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    Phosphatase activated crosslinking, conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating agents
    5.
    发明授权
    Phosphatase activated crosslinking, conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating agents 失效
    磷酸酶活化交联，共轭和还原剂; 使用这种药剂的方法; 和包含磷酸酶活化的交联和缀合剂的试剂

    公开(公告)号：US5736624A

    公开(公告)日：1998-04-07

    申请号：US349167

    申请日：1994-12-02

    申请人： Christopher Bieniarz ,  Douglas F. Young ,  Michael J. Cornwell ,  Mazhar Husain

    发明人： Christopher Bieniarz ,  Douglas F. Young ,  Michael J. Cornwell ,  Mazhar Husain

    IPC分类号： A61K47/48 ,  C07F9/165 ,  C07F9/553 ,  G01N33/543 ,  C07K16/26 ,  C07K17/00 ,  C12N9/96 ,  C12N11/08

    CPC分类号： G01N33/54353 ,  C07F9/1651 ,  C07F9/1652 ,  C07F9/5537 ,  Y10S530/811 ,  Y10S530/816

    摘要： The present invention provides crosslinking, conjugating and reducing agents which are functional with at least one phosphorothioate monoester group (--SPO.sub.3.sup.-2). Crosslinking and conjugation methods as well as solid phase reagents and conjugates which are useful in immunoassays are also provided. Crosslinking and conjugating agents of the invention generally comprise a compound corresponding to the formula (I), shown below, wherein n is at least 1 and Q is a straight or branched monomer, polymer or oligomer having an average molecular weight between about 200 and about 1,000,000. Additionally, when n is 1, Q comprises at least 1 additional reactive functionality. Q--(S--PO.sub.3.sup.-2)n (I) The reducing agents that are provided conform to a compound of the formula (Y), shown below, wherein (A) and (Z) can be independently selected from C.sub.1 -C.sub.5 alkyl and CONH(CH.sub.2).sub.p wherein p is an integer between 1 and 5. ##STR1##

    摘要翻译： 本发明提供了与至少一种硫代磷酸酯单酯基团（-SPO3-2）起作用的交联，缀合和还原剂。 还提供了可用于免疫测定的交联和缀合方法以及固相试剂和缀合物。 本发明的交联和缀合剂通常包含对应于下面所示的式（I）的化合物，其中n至少为1，Q为直链或支链单体，平均分子量为约200至约200的聚合物或低聚物 1,000,000。 另外，当n为1时，Q包含至少1个额外的反应性官能团。Q-（S-PO3-2）n（I）提供的还原剂符合下面所示的式（Y）化合物，其中 （A）和（Z）可以独立地选自C 1 -C 5烷基和CONH（CH 2）p，其中p是1和5之间的整数。

    Method and apparatus for obtaining blood for diagnostic tests
    7.
    发明授权
    Method and apparatus for obtaining blood for diagnostic tests 有权
    血液检测方法及装置

    公开(公告)号：US06283926B1

    公开(公告)日：2001-09-04

    申请号：US09532729

    申请日：2000-03-22

    申请人： David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young

    发明人： David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young

    IPC分类号： A61B500

    CPC分类号： A61B5/411 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/15136 ,  A61B5/157

    摘要： Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of: (a) forming an unobstructed opening in the area of the skin from which the sample of blood is to be extracted; and (b) extracting the sample of blood from the unobstructed opening in the skin, with the aid of a vacuum and a stretching of the skin. In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises: (a) a device for forming an unobstructed opening in an area of skin from which said sample is to be extracted, preferably a lancing assembly; and (b) a vacuum pump. Preferably, the apparatus also includes a housing.

    摘要翻译： 用于从患者获得血样的方法和装置用于随后的诊断测试，例如葡萄糖监测。 在本发明的一个方面，所述方法包括以下步骤：（a）在要从其中提取血液样本的皮肤区域中形成无障碍的开口; 并且（b）借助于皮肤的真空和拉伸，从皮肤中的无障碍的开口提取血液样品。在本发明的另一方面，提供了一种用于执行前述方法的装置。 该装置包括：（a）用于在皮肤区域形成无障碍的开口的装置，所述皮肤区域将从所述皮肤区域中提取所述样品，优选为采血组件; 和（b）真空泵。优选地，该装置还包括壳体。

    Phosphatase activated crosslinking conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating
    8.
    发明授权
    Phosphatase activated crosslinking conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating 失效
    磷酸酶活化交联共轭和还原剂; 使用这种药剂的方法; 和包含磷酸酶活化的交联和缀合剂的试剂

    公开(公告)号：US6160153A

    公开(公告)日：2000-12-12

    申请号：US498388

    申请日：2000-02-03

    申请人： Christopher Bieniarz ,  Douglas F. Young ,  Michael J. Cornwell ,  Zbigniew Skrzypczynski

    发明人： Christopher Bieniarz ,  Douglas F. Young ,  Michael J. Cornwell ,  Zbigniew Skrzypczynski

