公开(公告)号：US11994502B2

公开(公告)日：2024-05-28

申请号：US17340264

申请日：2021-06-07

申请人： Snapdragon Chemistry, Inc.

发明人： Adrian G. Amador ,  Yuanqing Fang ,  David D. Ford ,  Mikhail V. Goncharuk ,  Grace Russell

IPC分类号： G01N30/30 ,  G01N30/02 ,  G01N30/32 ,  G01N30/84 ,  G01N30/88

CPC分类号： G01N30/88 ,  G01N30/30 ,  G01N30/32 ,  G01N30/84 ,  G01N2030/027 ,  G01N2030/324 ,  G01N2030/8435 ,  G01N2030/8804 ,  G01N2030/8809

摘要： The present disclosure relates to a computer-implemented method for analyzing a product stream of a chemical reaction. The method includes withdrawing a portion of the product stream of the chemical reaction from a reactor, the portion of the product stream having a volume of less than about 200 μL. The method further includes mixing the portion of the product stream with a diluent to produce a sample and then transferring the sample to a liquid chromatography device. A measured chemical profile is then developed, via the liquid chromatography device, which can be used for process monitoring or real time decision making. In some embodiments, the method can include adjusting a reaction condition in the reactor based on differences between the measured chemical profile and a desired chemical profile.

公开(公告)号：US20190086373A1

公开(公告)日：2019-03-21

申请号：US16197601

申请日：2018-11-21

申请人： Waters Technologies Corporation

发明人： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

IPC分类号： G01N30/84 ,  G01N30/68 ,  G01N27/62

CPC分类号： G01N30/84 ,  G01N27/626 ,  G01N30/68 ,  G01N2030/8435

摘要： The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol. Upon exiting a chromatographic column, the mobile phase containing the polar modifier is flowed through an oxidizer that contains a catalyst to oxidize at least a portion of the polar modifier to a species that does not interfere with the function of the flame-based detector. The oxidizer allows for flame-based detection, such as flame ionization detection, in applications in which a polar modifier with a reduced form of carbon is used.

公开(公告)号：US20180346957A1

公开(公告)日：2018-12-06

申请号：US16053906

申请日：2018-08-03

申请人： Rodolfo Cesar BELLINZONI ,  Nicolás MAGI ,  Emmanuel Gérard Etienne RÉGULIER ,  Ana ROMO ,  Marcelo Arnolfo SPITTELER

发明人： Rodolfo Cesar BELLINZONI ,  Nicolás MAGI ,  Emmanuel Gérard Etienne RÉGULIER ,  Ana ROMO ,  Marcelo Arnolfo SPITTELER

IPC分类号： C12Q1/06 ,  G01N30/74 ,  B01D15/18 ,  B01D15/34 ,  C12Q1/04 ,  G01N15/02 ,  G01N30/46 ,  G01N30/84 ,  G01N30/60 ,  G01N30/78 ,  G01N15/00 ,  G01N30/02

CPC分类号： C12Q1/06 ,  B01D15/1864 ,  B01D15/1885 ,  B01D15/34 ,  C12Q1/04 ,  G01N15/0205 ,  G01N30/468 ,  G01N30/6043 ,  G01N30/74 ,  G01N30/78 ,  G01N30/84 ,  G01N2015/0065 ,  G01N2030/027 ,  G01N2030/8429 ,  G01N2030/8435 ,  G01N2333/005

摘要： The present invention provides a high throughput method to quantify and characterize the size and integrity of viruses and viral molecules. In one embodiment, the present invention provides a method to quantify and characterize size and integrity of Foot and Mouth Disease virus (FMDV) using chromatographic system and in-line Dynamic Light Scattering (DLS) technique. In one embodiment, the present invention further comprises a column-switching system for running multiple analyses simultaneously. The present invention also provides a method to develop and evaluate FMDV containing products for preventing Foot and Mouth Disease (FMD). In one embodiment, the methods described herein assess the stability of FMDV. In another embodiment, the methods described herein serve as in-process quality control for a manufacturing process of FMD vaccine.

