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公开(公告)号：US20100216689A1
公开(公告)日：2010-08-26
申请号：US12599194
申请日：2008-05-07
IPC分类号： A61K38/00 , A61K31/433 , A61K31/41 , A61K31/4245 , A61K31/40 , A61K31/10 , A61P35/04 , A61P31/04 , A61P31/10 , C07D207/04 , A61P31/12
CPC分类号： A61K31/5575 , A61K39/0011 , A61K39/12 , A61K39/245 , A61K45/06 , A61K2039/55588 , A61K2039/57 , C12N2710/16634 , A61K2300/00
摘要： Disclosed is a substance which has a low molecular weight, can be applied in a simpler manner, and has an immunopotentiating activity against cancer and/or a microorganism-mediated infectious disease.An EP4 agonist exhibits an immunopotentiating activity through the activation of a cytotoxic T cell, and is therefore useful for the prevention and/or treatment of cancer or a microorganism-mediated infection disease.
摘要翻译： 公开了具有低分子量的物质，可以以更简单的方式施用，并且具有抗癌和/或微生物介导的感染性疾病的免疫增强活性。 EP4激动剂通过激活细胞毒性T细胞表现出免疫增强活性，因此可用于预防和/或治疗癌症或微生物介导的感染疾病。
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公开(公告)号：US20100076038A1
公开(公告)日：2010-03-25
申请号：US12527340
申请日：2008-02-15
IPC分类号： A61K31/426 , A61P13/12
CPC分类号： C07D213/71 , A61K31/426 , A61K31/4402 , A61K45/06 , C07D277/20 , C07D277/36 , A61K2300/00
摘要： Disclosed is an EP1 antagonist, particularly a compound represented by the formula (I): wherein all symbols are as defined in the description, a salt thereof, a solvate thereof or a prodrug thereof. The compound, a salt thereof, a solvate thereof or a prodrug thereof is effective for prevention, treatment and/or symptom improvement of a dysuria (e.g., slow stream, splitting or spraying of the urine stream, intermittent stream, hesitancy, straining to void or terminal dribble).
摘要翻译： 公开了EP1拮抗剂，特别是由式（I）表示的化合物：其中所有符号如说明书中所定义，其盐，其溶剂化物或其前药。 该化合物，其盐，其溶剂合物或其前体药物对于排尿困难的预防，治疗和/或症状改善（例如，缓慢的流，尿流的分裂或喷雾，间歇流，犹豫，紧张到空隙中是有效的 或终点运球）。
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公开(公告)号：US07553373B2
公开(公告)日：2009-06-30
申请号：US11435762
申请日：2006-05-18
IPC分类号： C30B25/12
CPC分类号： C30B23/025 , C30B29/36
摘要： A method of producing a silicon carbide single crystal, having: fixing a seed crystal, including setting a seed crystal on a seed crystal fixing part with interposition of an adhesive; applying a uniform pressure on the entire surface of the seed crystal by contacting a flexible bag which is inflatable and deflatable to the seed crystal by charging a gas into the to flexible bag; hardening the adhesive; and sublimating a silicon carbide powder obtained by calcinating a mixture containing at least a silicon source and a resol xylene resin, having a nitrogen content of 100 mass ppm or less and having a content of each impurity elements of 0.1 mass ppm or less, and re-crystallizing for growing a silicon carbide single crystal.
摘要翻译： 一种碳化硅单晶的制造方法，其特征在于，具有：将晶种固定，包括将晶种固定在具有粘合剂的晶种固定部分上; 通过将气体充入到柔性袋中使可充气和可充气的柔性袋接触到晶种的整个表面上施加均匀的压力; 硬化粘合剂; 和通过煅烧至少包含硅源和甲阶戊二醛二甲苯树脂的混合物而获得的碳化硅粉末，其氮含量为100质量ppm以下，杂质元素的含量为0.1质量ppm以下，并且re - 用于生长碳化硅单晶的结晶。
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公开(公告)号：US20090058591A1
公开(公告)日：2009-03-05
申请号：US12197941
申请日：2008-08-25
申请人： Yoshinari Nakada , Takayuki Maruyama , Hideharu Suzuki , Koihci Iguchi , Takahiro Samata , Satoshi Kimura
发明人： Yoshinari Nakada , Takayuki Maruyama , Hideharu Suzuki , Koihci Iguchi , Takahiro Samata , Satoshi Kimura
IPC分类号： H01F17/04
CPC分类号： H01F27/292 , H01F1/344 , H01F17/045 , H01F41/005 , H01F41/10 , H01F2017/048 , Y10T29/4902
摘要： A wire wound electronic part includes a ferrite core comprising ferrite having a columnar wire wound core and flanges formed at both ends thereof, a coil conductor wound around the wire wound core of the ferrite core, and at least a pair of terminal electrodes having a Cu conduction layer disposed to the outer surface of the flange, in which both ends of the coil conductor wound around the wire wound core are conductively connected to the terminal electrodes. The terminal electrode is formed by coating an electrode paste containing a Cu powder and a glass frit to the outer surface of the ferrite core, and then applying a heat treatment to the ferrite core. There is a reaction layer of a portion of the ferrite core and the glass frit at a boundary between the ferrite core and the Cu conduction layer. The terminal electrodes has the peel strength identical with that of an existent Ag terminal electrode, without forming a plate layer.
