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公开(公告)号：US5741641A
公开(公告)日：1998-04-21
申请号：US451953
申请日：1995-05-26
申请人： John E. Smart , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
发明人： John E. Smart , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61K38/17 , A61K38/18 , A61L27/22 , A61L27/24 , C07K14/495 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/68 , G01N33/50 , G01N33/74 , G01N33/53
CPC分类号： G01N33/74 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/6881 , G01N33/5008 , G01N33/5023 , G01N33/5044 , A61F2310/00365 , C12Q2600/136 , C12Q2600/158 , G01N2333/495 , G01N2333/51 , G01N2500/02 , G01N2500/10 , G01N2510/00
摘要： Disclosed is a method of screening candidate compounds for the ability to modulate the level of morphogenic protein in mammalian system. The method includes determining a parameter indicative of the level of production of a morphogenic in a cell culture known to produce the morphogen, incubating a candidate compound with the culture for a time sufficient to allow the compound to affect the production of the morphogenic protein, and then assaying the culture again to detect a change in the level of morphogenic protein production.
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公开(公告)号：US5739107A
公开(公告)日：1998-04-14
申请号：US462623
申请日：1995-06-05
申请人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
发明人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61K38/17 , A61K38/18 , A61L27/22 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , G01N33/68
CPC分类号： G01N33/6872 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , A61F2310/00365 , G01N2500/10 , G01N2800/06
摘要： Disclosed are methods and compositions for maintaining the integrity of the gastrointestinal tract luminal lining in a mammal, including (1) limiting epithelial cell proliferation, (2) inhibiting ulcerative lesion formation, (3) inhibiting inflammation normally associated with ulcerative diseases, and (4) stimulating the repair of ulcerative lesions and the regeneration of the luminal tissue. The methods and compositions include a therapeutically effective amount of a morphogen as defined herein.
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公开(公告)号：US5182365A
公开(公告)日：1993-01-26
申请号：US621988
申请日：1990-12-04
IPC分类号： A61C8/00 , A61F2/00 , A61K9/00 , A61K38/00 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/36 , A61L27/56 , C07K14/51 , C12N15/18
CPC分类号： A61K9/0024 , A61C8/0006 , A61F2310/00365 , A61K38/00 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/56 , A61L2430/02 , C07K14/51 , Y10S530/84 , C08L89/06
摘要： Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.
摘要翻译： 公开的是1）包含含有成骨蛋白的基质的成骨装置和使用该装置在哺乳动物中诱导软骨内骨生长的方法; 2）氨基酸序列数据，氨基酸组成，溶解性，结构特征，同源性和各种其他数据表征成骨蛋白，3）使用重组DNA技术生产成骨蛋白的方法，以及4）成骨和软骨形成活性合成蛋白质构建体。
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公开(公告)号：US5011691A
公开(公告)日：1991-04-30
申请号：US315342
申请日：1989-02-23
CPC分类号： A61K9/0024 , A61L27/227 , A61L27/56 , C07K14/51 , A61C8/0006 , A61F2310/00365 , A61K38/00 , A61L2430/02 , Y10S530/84
摘要： Disclosed are (1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; (2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, (3) methods of producing osteogenic proteins using recombinant DNA technology, and (4) osteogenically and chondrogenically active synthetic protein constructs.
摘要翻译： 公开的是（1）包含含有成骨蛋白的基质的成骨装置和使用该装置在哺乳动物中诱导软骨内骨生长的方法; （2）氨基酸序列数据，氨基酸组成，溶解性，结构特征，同源性和各种其他数据表征成骨蛋白，（3）使用重组DNA技术生产成骨蛋白的方法，（4）成骨和软骨形成活性合成蛋白 结构体。
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公开(公告)号：US07078221B2
公开(公告)日：2006-07-18
申请号：US09754831
申请日：2001-01-03
CPC分类号： A61K9/0024 , A61C8/0006 , A61F2310/00365 , A61K38/00 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/56 , A61L2430/02 , C07K14/51 , Y10S530/84 , C08L89/06
摘要： Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.
摘要翻译： 公开的是1）包含含有成骨蛋白的基质的成骨装置和使用该装置在哺乳动物中诱导软骨内骨生长的方法; 2）氨基酸序列数据，氨基酸组成，溶解性，结构特征，同源性和各种其他数据表征成骨蛋白，3）使用重组DNA技术生产成骨蛋白的方法，以及4）成骨和软骨形成活性合成蛋白质构建体。
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公开(公告)号：US07060680B2
公开(公告)日：2006-06-13
申请号：US10050050
申请日：2002-01-15
申请人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
发明人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
CPC分类号： G01N33/6872 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , G01N2500/10 , G01N2800/06 , A61K2300/00
摘要： Disclosed are methods and compositions for maintaining the integrity of the gastrointestinal tract luminal lining in a mammal, including (1) limiting epithelial cell proliferation, (2) inhibiting ulcerative lesion formation, (3) inhibiting inflammation normally associated with ulcerative diseases, and (4) stimulating the repair of ulcerative lesions and the regeneration of the luminal tissue. The methods and compositions include a therapeutically effective amount of a morphogen as defined herein.