公开(公告)号：US20160274072A1

公开(公告)日：2016-09-22

申请号：US15002070

申请日：2016-01-20

申请人： Activated Research Company, LLC

发明人： Andrew JONES

IPC分类号： G01N30/68 ,  B29C67/00 ,  G01N31/10

CPC分类号： G01N30/68 ,  B22F3/1055 ,  B29L2031/752 ,  B33Y80/00 ,  G01N30/84 ,  G01N2030/8435

摘要： Provided is a system comprising a conduit from a gas chromatograph column to a single reactor comprising a Fe, Co, Pt, Ni, Rh, Pd and/or Ru catalyst(s), with hydrogen and oxygen feed conduits for providing hydrogen and oxygen to the reactor, and a conduit from the reactor to an FID detector. This allows one to practice a method for the detection and quantification of organic molecules from a gas chromatograph which comprises passing the effluent from a gas chromatograph column to a reactor comprising a Fe, Co, Pt, Ni, Rh, Pd and/or Ru catalyst; adding hydrogen and air/oxygen to the reactor; reacting the effluent from the gas chromatograph column in the reactor to sequentially oxidize then reduce all organic containing molecules to CH4 by heating to an elevated temperature, and passing the reactor effluent to an FID.

摘要翻译： 提供了一种系统，其包括从气相色谱柱到包含Fe，Co，Pt，Ni，Rh，Pd和/或Ru催化剂的单个反应器的管道，具有用于向氢气和氧气供应氢气和氧气的管道 反应器和从反应器到FID检测器的导管。 这允许从气相色谱仪中实施用于检测和定量有机分子的方法，该方法包括将来自气相色谱仪柱的流出物传送到包含Fe，Co，Pt，Ni，Rh，Pd和/或Ru催化剂的反应器 ; 向反应器中加入氢气和空气/氧气; 使来自反应器中的气相色谱柱的流出物依次氧化，然后通过加热至高温将所有含有机物的分子还原成CH 4，并将反应器流出物送至FID。

公开(公告)号：US20120128533A1

公开(公告)日：2012-05-24

申请号：US13386789

申请日：2010-05-26

申请人： Kisaburo Deguchi ,  Hironori Kaji ,  Kimihiko Ishii ,  Daisuke Akieda ,  Kunihiko Takao ,  Masaru Yamasaki ,  Kenji Hiraku ,  Yoshihiro Nagaoka

发明人： Kisaburo Deguchi ,  Hironori Kaji ,  Kimihiko Ishii ,  Daisuke Akieda ,  Kunihiko Takao ,  Masaru Yamasaki ,  Kenji Hiraku ,  Yoshihiro Nagaoka

IPC分类号： G01N31/00 ,  F16K15/00

CPC分类号： F04B23/06 ,  F04B13/00 ,  F04B49/08 ,  F04B49/22 ,  F04B2205/05 ,  F16K15/04 ,  F16K37/0058 ,  G01N30/32 ,  G01N30/74 ,  G01N2030/328 ,  G01N2030/8435 ,  Y10T137/7838

摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.

摘要翻译： 可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。 在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接 检测到。 止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

公开(公告)号：US08007742B2

公开(公告)日：2011-08-30

申请号：US11438390

申请日：2006-05-23

申请人： Stephen E. Long ,  David M. Bunk ,  Mariana Arce-Osuna

发明人： Stephen E. Long ,  David M. Bunk ,  Mariana Arce-Osuna

IPC分类号： G01N30/72

CPC分类号： G01N30/84 ,  G01N30/7273 ,  G01N2030/8435 ,  H01J49/0431 ,  Y10T436/24 ,  Y10T436/25125 ,  Y10T436/25375

摘要： A digester-evaporator for partially digesting a sample and for evaporating the solvent after partial digestion. The digester includes at least one reaction coil; a heating element arranged along a portion of the reaction coil; at least a portion of the reaction coil proximate to its output being preheated by the heating element to a degree sufficient to convert a partially digested sample into vapor; a collector spoon with carrier water for collecting sample vapor; and an evaporator portion including an evaporation chamber including a substantially vertically-oriented tube The collector spoon is arranged in the top of the substantially vertically-oriented tube, and a gas supply tube for supplying a preheated gas provided in a top of the substantially vertically-oriented tube so as to create a cyclonic gas flow into the chamber and carry the sample to a container area in a bottom portion of the chamber.

