公开(公告)号：US11794200B2

公开(公告)日：2023-10-24

申请号：US17155462

申请日：2021-01-22

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Emrys Jones ,  Steven Derek Pringle ,  Stephen Hattan ,  Gregory T. Roman

IPC: B05B5/03 ,  B05B12/32

CPC classification number: B05B5/03 ,  B05B12/32

Abstract: A sprayer assembly for an ion source is disclosed. The sprayer includes a capillary having an outlet, a sheath for the capillary, and an elastic member. The sheath can move relative to the capillary between a first position in which the sheath covers the outlet of the capillary and a second position in which the outlet of the capillary is exposed. When the sheath moves from the first position to or towards the second position, the elastic member provides a restoring force that acts to restore the position of the sheath to or towards the first position.

公开(公告)号：US11506641B2

公开(公告)日：2022-11-22

申请号：US17583559

申请日：2022-01-25

Applicant: Waters Technologies Corporation

Inventor： Sylvain Gilles Cormier ,  Charles T. Murphy ,  Joseph D. Michienzi

IPC: G01N30/20

Abstract: A rotary valve that includes a stator, a rotor and a plurality of sample channels. The stator includes a stator surface having an inlet port, an outlet port and a plurality of selectable ports. The rotor includes a rotor surface having a first rotor channel and a second rotor channel. The rotor is configurable in a plurality of rotor positions, each of which couples the inlet port to one of the selectable ports through the first rotor channel and couples the outlet port to another one of the selectable ports through the second rotor channel. The two selectable ports are coupled to each other through one of the sample channels. The rotor has a bypass state defined by a rotor position, or angular range of rotor positions, at which the inlet port is coupled to the outlet port through the second rotor channel.

公开(公告)号：US20220128527A1

公开(公告)日：2022-04-28

申请号：US17512864

申请日：2021-10-28

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Michael O. Fogwill

IPC: G01N30/60

Abstract: The exemplary embodiments provide chromatography column positioning assemblies that can ensure that the distance between face seals or other sealing surfaces/mechanisms at the respective ends of a liquid chromatography column is a desired distance (i.e., the length of the liquid chromatography column). The exemplary embodiments can adjust the separation between the face seals to accommodate different length liquid chromatography columns. For example, a chromatography column positioning assembly of an exemplary embodiment can set the distance between face seals to accommodate a 25 mm column, a 50 mm column or a 100 mm column.

公开(公告)号：US20210389284A1

公开(公告)日：2021-12-16

申请号：US17347807

申请日：2021-06-15

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Wade P. Leveille ,  Joseph D. Michienzi ,  Fabrice Gritti

IPC: G01N30/30

Abstract: Exemplary embodiments may compensate for expected frictional heating or Joule-Thomson cooling in chromatography columns. Frictional heating or Joule Thomson cooling are the same thing for a fluid decompressing along a porous material. Either heat is absorbed from or released to the external environment. The exemplary embodiments may cool the mobile phase to a sub-ambient temperature before the mobile phase passes through a chromatography column to compensate for the frictional heating or heat the mobile phase to a super-ambient temperature to compensate for Joule-Thomson cooling. The amount of temperature increase expected from the frictional heating or the amount of temperature decrease expected from the Joule-Thomson cooling may be calculated or estimated. Based on the amount of temperature increase or decrease expected, the set point for the heater/cooler may be determined and applied to the mobile phase. The analyte may be injected solely into a central portion of the chromatography column to further compensate for thermal gradients.

公开(公告)号：US20210199624A1

公开(公告)日：2021-07-01

申请号：US17057361

申请日：2019-05-20

Applicant: Waters Technologies Corporation

Inventor： Martin Gilar ,  Thomas S. McDonald ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Rachel Mumma ,  Keith Fadgen ,  Geoff C. Gerhardt

IPC: G01N30/06 ,  G01N1/40 ,  G01N30/54 ,  G01N30/60 ,  B01J20/24 ,  B01J20/28 ,  B01J20/288 ,  B01J20/32 ,  B01D15/38 ,  B01D15/22 ,  B01D15/16

Abstract: Sample preparation and separation can be performed using a sample cartridge (201). The cartridge includes a barrel (204) with a first and second end, a column segment (209) connected to the second end of the barrel, and a column (205) containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.

