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公开(公告)号：US10245098B2
公开(公告)日：2019-04-02
申请号：US14017210
申请日：2013-09-03
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , John H. Rossmeisl , Paulo A. Garcia
Abstract: A method is provided for ablating brain tissue of a living mammal comprising: placing first and second electrodes in a brain of the living mammal; applying a plurality of electrical pulses through the first and second placed electrodes which are predetermined to: cause irreversible electroporation (IRE) of brain tissue of the mammal within a target ablation zone; and cause a temporary disruption of a blood brain barrier (BBB) within a surrounding zone that surrounds the target ablation zone to allow material in a blood vessel to be transferred to the surrounding zone through the temporarily disrupted BBB. Such methods are useful for delivering large molecule material within a blood vessel of the brain across the BBB, where the large molecule is otherwise blocked by the BBB from passing through the blood vessel into the brain.
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22.发明申请公开(公告)号：US20180125565A1
公开(公告)日：2018-05-10
申请号：US15843888
申请日：2017-12-15
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Rafael V. Davalos , John L. Robertson , Paulo A. Garcia , Robert E. Neal
Abstract: The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
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公开(公告)号：US20250152230A1
公开(公告)日：2025-05-15
申请号：US19026703
申请日：2025-01-17
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , John H. Rossmeisl , Paulo A. Garcia
Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.
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公开(公告)号：US20250120762A1
公开(公告)日：2025-04-17
申请号：US18930252
申请日：2024-10-29
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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公开(公告)号：US12232792B2
公开(公告)日：2025-02-25
申请号：US18502967
申请日：2023-11-06
Inventor： Robert E. Neal , Paulo A. Garcia , Rafael V. Davalos , Peter Callas
Abstract: The present invention relates to medical devices and methods for treating a lesion such as a vascular stenosis using non-thermal irreversible electroporation (NTIRE). Embodiments of the present invention provide a balloon catheter type NTIRE device for treating a target lesion comprising a plurality of electrodes positioned along the balloon that are electrically independent from each other so as to be individually selectable in order to more precisely treat an asymmetrical lesion in which the lesion extends only partially around the vessel.
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Patent Agency Ranking
公开(公告)号：US20250000569A1
公开(公告)日：2025-01-02
申请号：US18767746
申请日：2024-07-09
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Paulo A. Garcia , John L. Robertson , John H. Rossmeisl , Robert E. Neal, II
Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
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公开(公告)号：US11952568B2
公开(公告)日：2024-04-09
申请号：US16375878
申请日：2019-04-05
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
CPC classification number: C12N13/00 , A61B18/12 , A61B34/10 , A61B2018/00613 , A61B2034/104 , A61B2034/105 , A61N1/0412 , G16H50/50
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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28.发明公开公开(公告)号：US20240074804A1
公开(公告)日：2024-03-07
申请号：US18502967
申请日：2023-11-06
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal , Paulo A. Garcia , Rafael V. Davalos , Peter Callas
CPC classification number: A61B18/00 , A61B18/1492 , A61B2018/0022 , A61B2018/00613 , A61B2018/00767 , A61B2018/00875 , A61B2018/1467 , A61B2090/3966
Abstract: The present invention relates to medical devices and methods for treating a lesion such as a vascular stenosis using non-thermal irreversible electroporation (NTIRE). Embodiments of the present invention provide a balloon catheter type NTIRE device for treating a target lesion comprising a plurality of electrodes positioned along the balloon that are electrically independent from each other so as to be individually selectable in order to more precisely treat an asymmetrical lesion in which the lesion extends only partially around the vessel.
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公开(公告)号：US20220022945A9
公开(公告)日：2022-01-27
申请号：US16152743
申请日：2018-10-05
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Paulo A. Garcia , Christopher B. Arena , Michael B. Sano , Rafael V. Davalos
IPC: A61B18/14
Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.
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30.发明申请公开(公告)号：US20200323576A1
公开(公告)日：2020-10-15
申请号：US16865772
申请日：2020-05-04
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal , Paulo A. Garcia , Rafael V. Davalos , Peter Callas
Abstract: The present invention relates to medical devices and methods for treating a lesion such as a vascular stenosis using non-thermal irreversible electroporation (NTIRE). Embodiments of the present invention provide a balloon catheter type NTIRE device for treating a target lesion comprising a plurality of electrodes positioned along the balloon that are electrically independent from each other so as to be individually selectable in order to more precisely treat an asymmetrical lesion in which the lesion extends only partially around the vessel.
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