摘要翻译： 用于部分消化样品并在部分消化后蒸发溶剂的消化器 - 蒸发器。 消化器包括至少一个反应线圈; 沿所述反应线圈的一部分布置的加热元件; 靠近其输出的反应线圈的至少一部分被加热元件预热到足以将部分消化的样品转化为蒸气的程度; 收集器勺子，带有载体水，用于收集样品蒸气; 以及蒸发器部分，其包括包括基本上垂直取向的管的蒸发室。收集器勺被布置在基本垂直取向的管的顶部中，并且气体供应管用于提供设置在基本垂直取向的管的顶部中的预热气体， 以便产生旋转气流进入腔室并将样品运送到腔室底部的容器区域。

公开(公告)号：US20090278055A1

公开(公告)日：2009-11-12

申请号：US12116887

申请日：2008-05-07

申请人： Gary Lynn Emmert ,  Paul Steven Simone, JR.

发明人： Gary Lynn Emmert ,  Paul Steven Simone, JR.

IPC分类号： G01J1/58 ,  G01N1/00

CPC分类号： G01N30/96 ,  G01N30/74 ,  G01N30/84 ,  G01N2030/8435

摘要： Post-column reaction-ion chromatography (PCR-IC) analysis of drinking water samples for quantity measurements and species identification of haloacetic acid contaminants therein is provided. With the necessity to chlorinate drinking water to remove harmful bacteria and other potential toxins, haloacetic acid byproducts are generated that may harm humans after consumption as well. A reliable manner of measuring such drinking water supplies for haloacetic acids at locations far from the source and closer to dispensers is highly desirable. The PCR-IC analysis method of the invention has been found to be nearly as reliable as source measuring methods for the same purpose, but with the versatility to measure for such haloacetic acid contaminants anywhere along the drinking water supply line.

摘要翻译： 提供饮用水样品的柱后反应离子色谱（PCR-IC）分析，用于数量测量和其中卤代乙酸污染物的物种鉴定。 由于需要对饮用水进行氯化除去有害细菌和其他潜在的毒素，所以产生的卤代乙酸副产物也会在消费后对人造成伤害。 非常需要一种可靠的方法来测量这样的饮用水供应的卤代乙酸在远离源和更靠近分配器的位置。 已经发现本发明的PCR-IC分析方法几乎与用于相同目的的源测量方法一样可靠，但是具有在沿着饮用水供应管线的任何地方测量这些卤代乙酸污染物的通用性。

公开(公告)号：US20060218990A1

公开(公告)日：2006-10-05

申请号：US11391432

申请日：2006-03-29

申请人： Shuichi Kawana

发明人： Shuichi Kawana

IPC分类号： G01N30/02 ,  G01N30/90

CPC分类号： G01N30/7206 ,  G01N30/8672 ,  G01N2030/8435

摘要： A method of gas chromatograph mass spectrometry with a negative chemical ionization (NCI) process includes analyzing a standard substance for the NCI by deriving with a derivatization reagent a fatty acid with a multiple number of carbon atoms, measuring the standard substance for the NCI by negative chemical ionization, and obtaining a retention time for each of the number of carbon atoms. The method includes measuring, under a same condition, a standard sample of each of from one to a plurality of measurement object components by negative chemical ionization, and obtaining a respective retention time for each of the measurement object components, and obtaining a retention index for the NCI of each measurement object component using the respective retention time of the measurement object component, and the retention time of the standard substance. The index facilitates both correcting the retention time of each measurement object component, and identifying substances.

