公开(公告)号：US20120188540A1

公开(公告)日：2012-07-26

申请号：US13014688

申请日：2011-01-26

Applicant: Alexandre M. Bratkovski ,  Wei Wu ,  Zhiyong Li

Inventor： Alexandre M. Bratkovski ,  Wei Wu ,  Zhiyong Li

IPC: G01J3/44 ,  B82Y20/00

CPC classification number: G01N21/658 ,  B82Y20/00

Abstract: A reconfigurable surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a stimulus responsive material to move nanorods of a plurality between inactive and active configurations. The apparatus includes the plurality of nanorods and the stimulus responsive material. The system further includes a Raman signal detector. The method of reconfigurable SERS includes providing the plurality of nanorods and exposing the stimulus responsive material to a stimulus. The exposure causes a change in one or more of a size, a shape and a volume of the stimulus responsive material that moves the nanorods between the inactive and active configurations. The active configuration facilitates one or both of production and detection of a Raman scattering signal emitted by the analyte.

Abstract translation: 可重新配置的表面增强拉曼光谱（SERS）装置，系统和方法使用刺激响应材料来移动多个非活动和活动配置之间的纳米棒。 该装置包括多个纳米棒和刺激响应材料。 该系统还包括拉曼信号检测器。 可重新配置的SERS的方法包括提供多个纳米棒并将刺激响应材料暴露于刺激。 暴露导致在非活性和活动配置之间移动纳米棒的刺激响应材料的尺寸，形状和体积中的一种或多种的变化。 活性配置有利于分析物发射的拉曼散射信号的生成和检测中的一个或两个。

公开(公告)号：US20120074378A1

公开(公告)日：2012-03-29

申请号：US12889389

申请日：2010-09-23

Applicant: Wei Wu ,  Jianhua Yang ,  Zhiyong Li ,  Shih-Yuan Wang ,  Dmitri Strukov ,  Alexandre Bratkovski

Inventor： Wei Wu ,  Jianhua Yang ,  Zhiyong Li ,  Shih-Yuan Wang ,  Dmitri Strukov ,  Alexandre Bratkovski

IPC: H01L45/00 ,  H01L25/03

CPC classification number: H01L27/10 ,  B82Y10/00 ,  G11C13/0016 ,  G11C13/0069 ,  G11C2013/0095 ,  H01L27/0688 ,  H01L27/105 ,  H01L27/115 ,  H01L27/11551 ,  H01L27/2472 ,  H01L27/2481 ,  H01L29/86 ,  H01L45/04 ,  H01L45/1233 ,  H01L45/14 ,  H01L45/146

Abstract: A memory element is provided that includes a first electrode, a second electrode, and an active region disposed between the first electrode and the second electrode, wherein at least a portion of the active region comprises an elastically deformable material, and wherein deformation of the elastically deformable material causes said memory element to change from a lower conductive state to a higher conductive state. A multilayer structure also is provided that includes a base and a multilayer circuit disposed above the base, where the multilayer circuit includes at least of the memory elements including the elastically deformable material.

Abstract translation: 提供了一种存储元件，其包括第一电极，第二电极和设置在第一电极和第二电极之间的有源区，其中有源区的至少一部分包括可弹性变形的材料，并且其中弹性变形 可变形材料使得所述存储元件从较低的导电状态变为较高的导电状态。 还提供了一种多层结构，其包括设置在基底之上的基底和多层电路，其中多层电路至少包括包括可弹性变形的材料的存储元件。

公开(公告)号：US20120026493A1

公开(公告)日：2012-02-02

申请号：US12847982

申请日：2010-07-30

Applicant: Michael J. Stuke ,  Michael R.T. Tan ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Wei Wu

Inventor： Michael J. Stuke ,  Michael R.T. Tan ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Wei Wu

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01N21/658

Abstract: Systems and methods employ a layer having a pattern that provides multiple discrete guided mode resonances for respective couplings of separated wavelengths into the layer. Further, a structure including features shaped to enhance Raman scattering to produce light of the resonant wavelengths can be employed with the patterned layer.

Abstract translation: 系统和方法采用具有图案的层，该图案为分离的波长的各个耦合提供到层中提供多个离散的引导模式谐振。 此外，可以使用包括成形为增强拉曼散射以产生谐振波长的光的特征的结构与图案化层。

公开(公告)号：US20110267608A1

公开(公告)日：2011-11-03

申请号：US12771779

申请日：2010-04-30

Applicant: Fung Suong Ou ,  Min Hu ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

Inventor： Fung Suong Ou ,  Min Hu ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

IPC: G01J3/44

CPC classification number: G01N21/658

Abstract: A tunable apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a deformable layer and a plurality of SERS-active nanoparticles disposed at one or more locations on the deformable layer, wherein the one or more locations are configured to be illuminated with light of a pump wavelength to cause Raman excitation light to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles. In addition, a morphology of the deformable layer is configured to be controllably varied to modify an intensity of the Raman scattered light produced from the molecules.