摘要翻译： 绕线电子部件包括铁氧体磁芯，该铁氧体磁芯包括铁氧体，该铁氧体具有圆柱形铁芯和其两端形成的凸缘，缠绕在铁氧体磁芯的绕线芯上的线圈导体，以及至少一对具有Cu 导电层设置在凸缘的外表面上，其中卷绕在绕线芯上的线圈导体的两端导电地连接到端子电极。 端子电极通过将包含Cu粉末和玻璃料的电极浆料涂覆到铁氧体磁芯的外表面，然后对铁氧体磁芯进行热处理而形成。 在铁氧体磁芯和Cu导电层之间的边界处存在铁氧体磁芯和玻璃料的一部分的反应层。 端子电极的剥离强度与存在的Ag端子电极的剥离强度相同，而不形成板层。
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公开(公告)号：US20060058394A1
公开(公告)日：2006-03-16
申请号：US11249484
申请日：2005-10-14
申请人： Shuh Narumiya , Takayuki Maruyama
发明人： Shuh Narumiya , Takayuki Maruyama
IPC分类号： A61K31/557
CPC分类号： A61K31/5575 , A61K31/00
摘要： The treatment and/or prophylactic drugs of post-traumatic stress disorder (PTSD) containing compounds (EP1 agonists), which activate EP1 receptor that is subtype of prostaglandin E2 receptor, as an active ingredient. EP1 agonists such as (13E)-(11α,15S,17S)-2,5-ethano-6,9-dioxo-11,15-dihydro-17,20-dimethylprosta-13-enoic acid, PGE1, or PGE2, etc. are useful for the treatment of post-traumatic stress disorder (PTSD).
摘要翻译： 包含化合物（EP 1激动剂）的创伤后应激障碍（PTSD）的治疗和/或预防药物，其激活作为前列腺素E2受体亚型的EP 1受体 ，作为活性成分。 EP 1激动剂如（13E） - （11α，15S，17S）-2,5-乙基-6,9-二氧代-11,15-二氢-17,20-二甲基丙基-13- 辛酸，PGE 1或PGE 2等可用于治疗创伤后应激障碍（PTSD）。
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公开(公告)号：US06235777B1
公开(公告)日：2001-05-22
申请号：US09078577
申请日：1998-05-14
申请人： Shuichi Ohuchida , Yuuki Nagao , Takayuki Maruyama
发明人： Shuichi Ohuchida , Yuuki Nagao , Takayuki Maruyama
IPC分类号： A61K3121
CPC分类号： C07C311/19 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2602/44
摘要： A benzenesulfonamide compound of the formula (I) (R1 is hydroxy, C1˜4 alkoxy, NR6R7 (each R6 and R7 is, independently, H or C1˜4 alkyl.); R2 is H, C1˜4 alkyl; R3, R4 are C1˜4 alkyl, halogen trifluoromethyl; R5 is H, C1˜4 alkyl, halogen, trifluoromethyl; Y is cis-vinylene, trans-vinylene; and the symbol (i) is single bond, double bond.), non-toxic salt thereof or cyclodextrin clathrate thereof and an antagonist of EP1 receptor which is a prostaglandin E2 receptor subtype comprising it as an active ingredient. The present invention compounds of the of the formula (I) can bind strongly to EP1 receptor which is a prostaglandin E2 receptor subtype and scarcely bind to the other receptor subtypes. Therefore, they are considered to be useful as antipyretic agents, as analgesics or as treating agent for pollakiuria having little side effect.