摘要翻译： 用负化学电离（NCI）方法的气相色谱质谱法的方法包括用衍生化试剂衍生出具有多个碳原子的脂肪酸来分析NCI的标准物质，通过阴性测量NCI的标准物质 化学电离，并获得每个碳原子的保留时间。 该方法包括在相同条件下通过负化学电离测量从一个到多个测量对象部件的标准样品，并获得每个测量对象部件的相应保留时间，并获得保留指数 每个测量对象组件的NCI使用测量对象组分的相应保留时间和标准物质的保留时间。 该指标有助于校正每个测量对象组分的保留时间和识别物质。

公开(公告)号：US06855555B2

公开(公告)日：2005-02-15

申请号：US10327125

申请日：2002-12-24

申请人： Hirotaka Kakita ,  Hiroshi Kamishima

发明人： Hirotaka Kakita ,  Hiroshi Kamishima

IPC分类号： G01N21/15 ,  B01J20/283 ,  G01N30/26 ,  G01N30/74 ,  G01N30/84 ,  G01N30/88 ,  G01N30/38

CPC分类号： G01N30/84 ,  G01N2030/8435 ,  Y10T436/143333 ,  Y10T436/144444

摘要： In conducting liquid chromatographic analysis of a saccharide mixture containing monosaccharides and oligosaccharides, elution is conducted by using two kinds or more of mobile phases to separate the saccharide mixture into individual constituent saccharides followed by conversion thereof into corresponding derivatives by reaction with reagents and detection of the derivatives as contained in a detector cell. The method of the invention is characterized in that the detector cell is cleaned by washing with a cleaning solvent after completion of the detection of each of the saccharide derivatives. The invention also provides an apparatus for efficiently conducting the above-mentioned inventive method comprising an analytical column, a reactor for converting the separated constituent saccharides into the derivatives, detector cell for containing the derivative, a detector for detecting the derivative contained in the detector cell, a solvent-feed means to introduce a cell-cleaning solvent into the cell and a flow channel-switching means.

摘要翻译： 在对含有单糖和寡糖的糖类混合物进行液相色谱分析时，通过使用两种以上的流动相进行洗脱，将糖类混合物分离为各成分糖类，然后通过与试剂反应转化成相应的衍生物， 衍生物包含在检测器单元中。 本发明的方法的特征在于，检测单元在完成每种糖衍生物的检测后用清洗溶剂进行清洗。 本发明还提供了一种用于有效地进行上述本发明方法的装置，包括分析柱，用于将分离的组成糖转化为衍生物的反应器，用于包含衍生物的检测器单元，用于检测检测器单元中所含的衍生物的检测器 ，将细胞清洗溶剂引入细胞的溶剂进料装置和流路切换装置。

公开(公告)号：US20040009517A1

公开(公告)日：2004-01-15

申请号：US10434918

申请日：2003-05-09

发明人： J. Michael Ramsey

IPC分类号： C12Q001/68 ,  G01L001/20

CPC分类号： B01L3/5027 ,  B01F13/0059 ,  B01F13/0062 ,  B01F13/0076 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00853 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00912 ,  B01J2219/00916 ,  B01J2219/00952 ,  B01J2219/0097 ,  B01J2219/00995 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502753 ,  B01L3/502776 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/0421 ,  B29C65/4895 ,  B29C66/026 ,  B29C66/034 ,  B29C66/54 ,  G01N27/44743 ,  G01N27/44791 ,  G01N30/02 ,  G01N30/16 ,  G01N30/6095 ,  G01N2030/027 ,  G01N2030/162 ,  G01N2030/285 ,  G01N2030/383 ,  G01N2030/8435 ,  Y10S366/01 ,  B01D15/3842

摘要： A microchip apparatus and method provide fluidic manipulations for a variety of applications, including sample injection for microchip liquid chromatography. The microchip fabricated using standard photolithographic procedures chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis is performed in channels formed in the substrate. Injections are made by electro-osmotically pumping sample through the injection channel that crosses the separation channel, followed by a switching of the potentials to force a plug into the separation channel.

摘要翻译： 微芯片装置和方法为各种应用提供流体操作，包括用于微芯片液相色谱的样品注入。 使用标准光刻程序化学湿蚀刻制造的微芯片，其中基板和盖板使用直接接合连接。 在基底中形成的通道中进行毛细管电泳。 注射通过电渗透泵送样品通过穿过分离通道的注入通道，然后切换电位以迫使插塞进入分离通道。