosammine chloride, nickel ion source, ammonium sulfate, ammonium chloride, and sufficient ammonium hydroxide to provide a pH of about 7.0 to about 8.3 at a temperature of about 60.degree. F. to about 90.degree. F.

Abstract translation: 通过从包含氯化帕拉多胺，镍离子源，硫酸铵，氯化铵和足够的氢氧化铵的电镀液中电镀，将钯 - 镍合金沉积在基底上，以在约60℃的温度下提供约7.0至约8.3的pH °F至约90°F