摘要翻译： 式（I）的苯磺酰胺化合物（R 1是羟基，C 1-4烷氧基，NR 6 R 7（各R 6和R 7独立地是H或C 1-4烷基）; R 2是H，C 1-4烷基; R 3，R 4 是C1〜4烷基，卤素三氟甲基; R5是H，C1〜4烷基，卤素，三氟甲基; Y是顺式亚乙烯基，反式亚乙烯基;符号（i）是单键，双键），无毒 其盐或环糊精包合物和作为前列腺素E2受体亚型的EP1受体的拮抗剂，其包含其作为活性成分。本发明式（I）的化合物可以强烈地与作为前列腺素E2受体的EP1受体结合 亚型，几乎不结合其他受体亚型。 因此，它们被认为可用作解热剂，作为止痛剂或作为尿酸治疗剂具有很小的副作用。
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公开(公告)号：US5290821A
公开(公告)日：1994-03-01
申请号：US967734
申请日：1992-10-28
摘要： An electro-responsive elastomeric material comprising (A) an electrically insulating polymer having a specific modulus of elasticity and (B) a fine powder dispersed in the polymer which electrically polarizes under an electric field independent of water changes its viscoelasticity upon voltage application. The powder has a mean particle size of 0.5 to 500 .mu.m and is (1) a fine carbonaceous powder having a C/H atomic ratio of from 1.2 to 5, (2) composite particles having minute particulates of an insulating material dispersed in a matrix phase of a carbonaceous or carbide material, (3) composite particles having minute particulates of a carbonaceous or carbide material dispersed in a matrix phase of an insulating material, or (4) a fine composite powder of a stratum clay mineral having a two-dimensional stratum structure with a carbonaceous or carbide material incorporated between the strata.
摘要翻译： 一种电响应性弹性体材料，其包含（A）具有比弹性模量的电绝缘聚合物和（B）分散在聚合物中的细粉末，其在电场下独立于水而电极化，在施加电压时改变其粘弹性。 粉末的平均粒度为0.5〜500（my）m，是（1）C / H原子比为1.2〜5的细小碳质粉末，（2）分散有绝缘材料的微小颗粒的复合粒子 在碳质或碳化物材料的基体相中，（3）具有分散在绝缘材料的基体相中的碳质或碳化物材料的微小颗粒的复合颗粒，或（4）具有层状粘土矿物的细微复合粉末， 二维地层结构，其中碳质或碳化物材料结合在地层之间。
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公开(公告)号：US5115549A
公开(公告)日：1992-05-26
申请号：US520514
申请日：1990-05-08
申请人： Takayuki Maruyama
发明人： Takayuki Maruyama
CPC分类号： B23Q1/545 , Y10T29/53961
摘要： A diagonal insertion apparatus of this invention inserts a shaft-like member into an insertion receiving component provided with a diagonal hole inclined with respect to a ground or horizontal plane and comprises a holding table or pallet for holding the insertion receiving component, an inclined positioning jig having a plurality of pins of different lengths to engage recess receivers in the bottom of the holding table and elevate and incline the holding table at a predetermined angular relationship to permit properly aligned insertion of the shaft-like member into the insertion receiving component. The inclined positioning jig contains reference means for determining the arrangement of the multiple pins so that the axis of a diagonal hole in the insertion receiving component is aligned with axis of the shaft-like member to be inserted therein. The use of an inclined positioning jig having such reference means provides for easy switching to different models of insertion receiving components as well as provides for easy aligned insertion of shaft-like members into the diagonal holes of insertion receiving components.