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公开(公告)号：US06551995B1
公开(公告)日：2003-04-22
申请号：US09148925
申请日：1998-09-04
申请人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang
发明人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang
IPC分类号： A61K3816
CPC分类号： A61K9/0024 , A61C8/0006 , A61F2310/00365 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/3604 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/3683 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2430/02 , C04B14/12 , C04B20/068 , C07K14/51 , Y10S530/84 , C08L89/06
摘要： Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.
摘要翻译： 公开的是（1）包含含有基本上纯天然来源的哺乳动物成骨蛋白质的基质的成骨装置; （2）可用作二聚成骨蛋白亚基的新型多肽链的DNA和氨基酸序列; （3）携带编码这些新型多肽链的序列的载体和用这些载体转染的宿主细胞; （4）使用重组DNA技术生产这些多肽链的方法; （5）对这些新型多肽链具有特异性的抗体; （6）包含这些重组产生的蛋白质与合适的载体基质相结合的成骨装置; 和（7）使用成骨装置来模拟哺乳动物软骨内骨形成的自然过程的方法。
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公开(公告)号：US06297213B1
公开(公告)日：2001-10-02
申请号：US09074299
申请日：1998-05-07
IPC分类号： A61K3818
CPC分类号： A61K9/0024 , A61C8/0006 , A61F2310/00365 , A61K38/00 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/3604 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/56 , A61L2430/02 , C07K14/51 , C08L89/06
摘要： Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.
摘要翻译： 公开的是1）包含含有成骨蛋白的基质的成骨装置和使用该装置在哺乳动物中诱导软骨内骨生长的方法; 2）氨基酸序列数据，氨基酸组成，溶解性，结构特征，同源性和各种其他数据表征成骨蛋白，3）使用重组DNA技术生产成骨蛋白的方法，以及4）成骨和软骨形成活性合成蛋白质构建体。
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公开(公告)号：US5994131A
公开(公告)日：1999-11-30
申请号：US912088
申请日：1997-08-15
申请人： John E. Smart , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
发明人： John E. Smart , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61K38/17 , A61K38/18 , A61L27/22 , A61L27/24 , C07K14/495 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/68 , G01N33/50 , G01N33/74 , C12N5/06 , C12N5/08
CPC分类号： G01N33/74 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/6881 , G01N33/5008 , G01N33/5023 , G01N33/5044 , A61F2310/00365 , C12Q2600/136 , C12Q2600/158 , G01N2333/495 , G01N2333/51 , G01N2500/02 , G01N2500/10 , G01N2510/00
摘要： Disclosed is a method of screening candidate compounds for the ability to modulate the level of morphogenic protein in mammalian system. The method includes determining a parameter indicative of the level of production of a morphogenic in a cell culture known to produce the morphogen, incubating a candidate compound with the culture for a time sufficient to allow the compound to affect the production of the morphogenic protein, and then assaying the culture again to detect a change in the level of morphogenic protein production.
摘要翻译： 公开了一种筛选候选化合物以调节哺乳动物系统中形态发生蛋白水平的能力的方法。 所述方法包括确定指示已知产生形态发生的细胞培养物中形态发生水平的参数的参数，将候选化合物与培养物孵育足以允许化合物影响形态发生蛋白质的产生的时间，以及 然后再次测定培养物以检测形态发生蛋白质生产水平的变化。
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公开(公告)号：US5652337A
公开(公告)日：1997-07-29
申请号：US479666
申请日：1995-06-07
申请人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
发明人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61L27/22 , A61L27/24 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/68 , C07K19/51
CPC分类号： C12Q1/6881 , A01N1/02 , A61L27/227 , A61L27/24 , C07K14/51 , C07K14/625 , C07K16/22 , A61F2310/00365 , A61K38/00 , C12Q2600/156 , C12Q2600/158 , G01N2500/10
摘要： Disclosed are (1) nucleic acid and amino acid sequences for a novel morphogenic protein; (2) methods for producing and expressing the protein in a biologically active form; and (3) methods for utilizing the protein to induce tissue morphogenesis in a mammal, including methods for increasing a progenitor cell population in a mammal, methods for stimulating progenitor cells to differentiate and maintain their differentiated phenotype in vivo or in vitro, methods for inducing tissue-specific growth in vivo and methods for the replacement of diseased or damaged tissue in vivo.
摘要翻译： 公开了（1）新型形态发生蛋白的核酸和氨基酸序列; （2）以生物活性形式生产和表达蛋白质的方法; 和（3）利用蛋白质诱导哺乳动物组织形态发生的方法，包括增加哺乳动物祖细胞群的方法，用于刺激祖细胞在体内或体外分化和维持其分化表型的方法，诱导方法 体内的组织特异性生长和体内替换患病或受损组织的方法。
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