Abstract translation: 用于进行表面增强拉曼光谱（SERS）的可调谐装置包括可变形层和设置在可变形层上的一个或多个位置处的多个SERS活性纳米颗粒，其中所述一个或多个位置被配置为用 泵浦波长以使拉曼激发光与纳米颗粒相互作用，并从靠近纳米颗粒的分子产生增强的拉曼散射光。 此外，可变形层的形态被配置为可控地改变以改变由分子产生的拉曼散射光的强度。

公开(公告)号：US07405822B2

公开(公告)日：2008-07-29

申请号：US11584020

申请日：2006-10-20

Applicant: Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang

Inventor： Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: Raman spectroscopy systems include an analyte, a radiation source configured to emit incident radiation having a wavelength, and a detector that is capable of detecting only radiation having wavelengths within a detectable range that includes at least one wavelength corresponding to hyper Raman scattered radiation scattered by the analyte. The wavelength of the incident radiation is outside the detectable range. In particular systems, all wavelengths of radiation that are scattered in the direction of the detector impinge on the detector. Raman spectroscopy methods include providing an analyte and irradiating the analyte with incident radiation having a wavelength, providing a detector capable of detecting only wavelengths of radiation within a detectable range that does not include the wavelength of the incident radiation, and detecting Raman scattered radiation scattered by the analyte. A continuous path free of radiation filters may be provided between the analyte and the detector.

Abstract translation: 拉曼光谱系统包括分析物，被配置为发射具有波长的入射辐射的辐射源，以及检测器，其能够仅检测波长在可检测范围内的辐射，所述波长包括对应于由所述波长散射的超拉曼散射辐射的至少一个波长 分析物。 入射辐射的波长在可检测范围之外。 在特定系统中，在检测器的方向上散射的所有辐射波长都照射在检测器上。 拉曼光谱方法包括提供分析物并用具有波长的入射辐射照射分析物，提供检测器，该检测器仅能够检测不包括入射辐射波长的可检测范围内的辐射波长，并且检测散射的拉曼散射辐射 分析物。 可以在分析物和检测器之间提供不含辐射过滤器的连续路径。

公开(公告)号：US07385691B2

公开(公告)日：2008-06-10

申请号：US11044676

申请日：2005-01-27

Applicant: M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

Inventor： M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01J3/44 ,  H01L31/02325 ,  H01L31/105

Abstract: Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed on the substrate or apart from the substrate. The molecular analysis device also include a radiation receiver disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.

Abstract translation: 公开了用于增强拉曼光谱和超拉曼的装置，系统和方法。 用于执行拉曼光谱的分子分析装置包括设置在基板上的基板和激光源。 激光源可以被配置为发射激光辐射，其可照射设置在拉曼增强结构上的分析物。 拉曼增强结构可以设置在基板上或者离开基板。 分子分析装置还包括设置在基板上并被配置为用于接收可以通过分析物的照射和拉曼增强结构产生的拉曼散射辐射的辐射接收器。

公开(公告)号：US20060275778A1

公开(公告)日：2006-12-07

申请号：US11144586

申请日：2005-06-03

Applicant: Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Philip Kuekes

Inventor： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Philip Kuekes

IPC: C12Q1/68 ,  C12M1/34

CPC classification number: G01N33/48721 ,  B82Y5/00 ,  B82Y10/00 ,  G01N27/414

Abstract: Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a single electron transistor including a first terminal, a second terminal, and a nanogap or at least one quantum dot positioned between the first terminal and the second terminal. A nitrogenous material disposed on the at least one quantum dot is configured for an interaction with an identifiable configuration of a molecule. The molecule sensor develops an electronic effect responsive to the interaction. The molecule guide is configured for guiding at least a portion of the molecule substantially near the molecule sensor to enable the interaction.