摘要翻译： 本发明的对角线插入装置将轴状构件插入到插入容纳部件中，该插入容纳部件具有相对于地面或水平面倾斜的对角孔，并且包括用于保持插入容纳部件的保持台或托盘，倾斜定位夹具 具有多个不同长度的销以接合保持台的底部中的凹部接收器，并以预定的角度关系提升和倾斜保持台，以允许轴状构件适当地对准地插入到插入接收部件中。 倾斜定位夹具包括用于确定多个销的布置的参考装置，使得插入接收部件中的对角孔的轴线与待插入其中的轴状构件的轴线对准。 具有这种参考装置的倾斜定位夹具的使用提供了容易地切换到不同型号的插入接收部件，并且提供了容易地将轴状构件对准地插入到插入接收部件的对角孔中。
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29.发明申请公开(公告)号：US20110287112A1
公开(公告)日：2011-11-24
申请号：US13147086
申请日：2010-01-29
申请人： Osamu Ogawa , Gozoh Tsujimoto , Eijiro Nakamura , Tomomi Kamba , Yosuke Shimizu , Naoki Terada , Toshiya Kanaji , Takayuki Maruyama
发明人： Osamu Ogawa , Gozoh Tsujimoto , Eijiro Nakamura , Tomomi Kamba , Yosuke Shimizu , Naoki Terada , Toshiya Kanaji , Takayuki Maruyama
IPC分类号： A61K33/24 , A61K31/573 , A61K31/566 , A61M37/00 , A61K31/337 , A61P35/00 , A61P5/28 , A61K31/277 , A61K38/09
CPC分类号： A61K31/277 , A61K45/06 , A61K2300/00
摘要： A prostate cancer progression inhibitor comprises 4-(4-cyano-2-{[2-(4-fluoro-1-naphthyl)propanoyl]amino}phenyl)butyric acid, a salt thereof, a solvate thereof, or a prodrug thereof. 4-(4-Cyano-2-{[2-(4-fluoro-1-naphthyl)propanoyl]amino}phenyl)butyric acid is useful as a prostate cancer progression inhibitor because this butyric acid has, for example, a growth inhibiting effect and a hormone responsiveness recovering effect on prostate cancer that has acquired hormone resistance.
摘要翻译： 前列腺癌进展抑制剂包括4-（4-氰基-2 - {[2-（4-氟-1-萘基）丙酰基]氨基}苯基）丁酸，其盐，其溶剂合物或其前药。 4-（4-氰基-2 - {[2-（4-氟-1-萘基）丙酰基]氨基}苯基）丁酸可用作前列腺癌进展抑制剂，因为该丁酸具有例如生长抑制 效应和激素反应恢复作用对获得激素抵抗的前列腺癌。
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30.发明授权Preventive and/or remedy for lower urinary tract diseases containing EP4 agonist 有权含有EP4激动剂的下尿路疾病的预防和/或补救措施公开(公告)号：US07858610B2
公开(公告)日：2010-12-28
申请号：US11660043
申请日：2005-08-09
申请人： Hiroki Okada , Takayuki Maruyama
发明人： Hiroki Okada , Takayuki Maruyama
IPC分类号： A61K31/54 , A61K31/535
CPC分类号： A61K9/2054 , A61K31/5575 , A61K31/559 , A61K45/06 , A61K2300/00
摘要： (1) A preventive and/or a remedy for lower urinary tract diseases such as inflammation in the lower urinary tract, cystitis (interstitial cystitis, etc.) and urethritis; (2) an agent for improving bladder compliance and/or bladder capacity; and (3) an agent for protecting bladder mucosa and/or bladder epithelial cells and/or promoting the regeneration thereof; each containing an EP4 agonist.An EP4 agonist is useful in ameliorating symptoms of lower urinary tract diseases such as (1) frequent urination, (2) urgency of urination, (3) pain in the reproductive organs and/or lower urinary tract (for example, bladder pain, urinary tract pain, vulvar pain, vaginal pain, scrotal pain, perineal pain, pelvic pain, etc.) and/or (4) discomfort in the reproductive organs and/or lower urinary tract. Among all, a selective EP4 agonist is useful as a preventive and/or remedy for lower urinary tract diseases having no side effect.
摘要翻译： （1）下泌尿道疾病如下泌尿道炎症，膀胱炎（间质性膀胱炎等）和尿道炎的预防和/或补救措施; （2）改善膀胱依从性和/或膀胱容量的药剂; 和（3）用于保护膀胱粘膜和/或膀胱上皮细胞和/或促进其再生的药剂; 每个含有EP4激动剂。 EP4激动剂可用于改善下尿路疾病的症状，例如（1）尿频，（2）排尿紧急，（3）生殖器官和/或下尿路疼痛（例如膀胱疼痛，尿液 肠痛，外阴疼痛，阴道疼痛，阴囊疼痛，会阴疼痛，盆腔疼痛等）和/或（4）生殖器官和/或下泌尿道的不适。 其中，选择性EP4激动剂可用作没有副作用的下尿路疾病的预防和/或治疗。
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