公开(公告)号：US11998862B2

公开(公告)日：2024-06-04

申请号：US18179835

申请日：2023-03-07

Applicant: Waters Technologies Corporation

Inventor： Raymond P. Fisk ,  Timothy J. Becker ,  Mary Elizabeth Lame ,  Frank John Marszalkowski ,  Matthew A. Lauber

IPC: B01L3/00 ,  B01D15/12 ,  B01D15/14 ,  B01D15/22 ,  B01D15/38 ,  B01D15/42 ,  B01L3/02

CPC classification number: B01D15/3809 ,  B01D15/12 ,  B01D15/14 ,  B01D15/22 ,  B01D15/424 ,  B01L3/5023 ,  B01L3/0275 ,  B01L3/5021 ,  B01L2200/0631 ,  B01L2200/0668 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2400/0409 ,  B01L2400/0433

Abstract: The present disclosure pertains to sample preparation devices useful for affinity capture and purification that include one or more internal structures that comprise a reservoir, a well, a fluid passageway, sorbent particles, and a filter element that blocks passage of the affinity sorbent particles, which sample preparation devices combine the attributes of both dispersive and flow through designs into a single sample preparation device. The present disclosure also pertains to kits that contain and methods that use such sample preparation devices.

公开(公告)号：US20210322896A1

公开(公告)日：2021-10-21

申请号：US17231808

申请日：2021-04-15

Applicant: Waters Technologies Corporation

Inventor： Pamela C. Iraneta ,  Stephen James Shiner ,  Raymond P. Fisk ,  Lavelay Kizekai

IPC: B01D15/34 ,  B01D71/06 ,  B01J20/281

Abstract: This disclosure pertains to performance enhancing conditioning and storage solvents containing low levels of buffer and salt for reproducible and improved size exclusion chromatography (SEC). In some embodiments, the present disclosure pertains to storage solvents for protein-based size exclusion chromatography that comprise water, a water-miscible organic solvent, a phosphate salt, and a neutral salt. In some embodiments, the present disclosure pertains to columns for protein-based size exclusion chromatography that comprise porous particles and such a storage solvent

公开(公告)号：US10802002B2

公开(公告)日：2020-10-13

申请号：US15990097

申请日：2018-05-25

Applicant: Waters Technologies Corporation

Inventor： Joseph D. Michienzi ,  Keith Fadgen ,  Wade P. Leveille ,  Raymond P. Fisk ,  Frank John Marszalkowski, Jr.

IPC: G01N30/60 ,  B01D15/10 ,  B01D15/22 ,  B05B5/16 ,  G01N30/72 ,  B01D15/18

Abstract: Described is a chromatographic column assembly that includes an outer tube comprising a metal, a first conduit disposed within the outer tube, a second conduit disposed within the outer tube, and a first joint located between the first conduit and the second conduit. The outer tube is deformed by a first uniform radial crimp at a longitudinal location along the outer tube that surrounds the first conduit on a first side of the first joint, and a second uniform radial cramp at a longitudinal location along the outer tube that surrounds the second conduit on a second side of the first joint. The first and second uniform radial cramps form a fluid-tight seal between the first conduit and the second conduit and each have a substantially flat base region over which a diameter of the outer tube is reduced for a non-zero longitudinal length.

公开(公告)号：US20160096943A1

公开(公告)日：2016-04-07

申请号：US14967647

申请日：2015-12-14

Applicant: Waters Technologies Corporation

Inventor： Zhiping Jiang ,  John E. O'Gara ,  Raymond P. Fisk ,  Kevin D. Wyndham ,  Darryl W. Brousmiche

IPC: C08J9/35

CPC classification number: C08J9/35 ,  B01J20/26 ,  B01J20/265 ,  B01J20/28019 ,  B01J20/28042 ,  B01J20/285 ,  B01J20/286 ,  B01J2220/82 ,  C08F230/08 ,  C08G77/442 ,  C08J2329/04 ,  C08J2383/06 ,  C08L53/00 ,  C08L53/005 ,  Y10T428/2982 ,  C08L2666/02

Abstract: The present invention relates to porous inorganic/organic homogenous copolymeric hybrid material materials, including particulates and monoliths, methods for their manufacture, and uses thereof, e.g., as chromatographic separations materials.

Abstract translation: 本发明涉及多孔无机/有机均相共聚混合材料材料，包括颗粒和整料，其制造方法及其用途，例如作为色谱分离材料。