Abstract translation: 公开了用于检测生物聚合物的组成部分的装置和方法。 分子分析装置包括分子传感器和分子引导件。 分子传感器包括单电子晶体管，其包括位于第一端子和第二端子之间的第一端子，第二端子和纳米隙隙或至少一个量子点。 设置在至少一个量子点上的含氮材料被配置用于与分子的可识别构型的相互作用。 分子传感器产生响应于相互作用的电子效应。 分子引导件被配置用于基本上在分子传感器附近引导分子的至少一部分，以实现相互作用。

公开(公告)号：US08477303B2

公开(公告)日：2013-07-02

申请号：US13014688

申请日：2011-01-26

Applicant: Alexandre M Bratkovski ,  Wei Wu ,  Zhiyong Li

Inventor： Alexandre M Bratkovski ,  Wei Wu ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y20/00

Abstract: A reconfigurable surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a stimulus responsive material to move nanorods of a plurality between inactive and active configurations. The apparatus includes the plurality of nanorods and the stimulus responsive material. The system further includes a Raman signal detector. The method of reconfigurable SERS includes providing the plurality of nanorods and exposing the stimulus responsive material to a stimulus. The exposure causes a change in one or more of a size, a shape and a volume of the stimulus responsive material that moves the nanorods between the inactive and active configurations. The active configuration facilitates one or both of production and detection of a Raman scattering signal emitted by the analyte.

Abstract translation: 可重新配置的表面增强拉曼光谱（SERS）装置，系统和方法使用刺激响应材料来移动多个非活动和活动配置之间的纳米棒。 该装置包括多个纳米棒和刺激响应材料。 该系统还包括拉曼信号检测器。 可重新配置的SERS的方法包括提供多个纳米棒并将刺激响应材料暴露于刺激。 暴露导致在非活性和活动配置之间移动纳米棒的刺激响应材料的尺寸，形状和体积中的一种或多种的变化。 活性配置有利于分析物发射的拉曼散射信号的生成和检测中的一个或两个。

公开(公告)号：US08462333B2

公开(公告)日：2013-06-11

申请号：US12905891

申请日：2010-10-15

Applicant: Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Michael Josef Stuke ,  Lars Helge Thylen ,  Fung Suong Ou ,  Min Hu

Inventor： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Michael Josef Stuke ,  Lars Helge Thylen ,  Fung Suong Ou ,  Min Hu

IPC: G01J3/44

CPC classification number: G01N21/658

Abstract: An apparatus for performing SERS includes a substrate and flexible nano-fingers, each of the nano-fingers having a first end attached to the substrate, a free second end, and a body portion extending between the first end and the second end, in which the nano-fingers are arranged in an array on the substrate. The apparatus also includes an active material layer disposed on each of the second ends of the plurality of nano-fingers, in which the nano-fingers are to be in a substantially collapsed state in which the active layers on at least two of the nano-fingers contact each other under dominant attractive forces between the plurality of nano-fingers and in which the active material layers are to repel each other when the active material layers are electrostatically charged.

Abstract translation: 用于执行SERS的装置包括基底和柔性纳米指，每个纳米指具有连接到基底的第一端，自由的第二端和在第一端和第二端之间延伸的主体部分，其中 纳米手指以阵列排列在基板上。 该装置还包括设置在多个纳米手指的每个第二端上的活性材料层，其中纳米指状物将处于基本上塌陷的状态，其中在至少两个纳米手指上的活性层， 手指在多个纳米手指之间的主导吸引力下彼此接触，并且当活性材料层被静电充电时，活性材料层将彼此排斥。

公开(公告)号：US08390804B2

公开(公告)日：2013-03-05

申请号：US12697136

申请日：2010-01-29

Applicant: Michael J. Stuke ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan (Sy) Wang ,  Wei Wu

Inventor： Michael J. Stuke ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan (Sy) Wang ,  Wei Wu

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: A surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a plurality of nanorods configured to vibrate. The apparatus includes the nanorods having tips at free ends opposite an end attached to a substrate. The tips are configured to adsorb an analyte and to vibrate at a vibration frequency. The apparatus further includes a vibration source configured to vibrate the free ends of the nanorods at the vibration frequency in a back-and-forth motion. Vibration of the nanorods is configured to facilitate detection of a Raman scattering signal emitted by the analyte adsorbed on the nanorod tips. The system further includes a synchronous detector configured to receive the Raman signal and to be gated cooperatively with the vibration of the nanorods. The method includes inducing a vibration of the nanorods, illuminating the vibrating tips to produce a Raman signal, and detecting the Raman signal using the detector.

Abstract translation: 表面增强拉曼光谱（SERS）装置，系统和方法采用配置成振动的多个纳米棒。 该装置包括纳米棒，其具有与连接到基底的端部相对的自由端处的尖端。 尖端被配置为吸附分析物并以振动频率振动。 该装置还包括一个振动源，其构造成以往复运动的振动频率使纳米棒的自由端振动。 纳米棒的振动被配置为便于检测由吸附在纳米棒尖端上的分析物发射的拉曼散射信号。 该系统还包括一个同步检测器，其被配置为接收拉曼信号并与纳米棒的振动协同地门控。 该方法包括诱导纳米棒的振动，照亮振动尖端以产生拉曼信号，以及使用检测器检测拉曼信号。