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公开(公告)号：US20220347126A1
公开(公告)日：2022-11-03
申请号：US17824235
申请日：2022-05-25
Inventor： Anuj Chauhan , Phillip J. Dixon
Abstract: Compositions for treatment of cystinosis, products for administering eye drops, and products for storing contact lenses are provided. Compositions include solutions that can contain an effective amount of cysteamine to treat cystinosis, and an oil with a lower density than the solution. Also provided is a product including a bottle for containing a solution, the bottle being substantially free of O2. Also provided is a contact lens holder for storing one or more contact lenses in a solution, the holder including barrier layers reducing the amount of O2 entering the contact lens holder.
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公开(公告)号：US20220331245A1
公开(公告)日：2022-10-20
申请号：US17809717
申请日：2022-06-29
Inventor： Anuj Chauhan , Russell Macoon
Abstract: In one aspect, the disclosure relates to compositions for the extended release of drugs in the retina. In a further aspect, the present disclosure provides methods of preparing extended release compositions comprising a therapeutic agent for use in retinal drug delivery. In various other aspects, the present disclosure provides methods for delivery of the disclosed compositions comprising a therapeutic agent to the retina via intravitreal injection. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US11406607B2
公开(公告)日：2022-08-09
申请号：US16418061
申请日：2019-05-21
Inventor： Anuj Chauhan , Phillip J. Dixon
Abstract: Compositions for treatment of cystinosis, products for administering eye drops, and products for storing contact lenses are provided. Compositions include solutions that can contain an effective amount of cysteamine to treat cystinosis, and an oil with a lower density than the solution. Also provided is a product including a bottle for containing a solution, the bottle being substantially free of O2. Also provided is a contact lens holder for storing one or more contact lenses in a solution, the holder including barrier layers reducing the amount of O2 entering the contact lens holder.
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公开(公告)号：US20220079890A1
公开(公告)日：2022-03-17
申请号：US17456956
申请日：2021-11-30
Inventor： Anuj Chauhan , Robert A. Damitz
Abstract: Disclosed herein is a composition comprising a biologically active agent; a base oil; an additional oil that is soluble in the base oil with a partition coefficient for the biologically active molecule that is at least twice that of the base oil; where the base oil and the additional oil are present in the composition in an amount effective to reduce the amount of the biologically active agent in an aqueous phase to less than 80 wt % of the amount with just the base oil present in an otherwise identical composition at the same total oil loading; a non-ionic surfactant; and water.
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公开(公告)号：US20200156336A1
公开(公告)日：2020-05-21
申请号：US16690324
申请日：2019-11-21
Inventor： Anuj Chauhan , Phillip J. Dixon , Poorvajan Sekar
Abstract: In general, the disclosure relates to methods and compositions for preparing colorants useful for preparing pigmented hydrogels. The disclosure further relates to pigmented hydrogels comprising the disclosed colorants. In some instances, the colorant is an alcohol extract of an agro-material, such as turmeric, paprika, spinach, and/or woad or the colorants comprise one or more of: a carotenoid, chlorophyll-a, chlorophyll-b, a curcumoid, or indigorubin. Alternatively, the colorant can be carbon black. The disclosure further relates to contact lenses comprising the disclosed pigmented hydrogels.
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Patent Agency Ranking
公开(公告)号：US10123904B2
公开(公告)日：2018-11-13
申请号：US15502876
申请日：2015-08-12
Inventor： Anuj Chauhan , Kuan-Hui Hsu
IPC: A61F9/008 , A61K31/5377 , A61K31/382 , A61F9/00 , A61J1/14 , A61K31/5575 , A61K31/573 , A61K47/18 , A61K9/00 , C08J9/28 , B01D15/00 , B01J20/26
Abstract: A BAK removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 μm and the plug has a surface area of 30 mm2 to 2 mm2 and a length of 2 mm to 25 mm and wherein the microparticles of a hydrophilic polymeric gel has a pore radius of 3 to 60 μm.
