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公开(公告)号：US07557078B1
公开(公告)日：2009-07-07
申请号：US08937756
申请日：1997-09-25
申请人： David C. Rueger , Thangavel Kuberasampath , Hermann Oppermann , Engin Ozkaynak , Roy H. L. Pang , Charles M. Cohen
发明人： David C. Rueger , Thangavel Kuberasampath , Hermann Oppermann , Engin Ozkaynak , Roy H. L. Pang , Charles M. Cohen
CPC分类号： C07K16/22 , A01N1/0226 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L2430/32 , C07K14/495 , C07K14/51 , G01N2500/10 , A61K2300/00
摘要： Disclosed are therapeutic treatment methods, compositions and devices for maintaining neural pathways in a mammal, including enhancing survival of neurons at risk of dying, inducing cellular repair of damaged neurons and neural pathways, and stimulating neurons to maintain their differentiated phenotype. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen or morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration.
摘要翻译： 公开了用于在哺乳动物中维持神经通路的治疗治疗方法，组合物和装置，包括增加有死亡风险的神经元的存活，诱导受损神经元和神经通路的细胞修复，以及刺激神经元维持其分化表型。 在一个实施方案中，本发明提供用于刺激神经元中的CAM表达的装置。 本发明还提供用于评估神经组织状态的手段，包括用于检测和监测哺乳动物神经病变的手段。 方法，装置和组合物包括以治疗有效浓度提供给哺乳动物的形态发生剂或形态发生剂。
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公开(公告)号：US06399569B1
公开(公告)日：2002-06-04
申请号：US08461113
申请日：1995-06-05
申请人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
发明人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
IPC分类号： A61K3818
CPC分类号： G01N33/6872 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , G01N2500/10 , G01N2800/06 , A61K2300/00
摘要： Disclosed are methods and compositions for maintaining the integrity of the gastrointestinal tract luminal lining in a mammal, including (1) limiting epithelial cell proliferation, (2) inhibiting ulcerative lesion formation, (3) inhibiting inflammation normally associated with ulcerative diseases, and (4) stimulating the repair of ulcerative lesions and the regeneration of the luminal tissue. The methods and compositions include a therapeutically effective amount of a morphogen as defined herein.
摘要翻译： 公开了用于维持哺乳动物胃肠道腔内衬的完整性的方法和组合物，包括（1）限制上皮细胞增殖，（2）抑制溃疡性病变形成，（3）抑制通常与溃疡性疾病相关的炎症，和（4 ）刺激溃疡性病变的修复和管腔组织的再生。 方法和组合物包括治疗有效量的如本文所定义的形态发生素。
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公开(公告)号：US06495513B1
公开(公告)日：2002-12-17
申请号：US08456033
申请日：1995-05-31
申请人： David C. Rueger , Thangavel Kuberasampath , Hermann Oppermann , Engin Ozkaynak , Roy H. L. Pang , Charles M. Cohen
发明人： David C. Rueger , Thangavel Kuberasampath , Hermann Oppermann , Engin Ozkaynak , Roy H. L. Pang , Charles M. Cohen
IPC分类号： A61K3800
CPC分类号： C07K16/22 , A01N1/0226 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L2430/32 , C07K14/495 , C07K14/51 , G01N2500/10 , A61K2300/00
摘要： Disclosed are therapeutic treatment methods, compositions and devices for maintaining neural pathways in a mammal, including enhancing survival of neurons at risk of dying, inducing cellular repair of damaged neurons and neural pathways, and stimulating neurons to maintain their differentiated phenotype. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen or morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration.
