公开(公告)号：US11204409B2

公开(公告)日：2021-12-21

申请号：US16599853

申请日：2019-10-11

Applicant: University of Virginia Patent Foundation

Inventor： Luonan Wang ,  Daniel Stuart Weller ,  John P. Mugler, III ,  Craig H. Meyer

IPC: G01V3/00 ,  G01R33/565 ,  G01R33/58 ,  G01R33/567 ,  G01R33/561 ,  G01R33/563

Abstract: Systems and methods for reconstructing a motion-compensated magnetic resonance image are presented. In certain implementations, a computer-implemented method is provided. The method may include a plurality of operations, including receiving a set of k-space data from a magnetic resonance imaging device, dividing the set of k-space data into a plurality of groups, performing a plurality of initialization operations, performing a first iterative process until a first criteria for the first iterative process is achieved for a current scale of motion estimation, performing a second iterative process until a second criteria for the second iterative process is achieved, and outputting a motion-compensated magnetic resonance image reconstructed in accordance with a predetermined scale of motion estimation.

公开(公告)号：US20190279361A1

公开(公告)日：2019-09-12

申请号：US16295939

申请日：2019-03-07

Applicant: University of Virginia Patent Foundation

Inventor： Craig H. Meyer ,  Anudeep Konda ,  Christopher M. Kramer ,  Xue Feng

IPC: G06T7/00 ,  G06T7/11 ,  G06T7/62 ,  G06T7/13 ,  G06T7/70 ,  G06K9/62 ,  A61B5/029 ,  A61B5/026 ,  A61B5/00 ,  A61B5/107

Abstract: In one aspect the disclosed technology relates to embodiments of a method which, includes acquiring magnetic resonance imaging data, for a plurality of images, of the heart of a subject. The method also includes segmenting, using cascaded convolutional neural networks (CNN), respective portions of the images corresponding to respective epicardium layers and endocardium layers for a left ventricle (LV) and a right ventricle (RV) of the heart. The segmenting is used for extracting biomarker data from segmented portions of the images and, in one embodiment, assessing hypertrophic cardiomyopathy from the biomarker data. The method further includes segmenting processes for T1 MRI data and LGE MRI data.

公开(公告)号：US10143384B2

公开(公告)日：2018-12-04

申请号：US14677905

申请日：2015-04-02

Applicant: University of Virginia Patent Foundation

Inventor： Xiao Chen ,  Frederick H. Epstein ,  Yang Yang ,  Michael Salerno ,  Craig H. Meyer

IPC: G01V3/00 ,  A61B5/02 ,  A61B5/055 ,  G01R33/561 ,  G01R33/48 ,  G01R33/54 ,  G01R33/56 ,  A61B5/00

Abstract: Some aspects of the present disclosure relate to accelerated imaging using variable-density sampling and compressed sensing with parallel imaging. In one embodiment, a method includes acquiring magnetic resonance data associated with a physiological activity in an area of interest of a subject. The acquiring includes performing accelerated variable-density sampling with phase-contrast displacement encoding. The method also includes reconstructing, from the acquired magnetic resonance data, images corresponding to the physiological activity in the area of interest. The reconstructing includes performing parallel imaging and compressed sensing.

公开(公告)号：US09989611B2

公开(公告)日：2018-06-05

申请号：US14677877

申请日：2015-04-02

Applicant: University of Virginia Patent Foundation

Inventor： Li Zhao ,  Craig H. Meyer

IPC: G01V3/00 ,  G01R33/561 ,  G01R33/48

CPC classification number: G01R33/5611 ,  G01R33/4818 ,  G01R33/4824

Abstract: In image reconstruction using a variable-density spiral trajectory, a method includes acquiring magnetic resonance (MR) data, which includes determining a multi-level undersampling pattern based on sampling distance and probability functions, and determining a desired variable-density spiral trajectory based on the undersampling pattern. Acquiring the MR data also includes generating spiral gradient waveforms based on the desired trajectory, and tracing a variable-density spiral trajectory using the spiral gradient waveforms. After tracing, the MR data can be sub-sampled based on the variable-density spiral trajectory. One or more images can be reconstructed based on the acquired MR data.

公开(公告)号：US09953439B2

公开(公告)日：2018-04-24

申请号：US14952859

申请日：2015-11-25

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Michael Salerno ,  Craig H. Meyer ,  Xiao Chen ,  Yang Yang ,  Frederick H. Epstein ,  Christopher M. Kramer

IPC: G06K9/00 ,  G06T11/00 ,  A61B5/055 ,  A61B5/00 ,  A61B5/026 ,  G01R33/48 ,  G01R33/56 ,  G01R33/561 ,  G01R33/563

CPC classification number: G06T11/003 ,  A61B5/0044 ,  A61B5/0263 ,  A61B5/055 ,  G01R33/4826 ,  G01R33/5601 ,  G01R33/5611 ,  G01R33/56366

Abstract: Some aspects of the present disclosure relate to systems and methods for three-dimensional spiral perfusion imaging. In one embodiment, a method for perfusion imaging of a subject includes acquiring perfusion imaging data associated with the heart of a subject. The acquiring includes applying an imaging pulse sequence with a three-dimensional stack-of-spirals trajectory. The method also includes reconstructing perfusion images from the acquired perfusion imaging data. The reconstructing includes parallel imaging and motion-guided compressed sensing. The method also includes determining, from the reconstructed perfusion images, absolute perfusion values based on time-intensity relationships to quantify myocardial blood flow of the heart of the subject, and generating a quantitative volumetric perfusion flow map based on the determined absolute perfusion values.