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公开(公告)号：US20140288206A1
公开(公告)日：2014-09-25
申请号：US14296899
申请日：2014-06-05
Inventor： Anuj Chauhan , Hyun-Jung Jung , Samuel B. Gause
CPC classification number: G02C7/108 , B29D11/00038 , B29D11/00346 , B29D11/00634 , B29K2083/00 , B82Y20/00 , B82Y30/00 , G02B1/043 , G02C7/049 , Y10S977/834 , Y10T428/2982 , C08L101/14 , C08L33/08 , C08L33/26 , C08L33/10
Abstract: UV absorbing appliances, such as contact lenses, are prepared by including at least one UV absorbing compound in the appliances. UV absorbing compounds can be water insoluble and/or reside in UV absorbing nanoparticles having a mean diameter less than 10 nm. The UV absorbing nanoparticles incorporate into an appliance by polymerizing a monomer mixture containing the UV absorbing nanoparticles to form an appliance comprising the UV absorbing nanoparticles. The UV absorbing compounds or the UV absorbing nanoparticles incorporate into an appliance by placing the appliance in a solution of the UV absorbing compound or a dispersion of the UV absorbing nanoparticles in a non-aqueous solvent that swells the appliance. The UV absorbing compound or the UV absorbing nanoparticles infuse into the swollen appliance and are retained within the appliance upon removal of the non-aqueous solvent.
Abstract translation: 通过在器具中包含至少一种UV吸收化合物来制备紫外线吸收器具，例如隐形眼镜。 UV吸收化合物可以是水不溶性的和/或驻留在平均直径小于10nm的UV吸收纳米颗粒中。 UV吸收纳米颗粒通过聚合含有UV吸收纳米颗粒的单体混合物结合到器具中以形成包含UV吸收纳米颗粒的器具。 UV吸收化合物或UV吸收纳米颗粒通过将该器具放置在UV吸收化合物或UV吸收纳米颗粒的分散体的溶液中而溶解在器具中，使其溶解在使水分膨胀的非水溶剂中。 UV吸收化合物或UV吸收纳米粒子注入溶胀的器具中，并且在除去非水溶剂后保留在器具内。
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公开(公告)号：US12186425B2
公开(公告)日：2025-01-07
申请号：US17455359
申请日：2021-11-17
Inventor： Anuj Chauhan , Phillip J. Dixon
IPC: A61K9/00 , A61K9/14 , A61K33/242 , A61K47/32 , B29D11/00
Abstract: According to some aspects, this application provides devices and methods for treating cystinosis in a patient. Removable intra-ocular devices and contact lenses containing cystine-sequestering materials effective for uptake of cystine from the eyes of a patient having cystinosis are provided. Methods of making the cystine-sequestering contact lenses are also provided.
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公开(公告)号：US12171875B2
公开(公告)日：2024-12-24
申请号：US17809717
申请日：2022-06-29
Inventor： Anuj Chauhan , Russell Macoon
Abstract: In one aspect, the disclosure relates to compositions for the extended release of drugs in the retina. In a further aspect, the present disclosure provides methods of preparing extended release compositions comprising a therapeutic agent for use in retinal drug delivery. In various other aspects, the present disclosure provides methods for delivery of the disclosed compositions comprising a therapeutic agent to the retina via intravitreal injection. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US20220413189A1
公开(公告)日：2022-12-29
申请号：US17929349
申请日：2022-09-02
Inventor： Anuj Chauhan , Kuan-Hui Hsu , Yifan Yu
Abstract: In one aspect, the present disclosure relates to a contact lens comprising a disclosed lubricious surface layer. In a further aspect, the lubricious surface layer comprises a polyacrylamide, e.g., a poly(N,N-dimethylacrylamide. In various aspects, the lubricious surface layer is formed at the surface of a contact lens. In a further aspect, the lens can be a hydrogel lens. In a further aspect, the lens can be a silicone hydrogel lens. The present disclosure also pertains to methods of forming the disclosed lubricious surface layers on a surface of a contact lens. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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