摘要翻译： 公开了用于在哺乳动物中维持神经通路的治疗治疗方法，组合物和装置，包括增加有死亡风险的神经元的存活，诱导受损神经元和神经通路的细胞修复，以及刺激神经元维持其分化表型。 在一个实施方案中，本发明提供用于刺激神经元中的CAM表达的装置。 本发明还提供用于评估神经组织状态的手段，包括用于检测和监测哺乳动物神经病变的手段。 方法，装置和组合物包括以治疗有效浓度提供给哺乳动物的形态发生剂或形态发生剂。
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公开(公告)号：US6153583A
公开(公告)日：2000-11-28
申请号：US219391
申请日：1998-12-23
申请人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
发明人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61L27/22 , A61L27/24 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/68 , A61K38/18
CPC分类号： C12Q1/6881 , A01N1/02 , A61L27/227 , A61L27/24 , C07K14/51 , C07K14/625 , C07K16/22 , A61F2310/00365 , A61K38/00 , C12Q2600/156 , C12Q2600/158 , G01N2500/10
摘要： Disclosed are (1) nucleic acid and amino acid sequences for a novel morphogenic protein; (2) methods for producing and expressing the protein in a biologically active form; and (3) methods for utilizing the protein to induce tissue morphogenesis in a mammal, including methods for increasing a progenitor cell population in a mammal, methods for stimulating progenitor cells to differentiate and maintain their differentiated phenotype in vivo or in vitro, methods for inducing tissue-specific growth in vivo and methods for the replacement of diseased or damaged tissue in vivo.
摘要翻译： 公开了（1）新型形态发生蛋白的核酸和氨基酸序列; （2）以生物活性形式生产和表达蛋白质的方法; 和（3）利用蛋白质诱导哺乳动物组织形态发生的方法，包括增加哺乳动物祖细胞群的方法，用于刺激祖细胞在体内或体外分化和维持其分化表型的方法，诱导方法 体内的组织特异性生长和体内替换患病或受损组织的方法。
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公开(公告)号：US5741641A
公开(公告)日：1998-04-21
申请号：US451953
申请日：1995-05-26
申请人： John E. Smart , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
发明人： John E. Smart , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61K38/17 , A61K38/18 , A61L27/22 , A61L27/24 , C07K14/495 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/68 , G01N33/50 , G01N33/74 , G01N33/53
CPC分类号： G01N33/74 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/6881 , G01N33/5008 , G01N33/5023 , G01N33/5044 , A61F2310/00365 , C12Q2600/136 , C12Q2600/158 , G01N2333/495 , G01N2333/51 , G01N2500/02 , G01N2500/10 , G01N2510/00
摘要： Disclosed is a method of screening candidate compounds for the ability to modulate the level of morphogenic protein in mammalian system. The method includes determining a parameter indicative of the level of production of a morphogenic in a cell culture known to produce the morphogen, incubating a candidate compound with the culture for a time sufficient to allow the compound to affect the production of the morphogenic protein, and then assaying the culture again to detect a change in the level of morphogenic protein production.
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公开(公告)号：US5739107A
公开(公告)日：1998-04-14
申请号：US462623
申请日：1995-06-05
申请人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
发明人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61K38/17 , A61K38/18 , A61L27/22 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , G01N33/68
CPC分类号： G01N33/6872 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , A61F2310/00365 , G01N2500/10 , G01N2800/06
摘要： Disclosed are methods and compositions for maintaining the integrity of the gastrointestinal tract luminal lining in a mammal, including (1) limiting epithelial cell proliferation, (2) inhibiting ulcerative lesion formation, (3) inhibiting inflammation normally associated with ulcerative diseases, and (4) stimulating the repair of ulcerative lesions and the regeneration of the luminal tissue. The methods and compositions include a therapeutically effective amount of a morphogen as defined herein.
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公开(公告)号：US07060680B2
公开(公告)日：2006-06-13
申请号：US10050050
申请日：2002-01-15
申请人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
发明人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
CPC分类号： G01N33/6872 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , G01N2500/10 , G01N2800/06 , A61K2300/00
摘要： Disclosed are methods and compositions for maintaining the integrity of the gastrointestinal tract luminal lining in a mammal, including (1) limiting epithelial cell proliferation, (2) inhibiting ulcerative lesion formation, (3) inhibiting inflammation normally associated with ulcerative diseases, and (4) stimulating the repair of ulcerative lesions and the regeneration of the luminal tissue. The methods and compositions include a therapeutically effective amount of a morphogen as defined herein.
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公开(公告)号：US5994131A
公开(公告)日：1999-11-30
申请号：US912088
申请日：1997-08-15
申请人： John E. Smart , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
发明人： John E. Smart , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61K38/17 , A61K38/18 , A61L27/22 , A61L27/24 , C07K14/495 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/68 , G01N33/50 , G01N33/74 , C12N5/06 , C12N5/08
CPC分类号： G01N33/74 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/6881 , G01N33/5008 , G01N33/5023 , G01N33/5044 , A61F2310/00365 , C12Q2600/136 , C12Q2600/158 , G01N2333/495 , G01N2333/51 , G01N2500/02 , G01N2500/10 , G01N2510/00
摘要： Disclosed is a method of screening candidate compounds for the ability to modulate the level of morphogenic protein in mammalian system. The method includes determining a parameter indicative of the level of production of a morphogenic in a cell culture known to produce the morphogen, incubating a candidate compound with the culture for a time sufficient to allow the compound to affect the production of the morphogenic protein, and then assaying the culture again to detect a change in the level of morphogenic protein production.
摘要翻译： 公开了一种筛选候选化合物以调节哺乳动物系统中形态发生蛋白水平的能力的方法。 所述方法包括确定指示已知产生形态发生的细胞培养物中形态发生水平的参数的参数，将候选化合物与培养物孵育足以允许化合物影响形态发生蛋白质的产生的时间，以及 然后再次测定培养物以检测形态发生蛋白质生产水平的变化。
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公开(公告)号：US5652337A
公开(公告)日：1997-07-29
申请号：US479666
申请日：1995-06-07
申请人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
发明人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61L27/22 , A61L27/24 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/68 , C07K19/51
CPC分类号： C12Q1/6881 , A01N1/02 , A61L27/227 , A61L27/24 , C07K14/51 , C07K14/625 , C07K16/22 , A61F2310/00365 , A61K38/00 , C12Q2600/156 , C12Q2600/158 , G01N2500/10
摘要： Disclosed are (1) nucleic acid and amino acid sequences for a novel morphogenic protein; (2) methods for producing and expressing the protein in a biologically active form; and (3) methods for utilizing the protein to induce tissue morphogenesis in a mammal, including methods for increasing a progenitor cell population in a mammal, methods for stimulating progenitor cells to differentiate and maintain their differentiated phenotype in vivo or in vitro, methods for inducing tissue-specific growth in vivo and methods for the replacement of diseased or damaged tissue in vivo.
摘要翻译： 公开了（1）新型形态发生蛋白的核酸和氨基酸序列; （2）以生物活性形式生产和表达蛋白质的方法; 和（3）利用蛋白质诱导哺乳动物组织形态发生的方法，包括增加哺乳动物祖细胞群的方法，用于刺激祖细胞在体内或体外分化和维持其分化表型的方法，诱导方法 体内的组织特异性生长和体内替换患病或受损组织的方法。
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公开(公告)号：US5854071A
公开(公告)日：1998-12-29
申请号：US901200
申请日：1997-07-28
申请人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
发明人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang , Charles M. Cohen
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61L27/22 , A61L27/24 , C07K14/51 , C07K14/625 , C07K16/22 , C12Q1/68 , C12N5/06 , C07K14/00 , C12N5/08
CPC分类号： C12Q1/6881 , A01N1/02 , A61L27/227 , A61L27/24 , C07K14/51 , C07K14/625 , C07K16/22 , A61F2310/00365 , A61K38/00 , C12Q2600/156 , C12Q2600/158 , G01N2500/10
摘要： Disclosed are (1) nucleic acid and amino acid sequences for a novel morphogenic protein; (2) methods for producing and expressing the protein in a biologically active form; and (3) methods for utilizing the protein to induce tissue morphogenesis in a mammal, including methods for increasing a progenitor cell population in a mammal, methods for stimulating progenitor cells to differentiate and maintain their differentiated phenotype in vivo or in vitro, methods for inducing tissue-specific growth in vivo and methods for the replacement of diseased or damaged tissue in vivo.
摘要翻译： 公开了（1）新型形态发生蛋白的核酸和氨基酸序列; （2）以生物活性形式生产和表达蛋白质的方法; 和（3）利用蛋白质诱导哺乳动物组织形态发生的方法，包括增加哺乳动物祖细胞群的方法，用于刺激祖细胞在体内或体外分化和维持其分化表型的方法，诱导方法 体内的组织特异性生长和体内替换患病或受损组织的方法。
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