公开(公告)号：US09910118B2

公开(公告)日：2018-03-06

申请号：US13867922

申请日：2013-04-22

Applicant: University of Virginia Patent Foundation

Inventor： Xue Feng ,  Michael Salerno ,  Christopher M. Kramer ,  Craig H. Meyer

IPC: G01V3/00 ,  G01R33/48 ,  G01R33/56 ,  G01R33/563 ,  G01R33/561

CPC classification number: G01R33/482 ,  G01R33/5608 ,  G01R33/5611 ,  G01R33/56308

Abstract: Systems and methods for Cartesian dynamic imaging are disclosed. In one aspect, in accordance with one example embodiment, a method includes acquiring magnetic resonance data for an area of interest of a subject that is associated with one or more physiological activities of the subject and performing image reconstruction comprising Kalman filtering or smoothing on Cartesian images associated with the acquired magnetic resonance data. Performing the image reconstruction includes increasing at least one of spatial and temporal resolution of the Cartesian images.

公开(公告)号：US20150282733A1

公开(公告)日：2015-10-08

申请号：US14677915

申请日：2015-04-02

Applicant: University of Virginia Patent Foundation

Inventor： Samuel Fielden ,  Li Zhao ,  Wilson Miller ,  Xue Feng ,  Max Wintermark ,  Kim Butts Pauly ,  Craig H. Meyer

IPC: A61B5/055 ,  A61N7/02 ,  A61B5/01

CPC classification number: A61B5/055 ,  A61B5/015 ,  A61B5/725 ,  A61B2018/00791 ,  A61B2090/374 ,  A61N7/02

Abstract: Aspects of the present disclosure relate to magnetic resonance thermometry. In one embodiment, a method includes acquiring undersampled magnetic resonance data associated with an area of interest of a subject receiving focused ultrasound treatment, and reconstructing images corresponding to the area of interest based on the acquired magnetic resonance data, where the reconstructing uses Kalman filtering.

Abstract translation: 本公开的方面涉及磁共振测温。 在一个实施例中，一种方法包括获取与接收聚焦超声治疗的受试者的感兴趣区域相关联的欠采样磁共振数据，以及基于所获取的磁共振数据重构与所述感兴趣区域相对应的图像，其中所述重建使用卡尔曼滤波。

公开(公告)号：US20240219501A1

公开(公告)日：2024-07-04

申请号：US18402720

申请日：2024-01-02

Applicant: University of Virginia Patent Foundation

Inventor： Zhixing Wang ,  John P. Mugler, III ,  Craig H. Meyer ,  Adrienne E. Campbell

IPC: G01R33/563 ,  G01R33/56 ,  G01R33/561 ,  G01R33/565

CPC classification number: G01R33/56341 ,  G01R33/5608 ,  G01R33/5617 ,  G01R33/56509

Abstract: Acquiring magnetic resonance imaging (MRI) data includes steps of using a computer to implement software program steps in a diffusion preparation software component and a spiral ring echo readout software component. The method implements the diffusion preparation software component by (i) applying at least a first diffusion gradient and a last diffusion gradient along a selected direction; and (ii) applying a magnitude stabilizer gradient, along said selected direction, after the last diffusion gradient. The method implements the spiral ring echo readout software component by (i) applying a rephasing gradient along said selected direction after a refocusing RF pulse; (ii) applying a dephasing gradient along said selected direction prior to a subsequent refocusing RF pulse; and (iii) acquiring spiral ring echo readout data between the refocusing RF pulse and the subsequent refocusing RF pulse.

公开(公告)号：US11846692B2

公开(公告)日：2023-12-19

申请号：US17733967

申请日：2022-04-29

Applicant: University of Virginia Patent Foundation

Inventor： Quan Dou ,  Zhixing Wang ,  Xue Feng ,  John P. Mugler, III ,  Craig H. Meyer

IPC: G01R33/56 ,  G01R33/565 ,  G06T7/262

CPC classification number: G01R33/5608 ,  G01R33/56509 ,  G06T7/262 ,  G06T2207/10088 ,  G06T2207/20084

Abstract: Training a neural network to correct motion-induced artifacts in magnetic resonance images includes acquiring motion-free magnetic resonance image (MRI) data of a target object and applying a spatial transformation matrix to the motion-free MRI data. Multiple frames of MRI data are produced having respective motion states. A Non-uniform Fast Fourier Transform (NUFFT) can be applied to generate respective k-space data sets corresponding to each of the multiple frames of MRI; the respective k-space data sets can be combined to produce a motion-corrupted k-space data set and an adjoint NUFFT can be applied to the motion-corrupted k-space data set. Updated frames of motion-corrupted MRI data can be formed. Using the updated frames of motion corrupted MRI data, a neural network can be trained that generates output frames of motion free MRI data; and the neural network can be saved.

公开(公告)号：US20220373627A1

公开(公告)日：2022-11-24

申请号：US17732181

申请日：2022-04-28

Applicant: University of Virginia Patent Foundation

Inventor： Zhixing Wang ,  Steven P. Allen ,  Xue Feng ,  John P. Mugler, III ,  Craig H. Meyer

IPC: G01R33/48 ,  G01R33/561 ,  G01R33/56 ,  G01R33/54 ,  G01R33/565

Abstract: Methods, computing devices, and magnetic resonance imaging systems that improve image quality in turbo spiral echo (TSE) imaging are disclosed. With this technology, a TSE pulse sequence is generated that includes a series of radio frequency (RF) refocusing pulses to produce a corresponding series of nuclear magnetic resonance (NMR) spin echo signals. A gradient waveform including a plurality of segments is generated. The plurality of segments collectively comprise a spiral ring retraced in-out trajectory. During an interval adjacent to each of the series of RF refocusing pulses, a first gradient pulse is generated according to the gradient waveform. The first gradient pulses encode the NMR spin echo signals. An image is then constructed from digitized samples of the NMR spin echo signals obtained based at least in part on the encoding.