    IPC分类号： A61K47/48 ,  C07F9/165 ,  C07F9/553 ,  G01N33/543

    CPC分类号： G01N33/54353 ,  C07F9/1651 ,  C07F9/1652 ,  C07F9/5537 ,  Y10S530/811 ,  Y10S530/816

    摘要： The present invention provides crosslinking, conjugating and reducing agents which are functional with at least one phosphorothioate monoester group (--SPO.sub.3.sup.--2). Crosslinking and conjugation methods as well as solid phase reagents and conjugates which are useful in immunoassays are also provided.Crosslinking and conjugating agents of the invention generally comprise a compound corresponding to the formula (I), shown below, wherein n at least 1 and Q is a straight or branched monomer, polymer or oligomer having an average molecular weight between about 200 and about 1,000,000. Additionally, when n is 1, Q comprises at least 1 additional reactive functionality.Q--(S--PO.sub.3.sup.-2).sub.n (I)The reducing agents that are provided conform to a compound of the formula (Y), shown below, wherein (A) and (Z) can be independently selected from C.sub.1 -C.sub.5 alkyl and CONH(CH.sub.2).sub.p wherein p is an integer between 1 and 5. ##STR1##

    摘要翻译： 本发明提供了与至少一种硫代磷酸酯单酯基团（-SPO3-2）起作用的交联，缀合和还原剂。 还提供了可用于免疫测定的交联和缀合方法以及固相试剂和缀合物。 本发明的交联和缀合剂通常包含对应于下式（I）的化合物，其中n至少为1且Q为直链或支链单体，平均分子量为约200至约1,000,000的聚合物或低聚物 。 另外，当n为1时，Q包含至少1个额外的反应性官能团。Q-（S-PO3-2）n（I）提供的还原剂符合下面所示的式（Y）化合物，其中 （A）和（Z）可以独立地选自C 1 -C 5烷基和CONH（CH 2）p，其中p是1和5之间的整数。

    Method and apparatus for obtaining interstitial fluid for diagnostic tests
    9.
    发明授权
    Method and apparatus for obtaining interstitial fluid for diagnostic tests 失效
    用于诊断测试的获得间质液的方法和装置

    公开(公告)号：US06155992A

    公开(公告)日：2000-12-05

    申请号：US982449

    申请日：1997-12-02

    申请人： Timothy P. Henning ,  Robert G. Hiltibran ,  David D. Cunningham ,  Eric B. Shain ,  Brian J. Tarkowski ,  Douglas F. Young

    发明人： Timothy P. Henning ,  Robert G. Hiltibran ,  David D. Cunningham ,  Eric B. Shain ,  Brian J. Tarkowski ,  Douglas F. Young

    IPC分类号： A61B5/151 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1477 ,  A61B5/15 ,  A61B10/00

    CPC分类号： A61B5/14514 ,  A61B10/0045 ,  A61B5/14532 ,  A61B2010/008 ,  A61M2037/0007

    摘要： A method and apparatus for obtaining a sample of interstitial fluid from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of (a) treating an area of the skin with vacuum or heat or both vacuum and heat to increase the availability of interstitial fluid at that area of the skin; (b) forming an opening in the treated area of the skin; and (c) extracting the sample of interstitial fluid from the opening in the skin, with the aid of vacuum and stretching of the skin. In another aspect of the invention, an apparatus for carrying out the method described previously is provided. Th apparatus comprises (a) a device for forming an unobstructed opening in the area of the skin from which the sample is to be extracted, preferably a lancing assembly; and (b) a vacuum pump. Preferably, the apparatus also includes a housing.

    摘要翻译： 一种从患者获得间质液样品的方法和装置，用于随后的诊断测试，例如葡萄糖监测。 在本发明的一个方面，该方法包括以下步骤：（a）用真空或热或真空和热处理皮肤区域，以增加皮肤区域间隙液的可用性; （b）在皮肤的处理区域中形成开口; 并且（c）借助真空和皮肤拉伸从皮肤开口提取间质液样品。 在本发明的另一方面，提供一种用于执行前述方法的装置。 Th装置包括（a）用于在要从其中提取样品的皮肤区域中形成无障碍的开口的装置，优选为采血组件; 和（b）真空泵。 优选地，该装置还包括壳体。

    Method and apparatus for obtaining blood for diagnostic tests
    10.
    发明授权
    Method and apparatus for obtaining blood for diagnostic tests 失效
    血液检测方法及装置

    公开(公告)号：US6063039A

    公开(公告)日：2000-05-16

    申请号：US759698

    申请日：1996-12-06

    申请人： David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young

    发明人： David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young

    IPC分类号： A61B5/00 ,  A61B5/15 ,  A61B10/00

    CPC分类号： A61B5/411 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/157 ,  A61B5/14532 ,  A61B5/15136

    摘要： Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of:(a) forming an unobstructed opening in the area of the skin from which the sample of blood is to be extracted; and(b) extracting the sample of blood from the unobstructed opening in the skin, with the aid of a vacuum and a stretching of the skin.In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises:(a) a device for forming an unobstructed opening in an area of skin from which said sample is to be extracted, preferably a lancing assembly; and(b) a vacuum pump.Preferably, the apparatus also includes a housing.

    摘要翻译： 用于从患者获得血样的方法和装置用于随后的诊断测试，例如葡萄糖监测。 在本发明的一个方面，所述方法包括以下步骤：（a）在要从其中提取血液样本的皮肤区域中形成无障碍的开口; 和（b）借助于真空和皮肤拉伸从皮肤中的无阻塞的开口提取血液样品。 在本发明的另一方面，提供一种用于执行前述方法的装置。 该装置包括：（a）用于在皮肤区域形成无障碍的开口的装置，所述皮肤区域将从所述皮肤区域中提取所述样品，优选为采血组件; 和（b）真空泵。 优选地，该装置还包括壳体。