公开(公告)号：US20200333301A1

公开(公告)日：2020-10-22

申请号：US16917178

申请日：2020-06-30

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  Geoff Gerhardt ,  James P. Murphy

IPC: G01N30/32 ,  B01D15/16 ,  G01N30/86 ,  B01D15/08 ,  B01D15/40

Abstract: Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column. A method for configuring a chromatography system with independent control of system pressure and mass flow rate of a compressible mobile phase includes determining a type of chromatography separation column to be used in the chromatography system, matching a thermally modulated variable restrictor to the type of chromatography separation column for use together during operation of the chromatography system, and bundling the chromatography column with its matching thermally modulated variable restrictor for distribution as a single package.

公开(公告)号：US20190383277A1

公开(公告)日：2019-12-19

申请号：US16444180

申请日：2019-06-18

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Jacob N. Fairchild ,  Jeffrey Musacchio ,  Joseph D. Michienzi

IPC: F04B25/00 ,  F16K15/03

Abstract: Described is a multi-stage pump having at least two stages. The multi-stage pump includes a first pump stage and a second pump stage each having a chamber of different diameter and volume. The multi-stage pump also includes a plunger having first and second plunger sections. The first plunger section has a first plunger diameter, a first end configured for coupling to a drive mechanism, and a second end opposite to the first end. The second plunger section has a second plunger diameter that is less than the first plunger diameter, a third end in contact with the second end of the first plunger, and a fourth end opposite the third end. Movement of the plunger produces a displacement volume for the first chamber that is different than a displacement volume produced for the second chamber. The multi-stage pump can be configured in different operational modes to provide different flow rates.

公开(公告)号：US10401332B2

公开(公告)日：2019-09-03

申请号：US15062405

申请日：2016-03-07

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  Joshua A. Shreve ,  Abhijit Tarafder

IPC: G01N30/30 ,  G01N30/02 ,  G01N30/54 ,  B01D15/40 ,  B01D15/16 ,  H01L33/64

Abstract: A system and method of reducing chromatographic band broadening within a separation column include passing a mobile phase through a length of a separation column, and generating a spatial thermal gradient external to and along the length of the separation column. The spatial thermal gradient is specifically configured to counteract a particular change in a property of the mobile phase as the mobile phase passes through the separation column. For example, the particular change counteracted may be a change in density or in temperature of the mobile phase. For analytical-scale columns, for example, the spatial thermal gradient may be configured to produce temperatures external to and along the length of the separation column that substantially matches temperatures predicted to form in the mobile phase along the column length as the mobile phase passes through the separation column, thereby substantially preventing formation of a radial thermal gradient in the mobile phase.

公开(公告)号：US20190086373A1

公开(公告)日：2019-03-21

申请号：US16197601

申请日：2018-11-21

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

IPC: G01N30/84 ,  G01N30/68 ,  G01N27/62

CPC classification number: G01N30/84 ,  G01N27/626 ,  G01N30/68 ,  G01N2030/8435

Abstract: The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol. Upon exiting a chromatographic column, the mobile phase containing the polar modifier is flowed through an oxidizer that contains a catalyst to oxidize at least a portion of the polar modifier to a species that does not interfere with the function of the flame-based detector. The oxidizer allows for flame-based detection, such as flame ionization detection, in applications in which a polar modifier with a reduced form of carbon is used.

公开(公告)号：US10155177B2

公开(公告)日：2018-12-18

申请号：US14747074

申请日：2015-06-23

Applicant: Waters Technologies Corporation

Inventor： David P. Prentice ,  Russell L. Keene ,  Stanislaw Koziol ,  Joseph D. Michienzi ,  Paul E. Linderson ,  Gary W. Bertone

IPC: B01D15/10 ,  B01L3/00 ,  G01N30/60 ,  G01N30/72 ,  H01J49/16 ,  G01N27/447 ,  B05B1/02 ,  B05B1/00

Abstract: A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate.