公开(公告)号：US20230374075A1

公开(公告)日：2023-11-23

申请号：US18319343

申请日：2023-05-17

Applicant: University of Washington

Inventor： David Baker ,  Ryanne Ballard ,  Asim Bera ,  Christine Kang ,  Alex Kang ,  Xinting Li ,  Hannah Nguyen ,  Meerit Said ,  Patrick Salveson ,  William H. Sheffler ,  Shunzhi Wang

IPC: C07K7/64 ,  C07K17/14 ,  B01J31/16

CPC classification number: C07K7/64 ,  C07K17/14 ,  B01J31/1691

Abstract: Cyclic peptides including the amino acid sequence selected from SEQ ID NO:1-6, multimers thereof, and metal organic frameworks including the cyclic peptides or multimers thereof are provided.

公开(公告)号：US20230313167A1

公开(公告)日：2023-10-05

申请号：US18174041

申请日：2023-02-24

Applicant: University of Washington ,  University of Utah Research Foundation

Inventor： Neil King ,  Wesley Sundquist ,  Joerg Votteler ,  Yang Hsia ,  David Baker ,  Jacob Bale ,  Marc Lajoie ,  Gabriel Butterfield ,  Elizabeth Gray ,  Daniel Stetson

IPC: C12N9/88 ,  C07K14/00 ,  C07K14/435

CPC classification number: C12N9/88 ,  C07K14/00 ,  C07K14/435 ,  C12Y401/02014 ,  C07K2319/03 ,  C07K2319/06 ,  C07K2319/735

Abstract: The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface (“O interface”); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex (“L domain”); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.

公开(公告)号：US20230114825A1

公开(公告)日：2023-04-13

申请号：US17938752

申请日：2022-10-07

Applicant: University of Washington

Inventor： David Baker ,  Derrick Hicks

IPC: C07K14/47 ,  C12N15/63

Abstract: Polypeptides including an amino acid sequence at least 50% identical to the amino acid sequence selected from the group consisting of SEQ ID NOS: 1-3297 are provided, which are capable of forming protein homodimers containing tunable symmetric pockets.

公开(公告)号：US11439664B2

公开(公告)日：2022-09-13

申请号：US16289274

申请日：2019-02-28

Applicant: The Board of Trustees of the Leland Stanford Junior University ,  UNIVERSITY OF WASHINGTON

Inventor： Kenan Christopher Garcia ,  Jonathan Sockolosky ,  David Baker ,  Chris King

IPC: A61K38/17 ,  A61K38/20 ,  C07K14/55 ,  C12N5/0783 ,  C12N15/10 ,  A61K35/17 ,  A61K39/00

Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.

公开(公告)号：US20220056095A1

公开(公告)日：2022-02-24

申请号：US17473731

申请日：2021-09-13

Applicant: UNIVERSITY OF WASHINGTON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Daniel Adriano Silva Manzano ,  Shawn Yu ,  David Baker ,  Kenan Christopher Garcia ,  Jamie Spangler ,  Alfredo Quijano Rubio

IPC: C07K14/55 ,  C07K14/54 ,  A61K47/62 ,  A61K47/60

Abstract: De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγcheterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.

公开(公告)号：US11142577B2

公开(公告)日：2021-10-12

申请号：US15508779

申请日：2015-09-11

Applicant: The Board of Trustees of the Leland Stanford Junior University ,  University of Washington

Inventor： Kenan Christopher Garcia ,  David Baker ,  Claudia Yvonne Janda ,  Luke Dang ,  James Daniel Moody

IPC: C07K16/28 ,  C07K16/30

Abstract: Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety.

公开(公告)号：US11136573B2

公开(公告)日：2021-10-05

申请号：US17091847

申请日：2020-11-06

Applicant: University of Washington

Inventor： David Baker ,  David Younger ,  Eric Klavins

IPC: C12N15/81 ,  C12N15/10

Abstract: The present invention relates to methods and compositions for the high throughput screening of protein-protein interactions in yeast liquid culture. Protein fusions non-native to yeast may be expressed to replace endogenous sexual agglutination proteins and mediate library-by-library interrogation of protein interactions. The methods and compositions of the invention can be utilized for the characterization of protein interaction networks in high throughput for both binding affinity and specificity, which is crucial for understanding cellular functions, screening therapeutic candidates, and evaluating engineered protein networks.

公开(公告)号：US20210183465A1

公开(公告)日：2021-06-17

申请号：US17028377

申请日：2020-09-22

Applicant: University of Washington

Inventor： David Baker ,  Jorge Fallas ,  George Ueda ,  William H. Sheffler ,  Vanessa Nguyen

IPC: G16B5/00 ,  A61K38/03 ,  C07K14/00 ,  G16B15/30

Abstract: Described herein are polypeptides capable of self-assembling to form homo-oligomers, and methods for designing such polypeptides.

公开(公告)号：US11008558B2

公开(公告)日：2021-05-18

申请号：US16693057

申请日：2019-11-22

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Justin Bloomfield Siegel ,  David Baker ,  Ingrid Swanson Pultz

IPC: C12N9/52 ,  C12N9/64 ,  A61K38/00 ,  A61P43/00 ,  A61P37/06 ,  A61P37/02 ,  A61P29/00 ,  A61P1/04

Abstract: The invention provides compositions and methods for treating celiac sprue.

公开(公告)号：US10988514B2

公开(公告)日：2021-04-27

申请号：US16088686

申请日：2017-03-31

Applicant: UNIVERSITY OF WASHINGTON

Inventor： David Baker ,  Scott Boyken ,  Zibo Chen ,  Chunfu Xu ,  Sherry Bermeo ,  Robert Langan

IPC: C07K14/00 ,  C07K14/435 ,  C07K1/113 ,  G16B15/20 ,  C07K2/00 ,  C07K16/18

Abstract: Methods and apparatus for identifying and screening hydrogen bond networks are provided. A computing device can determine a search space for hydrogen bond networks related to one or more molecules, where the search space can include a plurality of energy terms related to a plurality of residues related to the hydrogen bond networks. The computing device can search the search space to identify one or more hydrogen bond networks based on the plurality of energy terms. The computing device can screen the identified hydrogen bond networks to identity one or more screened hydrogen bond networks based on scores for the identified hydrogen bond networks. An output can be generated that is related to the one or more screened hydrogen bond networks. Also provided are polypeptides that can form homo-oligomers with modular hydrogen bond network-mediated specificity.